{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T08:08:41Z","timestamp":1779350921195,"version":"3.51.4"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":49,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071147"],"award-info":[{"award-number":["82071147"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-41804-9","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T13:34:04Z","timestamp":1775136844000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A low-magnitude high-frequency vibrator utilizing a specific amplitude and frequency for bone remodeling conducive to orthodontic tooth movement"],"prefix":"10.1038","volume":"16","author":[{"given":"Zhouqiang","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingsong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiyin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenli","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuepeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"issue":"1","key":"41804_CR1","doi-asserted-by":"publisher","first-page":"4716","DOI":"10.1038\/s41598-018-22900-x","volume":"8","author":"L Shen","year":"2018","unstructured":"Shen, L., He, F., Zhang, C., Jiang, H. & Wang, J. Prevalence of malocclusion in primary dentition in mainland China, 1988\u20132017: A systematic review and meta-analysis. Sci. Rep. 8 (1), 4716 (2018).","journal-title":"Sci. Rep."},{"issue":"5","key":"41804_CR2","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1093\/ejo\/cjad011","volume":"45","author":"HM Dawood","year":"2023","unstructured":"Dawood, H. M., Kroeger, A., Chavda, V. & Kebschull, I. L. C. C. M. Under pressure-mechanisms and risk factors for orthodontically induced inflammatory root resorption: A systematic review. Eur. J. Orthod. 45 (5), 612\u2013626 (2023).","journal-title":"Eur. J. Orthod."},{"issue":"2","key":"41804_CR3","doi-asserted-by":"publisher","first-page":"197","DOI":"10.17219\/dmp\/90989","volume":"55","author":"A KacprzakA","year":"2018","unstructured":"KacprzakA, A. & Strzecki, A. Methods of accelerating orthodontic tooth movement: A review of contemporary literature. Dent. Med. Probl. 55 (2), 197\u2013206 (2018).","journal-title":"Dent. Med. Probl."},{"key":"41804_CR4","doi-asserted-by":"publisher","first-page":"767136","DOI":"10.3389\/fphys.2021.767136","volume":"12","author":"Y Jiang","year":"2021","unstructured":"Jiang, Y. et al. Mechanosensitive Piezo1 in periodontal ligament cells promotes alveolar bone remodeling during orthodontic tooth movement. Front. Physiol. 12, 767136 (2021).","journal-title":"Front. Physiol."},{"key":"41804_CR5","doi-asserted-by":"crossref","unstructured":"Shen, Y. et al. The roles of mechanosensitive ion channels and associated downstream MAPK signaling pathways in PDLC mechanotransduction. Mol. Med. Rep. 21 (5), 2113\u20132122 (2020).","DOI":"10.3892\/mmr.2020.11006"},{"issue":"6","key":"41804_CR6","first-page":"628","volume":"38","author":"L. Wang","year":"2020","unstructured":"Wang, L. Mechanisms of the mechanically activated ion channel Piezo1 protein in mediating osteogenic differentiation of periodontal ligament stem cells via the Notch signaling pathway. West. China J. Stomatol. 38 (6), 628 (2020).","journal-title":"West. China J. Stomatology"},{"issue":"1","key":"41804_CR7","doi-asserted-by":"publisher","first-page":"4503","DOI":"10.1038\/s41467-019-12501-1","volume":"10","author":"M Wesley","year":"2019","unstructured":"Wesley, M. et al. LacroixYun Luo. A mechanism for the activation of the mechanosensitive Piezo1 channel by the small molecule Yoda1. Nat. Commun. 10 (1), 4503 (2019).","journal-title":"Nat. Commun."},{"issue":"1","key":"41804_CR8","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.bpj.2016.11.013","volume":"112","author":"C Radhakrishnan Gnanasambandam","year":"2017","unstructured":"Gnanasambandam, R. et al. GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels. Biophys. J. 112 (1), 31\u201345 (2017).","journal-title":"Biophys. J."},{"key":"41804_CR9","doi-asserted-by":"crossref","unstructured":"Huang, Z., Huang, Y., Ning, X., Li, H. & Li, J, Wu, Q. The functional effects of Piezo channels in mesenchymal stem cells. Stem Cell. Res. Ther. 14 (1), 222 (2023).","DOI":"10.1186\/s13287-023-03452-y"},{"issue":"4","key":"41804_CR10","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.jpor.2018.07.004","volume":"62","author":"T Shuhua Wang","year":"2018","unstructured":"Wang, S. et al. The effect of low-magnitude high-frequency loading on peri-implant bone healing and implant osseointegration in Beagle dogs. J. Prosthodontic Res. 62 (4), 497\u2013502 (2018).","journal-title":"J. Prosthodontic Res."},{"key":"41804_CR11","doi-asserted-by":"crossref","unstructured":"Lin, C. Y. et al. Yoda1 Enhanced low-magnitude high-frequency vibration on osteocytes in regulation of MDA-MB-231 breast cancer cell migration. Cancers (Basel) 14 (14) (2022).","DOI":"10.3390\/cancers14143395"},{"issue":"3","key":"41804_CR12","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1615\/JEnvironPatholToxicolOncol.2019030625","volume":"38","author":"W Zhao","year":"2019","unstructured":"Zhao, W., Tang, Y., Yang, Y. & WangH, M. Yu. Low-magnitude, high-frequency vibration promotes osteogenic differentiation via intensifying miRNA-335-5p expression. J. Environ. Pathol. Toxicol. Oncol. 38 (3), 271\u2013283 (2019).","journal-title":"J. Environ. Pathol. Toxicol. Oncol."},{"issue":"4","key":"41804_CR13","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1093\/ejo\/cjx062","volume":"40","author":"S Benjakul","year":"2018","unstructured":"Benjakul, S. & JitpukdeebodintraC, S. Leethanakul. Effects of low magnitude high frequency mechanical vibration combined with compressive force on human periodontal ligament cells in vitro. Eur. J. Orthod. 40 (4), 356\u2013363 (2018).","journal-title":"Eur. J. Orthod."},{"key":"41804_CR14","doi-asserted-by":"publisher","first-page":"104860","DOI":"10.1016\/j.archoralbio.2020.104860","volume":"118","author":"W Hou","year":"2020","unstructured":"Hou, W., Zhang, D. & FengY, X. Zhou. Low magnitude high frequency vibration promotes chondrogenic differentiation of bone marrow stem cells with involvement of beta-catenin signaling pathway. Arch. Oral Biol. 118, 104860 (2020).","journal-title":"Arch. Oral Biol."},{"key":"41804_CR15","doi-asserted-by":"crossref","unstructured":"Shibamoto, A., Ogawa, T., Duyck, J., Vandamme, K. & NaertK, I. Sasaki. Effect of high-frequency loading and parathyroid hormone administration on peri-implant bone healing and osseointegration. Int. J. Oral Sci. 10 (1), 6 (2018).","DOI":"10.1038\/s41368-018-0009-y"},{"issue":"4","key":"41804_CR16","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1615\/CritRevEukarGeneExpr.v19.i4.50","volume":"19","author":"AG RoblingC","year":"2009","unstructured":"RoblingC., A. G. & Turner, H. Mechanical signaling for bone modeling and remodeling. Crit. Rev. Eukaryot. Gene Expr. 19 (4), 319\u2013338 (2009).","journal-title":"Crit. Rev. Eukaryot. Gene Expr"},{"issue":"1","key":"41804_CR17","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1186\/s12951-024-02669-0","volume":"22","author":"X He","year":"2024","unstructured":"He, X. et al. Hu. Yoda1 pretreated BMSC derived exosomes accelerate osteogenesis by activating phospho-ErK signaling via Yoda1-mediated signal transmission. J. Nanobiotechnol. 22 (1), 407 (2024).","journal-title":"J. Nanobiotechnol."},{"key":"41804_CR18","doi-asserted-by":"crossref","unstructured":"Karsten, J. & Hellsing, E. Effect of phenytoin on periodontal tissues exposed to orthodontic force\u2013an experimental study in rats. Br. J. Orthod. 24 (3), 209\u2013215 (2014).","DOI":"10.1093\/ortho\/24.3.209"},{"key":"41804_CR19","doi-asserted-by":"crossref","unstructured":"Andressa, V. B. et al. Experimental models of orthodontic tooth movement and their effects on periodontal tissues remodelling. Arch. Oral Biol. 130, 105216 (2021).","DOI":"10.1016\/j.archoralbio.2021.105216"},{"key":"41804_CR20","doi-asserted-by":"crossref","unstructured":"Shen, X. et al. A regulatory role of Piezo1 in apoptosis of periodontal tissue and periodontal ligament fibroblasts during orthodontic tooth movement. Aust. Endodontic J. 49 (S1), 228\u2013237 (2023).","DOI":"10.1111\/aej.12721"},{"key":"41804_CR21","doi-asserted-by":"crossref","unstructured":"Yang, Y. et al. Cyclic Stretch enhances osteogenic differentiation of human periodontal ligament cells via YAP activation. BioMed Res. Int. 2018, 1\u201312 (2018).","DOI":"10.1155\/2018\/2174824"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-41804-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-41804-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-41804-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T07:29:01Z","timestamp":1779348541000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-41804-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,2]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["41804"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-41804-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,2]]},"assertion":[{"value":"12 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"15775"}}