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This study examined the association between the\n                    <jats:italic>ALDH2<\/jats:italic>\n                    rs671 polymorphism and incident CKD in a population-based cohort, and whether alcohol consumption modifies this relationship. We analyzed 5,369 Korean adults aged 40\u201369 years without CKD at baseline from the community-based Korean Genome and Epidemiology Stud\n                    <jats:bold>y<\/jats:bold>\n                    , followed biennially for up to 18 years. The main exposures were\n                    <jats:italic>ALDH2<\/jats:italic>\n                    genotype (GG vs. GA\/AA) and categorized alcohol consumption (none, low, moderate, high). Incident CKD was defined as an estimated glomerular filtration rate (eGFR)\u2009&lt;\u200960 mL\/min\/1.73\u00a0m\u00b2 or new-onset proteinuria (\u2265\u20091\u2009+\u2009on dipstick). Cox proportional hazards models estimated adjusted hazard ratios (HRs). During a mean 11.7-year follow-up, 1,396 participants (26.0%) developed CKD. CKD risk did not differ significantly between genotypes, and alcohol intake was not associated with CKD incidence. These associations were consistent across genotype or sex. Overall,\n                    <jats:italic>ALDH2<\/jats:italic>\n                    rs671 and alcohol intake showed limited relevance to CKD onset, suggesting that\n                    <jats:italic>ALDH2<\/jats:italic>\n                    -related biological effects may be more pertinent to disease progression rather than initiation in the general population.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-43186-4","type":"journal-article","created":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T05:35:39Z","timestamp":1773552939000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of ALDH2 rs671 Polymorphism with chronic kidney disease incidence in a population-based Korean cohort"],"prefix":"10.1038","volume":"16","author":[{"given":"Hyun Jin","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaekyung","family":"Noh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seunghwan","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heeyeon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haekyung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyoungnae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Seok","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyunjin","family":"Noh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon Hyo","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,15]]},"reference":[{"issue":"4","key":"43186_CR1","first-page":"245","volume":"29","author":"S Zakhari","year":"2006","unstructured":"Zakhari, S. 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