{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:24:33Z","timestamp":1777983873581,"version":"3.51.4"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":44,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K12170"],"award-info":[{"award-number":["22K12170"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H05072"],"award-info":[{"award-number":["22H05072"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-43009-6","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T19:34:11Z","timestamp":1773689651000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Detection and classification of chromosomes with sister chromatid cohesion defects using object detection models"],"prefix":"10.1038","volume":"16","author":[{"given":"Shinya","family":"Matsumoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miku","family":"Sojo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kan","family":"Okubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"43009_CR1","doi-asserted-by":"publisher","first-page":"a011130","DOI":"10.1101\/cshperspect.a011130","volume":"4","author":"JM Peters","year":"2012","unstructured":"Peters, J. M. & Nishiyama, T. Sister Chromatid Cohesion. Cold Spring Harb Perspect. Biol. 4, (2012).","journal-title":"Cold Spring Harb Perspect. Biol."},{"key":"43009_CR2","doi-asserted-by":"publisher","first-page":"3455","DOI":"10.3390\/cells10123455","volume":"10","author":"JJM van Schie","year":"2021","unstructured":"van Schie, J. J. M. & de Lange, J. The Interplay of Cohesin and the Replisome at Processive and Stressed DNA Replication Forks. Cells 10, 3455 (2021).","journal-title":"Cells"},{"key":"43009_CR3","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.cell.2017.12.021","volume":"172","author":"Y Murayama","year":"2018","unstructured":"Murayama, Y., Samora, C. P., Kurokawa, Y., Iwasaki, H. & Uhlmann, F. Establishment of DNA-DNA Interactions by the Cohesin Ring. Cell 172, 465\u2013477e15 (2018).","journal-title":"Cell"},{"key":"43009_CR4","doi-asserted-by":"publisher","first-page":"4287","DOI":"10.1038\/s41467-020-18066-8","volume":"11","author":"JJM van Schie","year":"2020","unstructured":"van Schie, J. J. M. et al. Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion. Nat. Commun. 11, 4287 (2020).","journal-title":"Nat. Commun."},{"key":"43009_CR5","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1002\/cyto.a.10004","volume":"51A","author":"W Deng","year":"2003","unstructured":"Deng, W., Tsao, S. W., Lucas, J. N., Leung, C. S. & Cheung, A. L. M. A new method for improving metaphase chromosome spreading. Cytometry Part. A. 51A, 46\u201351 (2003).","journal-title":"Cytometry Part. A"},{"key":"43009_CR6","doi-asserted-by":"crossref","unstructured":"Ivanov, M. P. et al. The replicative helicase MCM recruits cohesin acetyltransferase ESCO2 to mediate centromeric sister chromatid cohesion. EMBO J. 37, (2018).","DOI":"10.15252\/embj.201797150"},{"key":"43009_CR7","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1038\/s41598-023-28742-6","volume":"13","author":"D Ikemoto","year":"2023","unstructured":"Ikemoto, D. et al. Application of neural network-based image analysis to detect sister chromatid cohesion defects. Sci. Rep. 13, 2133 (2023).","journal-title":"Sci. Rep."},{"key":"43009_CR8","doi-asserted-by":"publisher","unstructured":"Matsumoto, S., Ikemoto, D., Abe, T., Okubo, K. & Nishikawa, K. Automatic classification of human chromosome shapes using convolutional neural network models. IEICE Trans. Fundamentals Electron. Commun. Comput. Sci. 2024EAL2053 https:\/\/doi.org\/10.1587\/transfun.2024EAL2053 (2025).","DOI":"10.1587\/transfun.2024EAL2053"},{"key":"43009_CR9","doi-asserted-by":"publisher","unstructured":"Matsumoto, S., Okubo, K., Abe, T. & Nishikawa, K. Detection model of sister chromatid cohesion defects based on Vision Transformer. in Asia Pacific Signal and Information Processing Association Annual Summit and Conference (APSIPA ASC) 27\u201331 (IEEE, 2023). 27\u201331 (IEEE, 2023). (2023). https:\/\/doi.org\/10.1109\/APSIPAASC58517.2023.10317257","DOI":"10.1109\/APSIPAASC58517.2023.10317257"},{"key":"43009_CR10","doi-asserted-by":"publisher","unstructured":"(Sergios Theodoridis & Konstantinos Koutroumbas. Pattern Recognition & Elsevier https:\/\/doi.org\/10.1016\/B978-1-59749-272-0.X0001-2 (2009).","DOI":"10.1016\/B978-1-59749-272-0.X0001-2"},{"key":"43009_CR11","unstructured":"Kevin, P. & Murphy Machine Learning: A Probabilistic Perspective (MIT Press, 2012)."},{"key":"43009_CR12","doi-asserted-by":"publisher","first-page":"105891","DOI":"10.1016\/j.bspc.2023.105891","volume":"91","author":"S Kang","year":"2024","unstructured":"Kang, S. et al. Chromosome analysis method based on deep learning: Counting chromosomes and detecting abnormal chromosomes. Biomed. Signal. Process. Control. 91, 105891 (2024).","journal-title":"Biomed. Signal. Process. Control"},{"key":"43009_CR13","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1472-6750-1-7","volume":"1","author":"H Arakawa","year":"2001","unstructured":"Arakawa, H., Lodygin, D. & Buerstedde, J. M. Mutant loxP vectors for selectable marker recycle and conditional knock-outs. BMC Biotechnol. 1, 7 (2001).","journal-title":"BMC Biotechnol."},{"key":"43009_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1145\/3578495.3578502","volume":"13","author":"D Stefanics","year":"2021","unstructured":"Stefanics, D., Fox, M. C. O. C. O. & Annotator ACM SIGMultimedia Records 13, 1\u20131 (2021).","journal-title":"ACM SIGMultimedia Records"},{"key":"43009_CR15","unstructured":"Glenn Jocher. Ultralytics YOLOv5.https:\/\/github.com\/ultralytics\/yolov5 (2020)."},{"key":"43009_CR16","unstructured":"Glenn & Jocher Ayush Chaurasia & Jing Qiu. Ultralytics YOLOv8. https:\/\/github.com\/ultralytics\/ultralytics. (2023)."},{"key":"43009_CR17","unstructured":"Glenn, J. & Jing Qiu. Ultralytics YOLO11.https:\/\/github.com\/ultralytics\/ultralytics (2024)."},{"key":"43009_CR18","unstructured":"Ren, S., He, K., Girshick, R., Sun, J. & Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks. (2015)."},{"key":"43009_CR19","doi-asserted-by":"publisher","unstructured":"Liu, W. et al. SSD: Single Shot MultiBox Detector. in 21\u201337https:\/\/doi.org\/10.1007\/978-3-319-46448-0_2 (2016).","DOI":"10.1007\/978-3-319-46448-0_2"},{"key":"43009_CR20","doi-asserted-by":"crossref","unstructured":"Carion, N. et al. End-to-End Object Detection with Transformers. (2020).","DOI":"10.1007\/978-3-030-58452-8_13"},{"key":"43009_CR21","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s11263-009-0275-4","volume":"88","author":"M Everingham","year":"2010","unstructured":"Everingham, M., Van Gool, L., Williams, C. K. I., Winn, J. & Zisserman, A. The Pascal Visual Object Classes (VOC) Challenge. Int. J. Comput. Vis. 88, 303\u2013338 (2010).","journal-title":"Int. J. Comput. Vis."},{"key":"43009_CR22","doi-asserted-by":"crossref","unstructured":"Lin, T. Y. et al. Microsoft COCO: Common Objects in Context. (2014).","DOI":"10.1007\/978-3-319-10602-1_48"},{"key":"43009_CR23","unstructured":"Redmon, J. & Farhadi, A. YOLOv3: An Incremental Improvement. (2018)."},{"key":"43009_CR24","doi-asserted-by":"publisher","unstructured":"Bodla, N., Singh, B., Chellappa, R., Davis, L. S. & Soft -NMS \u2014 Improving Object Detection with One Line of Code. in IEEE International Conference on Computer Vision (ICCV) 5562\u20135570 IEEE,https:\/\/doi.org\/10.1109\/ICCV.2017.593. (2017).","DOI":"10.1109\/ICCV.2017.593"},{"key":"43009_CR25","doi-asserted-by":"crossref","unstructured":"Bodla, N., Singh, B., Chellappa, R. & Davis, L. S. Soft-NMS -- Improving Object Detection With One Line of Code. (2017).","DOI":"10.1109\/ICCV.2017.593"},{"key":"43009_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1109\/TGRS.2021.3076050","volume":"60","author":"M Zand","year":"2022","unstructured":"Zand, M., Etemad, A. & Greenspan, M. Oriented Bounding Boxes for Small and Freely Rotated Objects. IEEE Trans. Geosci. Remote Sens. 60, 1\u201315 (2022).","journal-title":"IEEE Trans. Geosci. Remote Sens."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-43009-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-43009-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-43009-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:35:09Z","timestamp":1777419309000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-43009-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,16]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["43009"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-43009-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7405049\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,16]]},"assertion":[{"value":"19 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"13719"}}