{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:50:40Z","timestamp":1792785040318,"version":"4.5.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:00:00Z","timestamp":1775260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":52,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Gansu Province Joint Research Fund","award":["24JRRA949"],"award-info":[{"award-number":["24JRRA949"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-42308-2","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:38:04Z","timestamp":1775281084000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between periodontitis and non-alcoholic fatty liver disease in community-dwelling adults: a systematic review and meta-analysis"],"prefix":"10.1038","volume":"16","author":[{"given":"Hanyi","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxuan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruomeng","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,4]]},"reference":[{"issue":"3","key":"42308_CR1","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1007\/s10266-024-01032-x","volume":"113","author":"K Renu","year":"2025","unstructured":"Renu, K., Gopalakrishnan, A. V. & Madhyastha, H. Is periodontitis triggering an inflammatory response in the liver, and does this reaction entail oxidative stress? Odontology 113 (3), 889\u2013902 (2025).","journal-title":"Odontology"},{"issue":"3","key":"42308_CR2","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/jcpe.13189","volume":"47","author":"M Sanz","year":"2020","unstructured":"Sanz, M. et al. Periodontitis and cardiovascular diseases: Consensus report. J. Clin. Periodontol. 47 (3), 268\u2013288 (2020).","journal-title":"J. Clin. Periodontol"},{"issue":"1","key":"42308_CR3","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/prd.12270","volume":"83","author":"RJ Genco","year":"2020","unstructured":"Genco, R. J. & Borgnakke, W. S. Diabetes as a potential risk for periodontitis: association studies. Periodontol 2000. 83 (1), 40\u201345 (2020).","journal-title":"Periodontol 2000"},{"issue":"Suppl 20","key":"42308_CR4","first-page":"S162","volume":"45","author":"PN Papapanou","year":"2018","unstructured":"Papapanou, P. N. et al. Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J. Clin. Periodontol. 45 (Suppl 20), S162\u2013S170 (2018).","journal-title":"J. Clin. Periodontol"},{"issue":"3","key":"42308_CR5","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41368-019-0064-z","volume":"11","author":"W Pan","year":"2019","unstructured":"Pan, W., Wang, Q. & Chen, Q. The cytokine network involved in the host immune response to periodontitis. Int. J. Oral Sci. 11 (3), 30 (2019).","journal-title":"Int. J. Oral Sci."},{"issue":"4\u20136","key":"42308_CR6","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s44445-025-00024-z","volume":"37","author":"AI Al Kharusi","year":"2025","unstructured":"Al Kharusi, A. I. & Al Harthi, L. Assessment of periodontitis as a predictive sign of occurrence of type-II diabetes mellitus. Saudi Dent. J. 37 (4\u20136), 11 (2025).","journal-title":"Saudi Dent. J."},{"key":"42308_CR7","doi-asserted-by":"publisher","first-page":"111770","DOI":"10.1016\/j.cellsig.2025.111770","volume":"132","author":"Y Lai","year":"2025","unstructured":"Lai, Y. et al. An update on the role and mechanisms of periodontitis in cardiovascular diseases. Cell. Signal. 132, 111770 (2025).","journal-title":"Cell. Signal."},{"key":"42308_CR8","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.jdsr.2023.10.004","volume":"59","author":"P Lin","year":"2023","unstructured":"Lin, P. et al. Association between periodontal disease and chronic obstructive pulmonary disease. Jpn Dent. Sci. Rev. 59, 389\u2013402 (2023).","journal-title":"Jpn Dent. Sci. Rev."},{"issue":"12","key":"42308_CR9","doi-asserted-by":"publisher","first-page":"2650","DOI":"10.1016\/j.cgh.2019.07.060","volume":"18","author":"AM Moon","year":"2020","unstructured":"Moon, A. M., Singal, A. G. & Tapper, E. B. Contemporary Epidemiology of Chronic Liver Disease and Cirrhosis. Clin. Gastroenterol. Hepatol. 18 (12), 2650\u20132666 (2020).","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"2","key":"42308_CR10","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3748\/wjg.v26.i2.109","volume":"26","author":"S Tanwar","year":"2020","unstructured":"Tanwar, S., Rhodes, F., Srivastava, A., Trembling, P. M. & Rosenberg, W. M. Inflammation and fibrosis in chronic liver diseases including non-alcoholic fatty liver disease and hepatitis C. World J. Gastroenterol. 26 (2), 109\u2013133 (2020).","journal-title":"World J. Gastroenterol."},{"issue":"10127","key":"42308_CR11","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/S0140-6736(18)30010-2","volume":"391","author":"A Forner","year":"2018","unstructured":"Forner, A., Reig, M. & Bruix, J. Hepatocellular carcinoma. Lancet 391 (10127), 1301\u20131314 (2018).","journal-title":"Lancet"},{"issue":"9615","key":"42308_CR12","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/S0140-6736(08)60383-9","volume":"371","author":"D Schuppan","year":"2008","unstructured":"Schuppan, D. & Afdhal, N. H. Liver cirrhosis. Lancet 371 (9615), 838\u2013851 (2008).","journal-title":"Lancet"},{"issue":"12","key":"42308_CR13","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1016\/j.cgh.2015.08.015","volume":"13","author":"P Udompap","year":"2015","unstructured":"Udompap, P., Kim, D. & Kim, W. R. Current and Future Burden of Chronic Nonmalignant Liver Disease. Clin. Gastroenterol. Hepatol. 13 (12), 2031\u20132041 (2015).","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"Suppl","key":"42308_CR14","doi-asserted-by":"publisher","first-page":"S32","DOI":"10.3350\/cmh.2022.0365","volume":"29","author":"ML Teng","year":"2023","unstructured":"Teng, M. L. et al. Global incidence and prevalence of nonalcoholic fatty liver disease. Clin. Mol. Hepatol. 29 (Suppl), S32\u2013S42 (2023).","journal-title":"Clin. Mol. Hepatol."},{"issue":"1","key":"42308_CR15","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jhep.2020.03.039","volume":"73","author":"M Eslam","year":"2020","unstructured":"Eslam, M. et al. A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement. J. Hepatol. 73 (1), 202\u2013209 (2020).","journal-title":"J. Hepatol."},{"issue":"6","key":"42308_CR16","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/nrgastro.2013.41","volume":"10","author":"QM Anstee","year":"2013","unstructured":"Anstee, Q. M., Targher, G. & Day, C. P. Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis. Nat. Rev. Gastroenterol. Hepatol. 10 (6), 330\u2013344 (2013).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"42308_CR17","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/prd.12427","volume":"89","author":"E Albuquerque-Souza","year":"2022","unstructured":"Albuquerque-Souza, E. & Sahingur, S. E. Periodontitis, chronic liver diseases, and the emerging oral-gut-liver axis. Periodontology 2000. 89 (1), 125\u2013141 (2022).","journal-title":"Periodontology 2000"},{"issue":"3","key":"42308_CR18","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.jhep.2019.10.003","volume":"72","author":"A Albillos","year":"2020","unstructured":"Albillos, A., de Gottardi, A. & Rescigno, M. The gut-liver axis in liver disease: Pathophysiological basis for therapy. J. Hepatol. 72 (3), 558\u2013577 (2020).","journal-title":"J. Hepatol."},{"issue":"6","key":"42308_CR19","doi-asserted-by":"publisher","first-page":"967","DOI":"10.3748\/wjg.v29.i6.967","volume":"29","author":"R Kuraji","year":"2023","unstructured":"Kuraji, R., Shiba, T., Dong, T. S., Numabe, Y. & Kapila, Y. L. Periodontal treatment and microbiome-targeted therapy in management of periodontitis-related nonalcoholic fatty liver disease with oral and gut dysbiosis. World J. Gastroenterol. 29 (6), 967\u2013996 (2023).","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"42308_CR20","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1034\/j.1600-0765.2001.00011.x","volume":"36","author":"PP Hujoel","year":"2001","unstructured":"Hujoel, P. P., White, B. A., Garc\u00eda, R. I. & Listgarten, M. A. The dentogingival epithelial surface area revisited. J. Periodontal Res. 36 (1), 48\u201355 (2001).","journal-title":"J. Periodontal Res."},{"issue":"5","key":"42308_CR21","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1111\/jcpe.12396","volume":"42","author":"TED Gon\u00e7alves","year":"2015","unstructured":"Gon\u00e7alves, T. E. D. et al. Local and serum levels of adipokines in patients with obesity after periodontal therapy: one-year follow-up. J. Clin. Periodontol. 42 (5), 431\u2013439 (2015).","journal-title":"J. Clin. Periodontol"},{"issue":"2","key":"42308_CR22","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1002\/hep.26093","volume":"57","author":"L Zhu","year":"2013","unstructured":"Zhu, L. et al. Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH. Hepatology 57 (2), 601\u2013609 (2013).","journal-title":"Hepatology"},{"issue":"9","key":"42308_CR23","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","volume":"25","author":"A Stang","year":"2010","unstructured":"Stang, A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur. J. Epidemiol. 25 (9), 603\u2013605 (2010).","journal-title":"Eur. J. Epidemiol."},{"issue":"Suppl 1","key":"42308_CR24","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1093\/intqhc\/14.suppl_1.75","volume":"14","author":"TT Catsambas","year":"2002","unstructured":"Catsambas, T. T., Kelley, E., Legros, S., Massoud, R. & Bouchet, B. The evaluation of quality assurance: developing and testing practical methods for managers. Int. J. Qual. Health Care. 14 (Suppl 1), 75\u201381 (2002).","journal-title":"Int. J. Qual. Health Care"},{"key":"42308_CR25","doi-asserted-by":"crossref","unstructured":"Iwasaki, T. et al. Correlation between ultrasound-diagnosed non-alcoholic fatty liver and periodontal condition in a cross-sectional study in Japan. Scientific reports ;8. (2018).","DOI":"10.1038\/s41598-018-25857-z"},{"issue":"12","key":"42308_CR26","doi-asserted-by":"publisher","first-page":"e0185902","DOI":"10.1371\/journal.pone.0185902","volume":"12","author":"W Alazawi","year":"2017","unstructured":"Alazawi, W. et al. Periodontitis is associated with significant hepatic fibrosis in patients with non-alcoholic fatty liver disease. PloS one. 12 (12), e0185902 (2017).","journal-title":"PloS one"},{"issue":"11","key":"42308_CR27","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1177\/0022034519866442","volume":"98","author":"JA Weintraub","year":"2019","unstructured":"Weintraub, J. A., Lopez Mitnik, G. & Dye, B. A. Oral Diseases Associated with Nonalcoholic Fatty Liver Disease in the United States. J. Dent. Res. 98 (11), 1219\u20131226 (2019).","journal-title":"J. Dent. Res."},{"issue":"8","key":"42308_CR28","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1002\/JPER.17-0579","volume":"89","author":"AA Akinkugbe","year":"2018","unstructured":"Akinkugbe, A. A. et al. Periodontitis and prevalence of elevated aminotransferases in the Hispanic Community Health Study\/Study of Latinos. J. Periodontol. 89 (8), 949\u2013958 (2018).","journal-title":"J. Periodontol."},{"key":"42308_CR29","doi-asserted-by":"crossref","unstructured":"Wilensky, A. et al. Periodontitis and Metabolic Syndrome: Statistical and Machine Learning Analytics of a Nationwide Study. Bioengineering (Basel Switzerland). 10(12), 1384 (2023).","DOI":"10.3390\/bioengineering10121384"},{"key":"42308_CR30","doi-asserted-by":"crossref","unstructured":"Ram, D., Wilensky, A., Zur, D. & Almoznino, G. The Triangle of Nonalcoholic Fatty Liver Disease, Metabolic Dysfunction, and Periodontitis: Analysis of the Dental, Oral, Medical and Epidemiological (DOME) Records-Based Nationwide Research. Metabolites. 12(12), 1212 (2022).","DOI":"10.3390\/metabo12121212"},{"issue":"4","key":"42308_CR31","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1002\/JPER.19-0291","volume":"91","author":"H-S Shin","year":"2020","unstructured":"Shin, H-S. Association between periodontal status and non-alcoholic fatty liver disease in a Korean adult population: A nationwide cross-sectional study. J. Periodontol. 91 (4), 524\u2013532 (2020).","journal-title":"J. Periodontol."},{"issue":"1","key":"42308_CR32","doi-asserted-by":"publisher","first-page":"3805","DOI":"10.1038\/s41598-020-60797-7","volume":"10","author":"JY Kim","year":"2020","unstructured":"Kim, J. Y. et al. Association between Fatty Liver Index and Periodontitis: the Korea National Health and Nutrition Examination Survey. Sci. Rep. 10 (1), 3805 (2020).","journal-title":"Sci. Rep."},{"issue":"11","key":"42308_CR33","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1111\/jcpe.12800","volume":"44","author":"AA Akinkugbe","year":"2017","unstructured":"Akinkugbe, A. A. et al. Periodontitis and Non-alcoholic Fatty Liver Disease, a population-based cohort investigation in the Study of Health in Pomerania. J. Clin. Periodontol. 44 (11), 1077\u20131087 (2017).","journal-title":"J. Clin. Periodontol."},{"key":"42308_CR34","doi-asserted-by":"crossref","unstructured":"Joo, K., Kang, Y. W., Moon, S. Y., Baek, Y. H. & Son, M. Association between nonalcoholic fatty liver disease scores and chronic periodontitis: A retrospective cohort study. Journal periodontology. 96(5), 490-498 (2024).","DOI":"10.1002\/JPER.24-0171"},{"issue":"2","key":"42308_CR35","doi-asserted-by":"publisher","first-page":"211","DOI":"10.15403\/jgld-841","volume":"29","author":"K Wijarnpreecha","year":"2020","unstructured":"Wijarnpreecha, K. et al. The Association between Periodontitis and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis. J. Gastrointestin Liver Dis. 29 (2), 211\u2013217 (2020).","journal-title":"J. Gastrointestin Liver Dis."},{"issue":"4","key":"42308_CR36","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.ajg.2023.09.005","volume":"24","author":"ILS Aguiar","year":"2023","unstructured":"Aguiar, I. L. S., Santos-Lins, L. S., Brasil-Oliveira, R., Cotrim, H. P. & Lins-Kusterer, L. Non-alcoholic fatty liver disease and periodontal disease: A systematic review and meta-analysis of cross-sectional studies. Arab. J. Gastroenterol. 24 (4), 198\u2013203 (2023).","journal-title":"Arab. J. Gastroenterol."},{"issue":"1","key":"42308_CR37","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s12882-023-03102-8","volume":"24","author":"Z Chen","year":"2023","unstructured":"Chen, Z. et al. Prevalence of chronic periodontitis in patients undergoing peritoneal dialysis and its correlation with peritoneal dialysis-related complications. BMC Nephrol. 24 (1), 71 (2023).","journal-title":"BMC Nephrol."},{"issue":"3","key":"42308_CR38","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/jcpe.12664","volume":"44","author":"RT Demmer","year":"2017","unstructured":"Demmer, R. T. et al. The subgingival microbiome, systemic inflammation and insulin resistance: The Oral Infections, Glucose Intolerance and Insulin Resistance Study. J. Clin. Periodontol. 44 (3), 255\u2013265 (2017).","journal-title":"J. Clin. Periodontol"},{"issue":"12","key":"42308_CR39","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1177\/0022034517720924","volume":"96","author":"AA Akinkugbe","year":"2017","unstructured":"Akinkugbe, A. A. et al. Do Genetic Markers of Inflammation Modify the Relationship between Periodontitis and Nonalcoholic Fatty Liver Disease? Findings from the SHIP Study. J. Dent. Res. 96 (12), 1392\u20131399 (2017).","journal-title":"J. Dent. Res."},{"issue":"4","key":"42308_CR40","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1111\/odi.13616","volume":"27","author":"Y Yue","year":"2021","unstructured":"Yue, Y., Liu, X., Li, Y., Xia, B. & Yu, W. The role of TLR4\/MyD88\/NF-\u03baB pathway in periodontitis-induced liver inflammation of rats. Oral Dis. 27 (4), 1012\u20131021 (2021).","journal-title":"Oral Dis."},{"issue":"1","key":"42308_CR41","doi-asserted-by":"publisher","first-page":"2205291","DOI":"10.1080\/20002297.2023.2205291","volume":"15","author":"CA de Jongh","year":"2023","unstructured":"de Jongh, C. A., de Vries, T. J., Bikker, F. J., Gibbs, S. & Krom, B. P. Mechanisms of Porphyromonas gingivalis to translocate over the oral mucosa and other tissue barriers. J. Oral Microbiol. 15 (1), 2205291 (2023).","journal-title":"J. Oral Microbiol."},{"key":"42308_CR42","doi-asserted-by":"publisher","first-page":"547","DOI":"10.3389\/fphar.2017.00547","volume":"8","author":"P Cheng","year":"2017","unstructured":"Cheng, P. et al. Baicalin Alleviates Lipopolysaccharide-Induced Liver Inflammation in Chicken by Suppressing TLR4-Mediated NF-\u03baB Pathway. Front. Pharmacol. 8, 547 (2017).","journal-title":"Front. Pharmacol."},{"issue":"7","key":"42308_CR43","doi-asserted-by":"publisher","first-page":"167343","DOI":"10.1016\/j.bbadis.2024.167343","volume":"1870","author":"C Ding","year":"2024","unstructured":"Ding, C. et al. Exosomes derived from periodontitis induce hepatic steatosis through the SCD-1\/AMPK signaling pathway. Biochim. Biophys. Acta Mol. Basis Dis. 1870 (7), 167343 (2024).","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"issue":"4","key":"42308_CR44","doi-asserted-by":"publisher","first-page":"100825","DOI":"10.1016\/j.identj.2025.03.029","volume":"75","author":"C Lv","year":"2025","unstructured":"Lv, C. et al. Emerging Roles of Periodontal Pathogen-Derived Outer Membrane Vesicles in NAFLD. Int. Dent. J. 75 (4), 100825 (2025).","journal-title":"Int. Dent. J."},{"issue":"1\u20132","key":"42308_CR45","doi-asserted-by":"publisher","first-page":"105040","DOI":"10.1016\/j.micinf.2022.105040","volume":"25","author":"C Yao","year":"2023","unstructured":"Yao, C. et al. Porphyromonas gingivalis is a risk factor for the development of nonalcoholic fatty liver disease via ferroptosis. Microbes Infect. 25 (1\u20132), 105040 (2023).","journal-title":"Microbes Infect."},{"issue":"1","key":"42308_CR46","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/prd.12387","volume":"87","author":"R Kuraji","year":"2021","unstructured":"Kuraji, R., Sekino, S., Kapila, Y. & Numabe, Y. Periodontal disease-related nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: An emerging concept of oral-liver axis. Periodontology 2000. 87 (1), 204\u2013240 (2021).","journal-title":"Periodontology 2000"},{"key":"42308_CR47","doi-asserted-by":"crossref","unstructured":"Lang, N. P. & Bartold, P. M. Periodontal health. J Periodontol. 89(Suppl 1), S9-S16 (2018).","DOI":"10.1002\/JPER.16-0517"},{"issue":"1","key":"42308_CR48","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3109\/00016350903291913","volume":"68","author":"M Furuta","year":"2010","unstructured":"Furuta, M. et al. Relationship between periodontitis and hepatic abnormalities in young adults. Acta Odontol. Scand. 68 (1), 27\u201333 (2010).","journal-title":"Acta Odontol. Scand."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-42308-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-42308-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-42308-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T01:02:36Z","timestamp":1779757356000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-42308-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,4]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["42308"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-42308-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7434817\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,4]]},"assertion":[{"value":"22 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"16217"}}