{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:15:59Z","timestamp":1788948959528,"version":"build-2803163510"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":49,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Scientific Research Fund of Anhui Provincial Education Department","award":["2024AH050763"],"award-info":[{"award-number":["2024AH050763"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-44845-2","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T15:14:26Z","timestamp":1775142866000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Elucidating the potential mechanism of short-chain chlorinated paraffins in breast cancer via computational prediction integrating network toxicology and molecular docking"],"prefix":"10.1038","volume":"16","author":[{"given":"Shanwen","family":"Si","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"issue":"5","key":"44845_CR1","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1039\/D2EM00494A","volume":"25","author":"S Kutarna","year":"2023","unstructured":"Kutarna, S., Du, X., Diamond, M. L., Blum, A. & Peng, H. Widespread presence of chlorinated paraffins in consumer products. Environ. Sci. Process. Impacts. 25 (5), 893\u2013900 (2023).","journal-title":"Environ. Sci. Process. Impacts"},{"key":"44845_CR2","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.chemosphere.2016.04.037","volume":"155","author":"LM van Mourik","year":"2016","unstructured":"van Mourik, L. M., Gaus, C., Leonards, P. E. G. & de Boer, J. Chlorinated paraffins in the environment: A review on their production, fate, levels and trends between 2010 and 2015. Chemosphere 155, 415\u2013428 (2016).","journal-title":"Chemosphere"},{"key":"44845_CR3","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1016\/j.scitotenv.2016.08.105","volume":"573","author":"J Gl\u00fcge","year":"2016","unstructured":"Gl\u00fcge, J., Wang, Z., Bogdal, C., Scheringer, M. & Hungerb\u00fchler, K. Global production, use, and emission volumes of short-chain chlorinated paraffins - A minimum scenario. Sci. Total Environ. 573, 1132\u20131146 (2016).","journal-title":"Sci. Total Environ."},{"key":"44845_CR4","doi-asserted-by":"publisher","first-page":"149257","DOI":"10.1016\/j.scitotenv.2021.149257","volume":"798","author":"X Han","year":"2021","unstructured":"Han, X. et al. Hair and nails as noninvasive bioindicators of human exposure to chlorinated paraffins: Contamination patterns and potential influencing factors. Sci. Total Environ. 798, 149257 (2021).","journal-title":"Sci. Total Environ."},{"key":"44845_CR5","doi-asserted-by":"publisher","first-page":"116922","DOI":"10.1016\/j.envpol.2021.116922","volume":"279","author":"C Xu","year":"2021","unstructured":"Xu, C. et al. Highly elevated levels, infant dietary exposure and health risks of medium-chain chlorinated paraffins in breast milk from China: Comparison with short-chain chlorinated paraffins. Environ. Pollut. 279, 116922 (2021).","journal-title":"Environ. Pollut"},{"issue":"17","key":"44845_CR6","doi-asserted-by":"publisher","first-page":"11693","DOI":"10.1021\/acs.est.1c02428","volume":"55","author":"S Niu","year":"2021","unstructured":"Niu, S. et al. Guidance on the Application of Polyurethane Foam Disk Passive Air Samplers for Measuring Nonane and Short-Chain Chlorinated Paraffins in Air: Results from a Screening Study in Urban Air. Environ. Sci. Technol. 55 (17), 11693\u201311702 (2021).","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"44845_CR7","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1021\/acs.est.7b04657","volume":"52","author":"W Gao","year":"2018","unstructured":"Gao, W. et al. External Exposure to Short- and Medium-Chain Chlorinated Paraffins for the General Population in Beijing, China. Environ. Sci. Technol. 52 (1), 32\u201339 (2018).","journal-title":"Environ. Sci. Technol."},{"key":"44845_CR8","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.jhazmat.2019.02.089","volume":"371","author":"D Xia","year":"2019","unstructured":"Xia, D. et al. Identification and evaluation of chlorinated nonane paraffins in the environment: A persistent organic pollutant candidate for the Stockholm Convention? J. Hazard. Mater. 371, 449\u2013455 (2019).","journal-title":"J. Hazard. Mater."},{"key":"44845_CR9","doi-asserted-by":"publisher","first-page":"122379","DOI":"10.1016\/j.envpol.2023.122379","volume":"336","author":"X Liu","year":"2023","unstructured":"Liu, X. et al. Freshwater environment risk assessment and derivation of human health ambient water quality criteria for SCCPs in China. Environ. Pollut. 336, 122379 (2023).","journal-title":"Environ. Pollut"},{"issue":"9","key":"44845_CR10","doi-asserted-by":"publisher","first-page":"172","DOI":"10.46234\/ccdcw2022.043","volume":"4","author":"Y Liu","year":"2022","unstructured":"Liu, Y. et al. Exposure to Chlorinated Paraffins in the Sixth Total Diet Study - China, 2016\u20132019. China CDC Wkly. 4 (9), 172\u2013175 (2022).","journal-title":"China CDC Wkly."},{"issue":"11","key":"44845_CR11","doi-asserted-by":"publisher","first-page":"7335","DOI":"10.1021\/acs.est.0c07058","volume":"55","author":"C Chen","year":"2021","unstructured":"Chen, C. et al. Distribution and Emission Estimation of Short- and Medium-Chain Chlorinated Paraffins in Chinese Products through Detection-Based Mass Balancing. Environ. Sci. Technol. 55 (11), 7335\u20137343 (2021).","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"44845_CR12","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/s00204-009-0489-9","volume":"84","author":"GD Warnasuriya","year":"2010","unstructured":"Warnasuriya, G. D., Elcombe, B. M., Foster, J. R. & Elcombe, C. R. A Mechanism for the induction of renal tumours in male Fischer 344 rats by short-chain chlorinated paraffins. Arch. Toxicol. 84 (3), 233\u2013243 (2010).","journal-title":"Arch. Toxicol."},{"key":"44845_CR13","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.ecoenv.2019.06.003","volume":"181","author":"Y Gong","year":"2019","unstructured":"Gong, Y. et al. Short-chain chlorinated paraffins (SCCPs) disrupt hepatic fatty acid metabolism in liver of male rat via interacting with peroxisome proliferator-activated receptor \u03b1 (PPAR\u03b1). Ecotoxicol. Environ. Saf. 181, 164\u2013171 (2019).","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"44845_CR14","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1016\/j.envpol.2016.09.016","volume":"219","author":"L Liu","year":"2016","unstructured":"Liu, L. et al. Relative developmental toxicity of short-chain chlorinated paraffins in Zebrafish (Danio rerio) embryos. Environ. Pollut. 219, 1122\u20131130 (2016).","journal-title":"Environ. Pollut"},{"key":"44845_CR15","doi-asserted-by":"publisher","first-page":"108365","DOI":"10.1016\/j.mrrev.2021.108365","volume":"787","author":"AW Caliri","year":"2021","unstructured":"Caliri, A. W., Tommasi, S. & Besaratinia, A. Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer. Mutat. Res. Rev. Mutat. Res. 787, 108365 (2021).","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"44845_CR16","doi-asserted-by":"publisher","first-page":"102673","DOI":"10.1016\/j.dnarep.2019.102673","volume":"83","author":"J Kay","year":"2019","unstructured":"Kay, J., Thadhani, E., Samson, L. & Engelward, B. Inflammation-induced DNA damage, mutations and cancer. DNA Repair. (Amst). 83, 102673 (2019).","journal-title":"DNA Repair. (Amst)"},{"issue":"3","key":"44845_CR17","first-page":"229","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray, F. et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 74 (3), 229\u2013263 (2024).","journal-title":"CA Cancer J. Clin."},{"key":"44845_CR18","doi-asserted-by":"publisher","first-page":"175883592312058","DOI":"10.1177\/17588359231205848","volume":"15","author":"D Pavlovic","year":"2023","unstructured":"Pavlovic, D., Niciforovic, D., Papic, D., Milojevic, K. & Markovic, M. CDK4\/6 inhibitors: basics, pros, and major cons in breast cancer treatment with specific regard to cardiotoxicity - a narrative review. Ther. Adv. Med. Oncol. 15, 17588359231205848 (2023).","journal-title":"Ther. Adv. Med. Oncol."},{"issue":"11","key":"44845_CR19","doi-asserted-by":"publisher","first-page":"Itc161","DOI":"10.7326\/AITC202311210","volume":"176","author":"AH Farkas","year":"2023","unstructured":"Farkas, A. H. & Nattinger, A. B. Breast Cancer Screening and Prevention. Ann. Intern. Med. 176 (11), Itc161\u2013itc176 (2023).","journal-title":"Ann. Intern. Med."},{"key":"44845_CR20","doi-asserted-by":"crossref","unstructured":"Neagu, A. N., Jayaweera, T., Corrice, L., Johnson, K. & Darie, C. C. Breast cancer exposomics. Life (Basel) 14 (3). (2024).","DOI":"10.3390\/life14030402"},{"key":"44845_CR21","doi-asserted-by":"publisher","first-page":"172988","DOI":"10.1016\/j.scitotenv.2024.172988","volume":"933","author":"C Panis","year":"2024","unstructured":"Panis, C. & Lemos, B. Pesticide exposure and increased breast cancer risk in women population studies. Sci. Total Environ. 933, 172988 (2024).","journal-title":"Sci. Total Environ."},{"key":"44845_CR22","doi-asserted-by":"crossref","unstructured":"Zainab, B. et al. Role of persistent organic pollutants in breast cancer progression and identification of estrogen receptor alpha inhibitors using in-silico mining and drug-drug interaction network approaches. Biology (Basel) 10 (7). (2021).","DOI":"10.3390\/biology10070681"},{"issue":"10","key":"44845_CR23","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1038\/nbt1007-1110","volume":"25","author":"AL Hopkins","year":"2007","unstructured":"Hopkins, A. L. Network pharmacology. Nat. Biotechnol. 25 (10), 1110\u20131111 (2007).","journal-title":"Nat. Biotechnol."},{"issue":"14","key":"44845_CR24","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.2174\/1389557520666200204121129","volume":"20","author":"M Dos Santos Maia","year":"2020","unstructured":"Dos Santos Maia, M., Soares Rodrigues, G. C., Silva Cavalcanti, A. B., Scotti, L. & Scotti, M. T. Consensus Analyses in Molecular Docking Studies Applied to Medicinal Chemistry. Mini Rev. Med. Chem. 20 (14), 1322\u20131340 (2020).","journal-title":"Mini Rev. Med. Chem."},{"issue":"7","key":"44845_CR25","doi-asserted-by":"publisher","first-page":"4047","DOI":"10.1021\/acs.jctc.1c01214","volume":"18","author":"D Jones","year":"2022","unstructured":"Jones, D. et al. Accelerators for Classical Molecular Dynamics Simulations of Biomolecules. J. Chem. Theory Comput. 18 (7), 4047\u20134069 (2022).","journal-title":"J. Chem. Theory Comput."},{"issue":"W1","key":"44845_CR26","doi-asserted-by":"publisher","first-page":"W257","DOI":"10.1093\/nar\/gky318","volume":"46","author":"P Banerjee","year":"2018","unstructured":"Banerjee, P., Eckert, A. O., Schrey, A. K. & Preissner, R. ProTox-II: a webserver for the prediction of toxicity of chemicals. Nucleic Acids Res. 46 (W1), W257\u2013w263 (2018).","journal-title":"Nucleic Acids Res."},{"issue":"W1","key":"44845_CR27","doi-asserted-by":"publisher","first-page":"W5","DOI":"10.1093\/nar\/gkab255","volume":"49","author":"G Xiong","year":"2021","unstructured":"Xiong, G. et al. ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties. Nucleic Acids Res. 49 (W1), W5\u2013w14 (2021).","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"44845_CR28","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie, M. E. et al. Smyth GK: limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43 (7), e47 (2015).","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"44845_CR29","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou, Y. et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat. Commun. 10 (1), 1523 (2019).","journal-title":"Nat. Commun."},{"key":"44845_CR30","doi-asserted-by":"crossref","unstructured":"Dolinsky, T. J. et al. PDB2PQR: expanding and upgrading automated preparation of biomolecular structures for molecular simulations. Nucleic Acids Res. 35 W522\u2013525. (2007).","DOI":"10.1093\/nar\/gkm276"},{"issue":"6","key":"44845_CR31","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1093\/bioinformatics\/btr009","volume":"27","author":"Y Cao","year":"2011","unstructured":"Cao, Y. et al. Improved side-chain modeling by coupling clash-detection guided iterative search with rotamer relaxation. Bioinformatics 27 (6), 785\u2013790 (2011).","journal-title":"Bioinformatics"},{"issue":"1","key":"44845_CR32","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1002\/prot.10250","volume":"50","author":"R Br\u00fcschweiler","year":"2003","unstructured":"Br\u00fcschweiler, R. Efficient RMSD measures for the comparison of two molecular ensembles. Root-mean-square deviation. Proteins 50 (1), 26\u201334 (2003).","journal-title":"Proteins"},{"issue":"8","key":"44845_CR33","doi-asserted-by":"publisher","first-page":"2958","DOI":"10.1021\/j100854a047","volume":"72","author":"LS Baskin","year":"1968","unstructured":"Baskin, L. S. Electric conductance and pH measurements of isoionic salt-free bovine mercaptalbumin solutions. An evaluation of root-mean-square proton fluctuations. J. Phys. Chem. 72 (8), 2958\u20132962 (1968).","journal-title":"J. Phys. Chem."},{"issue":"4","key":"44845_CR34","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1134\/S0026893308040195","volume":"42","author":"M Lobanov","year":"2008","unstructured":"Lobanov, M., Bogatyreva, N. S. & Galzitskaia, O. V. [Radius of gyration is indicator of compactness of protein structure]. Mol. Biol. (Mosk). 42 (4), 701\u2013706 (2008).","journal-title":"Mol. Biol. (Mosk)"},{"issue":"17","key":"44845_CR35","doi-asserted-by":"publisher","first-page":"6524","DOI":"10.1080\/07391102.2020.1801507","volume":"39","author":"P Sharma","year":"2021","unstructured":"Sharma, P., Joshi, T., Joshi, T., Chandra, S. & Tamta, S. Molecular dynamics simulation for screening phytochemicals as \u03b1-amylase inhibitors from medicinal plants. J. Biomol. Struct. Dyn. 39 (17), 6524\u20136538 (2021).","journal-title":"J. Biomol. Struct. Dyn."},{"key":"44845_CR36","doi-asserted-by":"publisher","first-page":"139552","DOI":"10.1016\/j.chemosphere.2023.139552","volume":"338","author":"O Mendo Diaz","year":"2023","unstructured":"Mendo Diaz, O. et al. Fingerprinting of chlorinated paraffins and their transformation products in plastic consumer products. Chemosphere 338, 139552 (2023).","journal-title":"Chemosphere"},{"key":"44845_CR37","doi-asserted-by":"publisher","first-page":"162681","DOI":"10.1016\/j.scitotenv.2023.162681","volume":"875","author":"G Choo","year":"2023","unstructured":"Choo, G., Ekpe, O. D., Kim, D. H. & Oh, J. E. Human exposure to short-chain chlorinated paraffins and organophosphate flame retardants in relation to paired multiple sources. Sci. Total Environ. 875, 162681 (2023).","journal-title":"Sci. Total Environ."},{"issue":"1","key":"44845_CR38","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s12943-020-01258-7","volume":"19","author":"S Zou","year":"2020","unstructured":"Zou, S. et al. Targeting STAT3 in Cancer Immunotherapy. Mol. Cancer. 19 (1), 145 (2020).","journal-title":"Mol. Cancer"},{"key":"44845_CR39","doi-asserted-by":"publisher","first-page":"110275","DOI":"10.1016\/j.cellsig.2022.110275","volume":"92","author":"M El-Tanani","year":"2022","unstructured":"El-Tanani, M. et al. Importance of STAT3 signalling in cancer, metastasis and therapeutic interventions. Cell. Signal. 92, 110275 (2022).","journal-title":"Cell. Signal."},{"key":"44845_CR40","doi-asserted-by":"publisher","first-page":"120996","DOI":"10.1016\/j.lfs.2022.120996","volume":"309","author":"YH Dinakar","year":"2022","unstructured":"Dinakar, Y. H. et al. Role of STAT3 in the initiation, progression, proliferation and metastasis of breast cancer and strategies to deliver JAK and STAT3 inhibitors. Life Sci. 309, 120996 (2022).","journal-title":"Life Sci."},{"issue":"3","key":"44845_CR41","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1007\/s12094-012-0789-z","volume":"14","author":"A Sonnenblick","year":"2012","unstructured":"Sonnenblick, A. et al. Tissue microarray-based study of patients with lymph node-positive breast cancer shows tyrosine phosphorylation of signal transducer and activator of transcription 3 (tyrosine705-STAT3) is a marker of good prognosis. Clin. Transl Oncol. 14 (3), 232\u2013236 (2012).","journal-title":"Clin. Transl Oncol."},{"issue":"12","key":"44845_CR42","doi-asserted-by":"publisher","first-page":"2501","DOI":"10.1002\/ptr.6189","volume":"32","author":"J Chun","year":"2018","unstructured":"Chun, J., Song, K. & Kim, Y. S. Sesquiterpene lactones-enriched fraction of Inula helenium L. induces apoptosis through inhibition of signal transducers and activators of transcription 3 signaling pathway in MDA-MB-231 breast cancer cells. Phytother Res. 32 (12), 2501\u20132509 (2018).","journal-title":"Phytother Res."},{"issue":"10","key":"44845_CR43","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1038\/s41388-021-02172-y","volume":"41","author":"L Avalle","year":"2022","unstructured":"Avalle, L. et al. STAT3 induces breast cancer growth via ANGPTL4, MMP13 and STC1 secretion by cancer associated fibroblasts. Oncogene 41 (10), 1456\u20131467 (2022).","journal-title":"Oncogene"},{"issue":"5","key":"44845_CR44","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.molmed.2016.03.002","volume":"22","author":"G Cildir","year":"2016","unstructured":"Cildir, G., Low, K. C. & Tergaonkar, V. Noncanonical NF-\u03baB Signaling in Health and Disease. Trends Mol. Med. 22 (5), 414\u2013429 (2016).","journal-title":"Trends Mol. Med."},{"issue":"7","key":"44845_CR45","doi-asserted-by":"publisher","first-page":"2770","DOI":"10.1002\/jcp.30759","volume":"237","author":"S Mirzaei","year":"2022","unstructured":"Mirzaei, S. et al. NF-\u03baB as a regulator of cancer metastasis and therapy response: A focus on epithelial-mesenchymal transition. J. Cell. Physiol. 237 (7), 2770\u20132795 (2022).","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"44845_CR46","first-page":"152","volume":"25","author":"J Hu","year":"2020","unstructured":"Hu, J., Guo, P., Zhang, Y., Huang, Z. & Chen, B. MicroRNA-322 regulates the growth, chemosensitivity, migration and invasion of breast cancer cells by targeting NF-kB1. J. buon. 25 (1), 152\u2013158 (2020).","journal-title":"J. buon"},{"key":"44845_CR47","doi-asserted-by":"crossref","unstructured":"Rashid, Z. A. & Bardaweel, S. K. Novel matrix metalloproteinase-9 (MMP-9) inhibitors in cancer treatment. Int. J. Mol. Sci. 24 (15). (2023).","DOI":"10.3390\/ijms241512133"},{"issue":"29","key":"44845_CR48","doi-asserted-by":"publisher","first-page":"4832","DOI":"10.1038\/s41388-021-01873-8","volume":"40","author":"X Bi","year":"2021","unstructured":"Bi, X. et al. Msi1 promotes breast cancer metastasis by regulating invadopodia-mediated extracellular matrix degradation via the Timp3-Mmp9 pathway. Oncogene 40 (29), 4832\u20134845 (2021).","journal-title":"Oncogene"},{"key":"44845_CR49","doi-asserted-by":"crossref","unstructured":"Owyong, M. et al. MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy. Life Sci. Alliance 2 (6). (2019).","DOI":"10.26508\/lsa.201800226"},{"issue":"7","key":"44845_CR50","first-page":"1415","volume":"9","author":"J Qu","year":"2019","unstructured":"Qu, J. et al. Natriuretic peptide receptor a promotes breast cancer development by upregulating MMP9. Am. J. Cancer Res. 9 (7), 1415\u20131428 (2019).","journal-title":"Am. J. Cancer Res."},{"issue":"2","key":"44845_CR51","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s10549-020-05670-x","volume":"182","author":"C Joseph","year":"2020","unstructured":"Joseph, C. et al. Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival. Breast Cancer Res. Treat. 182 (2), 267\u2013282 (2020).","journal-title":"Breast Cancer Res. Treat."},{"issue":"8","key":"44845_CR52","doi-asserted-by":"publisher","first-page":"119542","DOI":"10.1016\/j.bbamcr.2023.119542","volume":"1870","author":"X Jing","year":"2023","unstructured":"Jing, X. et al. IGF2BP3-EGFR-AKT axis promotes breast cancer MDA-MB-231 cell growth. Biochim. Biophys. Acta Mol. Cell. Res. 1870 (8), 119542 (2023).","journal-title":"Biochim. Biophys. Acta Mol. Cell. Res."},{"key":"44845_CR53","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.bbrc.2022.02.072","volume":"601","author":"T Huang","year":"2022","unstructured":"Huang, T. et al. GALNT8 suppresses breast cancer cell metastasis potential by regulating EGFR O-GalNAcylation. Biochem. Biophys. Res. Commun. 601, 16\u201323 (2022).","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"44845_CR54","doi-asserted-by":"publisher","first-page":"6003","DOI":"10.18632\/oncotarget.13990","volume":"8","author":"F Xu","year":"2017","unstructured":"Xu, F. et al. Clinicopathological and prognostic significance of COX-2 immunohistochemical expression in breast cancer: a meta-analysis. Oncotarget 8 (4), 6003\u20136012 (2017).","journal-title":"Oncotarget"},{"key":"44845_CR55","doi-asserted-by":"crossref","unstructured":"Balamurugan, K. et al. Stabilization of E-cadherin adhesions by COX-2\/GSK3\u03b2 signaling is a targetable pathway in metastatic breast cancer. JCI Insight 8 (6). (2023).","DOI":"10.1172\/jci.insight.156057"},{"issue":"9","key":"44845_CR56","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1158\/1940-6207.CAPR-20-0095","volume":"13","author":"S Bayraktar","year":"2020","unstructured":"Bayraktar, S. et al. Biomarker Modulation Study of Celecoxib for Chemoprevention in Women at Increased Risk for Breast Cancer: A Phase II Pilot Study. Cancer Prev. Res. (Phila). 13 (9), 795\u2013802 (2020).","journal-title":"Cancer Prev. Res. (Phila)"},{"issue":"12","key":"44845_CR57","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.7150\/ijbs.15943","volume":"12","author":"L Gan","year":"2016","unstructured":"Gan, L. et al. Cyclooxygenase-2 in tumor-associated macrophages promotes metastatic potential of breast cancer cells through Akt pathway. Int. J. Biol. Sci. 12 (12), 1533\u20131543 (2016).","journal-title":"Int. J. Biol. Sci."},{"issue":"6","key":"44845_CR58","doi-asserted-by":"publisher","first-page":"4121","DOI":"10.1002\/jcp.30166","volume":"236","author":"B Kashani","year":"2021","unstructured":"Kashani, B., Zandi, Z., Pourbagheri-Sigaroodi, A., Bashash, D. & Ghaffari, S. H. The role of toll-like receptor 4 (TLR4) in cancer progression: A possible therapeutic target? J. Cell. Physiol. 236 (6), 4121\u20134137 (2021).","journal-title":"J. Cell. Physiol."},{"issue":"10","key":"44845_CR59","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/s41568-023-00604-3","volume":"23","author":"M Will","year":"2023","unstructured":"Will, M., Liang, J., Metcalfe, C. & Chandarlapaty, S. Therapeutic resistance to anti-oestrogen therapy in breast cancer. Nat. Rev. Cancer. 23 (10), 673\u2013685 (2023).","journal-title":"Nat. Rev. Cancer"},{"key":"44845_CR60","doi-asserted-by":"crossref","unstructured":"Hern\u00e1ndez-Quiles, M. et al. TRIB3 modulates PPAR\u03b3-mediated growth inhibition by interfering with the MLL complex in breast cancer cells. Int. J. Mol. Sci. 23 (18). (2022).","DOI":"10.3390\/ijms231810535"},{"issue":"17\u201318","key":"44845_CR61","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1101\/gad.316646.118","volume":"32","author":"R Siersb\u00e6k","year":"2018","unstructured":"Siersb\u00e6k, R., Kumar, S. & Carroll, J. S. Signaling pathways and steroid receptors modulating estrogen receptor \u03b1 function in breast cancer. Genes Dev. 32 (17\u201318), 1141\u20131154 (2018).","journal-title":"Genes Dev."},{"issue":"12","key":"44845_CR62","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/j.annonc.2023.09.3103","volume":"34","author":"S Damodaran","year":"2023","unstructured":"Damodaran, S. et al. Open-label, phase II, multicenter study of lasofoxifene plus abemaciclib for treating women with metastatic ER+\/HER2- breast cancer and an ESR1 mutation after disease progression on prior therapies: ELAINE 2. Ann. Oncol. 34 (12), 1131\u20131140 (2023).","journal-title":"Ann. Oncol."},{"issue":"28","key":"44845_CR63","doi-asserted-by":"publisher","first-page":"3246","DOI":"10.1200\/JCO.22.00338","volume":"40","author":"FC Bidard","year":"2022","unstructured":"Bidard, F. C. et al. Elacestrant (oral selective estrogen receptor degrader) Versus Standard Endocrine Therapy for Estrogen Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Advanced Breast Cancer: Results From the Randomized Phase III EMERALD Trial. J. Clin. Oncol. 40 (28), 3246\u20133256 (2022).","journal-title":"J. Clin. Oncol."},{"issue":"9","key":"44845_CR64","doi-asserted-by":"publisher","first-page":"6886","DOI":"10.1002\/fsn3.4320","volume":"12","author":"Y Dong","year":"2024","unstructured":"Dong, Y. et al. Garlic peel extract as an antioxidant inhibits triple-negative breast tumor growth and angiogenesis by inhibiting cyclooxygenase-2 expression. Food Sci. Nutr. 12 (9), 6886\u20136895 (2024).","journal-title":"Food Sci. Nutr."},{"issue":"3","key":"44845_CR65","doi-asserted-by":"publisher","first-page":"604","DOI":"10.34172\/apb.2024.055","volume":"14","author":"MM Akl","year":"2024","unstructured":"Akl, M. M. & Ahmed, A. Cytobiological Alterations Induced by Celecoxib as an Anticancer Agent for Breast and Metastatic Breast Cancer. Adv. Pharm. Bull. 14 (3), 604\u2013612 (2024).","journal-title":"Adv. Pharm. Bull."},{"issue":"21","key":"44845_CR66","doi-asserted-by":"publisher","first-page":"6823","DOI":"10.1021\/acs.jcim.3c01154","volume":"63","author":"GP Pereira","year":"2023","unstructured":"Pereira, G. P. et al. Rational Prediction of PROTAC-Compatible Protein-Protein Interfaces by Molecular Docking. J. Chem. Inf. Model. 63 (21), 6823\u20136833 (2023).","journal-title":"J. Chem. Inf. Model."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-44845-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-44845-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-44845-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T20:02:52Z","timestamp":1779393772000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-44845-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,2]]},"references-count":66,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["44845"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-44845-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,2]]},"assertion":[{"value":"19 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"15792"}}