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This was a descriptive-analytical cross-sectional study conducted in Mashhad (a metropolitan area in northeast of Iran) in 2021. A census method was employed for the research, involving HIV-positive patients and a random sample of healthy individuals visiting the Comprehensive Health Center, who participated after giving informed consent. The demographic form and the Spiritual Well-Being Questionnaire (SWBQ) were completed by the patients. The statistical analysis was performed using SPSS software (version 11.5), and the significance level was considered at\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05. A total of 201 participants entered the study with a mean age of 38.29\u2009\u00b1\u200910.53 years, including 102 HIV-positive patients and 99 healthy individuals. The total spiritual well-being score in the HIV group was 77 (57\u201384), while the healthy group scored 100 (88\u2013107) (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001). Regression analysis showed that occupation and HIV infection were two significant variables in the model for prediction the total spiritual well-being score. The total score of AIDS patients on the Spiritual Well-Being Questionnaire was significantly lower than that of healthy individuals. It is recommended that the health system authorities take action to increase the spiritual well-being of HIV-positive patients.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-42631-8","type":"journal-article","created":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T06:05:48Z","timestamp":1776578748000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A comparative study of spiritual health in HIV-positive patients and healthy individuals"],"prefix":"10.1038","volume":"16","author":[{"given":"Maryam Ansari","family":"Aval","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Ayoubi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Khajedaluee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4797-8714","authenticated-orcid":false,"given":"Maliheh","family":"Dadgarmoghaddam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,19]]},"reference":[{"issue":"6","key":"42631_CR1","doi-asserted-by":"publisher","first-page":"431","DOI":"10.3325\/cmj.2017.58.431","volume":"58","author":"AL Svalastog","year":"2017","unstructured":"Svalastog, A. 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All information related to the participants was kept confidential, and codes were used instead of names for recording.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"18116"}}