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In this multicentre, randomised (2:1), double-blind, placebo-controlled trial, 93 patients with anterior STEMI were randomised to calcifediol or placebo, for 12\u00a0months. The primary endpoint was left ventricular remodelling, defined as a 15% increase in left ventricular end-diastolic volume (EDV) on magnetic resonance imaging. Sixty-five patients were allocated to calcifediol and 28 to placebo. Calcidiol levels increased in the intervention group (20.0[8.4, 36.5] vs. 2.0[\u2212\u20090.3, 4.5] ng\/mL,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). No differences were observed in the incidence of left ventricular remodelling (26.2% vs. 21.4%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.824) and in these secondary end points: increment in end-diastolic volume (6.0[\u2212\u20096.5, 21.6] vs. 6.1[\u2212\u20098.1, 23.8] mL;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.773), end-systolic volume (\u2212\u20096.9[\u2212\u200915.9, 4.5] vs. 1.3[\u2212\u200920.9, 17.2] mL;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.908), ejection fraction (5.1[2.1, 10.0] vs. 7.7[\u2212\u20090.9, 11.0]%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.992), and in plasma levels of N-terminal pro-brain natriuretic peptide, galectin-3, ST2, growth differentiation factor-15, fibroblast growth factor-23 (FGF23), high-sensitivity C-reactive protein, and monocyte chemoattractant protein-1. Similar results were observed in patients with baseline FGF23 above the median, in those with calcidiol\u2009&lt;\u200930\u00a0ng\/mL, and in the subgroup with ejection fraction\u2009\u2264\u200940%. In conclusion, calcifediol does not improve left ventricular remodelling or affect biomarkers related to heart failure and inflammation following a STEMI.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial registration<\/jats:bold>\n                    : NCT02548364.\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT02548364?term=VITDAMI%20Vitamin%20D%20in%20acute%20myocardial%20infarction%26rank=1\" ext-link-type=\"uri\">https:\/\/clinicaltrials.gov\/study\/NCT02548364?term=VITDAMI%20Vitamin%20D%20in%20acute%20myocardial%20infarction&amp;rank=1<\/jats:ext-link>\n                    .\n                  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