{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T20:59:24Z","timestamp":1781643564142,"version":"3.54.5"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002352","name":"Ain Shams University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002352","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cat allergy is a common cause of respiratory allergic diseases, such as asthma and allergic rhinitis. Secretoglobin Felis domesticus 1 (Fel d 1) is the major cat allergen, widely distributed in the environment and difficult to avoid. Measuring Fel d 1-specific Immunoglobulin E (sIgE) provides an important diagnostic approach for evaluating sensitisation and disease severity. The present study assessed the diagnostic value of allergen-specific IgE to secretoglobin Fel d 1 in Egyptian adult patients with respiratory allergy sensitised to cats. This cross-sectional study included 35 patients with clinical diagnoses of asthma and\/or allergic rhinitis, all positive for cat dander by skin prick test (SPT). Complete blood count, total IgE, and serum Fel d 1-sIgE (measured using ImmunoCAP) were performed. Of the 35 patients, 40% tested positive for Fel d 1-sIgE. Positive Fel d1 -sIgE was significantly associated with older age, history of cat exposure, and family history of allergy (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Patients with positive Fel d 1-sIgE levels showed significantly higher total IgE, leukocyte, and eosinophil counts. Fel d 1-sIgE levels were positively correlated with asthma and allergic rhinitis severity. ImmunoCAP Fel d 1-sIgE testing accurately differentiates true cat allergy from cross-sensitization. This study represents one of the first regional data utilizing this method in an Egyptian cohort, enhancing diagnostic precision, assessing disease severity, and supporting personalized treatment strategies.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-42206-7","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T15:38:54Z","timestamp":1774366734000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Secretoglobin Felis Domesticus 1 (Fel d 1) specific immunoglobulin E in diagnosis of patients with respiratory allergy to cats"],"prefix":"10.1038","volume":"16","author":[{"given":"Nermine Yehia Moawad","family":"Alshenawy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal Zaghloul","family":"Mahran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa Rushdy","family":"ElNajjar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai Asem Ali","family":"AlBdry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab Ahmed","family":"Ashour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6790-8203","authenticated-orcid":false,"given":"Lamyaa","family":"Salem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"issue":"1","key":"42206_CR1","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13601-017-0180-9","volume":"7","author":"A Bro\u017cek","year":"2017","unstructured":"Bro\u017cek, A., Ko\u0142odziejczyk, K., Koz\u0142owska, R. & Canonica, G. W. Evidence of the efficacy and safety of house dust mite subcutaneous immunotherapy in elderly allergic rhinitis patients: a randomized, double-blind placebo-controlled trial. Clin. Transl Allergy. 7 (1), 43 (2017).","journal-title":"Clin. Transl Allergy"},{"issue":"1","key":"42206_CR2","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s13223-020-00436-y","volume":"16","author":"L Hossenbaccus","year":"2020","unstructured":"Hossenbaccus, L., Linton, S., Garvey, S. & Ellis, A. K. Towards definitive management of allergic rhinitis: best use of new and established therapies. Allergy Asthma Clin. Immunol. 16 (1), 39 (2020).","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"42206_CR3","unstructured":"Global Initiative for Asthma (GINA). Global Strategy for Asthma Management and Prevention, 2025. Updated May 2025. (2025). 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Keep the cat, change the care pathway: A transformational approach to managing Fel d 1, the major cat allergen. Allergy 74 (Suppl 107), 5\u201317 (2019).","journal-title":"Allergy"},{"issue":"4","key":"42206_CR7","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.3390\/ijms21041365","volume":"21","author":"C Bienboire-Frosini","year":"2020","unstructured":"Bienboire-Frosini, C., Durairaj, R., Pelosi, P. & Pageat, P. The major cat allergen Fel d 1 binds steroid and fatty acid semiochemicals: A combined in silico and in vitro study. Int. J. Mol. Sci. 21 (4), 1365 (2020).","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"42206_CR8","doi-asserted-by":"publisher","first-page":"46","DOI":"10.5662\/wjm.v11.i3.46","volume":"11","author":"FD Popescu","year":"2021","unstructured":"Popescu, F. D., Ganea, C. S., Panaitescu, C. & Vieru, M. Molecular diagnosis in cat allergy. World J. Methodol. 11 (3), 46\u201360 (2021).","journal-title":"World J. 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Proof-of-concept study of anti-Fel d 1 IgY antibodies in cat food using the MASK-air\u00ae app. Clin. translational allergy, 14(5), e12353. (2024).","DOI":"10.1002\/clt2.12353"},{"key":"42206_CR32","doi-asserted-by":"publisher","first-page":"1355390","DOI":"10.3389\/fvets.2024.1355390","volume":"11","author":"ED Hedrick","year":"2024","unstructured":"Hedrick, E. D., Matulka, R. A., Conboy-Schmidt, L. & May, K. A. Evaluation of anti-Fel d 1 IgY ingredient for pet food on growth performance in kittens. Front. veterinary Sci. 11, 1355390 (2024).","journal-title":"Front. veterinary Sci."},{"issue":"1","key":"42206_CR33","doi-asserted-by":"publisher","first-page":"142","DOI":"10.9734\/aji\/2025\/v8i1168","volume":"8","author":"CE Olivier","year":"2025","unstructured":"Olivier, C. E. et al. Endotyping Cellular and Humoral Cross-reactivity among Canine, Feline, and Swine Allergens in Patients with Allergic Multimorbidity. Asian J. Immunol. 8 (1), 142\u2013162 (2025).","journal-title":"Asian J. 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