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We investigated whether JB and tributary sizes are associated with ASL+. We retrospectively analyzed MRIs from 25 ASL+ patients and 25 controls, using post-contrast SPGR images to measure JB and tributary diameters. Group comparisons, effect sizes, false discovery rate (FDR) correction, and receiver operating characteristic (ROC) analyses were performed, with leave-one-out cross-validation (LOOCV) to assess model stability. ASL+ patients demonstrated smaller JB midportion (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.047, Cohen\u2019s d\u2009=\u20090.58), JB outflow (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.030, d\u2009=\u20090.63), and posterior condylar vein (PCV) diameters (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.009, d\u2009=\u20091.02). After FDR correction across eight comparisons, only PCV remained statistically significant. ROC analysis demonstrated moderate discrimination for JB measures (AUC\u2009\u2248\u20090.67) and stronger discrimination for PCV (AUC\u2009=\u20090.78). A multivariate model achieved AUC\u2009=\u20090.83 with stable LOOCV performance (AUC\u2009=\u20090.77), suggesting limited overfitting. Thus, we identify a venous morphometric pattern associated with ASL+, characterized by smaller JB and PCV calibers. However, given multiplicity adjustment and spatial-resolution constraints for PCVs, these associations should be interpreted as exploratory. This composite anatomical configuration may contribute to delayed venous transit and ASL signal trapping, providing a plausible structural contributor to this imaging pitfall and informing future mechanistic investigations.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-43549-x","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T12:26:06Z","timestamp":1772972766000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Narrower jugular bulbs and their tributaries are associated with skull base venous hyperintensity on arterial spin-labeling MRI"],"prefix":"10.1038","volume":"16","author":[{"given":"Periakaruppan V.","family":"Manickam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusef","family":"Qazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddhant Suri","family":"Dhawan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R.","family":"Geisbush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarik F.","family":"Massoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,8]]},"reference":[{"key":"43549_CR1","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1002\/mrm.29572","volume":"89","author":"T Lindner","year":"2023","unstructured":"Lindner, T. et al. 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