{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T10:52:30Z","timestamp":1773053550528,"version":"3.50.1"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-41578-0","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T05:53:19Z","timestamp":1771998799000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictive role of vulnerable elderly study-13 screening tools in chemotherapy-related toxicity in elderly patients with lung cancer"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5896-2497","authenticated-orcid":false,"given":"Kaan","family":"Kara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5885-3047","authenticated-orcid":false,"given":"Eyyup","family":"Cavdar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"41578_CR1","first-page":"31","volume":"73","author":"RL Siegel","year":"2023","unstructured":"Siegel, R. L., Miller, K. D., Wagle, N. S. & Jemal, A. Cancer statistics, 2023. CA Cancer J. Clin. 73, 31\u201349 (2023).","journal-title":"CA Cancer J. Clin."},{"key":"41578_CR2","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.1200\/JCO.2013.54.8347","volume":"32","author":"H Wildiers","year":"2014","unstructured":"Wildiers, H. et al. International Society of Geriatric Oncology consensus on geriatric assessment in older patients with cancer. J. Clin. Oncol. 32, 2595\u20132603 (2014).","journal-title":"J. Clin. Oncol."},{"key":"41578_CR3","doi-asserted-by":"crossref","unstructured":"Hurria, A. et al. Designing therapeutic clinical trials for older and frail adults with cancer: U13 conference recommendations. J. Clin. Oncol. 32, 2587\u201394 (2014).","DOI":"10.1200\/JCO.2013.55.0418"},{"key":"41578_CR4","doi-asserted-by":"publisher","first-page":"2366","DOI":"10.1200\/JCO.2015.65.4327","volume":"34","author":"A Hurria","year":"2016","unstructured":"Hurria, A. et al. Validation of a prediction tool for chemotherapy toxicity in older adults with cancer. J. Clin. Oncol. 34, 2366\u201371 (2016).","journal-title":"J. Clin. Oncol."},{"key":"41578_CR5","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.jgo.2015.12.002","volume":"7","author":"GR Williams","year":"2016","unstructured":"Williams, G. R. et al. Comorbidity in older adults with cancer. J. Geriatr. Oncol. 7, 249\u201357 (2016).","journal-title":"J. Geriatr. Oncol."},{"key":"41578_CR6","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1200\/JCO.2014.55.3065","volume":"32","author":"A Naeim","year":"2014","unstructured":"Naeim, A., Aapro, M., Subbarao, R. & Balducci, L. Supportive care considerations for older adults with cancer. J. Clin. Oncol. 32, 2627\u20132634 (2014).","journal-title":"J. Clin. Oncol."},{"key":"41578_CR7","doi-asserted-by":"publisher","first-page":"3620","DOI":"10.1200\/JCO.2010.32.0796","volume":"29","author":"R Kanesvaran","year":"2011","unstructured":"Kanesvaran, R., Li, H., Koo, K. N. & Poon, D. Analysis of prognostic factors of comprehensive geriatric assessment and development of a clinical scoring system in elderly Asian patients with cancer. J. Clin. Oncol. 29, 3620\u20137 (2011).","journal-title":"J. Clin. Oncol."},{"key":"41578_CR8","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/j.jgo.2019.04.016","volume":"10","author":"IC Van Walree","year":"2019","unstructured":"Van Walree, I. C. et al. A systematic review on the association of the G8 with geriatric assessment, prognosis and course of treatment in older patients with cancer. J. Geriatr. Oncol. 10, 847\u201358 (2019).","journal-title":"J. Geriatr. Oncol."},{"key":"41578_CR9","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.jgo.2020.10.013","volume":"12","author":"WL Chan","year":"2021","unstructured":"Chan, W. L. et al. The predictive value of G8 and the Cancer and aging research group chemotherapy toxicity tool in treatment-related toxicity in older Chinese patients with cancer. J. Geriatr. Oncol. 12, 557\u201362 (2021).","journal-title":"J. Geriatr. Oncol."},{"key":"41578_CR10","doi-asserted-by":"publisher","first-page":"12","DOI":"10.6004\/jnccn.2020.0002","volume":"18","author":"PS Becker","year":"2020","unstructured":"Becker, P. S. et al. NCCN Guidelines Insights: Hematopoietic Growth Factors, Version 1. J. Natl. Compr. Canc Netw. 18, 12\u201322 (2020).","journal-title":"J. Natl. Compr. Canc Netw."},{"key":"41578_CR11","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ejca.2010.10.013","volume":"47","author":"MS Aapro","year":"2011","unstructured":"Aapro, M. S. et al. 2010 update of EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphoproliferative disorders and solid tumors. Eur. J. Cancer 47, 8\u201332 (2011).","journal-title":"Eur. J. Cancer"},{"key":"41578_CR12","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1046\/j.1532-5415.2001.49281.x","volume":"49","author":"D Saliba","year":"2001","unstructured":"Saliba, D. et al. The vulnerable elders survey: A tool for identifying vulnerable older people in the community. J. Am. Geriatr. Soc. 49, 1691\u20139 (2001).","journal-title":"J. Am. Geriatr. Soc."},{"key":"41578_CR13","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.jgo.2022.03.004","volume":"13","author":"E Cavdar","year":"2022","unstructured":"Cavdar, E., Iriagac, Y., Karaboyun, K., Avci, O. & Seber, E. S. Prospective comparison of the value of CARG, G8, and VES-13 toxicity tools in predicting chemotherapy-related toxicity in older Turkish patients with cancer. J. Geriatr. Oncol. 13, 821\u20137 (2022).","journal-title":"J. Geriatr. Oncol."},{"key":"41578_CR14","first-page":"4947","volume":"18","author":"J Zhang","year":"2019","unstructured":"Zhang, J., Liao, X., Feng, J., Yin, T. & Liang, Y. Prospective comparison of the value of CRASH and CARG toxicity scores in predicting chemotherapy toxicity in geriatric oncology. Oncol. Lett. 18, 4947\u20134955 (2019).","journal-title":"Oncol. Lett."},{"key":"41578_CR15","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1016\/j.jgo.2022.07.011","volume":"13","author":"M Kanazu","year":"2022","unstructured":"Kanazu, M. et al. Predicting systemic therapy toxicity in older adult patients with advanced non-small cell lung cancer: A prospective multicenter study of National Hospital Organization in Japan. J. Geriatr. Oncol. 13, 1216\u201322 (2022).","journal-title":"J. Geriatr. Oncol."},{"key":"41578_CR16","doi-asserted-by":"publisher","first-page":"14","DOI":"10.4103\/0973-1482.19767","volume":"2","author":"A Bahl","year":"2006","unstructured":"Bahl, A., Sharma, D. N., Julka, P. K. & Rath, G. K. Chemotherapy related toxicity in locally advanced non-small cell lung cancer. J. Cancer Res. Ther. 2, 14\u201316 (2006).","journal-title":"J. Cancer Res. Ther."},{"key":"41578_CR17","volume":"6","author":"S Pathak","year":"2023","unstructured":"Pathak, S. et al. Clinical outcomes of chemotherapy in cancer patients with different ethnicities. Cancer Rep. (Hoboken) 6, 1830 (2023).","journal-title":"Cancer Rep. (Hoboken)"},{"key":"41578_CR18","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s10549-004-0783-4","volume":"88","author":"VK Todorova","year":"2004","unstructured":"Todorova, V. K. et al. Effect of dietary glutamine on tumor glutathione levels and apoptosis-related proteins in DMBA-induced breast cancer of rats. Breast Cancer Res. Treat. 88, 247\u201356 (2004).","journal-title":"Breast Cancer Res. Treat."},{"key":"41578_CR19","doi-asserted-by":"publisher","first-page":"4397","DOI":"10.3390\/nu13124397","volume":"13","author":"PM Anderson","year":"2021","unstructured":"Anderson, P. M. et al. Strategies to mitigate chemotherapy and radiation toxicities that affect eating. Nutrients 13, 4397 (2021).","journal-title":"Nutrients"},{"key":"41578_CR20","first-page":"4299","volume":"67","author":"K Satish","year":"2007","unstructured":"Satish, K. et al. The use of the Vulnerable Elders Survey (VES-13) geriatric screening tool for selecting elderly patients for adjuvant chemotherapy. Cancer Res. 67, 4299 (2007).","journal-title":"Cancer Res."},{"key":"41578_CR21","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.jgo.2015.02.005","volume":"6","author":"A Luciani","year":"2015","unstructured":"Luciani, A. et al. Estimating the risk of chemotherapy toxicity in older patients with cancer: The role of the Vulnerable Elders Survey-13(VES-13). J. Geriatr. Oncol. 6, 272\u20139 (2015).","journal-title":"J. Geriatr. Oncol."},{"key":"41578_CR22","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012298","volume":"97","author":"A Ferrero","year":"2018","unstructured":"Ferrero, A., Villa, M., Tripodi, E., Fuso, L. & Menato, G. Can Vulnerable Elders Survey-13 predict the impact of frailty on chemotherapy in elderly patients with gynecological malignancies?. Medicine (Baltimore) 97, 12298 (2018).","journal-title":"Medicine (Baltimore)"},{"key":"41578_CR23","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.6004\/jnccn.2021.0043","volume":"19","author":"E Dotan","year":"2021","unstructured":"Dotan, E. et al. NCCN guidelines\u00ae insights: Older adult oncology, version 1.2021. J. Natl. Compr. Canc. Netw. 19, 1006\u201319 (2021).","journal-title":"J. Natl. Compr. Canc. Netw."},{"key":"41578_CR24","first-page":"363","volume":"25","author":"Lung Cancer Specialty Committee of Chinese Elderly Health Care Association","year":"2022","unstructured":"Lung Cancer Specialty Committee of Chinese Elderly Health Care Association, Lung Cancer Specialty Committee of Beijing Cancer Society. [Consensus of Chinese Experts on Medical Treatment of Advanced Lung Cancer in the Elderly (2022 Edition)]. Zhongguo Fei Ai Za Zhi 25, 363\u201384 (2022).","journal-title":"Zhongguo Fei Ai Za Zhi"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-41578-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-41578-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-41578-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T08:58:50Z","timestamp":1773046730000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-41578-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,25]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["41578"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-41578-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,25]]},"assertion":[{"value":"10 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The present study was performed in accordance with the principles of the Declaration of Helsinki. Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, University of Health Sciences Ethics Committee, granted formal approval for this study (approval no: 2022\u2013215 on 14.04.2022). Verbal informed consent was obtained from the patients who participated in the study in accordance with national guidelines, and the ethics committee decision is available.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"8379"}}