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In a 10-year cohort of 10,330 adults aged 40\u201369 years, we assessed the risk of FFs (i.e., hip, vertebral compression, and distal radius fractures) associated with cancer status by using time-dependent Cox proportional hazards analyses. The models were adjusted for demographic, lifestyle, and medical factors. The time-dependent variables included cancer status and age. Analyses were performed according to cancer treatment status, number of primary cancers, and cancer site. Among the 10,330 participants (mean age, 56.4 years; females, 6148), 386 experienced FFs. Compared with participants without cancer, a higher risk of overall FFs was observed in participants with cancer (hazard ratio [HR], 1.40; 95% confidence interval [CI], 1.03\u20131.89). This risk was further elevated among participants with active cancer (HR, 1.71; 95% CI, 1.15\u20132.55), multiple primary cancers (HR, 1.42; 95% CI, 1.04\u20131.95), stomach cancer (HR, 1.84; 95% CI, 1.01\u20133.37), kidney cancer (HR, 3.74; 95% CI, 1.20\u201311.70), and hematologic cancer (HR, 7.70; 95% CI, 2.45\u201324.16). These findings highlight the importance of FF prevention strategies in cancer survivorship care in aging Asian populations.<\/jats:p>","DOI":"10.1038\/s41598-026-45389-1","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:16:33Z","timestamp":1774268193000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Japanese cancer survivors have a higher risk of fragility fractures over ten years"],"prefix":"10.1038","volume":"16","author":[{"given":"Takaomi","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuma","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chisato","family":"Shimanoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikako","family":"Horita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hinako","family":"Nanri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuki","family":"Higaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadatsugu","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keitaro","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"45389_CR1","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1007\/s10147-022-02194-w","volume":"27","author":"H Kawano","year":"2022","unstructured":"Kawano, H., Hirahata, M. & Imanishi, J. 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