{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:09:28Z","timestamp":1793909368473,"version":"4.8.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Departamento de Universidad, Innovaci\u00f3n y Transformaci\u00f3n Digital. Gobierno de Navarra","award":["0011-1408-2022-000010"],"award-info":[{"award-number":["0011-1408-2022-000010"]}]},{"name":"Departamento de Universidad, Innovaci\u00f3n y Transformaci\u00f3n Digital. Gobierno de Navarra","award":["0011-1408-2024-000011"],"award-info":[{"award-number":["0011-1408-2024-000011"]}]},{"name":"National Health System, Spain","award":["INT22\/00112"],"award-info":[{"award-number":["INT22\/00112"]}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/00333"],"award-info":[{"award-number":["PI21\/00333"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-45298-3","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:04:17Z","timestamp":1782860657000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mass spectrometry-based proteomics to study gastric carcinogenesis: pathophysiological molecular characterization"],"prefix":"10.1038","volume":"16","author":[{"given":"Nayra","family":"Fel\u00edpez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheyla","family":"Montori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Valero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Santamar\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Ausin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Peral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Llach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Florez-Diez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Barreiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Arruebo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Vicente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MTeresa","family":"Soria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Huerta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Patricia","family":"Ortega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henar","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"D\u00edez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Herreros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gadea","family":"Hontoria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Mar\u00eda","family":"Saiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Mangas-Sanjuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Patr\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Hijos-Mallada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Domper-Arnal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Zarraqui\u00f1os","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid Irene","family":"D\u00edez-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"de Frutos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Santiago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelina","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Mart\u00edn-Lagos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferm\u00edn","family":"Estremera-Ar\u00e9valo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"G\u00f3mez-Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anabella","family":"Cuestas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Balaguer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergi","family":"Castellv\u00ed-Bel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gl\u00f2ria","family":"Fernandez-Esparrach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Cuatrecasas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Fern\u00e1ndez-Irigoyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Alb\u00e9niz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"EpiGASTRIC EDGAR Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gl\u00f2ria","family":"Fernandez\u2011Esparrach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenifer","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Herrera\u2011Pariente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laia","family":"Bonjoch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricard","family":"Prat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergi","family":"Castellv\u00ed\u2011Bel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Luzko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Cant\u00fa\u2011Germano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angels","family":"Gines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignasi","family":"Elizalde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Saur\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Florez\u2011Diez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Barreiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Su\u00e1rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Arruebo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Vicente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MTeresa","family":"Soria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Polo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Yag\u00fce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Huerta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oiane","family":"Rique-Aguinaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Patricia","family":"Ortega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henar","family":"Nu\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"D\u00edez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima","family":"Valent\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Mar\u00eda","family":"Sa\u00edz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Mangas\u2011Sanjuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Jover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Tello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Hijos\u2011Mallada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Domper-Arnal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid Irene","family":"D\u00edez\u2011Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coral","family":"Tejido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Francisco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Puga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Baiocchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Alejandra","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Pereiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin","family":"Cubiella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Enrique","family":"Yip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Mart\u00edn\u2011Lagos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferm\u00edn","family":"Estremera\u2011Ar\u00e9valo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9","family":"Vila-Costas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Busto-Bea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carrascosa","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanesa","family":"Jusu\u00e9-Irurita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"C\u00f3rdoba-Iturriagagoitia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Llanos-Chavarri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Amat-Villegas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorio","family":"Aisa-Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene Fern\u00e1ndez","family":"de losReyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"de Lima-Pi\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Resano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Yag\u00fce-Hernando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Caballero-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"L\u00f3pez-Cousillas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Tejedor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Zaffalon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Pi\u00f1ol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Grajal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dulce","family":"Momblan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngeles","family":"P\u00e9rez\u2011Aisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Hinojosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Ledo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Victoria","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Garz\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Manuel","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Sobrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Garc\u00eda\u2011Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alazne","family":"Aguirre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainara","family":"Maiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e9s","family":"Ari\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores","family":"Pico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"de Riba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goretti","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mart\u00edn-Junco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"45298_CR1","doi-asserted-by":"publisher","first-page":"D1218","DOI":"10.1093\/nar\/gky899","volume":"47","author":"Y Moriya","year":"2019","unstructured":"Moriya, Y. et al. The JPOST environment: an integrated proteomics data repository and database. Nucleic Acids Res. 47, D1218-24. https:\/\/doi.org\/10.1093\/nar\/gky899 (2019).","journal-title":"Nucleic Acids Res."},{"key":"45298_CR2","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray, F. et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 74, 229\u201363. https:\/\/doi.org\/10.3322\/caac.21834 (2024).","journal-title":"CA Cancer J. Clin."},{"key":"45298_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00412","author":"KI Mukaisho","year":"2015","unstructured":"Mukaisho, K. I., Nakayama, T., Hagiwara, T., Hattori, T. & Sugihara, H. Two distinct etiologies of gastric cardia adenocarcinoma: Interactions among pH, Helicobacter pylori, and bile acids. Front. Media S.A Front. Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2015.00412 (2015).","journal-title":"Front. Media S.A Front. Microbiol."},{"key":"45298_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101404","volume":"47","author":"E Morgan","year":"2022","unstructured":"Morgan, E. et al. The current and future incidence and mortality of gastric cancer in 185 countries, 2020\u201340: a population-based modelling study. EClinicalMedicine 47, 101404. https:\/\/doi.org\/10.1016\/j.eclinm.2022.101404 (2022).","journal-title":"EClinicalMedicine"},{"key":"45298_CR5","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00747-0","author":"AP Thrift","year":"2023","unstructured":"Thrift, A. P., Wenker, T. N. & El-Serag, H. B. Global burden of gastric cancer: epidemiological trends, risk factors, screening and prevention. Nat. Rev. Clin. Oncol. https:\/\/doi.org\/10.1038\/s41571-023-00747-0 (2023).","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"45298_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-025-01042-2","author":"J Wizenty","year":"2025","unstructured":"Wizenty, J. & Sigal, M. Helicobacter pylori, microbiota and gastric cancer \u2014 principles of microorganism-driven carcinogenesis. Nat. Rev. Gastroenterol. Hepatol https:\/\/doi.org\/10.1038\/s41575-025-01042-2 (2025).","journal-title":"Nat. Rev. Gastroenterol. Hepatol"},{"key":"45298_CR7","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2857","author":"DB Polk","year":"2010","unstructured":"Polk, D. B. & Peek, R. M. Helicobacter pylori: gastric cancer and beyond. Nat. Rev. Cancer https:\/\/doi.org\/10.1038\/nrc2857 (2010).","journal-title":"Nat. Rev. Cancer"},{"key":"45298_CR8","unstructured":"Correa P. Human gastric carcinogenesis: a multistep and multifactorial process first american cancer society award lecture on cancer epidemiology and prevention 1 http:\/\/aacrjournals.org\/cancerres\/article-pdf\/52\/24\/6735\/2448984\/crs0520246735.pdf"},{"key":"45298_CR9","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1038\/nature13480","volume":"513","author":"Comprehensive molecular characterization of gastric adenocarcinoma","year":"2014","unstructured":"Comprehensive molecular characterization of gastric adenocarcinoma. Nature. 513, 202\u20139. https:\/\/doi.org\/10.1038\/nature13480 (2014).","journal-title":"Nature."},{"key":"45298_CR10","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.ccell.2018.12.003","volume":"35","author":"DG Mun","year":"2019","unstructured":"Mun, D. G. et al. Proteogenomic characterization of human early-onset gastric cancer. Cancer Cell 35, 111-124.e10. https:\/\/doi.org\/10.1016\/j.ccell.2018.12.003 (2019) (Cell Press).","journal-title":"Cancer Cell"},{"key":"45298_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103714","author":"X Li","year":"2021","unstructured":"Li, X. et al. Proteomic profiling identifies signatures associated with progression of precancerous gastric lesions and risk of early gastric cancer. EBioMedicine https:\/\/doi.org\/10.1016\/j.ebiom.2021.103714 (2021).","journal-title":"EBioMedicine"},{"key":"45298_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-35797-6","author":"W Shi","year":"2023","unstructured":"Shi, W. et al. Multilevel proteomic analyses reveal molecular diversity between diffuse-type and intestinal-type gastric cancer. Nat. Commun. https:\/\/doi.org\/10.1038\/s41467-023-35797-6 (2023).","journal-title":"Nat. Commun."},{"key":"45298_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3901","author":"S Tyanova","year":"2016","unstructured":"Tyanova, S. et al. The Perseus computational platform for comprehensive analysis of (prote)omics data. Nat. Methods https:\/\/doi.org\/10.1038\/nmeth.3901 (2016).","journal-title":"Nat. Methods"},{"key":"45298_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09234-6","author":"Y Zhou","year":"2019","unstructured":"Zhou, Y. et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat. Commun. https:\/\/doi.org\/10.1038\/s41467-019-09234-6 (2019).","journal-title":"Nat. Commun."},{"key":"45298_CR15","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","volume":"30","author":"A Kr\u00e4mer","year":"2014","unstructured":"Kr\u00e4mer, A., Green, J., Pollard, J. & Tugendreich, S. Causal analysis approaches in ingenuity pathway analysis. Bioinformatics 30, 523\u201330. https:\/\/doi.org\/10.1093\/bioinformatics\/btt703 (2014).","journal-title":"Bioinformatics"},{"key":"45298_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fgstr.2022.948323","author":"B Song","year":"2022","unstructured":"Song, B. et al. Biomarker identification of chronic atrophic gastritis and its potential drug analysis. Front. Gastroenterol. https:\/\/doi.org\/10.3389\/fgstr.2022.948323 (2022).","journal-title":"Front. Gastroenterol."},{"key":"45298_CR17","unstructured":"Juan Carlos Oliveros. Oliveros, J.C. (2007-2015) Venny. An interactive tool for comparing lists with Venn\u2019s diagrams. https:\/\/bioinfogp.cnb.csic.es\/tools\/venny\/index.html."},{"key":"45298_CR18","doi-asserted-by":"crossref","unstructured":"Ellis EM, Judaht DJ, Nealt GE, Hayes JD. An ethoxyquin-inducible aldehyde reductase from rat liver that metabolizes aflatoxin B1 defines a subfamily of aldo-keto reductases (chemprotection\/liver cancer\/antioiddant). Proc. Natl. Acad. Sci. USA. (1993).","DOI":"10.1073\/pnas.90.21.10350"},{"key":"45298_CR19","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1007\/s11427-022-2108-x","volume":"65","author":"B Li","year":"2022","unstructured":"Li, B. et al. CREB1 contributes colorectal cancer cell plasticity by regulating lncRNA CCAT1 and NF-\u03baB pathways. Sci. China Life Sci. 65, 1481\u201397. https:\/\/doi.org\/10.1007\/s11427-022-2108-x (2022).","journal-title":"Sci. China Life Sci."},{"key":"45298_CR20","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1016\/j.molonc.2014.05.008","volume":"8","author":"R Linnskog","year":"2014","unstructured":"Linnskog, R., J\u00f6nsson, G., Axelsson, L., Prasad, C. P. & Andersson, T. Interleukin-6 drives melanoma cell motility through p38\u03b1-MAPK-dependent up-regulation of WNT5A expression. Mol Oncol. 8, 1365\u201378. https:\/\/doi.org\/10.1016\/j.molonc.2014.05.008 (2014).","journal-title":"Mol Oncol."},{"key":"45298_CR21","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-07860-2","author":"H Jiang","year":"2021","unstructured":"Jiang, H. & Li, H. Prognostic values of tumoral MMP2 and MMP9 overexpression in breast cancer: a systematic review and meta-analysis. BMC Cancer https:\/\/doi.org\/10.1186\/s12885-021-07860-2 (2021).","journal-title":"BMC Cancer"},{"key":"45298_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.142","author":"K Taniguchi","year":"2018","unstructured":"Taniguchi, K. & Karin, M. NF-\u03baB, inflammation, immunity and cancer: coming of age. Nat. Rev. Immunol. https:\/\/doi.org\/10.1038\/nri.2017.142 (2018).","journal-title":"Nat. Rev. Immunol."},{"key":"45298_CR23","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.celrep.2014.08.049","volume":"9","author":"DJ Wang","year":"2014","unstructured":"Wang, D. J., Ratnam, N. M., Byrd, J. C. & Guttridge, D. C. NF-\u03baB functions in tumor initiation by suppressing the surveillance of both innate and adaptive immune cells. Cell Rep. 9, 90\u2013103. https:\/\/doi.org\/10.1016\/j.celrep.2014.08.049 (2014).","journal-title":"Cell Rep."},{"key":"45298_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2023.101042","author":"Y Li","year":"2024","unstructured":"Li, Y. et al. Inhibition of NF-\u03baB signaling unveils novel strategies to overcome drug resistance in cancers. Drug Resist. Updates https:\/\/doi.org\/10.1016\/j.drup.2023.101042 (2024).","journal-title":"Drug Resist. Updates"},{"key":"45298_CR25","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26322","author":"JL Luo","year":"2005","unstructured":"Luo, J. L., Kamata, H. & Karin, M. IKK\/NF-\u00a0B signaling: balancing life and death - a new approach to cancer therapy. J. Clin. Investig. https:\/\/doi.org\/10.1172\/JCI26322 (2005).","journal-title":"J. Clin. Investig."},{"key":"45298_CR26","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30759","author":"S Mirzaei","year":"2022","unstructured":"Mirzaei, S. et al. NF-\u03baB as a regulator of cancer metastasis and therapy response: a focus on epithelial\u2013mesenchymal transition. J. Cell. Physiol. https:\/\/doi.org\/10.1002\/jcp.30759 (2022).","journal-title":"J. Cell. Physiol."},{"key":"45298_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2399-y","author":"D Verzella","year":"2020","unstructured":"Verzella, D. et al. Life, death, and autophagy in cancer: NF-\u03baB turns up everywhere. Cell Death Dis. https:\/\/doi.org\/10.1038\/s41419-020-2399-y (2020) (Springer Nature;).","journal-title":"Cell Death Dis."},{"key":"45298_CR28","doi-asserted-by":"publisher","DOI":"10.3390\/cells5010012","author":"F Christian","year":"2016","unstructured":"Christian, F., Smith, E. L. & Carmody, R. J. The regulation of NF-\u03baB Subunits by Phosphorylation. Cells https:\/\/doi.org\/10.3390\/cells5010012 (2016).","journal-title":"Cells"},{"key":"45298_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2024.1417502","author":"X Sun","year":"2024","unstructured":"Sun, X. et al. Post-translational modifications of p65: state of the art. Front. Cell Dev. Biol https:\/\/doi.org\/10.3389\/fcell.2024.1417502 (2024).","journal-title":"Front. Cell Dev. Biol"},{"key":"45298_CR30","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s00384-011-1356-8","volume":"27","author":"A Lewander","year":"2012","unstructured":"Lewander, A. et al. NF-\u03baB p65 phosphorylated at serine-536 is an independent prognostic factor in Swedish colorectal cancer patients. Int. J. Colorectal Dis. 27, 447\u201352. https:\/\/doi.org\/10.1007\/s00384-011-1356-8 (2012).","journal-title":"Int. J. Colorectal Dis."},{"key":"45298_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-02062-x","author":"X Xu","year":"2021","unstructured":"Xu, X. et al. Phosphorylation of NF-\u03baBp65 drives inflammation-mediated hepatocellular carcinogenesis and is a novel therapeutic target. J. Exp. Clin. Cancer Res. https:\/\/doi.org\/10.1186\/s13046-021-02062-x (2021).","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"45298_CR32","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aab2820","author":"JP Prad\u00e8re","year":"2016","unstructured":"Prad\u00e8re, J. P. et al. Negative regulation of NF-\u03baB p65 activity by serine 536 phosphorylation. Sci. Signal. Am. Assoc. Adv. Sci. https:\/\/doi.org\/10.1126\/scisignal.aab2820 (2016).","journal-title":"Sci. Signal. Am. Assoc. Adv. Sci."},{"key":"45298_CR33","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-024-02140-0","author":"T Aoki","year":"2024","unstructured":"Aoki, T. et al. Phosphorylation of Serine 536 of p65(RelA) Downregulates inflammatory responses. Inflammation https:\/\/doi.org\/10.1007\/s10753-024-02140-0 (2024).","journal-title":"Inflammation"},{"key":"45298_CR34","doi-asserted-by":"publisher","DOI":"10.1038\/nature07205","author":"A Mantovani","year":"2008","unstructured":"Mantovani, A., Allavena, P., Sica, A. & Balkwill, F. Cancer-related inflammation. Nature https:\/\/doi.org\/10.1038\/nature07205 (2008).","journal-title":"Nature"},{"key":"45298_CR35","doi-asserted-by":"publisher","first-page":"11673","DOI":"10.3748\/wjg.v21.i41.11673","volume":"21","author":"M Yang","year":"2015","unstructured":"Yang, M. & Huang, C. Z. Mitogen-activated protein kinase signaling pathway and invasion and metastasis of gastric cancer. World J. Gastroenterol. 21, 11673\u20139. https:\/\/doi.org\/10.3748\/wjg.v21.i41.11673 (2015) (WJG Press;).","journal-title":"World J. Gastroenterol."},{"key":"45298_CR36","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.ccr.2014.02.019","volume":"25","author":"J Gupta","year":"2014","unstructured":"Gupta, J. et al. Dual function of p38\u03b1 MAPK in colon cancer: Suppression of colitis-associated tumor initiation but requirement for cancer cell survival. Cancer Cell 25, 484\u2013500. https:\/\/doi.org\/10.1016\/j.ccr.2014.02.019 (2014) (Cell Press;).","journal-title":"Cancer Cell"},{"key":"45298_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290105","author":"W Zhang","year":"2002","unstructured":"Zhang, W., Liu, H. T. & Tu, H. MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res. https:\/\/doi.org\/10.1038\/sj.cr.7290105 (2002).","journal-title":"Cell Res."},{"key":"45298_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290257","author":"T Zarubin","year":"2005","unstructured":"Zarubin, T. & Han, J. Activation and signaling of the p38 MAP kinase pathway. Cell Res. https:\/\/doi.org\/10.1038\/sj.cr.7290257 (2005).","journal-title":"Cell Res."},{"key":"45298_CR39","unstructured":"Hardwick JC, Van Den Brink GR, O\u20acerhaus GJ, Jh Van Deventer S, Peppelenbosch MP. NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps www.nature.com\/onc"},{"key":"45298_CR40","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-024-02000-2","author":"G Wang","year":"2024","unstructured":"Wang, G. et al. Her2 promotes early dissemination of breast cancer by inhibiting the p38 pathway through the downregulation of MAP3K4. Cell Commun. Signal. https:\/\/doi.org\/10.1186\/s12964-024-02000-2 (2024).","journal-title":"Cell Commun. Signal."},{"key":"45298_CR41","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1158\/0008-5472.CAN-13-1310","volume":"74","author":"AJ MacNeil","year":"2014","unstructured":"MacNeil, A. J. et al. MAPK kinase 3 is a tumor suppressor with reduced copy number in breast cancer. Cancer Res. 74, 162\u201372. https:\/\/doi.org\/10.1158\/0008-5472.CAN-13-1310 (2014).","journal-title":"Cancer Res."},{"key":"45298_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00322-w","author":"B Canovas","year":"2021","unstructured":"Canovas, B. & Nebreda, A. R. Diversity and versatility of p38 kinase signalling in health and disease. Nat. Rev. Mol. Cell Biol. https:\/\/doi.org\/10.1038\/s41580-020-00322-w (2021).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"45298_CR43","unstructured":"MAPKK-Independent Activation of p38 mediated by TAB1-dependent autophosphorylation of p38."},{"key":"45298_CR44","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/ni1177","volume":"6","author":"JM Salvador","year":"2005","unstructured":"Salvador, J. M. et al. Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases. Nat. Immunol. 6, 390\u20135. https:\/\/doi.org\/10.1038\/ni1177 (2005).","journal-title":"Nat. Immunol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-45298-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-45298-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-45298-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:04:30Z","timestamp":1782860670000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-45298-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["45298"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-45298-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"assertion":[{"value":"22 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Eduardo Alb\u00e9niz has a consulting agreement with Creo Medical, AGS MedTech, honoraria for lectures, teaching activities or travel grants from Olympus, Boston, Fujifilm, Norgine, Casen Recordati, 3D Matrix. The remaining authors disclose no conflicts.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"19985"}}