{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T11:22:48Z","timestamp":1774956168322,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Scientific Research Projects of Changsha Municipal Health Commission","award":["KJ-B2023073"],"award-info":[{"award-number":["KJ-B2023073"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This retrospective propensity score\u2013matched cohort study examined whether Platelet-Rich Plasma (PRP) use was associated with improved wound healing and functional recovery after shoulder surgery. We analyzed records from Changsha Hospital of Traditional Chinese Medicine (January 2018\u2013December 2023) and included 170 patients undergoing rotator cuff repair (n\u2009=\u2009100), shoulder replacement (n\u2009=\u200940), or subacromial decompression (n\u2009=\u200930). Within each surgery type, patients receiving PRP (treatment group [TG]) were matched 1:1 to patients not receiving PRP (control group [CG]) using propensity scores derived from age, sex, comorbidities, and baseline pain. Outcomes included wound healing time, postoperative pain (Visual Analog Scale [VAS]), shoulder function (Constant\u2013Murley score), complications, length of hospital stay, and patient satisfaction. In matched analyses, PRP use was associated with shorter wound healing time and improved postoperative pain and functional outcomes across procedures, with the largest and most robust differences observed in the rotator cuff repair cohort. PRP was also associated with a shorter hospitalization duration in all three surgery cohorts. Complication rates were lower in the rotator cuff repair cohort, while no clear between-group differences were observed in the shoulder replacement or subacromial decompression cohorts. Overall patient satisfaction was higher in the PRP groups. Given the retrospective design, potential residual confounding, and smaller sample sizes in non\u2013rotator cuff cohorts, these findings should be interpreted cautiously and warrant confirmation in prospective, surgery-specific studies using standardized PRP protocols.<\/jats:p>","DOI":"10.1038\/s41598-026-44844-3","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T06:22:32Z","timestamp":1774592552000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of platelet-rich plasma therapy in promoting wound healing and shoulder function recovery after shoulder surgery"],"prefix":"10.1038","volume":"16","author":[{"given":"Zheng","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Licheng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiguo","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihao","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangqing","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yilin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hepeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"44844_CR1","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1302\/2058-5241.6.200017","volume":"6","author":"T Collins","year":"2021","unstructured":"Collins, T., Alexander, D. & Barkatali, B. Platelet-rich plasma: A narrative review. EFORT Open Rev. 6, 225\u2013235. https:\/\/doi.org\/10.1302\/2058-5241.6.200017 (2021).","journal-title":"EFORT Open Rev."},{"key":"44844_CR2","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1159\/000477353","volume":"4","author":"R Alves","year":"2018","unstructured":"Alves, R. & Grimalt, R. A review of platelet-rich plasma: History, biology, mechanism of action, and classification. Skin Appendage Disord. 4, 18\u201324. https:\/\/doi.org\/10.1159\/000477353 (2018).","journal-title":"Skin Appendage Disord."},{"key":"44844_CR3","unstructured":"Long C, Cheng C, Tian J. Cellular and molecular mechanisms of platelet-rich plasma in promoting wound healing. Zhongguo Zuzhi Gongcheng Yanjiu. 29(13):2793\u20132801 (2025)."},{"key":"44844_CR4","doi-asserted-by":"publisher","first-page":"685","DOI":"10.4103\/idoj.IDOJ_369_19","volume":"11","author":"A Kaushik","year":"2020","unstructured":"Kaushik, A. & Kumaran, M. S. Platelet-rich plasma: The journey so far\u202f!. Indian Dermatol. Online J. 11, 685\u2013692. https:\/\/doi.org\/10.4103\/idoj.IDOJ_369_19 (2020).","journal-title":"Indian Dermatol. Online J."},{"key":"44844_CR5","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1111\/jocd.14229","volume":"20","author":"A Tuknayat","year":"2021","unstructured":"Tuknayat, A., Bhalla, M. & Thami, G. P. Platelet-rich plasma is a promising therapy for melasma. J. Cosmet. Dermatol. 20, 2431\u20132436. https:\/\/doi.org\/10.1111\/jocd.14229 (2021).","journal-title":"J. Cosmet. Dermatol."},{"key":"44844_CR6","first-page":"2233","volume":"37","author":"L Peng","year":"2021","unstructured":"Peng, L. & Sun, X. Research progress of platelet-rich plasma therapy in the treatment of knee osteoarthritis. Modern Med. Health 37, 2233\u20132237 (2021).","journal-title":"Modern Med. Health"},{"key":"44844_CR7","first-page":"3229","volume":"23","author":"M Zhao","year":"2019","unstructured":"Zhao, M., Feng, G. & Deng, Y. Application of platelet-rich plasma in the repair of Achilles tendon injury. Study Tissue Eng. China 23, 3229\u20133234 (2019).","journal-title":"Study Tissue Eng. China"},{"key":"44844_CR8","doi-asserted-by":"publisher","first-page":"364","DOI":"10.16038\/j.1000-6710.2013.04.013","volume":"04","author":"Z Yi","year":"2013","unstructured":"Yi, Z., Zhu, L. & Li, J. Biological mechanism of platelet-rich plasma therapy and its clinical application in bone and joint diseases. China J. Sports Med. 04, 364\u2013369. https:\/\/doi.org\/10.16038\/j.1000-6710.2013.04.013 (2013).","journal-title":"China J. Sports Med."},{"key":"44844_CR9","first-page":"160","volume":"13","author":"L Zhou","year":"2016","unstructured":"Zhou, L. & Lu, M. Research progress of athletes\u2019 shoulder injury. Pract. J. Clin. Med. 13, 160\u2013163 (2016).","journal-title":"Pract. J. Clin. Med."},{"key":"44844_CR10","doi-asserted-by":"publisher","first-page":"195","DOI":"10.19347\/j.cnki.2096-1413.202403048","volume":"9","author":"Z Yang","year":"2024","unstructured":"Yang, Z. & Fu, N. Research progress of acromion morphology in the diagnosis of degenerative rotator cuff tear. Clin. Med. Res. Pract. 9, 195\u2013198. https:\/\/doi.org\/10.19347\/j.cnki.2096-1413.202403048 (2024).","journal-title":"Clin. Med. Res. Pract."},{"key":"44844_CR11","doi-asserted-by":"publisher","first-page":"167","DOI":"10.16794\/j.cnki.cn33-1207\/r.2024.02.006","volume":"29","author":"Z Chen","year":"2024","unstructured":"Chen, Z. Effect of arthroscopic rotator cuff repair combined with early rehabilitation training on shoulder joint function of patients with rotator cuff tear. Zhejiang Pract. Med. 29, 167\u2013169. https:\/\/doi.org\/10.16794\/j.cnki.cn33-1207\/r.2024.02.006 (2024).","journal-title":"Zhejiang Pract. Med."},{"key":"44844_CR12","first-page":"226","volume":"35","author":"Y Liu","year":"2013","unstructured":"Liu, Y., Pan, Z. & Cui, Y. Observation on the curative effect of arthroscopic excision of acromion bursa for simple subacromial bursitis. J. Weifang Med. Coll. 35, 226\u2013228 (2013).","journal-title":"J. Weifang Med. Coll."},{"key":"44844_CR13","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13020-022-00606-7","volume":"19","author":"H Huang","year":"2022","unstructured":"Huang, H., Hang, X. & Wang, M. Application value of Prp intraosseous infiltration injection combined with articular cavity injection in tibial plateau fracture. Med. Innov. China 19, 52\u201356 (2022).","journal-title":"Med. Innov. China"},{"key":"44844_CR14","first-page":"5595","volume":"24","author":"J Ren","year":"2020","unstructured":"Ren, J., Zhao, Y. & Xiao, B. Platelet-rich plasma promotes bone healing in tibial fracture model rabbits. Tissue Eng. Study China 24, 5595\u20135599 (2020).","journal-title":"Tissue Eng. Study China"},{"key":"44844_CR15","first-page":"471","volume":"13","author":"K Yang","year":"2024","unstructured":"Yang, K., Zhou, Z. & Liang, C. Research progress of platelet-rich plasma in wound repair. Chin. J. Bone Joint 13, 471\u2013475 (2024).","journal-title":"Chin. J. Bone Joint"},{"key":"44844_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-05882-7","volume":"7","author":"M Li","year":"2024","unstructured":"Li, M. et al. In-situ gelation of fibrin gel encapsulating platelet-rich plasma-derived exosomes promotes rotator cuff healing. Commun. Biol. 7, 205. https:\/\/doi.org\/10.1038\/s42003-024-05882-7 (2024).","journal-title":"Commun. Biol."},{"key":"44844_CR17","doi-asserted-by":"publisher","first-page":"E175","DOI":"10.1097\/bsd.0000000000001154","volume":"35","author":"V Moorthy","year":"2022","unstructured":"Moorthy, V. et al. Shoulder balance following correction surgery for adolescent idiopathic scoliosis: When is it achieved and does the type of construct matter?. Clin. Spine Surg. 35, E175-e180. https:\/\/doi.org\/10.1097\/bsd.0000000000001154 (2022).","journal-title":"Clin. Spine Surg."},{"key":"44844_CR18","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.csm.2022.08.004","volume":"42","author":"MR Mancini","year":"2023","unstructured":"Mancini, M. R., Horinek, J. L., Phillips, C. J. & Denard, P. J. Arthroscopic rotator cuff repair: A review of surgical techniques and outcomes. Clin. Sports Med. 42, 81\u201394. https:\/\/doi.org\/10.1016\/j.csm.2022.08.004 (2023).","journal-title":"Clin. Sports Med."},{"key":"44844_CR19","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.pmr.2022.12.010","volume":"34","author":"W Polio","year":"2023","unstructured":"Polio, W. & Brolin, T. J. Postoperative rehabilitation after shoulder arthroplasty. Phys. Med. Rehabil. Clin. N. Am. 34, 469\u2013479. https:\/\/doi.org\/10.1016\/j.pmr.2022.12.010 (2023).","journal-title":"Phys. Med. Rehabil. Clin. N. Am."},{"key":"44844_CR20","doi-asserted-by":"publisher","first-page":"68","DOI":"10.4055\/cios.2020.12.1.68","volume":"12","author":"D Utashima","year":"2020","unstructured":"Utashima, D., Matsumura, N., Suzuki, T., Iwamoto, T. & Ogawa, K. Clinical results of surgical resection and histopathological evaluation of synovial chondromatosis in the shoulder: A retrospective study and literature review. Clin. Orthop. Surg. 12, 68\u201375. https:\/\/doi.org\/10.4055\/cios.2020.12.1.68 (2020).","journal-title":"Clin. Orthop. Surg."},{"key":"44844_CR21","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.arthro.2011.07.012","volume":"28","author":"BG Lee","year":"2012","unstructured":"Lee, B. G., Cho, N. S. & Rhee, Y. G. Effect of two rehabilitation protocols on range of motion and healing rates after arthroscopic rotator cuff repair: Aggressive versus limited early passive exercises. Arthroscopy 28, 34\u201342. https:\/\/doi.org\/10.1016\/j.arthro.2011.07.012 (2012).","journal-title":"Arthroscopy"},{"key":"44844_CR22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25147914","volume":"25","author":"PA Everts","year":"2024","unstructured":"Everts, P. A. et al. Profound properties of protein-rich, platelet-rich plasma matrices as novel, multi-purpose biological platforms in tissue repair, regeneration, and wound healing. Int. J. Mol. Sci. 25, 7914 (2024).","journal-title":"Int. J. Mol. Sci."},{"key":"44844_CR23","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1007\/s12178-018-9517-9","volume":"11","author":"A Schneider","year":"2018","unstructured":"Schneider, A., Burr, R., Garbis, N. & Salazar, D. Platelet-rich plasma and the shoulder: Clinical indications and outcomes. Curr. Rev. Musculoskelet. Med. 11, 593\u2013597. https:\/\/doi.org\/10.1007\/s12178-018-9517-9 (2018).","journal-title":"Curr. Rev. Musculoskelet. Med."},{"key":"44844_CR24","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1177\/0363546510390780","volume":"39","author":"R Castricini","year":"2011","unstructured":"Castricini, R. et al. Platelet-rich plasma augmentation for arthroscopic rotator cuff repair: A randomized controlled trial. Am. J. Sports Med. 39, 258\u2013265. https:\/\/doi.org\/10.1177\/0363546510390780 (2011).","journal-title":"Am. J. Sports Med."},{"key":"44844_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14062061","author":"AJ Goulian","year":"2025","unstructured":"Goulian AJ, Goldstein B, Saad MA. Advancements in Regenerative Therapies for Orthopedics: A Comprehensive Review of Platelet-Rich Plasma, Mesenchymal Stem Cells, Peptide Therapies, and Biomimetic Applications. J Clin Med. 14(6):2061. doi: 10.3390\/jcm14062061. PMID: 40142869; PMCID: PMC11943164 (2025).","journal-title":"J. Clin. Med."},{"key":"44844_CR26","doi-asserted-by":"publisher","DOI":"10.1177\/23259671211016847","volume":"9","author":"W Xu","year":"2021","unstructured":"Xu, W. & Xue, Q. Application of platelet-rich plasma in arthroscopic rotator cuff repair: A systematic review and meta-analysis. Orthop. J. Sports Med. 9, 23259671211016847. https:\/\/doi.org\/10.1177\/23259671211016847 (2021).","journal-title":"Orthop. J. Sports Med."},{"key":"44844_CR27","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/129515","volume":"2014","author":"P Randelli","year":"2014","unstructured":"Randelli, P. et al. Regenerative medicine in rotator cuff injuries. BioMed Res. Int. 2014, 129515. https:\/\/doi.org\/10.1155\/2014\/129515 (2014).","journal-title":"BioMed Res. Int."},{"key":"44844_CR28","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-019-1207-9","volume":"14","author":"C Han","year":"2019","unstructured":"Han, C. et al. Is platelet-rich plasma an ideal biomaterial for arthroscopic rotator cuff repair? A systematic review and meta-analysis of randomized controlled trials. J. Orthop. Surg. Res. 14, 183. https:\/\/doi.org\/10.1186\/s13018-019-1207-9 (2019).","journal-title":"J. Orthop. Surg. Res."},{"key":"44844_CR29","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1136\/jisakos-2019-000274","volume":"4","author":"G Milano","year":"2019","unstructured":"Milano, G. et al. Platelet-rich plasma in orthopaedic sports medicine: State of the art. J. ISAKOS 4, 188\u2013195. https:\/\/doi.org\/10.1136\/jisakos-2019-000274 (2019).","journal-title":"J. ISAKOS"},{"key":"44844_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207794","author":"P Everts","year":"2020","unstructured":"Everts P, Onishi K, Jayaram P, Lana JF, Mautner K. Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020. Int J Mol Sci. 21(20):7794. doi: 10.3390\/ijms21207794. PMID: 33096812; PMCID: PMC7589810 (2020).","journal-title":"Int. J. Mol. Sci."},{"key":"44844_CR31","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1016\/j.arthro.2018.10.115","volume":"35","author":"ET Hurley","year":"2019","unstructured":"Hurley, E. T. et al. Nonoperative treatment of rotator cuff disease with platelet-rich plasma: A systematic review of randomized controlled trials. Arthroscopy 35, 1584\u20131591. https:\/\/doi.org\/10.1016\/j.arthro.2018.10.115 (2019).","journal-title":"Arthroscopy"},{"key":"44844_CR32","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1177\/0363546506288850","volume":"34","author":"A Mishra","year":"2006","unstructured":"Mishra, A. & Pavelko, T. Treatment of chronic elbow tendinosis with buffered platelet-rich plasma. Am. J. Sports Med. 34, 1774\u20131778. https:\/\/doi.org\/10.1177\/0363546506288850 (2006).","journal-title":"Am. J. Sports Med."},{"key":"44844_CR33","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.77267","volume":"17","author":"OH Alzahrani","year":"2025","unstructured":"Alzahrani, O. H. et al. Efficacy of platelet-rich plasma injection in the management of lateral epicondylitis: A retrospective assessment. Cureus 17, e77267. https:\/\/doi.org\/10.7759\/cureus.77267 (2025).","journal-title":"Cureus"},{"key":"44844_CR34","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering10111276","author":"R Verron","year":"2023","unstructured":"Verron R, Zhang L, Bisseriex H, Grimandi R, Verrando A, Verdaguer C, Thomas M, Facione J, Borrini L. SAS-PRP Study: A Real-Life Satisfaction Assessment in Patients with Cartilage Lesions of the Knee Treated by Platelet-Rich Plasma. Bioengineering (Basel). 10(11):1276. doi: 10.3390\/bioengineering10111276. PMID: 38002400; PMCID: PMC10669872 (2023).","journal-title":"Bioengineering"},{"key":"44844_CR35","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-75090-0","volume":"14","author":"Y Li","year":"2024","unstructured":"Li, Y. et al. Efficacy and safety of allogeneic platelet-rich plasma in chronic wound treatment: A meta-analysis of randomized controlled trials. Sci. Rep. 14, 25209. https:\/\/doi.org\/10.1038\/s41598-024-75090-0 (2024).","journal-title":"Sci. Rep."},{"key":"44844_CR36","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1051\/ject\/200739177","volume":"39","author":"DP Zavadil","year":"2007","unstructured":"Zavadil, D. P., Satterlee, C. C., Costigan, J. M., Holt, D. W. & Shostrom, V. K. Autologous platelet gel and platelet-poor plasma reduce pain with total shoulder arthroplasty. J. Extra Corpor. Technol. 39, 177\u2013182 (2007).","journal-title":"J. Extra Corpor. Technol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-44844-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-44844-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-44844-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:42:40Z","timestamp":1774953760000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-44844-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,27]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["44844"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-44844-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,27]]},"assertion":[{"value":"26 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The current study was approved by the Ethics Committee of the Changsha Hospital of Traditional Chinese Medicine. All methods were performed in accordance with relevant guidelines and regulations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Due to the retrospective nature of the study, the ethics committee of the Changsha Hospital of Traditional Chinese Medicine waived the need of obtaining informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"10894"}}