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However, the role of\n                    <jats:italic>PRAC1<\/jats:italic>\n                    in prostate cancer is unclear. In this study, we found that\n                    <jats:italic>PRAC1<\/jats:italic>\n                    expression is upregulated in prostate cancer cells and that\n                    <jats:italic>PRAC1<\/jats:italic>\n                    knockdown represses the proliferation of prostate cancer cells. Moreover, lysine-specific demethylase 1 (LSD1) promoted prostate cancer cell proliferation by upregulating\n                    <jats:italic>PRAC1<\/jats:italic>\n                    expression. TAK-418, an LSD1 inhibitor, suppressed prostate cancer cell proliferation by downregulating\n                    <jats:italic>PRAC1<\/jats:italic>\n                    expression. Our results highlight\n                    <jats:italic>PRAC1<\/jats:italic>\n                    or LSD1 inhibition as promising avenues for prostate cancer treatment.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-42928-8","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:23:39Z","timestamp":1773163419000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LSD1 promotes prostate cancer cell proliferation by upregulating PRAC1 expression"],"prefix":"10.1038","volume":"16","author":[{"given":"Yang","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"42928_CR1","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.15585\/mmwr.mm6941a1","volume":"69","author":"DA Siegel","year":"2020","unstructured":"Siegel, D. 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