{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:54:16Z","timestamp":1787003656026,"version":"build-2736575974"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":48,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-45480-7","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T10:06:17Z","timestamp":1775037977000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Study on the relationship between coagulation function, homocysteine, serum oxidative stress and sudden deafness and its clinical implications"],"prefix":"10.1038","volume":"16","author":[{"given":"Buquan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"45480_CR1","doi-asserted-by":"publisher","first-page":"1121324","DOI":"10.3389\/fneur.2023.1121324","volume":"14","author":"N Chen","year":"2023","unstructured":"Chen, N. et al. Diagnosis, differential diagnosis, and treatment for sudden sensorineural hearing loss: current otolaryngology practices in China. Front. Neurol. 14, 1121324 (2023).","journal-title":"Front. Neurol."},{"issue":"Suppl","key":"45480_CR2","first-page":"S1","volume":"53","author":"J Chen","year":"2024","unstructured":"Chen, J. & Fraser-Kirk, K. Management of sudden sensorineural hearing loss: a time-critical diagnosis. Aust J. Gen. Pract. 53 (Suppl), S1\u2013S6 (2024).","journal-title":"Aust J. Gen. Pract."},{"key":"45480_CR3","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1002\/lary.28829","volume":"131","author":"JW Wood","year":"2021","unstructured":"Wood, J. W., Shaffer, A. D., Kitsko, D. & Chi, D. H. Sudden sensorineural hearing loss in children\u2014management and outcomes: a meta-analysis. Laryngoscope 131, 425\u2013434 (2021).","journal-title":"Laryngoscope"},{"key":"45480_CR4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1001\/jamaoto.2021.2685","volume":"148","author":"TG Joshua","year":"2022","unstructured":"Joshua, T. G., Ayub, A., Wijesinghe, P. & Nunez, D. A. Hyperbaric oxygen therapy for patients with sudden sensorineural hearing loss: a systematic review and meta-analysis. JAMA Otolaryngol. Head Neck Surg. 148, 5\u201311 (2022).","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"45480_CR5","first-page":"1862","volume":"72","author":"A Mughal","year":"2022","unstructured":"Mughal, A. et al. Sudden sensorineural hearing loss: a rare presentation of dengue fever. J. Pak Med. Assoc. 72, 1862\u20131864 (2022).","journal-title":"J. Pak Med. Assoc."},{"key":"45480_CR6","doi-asserted-by":"publisher","first-page":"22","DOI":"10.5604\/01.3001.0016.0050","volume":"76","author":"K Szkutnik","year":"2022","unstructured":"Szkutnik, K. & Olszewski, J. Analysis of the causes of the occurrence and treatment results of sudden hearing loss\/deafness in own material. Otolaryngol. Pol. 76, 22\u201329 (2022).","journal-title":"Otolaryngol. Pol."},{"key":"45480_CR7","doi-asserted-by":"publisher","first-page":"7248","DOI":"10.3390\/ijms21197248","volume":"21","author":"JG Doo","year":"2020","unstructured":"Doo, J. G. et al. Biomarkers suggesting favorable prognostic outcomes in sudden sensorineural hearing loss. Int. J. Mol. Sci. 21, 7248 (2020).","journal-title":"Int. J. Mol. Sci."},{"key":"45480_CR8","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1177\/01945998211064275","volume":"167","author":"CWD Chang","year":"2022","unstructured":"Chang, C. W. D. et al. Corticosteroid use in otolaryngology: current considerations during the COVID-19 era. Otolaryngol. Head Neck Surg. 167, 803\u2013820 (2022).","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"45480_CR9","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1097\/MAO.0000000000003661","volume":"43","author":"L Simani","year":"2022","unstructured":"Simani, L. et al. Is idiopathic sudden sensorineural hearing loss seasonal? Otol. Neurotol 43, 1016\u20131021 (2022).","journal-title":"Neurotol"},{"issue":"Suppl 3","key":"45480_CR10","doi-asserted-by":"publisher","first-page":"3947","DOI":"10.1007\/s12070-021-02713-7","volume":"74","author":"S Kanotra","year":"2022","unstructured":"Kanotra, S. et al. Intratympanic dexamethasone in sudden sensorineural hearing loss. Indian J. Otolaryngol. Head Neck Surg. 74 (Suppl 3), 3947\u20133956 (2022).","journal-title":"Indian J. Otolaryngol. Head Neck Surg."},{"key":"45480_CR11","first-page":"e21418","volume":"14","author":"WW Jung","year":"2022","unstructured":"Jung, W. W. & Hoegerl, C. Sudden sensorineural hearing loss and why it\u2019s an emergency. Cureus 14, e21418 (2022).","journal-title":"Cureus"},{"key":"45480_CR12","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1097\/MAO.0000000000003489","volume":"43","author":"TGA Elias","year":"2022","unstructured":"Elias, T. G. A. et al. Bilateral sudden sensorineural hearing loss: a distinct phenotype entity. Otol Neurotol. 43, 437\u2013442 (2022).","journal-title":"Otol Neurotol"},{"key":"45480_CR13","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.3390\/medicina59101718","volume":"59","author":"G Cavallaro","year":"2023","unstructured":"Cavallaro, G. et al. Endothelial dysfunction and metabolic disorders in patients with sudden sensorineural hearing loss. Medicina 59, 1718 (2023).","journal-title":"Medicina"},{"key":"45480_CR14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/lary.30141","volume":"133","author":"JFCPM Sim\u00f5es","year":"2023","unstructured":"Sim\u00f5es, J. F. C. P. M. et al. Cardiovascular risk and sudden sensorineural hearing loss: a systematic review and meta-analysis. Laryngoscope 133, 15\u201324 (2023).","journal-title":"Laryngoscope"},{"key":"45480_CR15","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1038\/s41598-020-80366-2","volume":"11","author":"K Wasano","year":"2021","unstructured":"Wasano, K. et al. Sudden sensorineural hearing loss in patients with vestibular schwannoma. Sci. Rep. 11, 1624 (2021).","journal-title":"Sci. Rep."},{"key":"45480_CR16","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.otorri.2021.07.005","volume":"73","author":"S Waissbluth","year":"2022","unstructured":"Waissbluth, S., Sep\u00falveda, V. & Urz\u00faa, P. Sudden sensorineural hearing loss: recovery rates according to audiometric patterns. Acta Otorrinolaringol Esp. 73, 346\u2013355 (2022).","journal-title":"Acta Otorrinolaringol Esp."},{"key":"45480_CR17","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1097\/MOO.0000000000000839","volume":"30","author":"X Goh","year":"2022","unstructured":"Goh, X., Muzaffar, J. & Bance, M. Cochlear implantation in systemic autoimmune disease. Curr. Opin. Otolaryngol. Head Neck Surg. 30, 291\u2013297 (2022).","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"45480_CR18","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1542\/pir.2021-004997","volume":"43","author":"LX Barrette","year":"2022","unstructured":"Barrette, L. X., Silverman, B. L., Lee, C. & Van Pelt, A. L. Sudden refusal to walk in a child with Stickler syndrome. Pediatr. Rev. 43, 724\u2013727 (2022).","journal-title":"Pediatr. Rev."},{"issue":"Suppl 2","key":"45480_CR19","doi-asserted-by":"publisher","first-page":"3028","DOI":"10.1007\/s12070-021-02756-w","volume":"74","author":"A Umashankar","year":"2022","unstructured":"Umashankar, A., Prakash, P. & Prabhu, P. Sudden sensorineural hearing loss post coronavirus disease: a systematic review of case reports. Indian J. Otolaryngol. Head Neck Surg. 74 (Suppl 2), 3028\u20133035 (2022).","journal-title":"Indian J. Otolaryngol. Head Neck Surg."},{"key":"45480_CR20","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1177\/01945998221087664","volume":"168","author":"ED McCoul","year":"2023","unstructured":"McCoul, E. D. et al. Systemic steroids for otolaryngology-head and neck surgery disorders: an evidence-based primer for clinicians. Otolaryngol. Head Neck Surg. 168, 643\u2013657 (2023).","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"45480_CR21","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1007\/s00405-023-07829-w","volume":"280","author":"X Niu","year":"2023","unstructured":"Niu, X., Chen, Y., Zhong, Y. & Xiao, X. The relationship between serum homocysteine levels and sudden sensorineural hearing loss: a meta-analysis. Eur. Arch. Otorhinolaryngol. 280, 2091\u20132097 (2023).","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"45480_CR22","doi-asserted-by":"publisher","first-page":"604","DOI":"10.21037\/apm.2019.10.08","volume":"8","author":"Y Huang","year":"2019","unstructured":"Huang, Y. et al. Blood homocysteine and folic acid levels may provide reference value for the treatment of sudden total frequency deafness. Ann. Palliat. Med. 8, 604\u2013610 (2019).","journal-title":"Ann. Palliat. Med."},{"key":"45480_CR23","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.3390\/jcm10051130","volume":"10","author":"K Sowula","year":"2021","unstructured":"Sowula, K. et al. Association between sudden sensorineural hearing loss and Lyme disease. J. Clin. Med. 10, 1130 (2021).","journal-title":"J. Clin. Med."},{"key":"45480_CR24","doi-asserted-by":"publisher","first-page":"64","DOI":"10.5152\/iao.2020.8902","volume":"17","author":"JCS Reading","year":"2021","unstructured":"Reading, J. C. S., Hall, A. & Nash, R. Paediatric sudden sensorineural hearing loss: pooled analysis and systematic review. J. Int. Adv. Otol. 17, 64\u201371 (2021).","journal-title":"J. Int. Adv. Otol"},{"key":"45480_CR25","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1016\/j.otc.2022.06.017","volume":"55","author":"M Abouzari","year":"2022","unstructured":"Abouzari, M., Tawk, K., Lee, D. & Djalilian, H. R. Migrainous vertigo, tinnitus, and ear symptoms and alternatives. Otolaryngol. Clin. N Am. 55, 1017\u20131033 (2022).","journal-title":"Otolaryngol. Clin. N Am."},{"key":"45480_CR26","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1016\/j.bjorl.2021.01.004","volume":"88","author":"YS \u00c7etin","year":"2022","unstructured":"\u00c7etin, Y. S. et al. The relationship between thiol-disulfide balance and idiopathic sudden sensorineural hearing loss. Braz J. Otorhinolaryngol. 88, 948\u2013953 (2022).","journal-title":"Braz J. Otorhinolaryngol."},{"key":"45480_CR27","doi-asserted-by":"publisher","first-page":"476","DOI":"10.3390\/audiolres12050048","volume":"12","author":"T Nishimura","year":"2022","unstructured":"Nishimura, T. et al. Evaluation of the recovery of idiopathic sudden sensorineural hearing loss based on estimated hearing disorders. Audiol. Res. 12, 476\u2013484 (2022).","journal-title":"Audiol. Res."},{"key":"45480_CR28","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1097\/AUD.0000000000000987","volume":"42","author":"M Okada","year":"2021","unstructured":"Okada, M. et al. Idiopathic sudden sensorineural hearing loss: speech intelligibility deficits following threshold recovery. Ear Hear. 42, 782\u2013792 (2021).","journal-title":"Ear Hear."},{"key":"45480_CR29","doi-asserted-by":"publisher","first-page":"378","DOI":"10.5152\/iao.2022.21485","volume":"18","author":"H Noh","year":"2022","unstructured":"Noh, H. et al. Downbeat nystagmus and bilateral sudden hearing loss by suicidal aspirin intoxication. J. Int. Adv. Otol. 18, 378\u2013380 (2022).","journal-title":"J. Int. Adv. Otol"},{"key":"45480_CR30","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.3390\/medicina59111977","volume":"59","author":"D Monzani","year":"2023","unstructured":"Monzani, D. et al. The role of fibrinogen, homocysteine and metabolic syndrome\u2019s alterations in sudden sensorineural hearing loss (SSHL): a narrative review. Medicina 59, 1977 (2023).","journal-title":"Medicina"},{"key":"45480_CR31","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.3109\/00016489.2015.1060629","volume":"135","author":"X Zhang","year":"2015","unstructured":"Zhang, X. et al. A clinical study of sudden deafness. Acta Otolaryngol. 135, 1030\u20131035 (2015).","journal-title":"Acta Otolaryngol."},{"key":"45480_CR32","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1177\/000348940611500710","volume":"115","author":"W Narozny","year":"2006","unstructured":"Narozny, W. et al. Prognostic factors in sudden sensorineural hearing loss: our experience and a review of the literature. Ann. Otol Rhinol Laryngol. 115, 553\u2013558 (2006).","journal-title":"Ann. Otol Rhinol Laryngol"},{"key":"45480_CR33","unstructured":"Browner, W. S., Newman, T. B., Cummings, S. R. & Grady, D. G. Designing Clinical Research (Lippincott Williams & Wilkins, 2022)."},{"issue":"Suppl 3","key":"45480_CR34","first-page":"S1","volume":"146","author":"RJ Stachler","year":"2012","unstructured":"Stachler, R. J. et al. Clinical practice guideline: sudden hearing loss. Otolaryngol. Head Neck Surg. 146 (Suppl 3), S1\u2013S35 (2012).","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"45480_CR35","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.otorri.2018.04.010","volume":"70","author":"M Herrera","year":"2019","unstructured":"Herrera, M. et al. Update on consensus on diagnosis and treatment of idiopathic sudden sensorineural hearing loss. Acta Otorrinolaringol Esp. 70, 290\u2013300 (2019).","journal-title":"Acta Otorrinolaringol Esp."},{"key":"45480_CR36","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1373\/clinchem.2003.021634","volume":"50","author":"H Refsum","year":"2004","unstructured":"Refsum, H. et al. Facts and recommendations about total homocysteine determinations: an expert opinion. Clin. Chem. 50, 3\u201332 (2004).","journal-title":"Clin. Chem."},{"key":"45480_CR37","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1093\/clinchem\/34.3.497","volume":"34","author":"YI Sun","year":"1988","unstructured":"Sun, Y. I., Oberley, L. W. & Li, Y. A simple method for clinical assay of superoxide dismutase. Clin. Chem. 34, 497\u2013500 (1988).","journal-title":"Clin. Chem."},{"key":"45480_CR38","doi-asserted-by":"publisher","first-page":"e927328","DOI":"10.12659\/MSM.927328","volume":"26","author":"Z Liu","year":"2020","unstructured":"Liu, Z. et al. Differential levels of endoplasmic reticulum stress in peripheral blood mononuclear cells from patients with sudden sensorineural hearing loss. Med. Sci. Monit. 26, e927328 (2020).","journal-title":"Med. Sci. Monit."},{"key":"45480_CR39","doi-asserted-by":"publisher","first-page":"7389","DOI":"10.1080\/14767058.2021.1949443","volume":"35","author":"HS Kim","year":"2022","unstructured":"Kim, H. S. et al. Risk factors associated with idiopathic sudden sensorineural hearing loss in pregnant South Korean women: a nationwide population-based study. J. Matern Fetal Neonatal Med. 35, 7389\u20137394 (2022).","journal-title":"J. Matern Fetal Neonatal Med."},{"key":"45480_CR40","doi-asserted-by":"publisher","first-page":"3139","DOI":"10.3390\/diagnostics12123139","volume":"12","author":"A Frosolini","year":"2022","unstructured":"Frosolini, A. et al. Sudden sensorineural hearing loss in the COVID-19 pandemic: a systematic review and meta-analysis. Diagnostics 12, 3139 (2022).","journal-title":"Diagnostics"},{"key":"45480_CR41","doi-asserted-by":"publisher","first-page":"20204","DOI":"10.1038\/s41598-021-99731-w","volume":"11","author":"N Tsuzuki","year":"2021","unstructured":"Tsuzuki, N. et al. Severe sudden sensorineural hearing loss related to risk of stroke and atherosclerosis. Sci. Rep. 11, 20204 (2021).","journal-title":"Sci. Rep."},{"key":"45480_CR42","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1111\/coa.14036","volume":"48","author":"H Chaushu","year":"2023","unstructured":"Chaushu, H. et al. Spontaneous recovery rate of idiopathic sudden sensorineural hearing loss: a systematic review and meta-analysis. Clin. Otolaryngol. 48, 395\u2013402 (2023).","journal-title":"Clin. Otolaryngol."},{"key":"45480_CR43","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1017\/S0022215121004254","volume":"136","author":"T Ringrose","year":"2022","unstructured":"Ringrose, T. et al. Salvage intratympanic steroid therapy for sudden sensorineural hearing loss: real-life experience in 32 patients. J. Laryngol Otol. 136, 827\u2013830 (2022).","journal-title":"J. Laryngol Otol"},{"key":"45480_CR44","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1002\/ohn.163","volume":"168","author":"ES Saba","year":"2023","unstructured":"Saba, E. S. et al. Cardiovascular risk factors in patients with sudden sensorineural hearing loss: a systematic review and meta-analysis. Otolaryngol. Head Neck Surg. 168, 907\u2013921 (2023).","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"45480_CR45","first-page":"84","volume":"16","author":"JL Riera","year":"2020","unstructured":"Riera, J. L. et al. Sudden sensorineural hearing loss in systemic lupus erythematosus and antiphospholipid syndrome: a clinical review. Curr. Rheumatol. Rev. 16, 84\u201391 (2020).","journal-title":"Curr. Rheumatol. Rev."},{"key":"45480_CR46","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s40463-021-00498-x","volume":"50","author":"B Ng","year":"2021","unstructured":"Ng, B., Crowson, M. G. & Lin, V. Management of sudden sensorineural hearing loss among primary care physicians in Canada: a survey study. J. Otolaryngol. Head Neck Surg. 50, 22 (2021).","journal-title":"J. Otolaryngol. Head Neck Surg."},{"key":"45480_CR47","doi-asserted-by":"publisher","first-page":"6387","DOI":"10.3390\/jcm11216387","volume":"11","author":"S Yamada","year":"2022","unstructured":"Yamada, S. et al. Update on findings about sudden sensorineural hearing loss and insight into its pathogenesis. J. Clin. Med. 11, 6387 (2022).","journal-title":"J. Clin. Med."},{"key":"45480_CR48","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.joto.2019.07.001","volume":"15","author":"A Singh","year":"2020","unstructured":"Singh, A. & Kumar Irugu, D. V. Sudden sensorineural hearing loss: a contemporary review of management issues. J. Otol. 15, 67\u201373 (2020).","journal-title":"J. Otol"},{"key":"45480_CR49","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.otc.2023.02.005","volume":"56","author":"KA Brooks","year":"2023","unstructured":"Brooks, K. A. & Vivas, E. X. Natural history of hearing loss in sporadic vestibular schwannoma. Otolaryngol. Clin. N Am. 56, 435\u2013444 (2023).","journal-title":"Otolaryngol. Clin. N Am."},{"key":"45480_CR50","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1186\/s12883-022-03024-2","volume":"22","author":"YS Kim","year":"2022","unstructured":"Kim, Y. S., Tehrani, A. S. S. & Lee, H. S. Sudden unilateral hearing loss and vertigo following isolated cerebellar hypoperfusion without infarction due to vertebral artery dissection. BMC Neurol. 22, 489 (2022).","journal-title":"BMC Neurol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-45480-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-45480-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-45480-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:03:41Z","timestamp":1779149021000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-45480-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["45480"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-45480-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]},"assertion":[{"value":"5 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}}],"article-number":"15384"}}