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Existing methods are often operator-dependent, lacking repeatability and reproducibility. This study introduces the Global Positioning Layout (GPL) method, an accuracy assessment technique integrated into the reconstruction protocol based on CAD-CAM and additive printing technology. We describe its methodology and present its implementation through an automated workflow. Key principles of accuracy assessment were identified and structured as Requirements, Data input, Data reference system, and Data output. The necessary 3D virtual models were defined: planned mandible, reference mandible, patient-specific implant (PSI), postoperative mandible, and postoperative PSI. A unique coordinate system (GPL-RS) was built on the reference mandible. Three Roto-Translational Matrices (RTMs) were applied to measure movements and deviations between the designed and postoperative models to assess reconstruction accuracy. Five clinical cases with different operational diseases and defects were analysed, comparing spatial deviations between manual and automated methods. 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