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EWcp cells exclusively express transient receptor potential ankyrin 1 (TRPA1) ion channels, implicated in neurodegenerative disorders. We hypothesized that the EWcp\/UCN1\n                    <jats:italic>\/Trpa1<\/jats:italic>\n                    neurons may be involved in AD-related pathologies. Age-dependent (2, 6, 9, 12 and 18\u00a0months)\n                    <jats:italic>Trpa1<\/jats:italic>\n                    mRNA expression (RNAscope in situ hybridization) and UCN1 peptide (immunostaining) content of the EWcp were examined in male triple transgenic mouse (3xTg-AD) model of AD.\n                    <jats:sup>1<\/jats:sup>\n                    H-MRI spectroscopy was performed in the hippocampus at 6, 12 and 18\u00a0months to evaluate the taurine and N-acetylaspartate levels, metabolites reflecting neuroprotection and neuronal integrity as AD prognostic markers.\n                    <jats:italic>Trpa1<\/jats:italic>\n                    expression was lower in 2 and 6-months-old 3xTg-AD than controls. Later the genotype differences disappeared due to the progressive, age-related reduction of\n                    <jats:italic>Trpa1<\/jats:italic>\n                    mRNA transcripts in the controls. In contrast, the\n                    <jats:italic>Trpa1<\/jats:italic>\n                    expression of transgenic mice remained persistently low. Similarly, the UCN1 peptide content was also lower in the 2 and 6-months-old 3xTg-AD compared to controls. However, UCN1 level increased with age, which was more pronounced in 3xTg-AD than controls abolishing the genotype differences. Age-dependent decrease in taurine level was detected in transgenic animals leading to significantly lower taurine\/creatine ratio in 12 and 18-months-old 3xTg-AD animals compared to the controls. This age-related dynamics of\n                    <jats:italic>Trpa1<\/jats:italic>\n                    and UCN1 expression of 3xTg-AD mice suggests that altered UCN1 signaling may contribute to AD-associated mood disorders and memory decline.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-44022-5","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:08:05Z","timestamp":1774328885000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Age-dependent alterations of TRPA1 and urocortin 1 signaling in the Edinger\u2013Westphal nucleus in a mouse model of Alzheimer\u2019s disease"],"prefix":"10.1038","volume":"16","author":[{"given":"Ant\u00f3nia Petra","family":"Pr\u00f3kay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e1nos","family":"Konkoly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikt\u00f3ria","family":"Kormos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00fcnde","family":"Bir\u00f3-S\u00fct\u0151","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"Kriszta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helga Panna","family":"Szentm\u00e1rtoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gergely","family":"Berta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bal\u00e1zs","family":"Gaszner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00f3ra","family":"Zelena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Pint\u00e9r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,24]]},"reference":[{"issue":"16","key":"44022_CR1","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1001\/jama.2019.4782","volume":"322","author":"Z Arvanitakis","year":"2019","unstructured":"Arvanitakis, Z., Shah, R. 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