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This study aimed to explore the relationship between AMU and AMR patterns of\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    isolated from commercial pig farms, using data-driven analytical methods. Farm-level records were harmonized with microbiological data from 203 isolates collected in December 2023 across four Hungarian farms. AMU was summarized over 3-, 6-, 9-, and 12-month retrospective windows and expressed in modified population-corrected units, while AMR was quantified as mean minimum inhibitory concentration (MIC) and AMR rate under epidemiological and clinical breakpoints. The results revealed substantial variation in AMU among farms, with amoxicillin predominating across timeframes. Farm-specific comparisons indicated that higher AMU may not always coincide with elevated resistance levels, and data analysis did not consistently identify a direct association between use and resistance at the individual farm level, which warrants further investigation in larger datasets. Correlation analyses identified strong intra-class relationships among \u03b2-lactams and fluoroquinolones, as well as a cross-class linking, suggesting concurrent selection pressures. Overall, the integration of AMU and AMR data demonstrated the feasibility of farm-level surveillance for AMR modelling and provides a foundation for future predictive systems to support antimicrobial stewardship in livestock production.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-43008-7","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T14:36:42Z","timestamp":1772548602000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antimicrobial use and Escherichia coli resistance patterns in Hungarian pig farms: a data-driven farm-level analysis"],"prefix":"10.1038","volume":"16","author":[{"given":"Kriszti\u00e1n","family":"Vrib\u00e9k","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1t\u00e9","family":"Farkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szilveszter","family":"Csorba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikl\u00f3s","family":"S\u00fcth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Gombos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1d\u00e1m","family":"Kerek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Somogyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1kos","family":"Jerzsele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsa","family":"Farkas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"key":"43008_CR1","unstructured":"WHO. 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