{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T11:11:44Z","timestamp":1779275504603,"version":"3.51.4"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":48,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-45880-9","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T07:46:58Z","timestamp":1775116018000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discordance between vibration controlled-transient elastography and ultrasound in cirrhosis assessment: prognostic implications for liver-related events in patients with chronic hepatitis B"],"prefix":"10.1038","volume":"16","author":[{"given":"Navavee","family":"Uman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naichaya","family":"Chamroonkul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apichat","family":"Kaewdech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pimsiri","family":"Sripongpun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"issue":"2","key":"45880_CR1","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s10238-022-00799-z","volume":"23","author":"AB Chowdhury","year":"2023","unstructured":"Chowdhury, A. B. & Mehta, K. J. Liver biopsy for assessment of chronic liver diseases: A synopsis. Clin. Exp. Med. 23(2), 273\u2013285. https:\/\/doi.org\/10.1007\/s10238-022-00799-z (2023).","journal-title":"Clin. Exp. Med."},{"issue":"8","key":"45880_CR2","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1136\/gutjnl-2020-321299","volume":"69","author":"J Neuberger","year":"2020","unstructured":"Neuberger, J. et al. Guidelines on the use of liver biopsy in clinical practice from the British society of gastroenterology, the royal college of radiologists and the royal college of pathology. Gut 69(8), 1382\u20131403. https:\/\/doi.org\/10.1136\/gutjnl-2020-321299 (2020).","journal-title":"Gut"},{"issue":"3","key":"45880_CR3","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.jhep.2021.05.025","volume":"75","author":"European Association for the Study of the Liver","year":"2021","unstructured":"European Association for the Study of the Liver. EASL clinical practice guidelines on non-invasive tests for evaluation of liver disease severity and prognosis\u20142021 update. J. Hepatol. 75(3), 659\u2013689. https:\/\/doi.org\/10.1016\/j.jhep.2021.05.025 (2021).","journal-title":"J. Hepatol."},{"issue":"45","key":"45880_CR4","doi-asserted-by":"publisher","first-page":"16820","DOI":"10.3748\/wjg.v20.i45.16820","volume":"20","author":"S Sharma","year":"2014","unstructured":"Sharma, S., Khalili, K. & Nguyen, G. C. Non-invasive diagnosis of advanced fibrosis and cirrhosis. World J. Gastroenterol. 20(45), 16820\u201316830. https:\/\/doi.org\/10.3748\/wjg.v20.i45.16820 (2014).","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"45880_CR5","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1097\/HEP.0000000000000845","volume":"81","author":"RK Sterling","year":"2025","unstructured":"Sterling, R. K. et al. AASLD Practice Guideline on blood-based noninvasive liver disease assessment of hepatic fibrosis and steatosis. Hepatology 81(1), 321\u2013357. https:\/\/doi.org\/10.1097\/HEP.0000000000000845 (2025).","journal-title":"Hepatology"},{"issue":"2","key":"45880_CR6","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1097\/HEP.0000000000000843","volume":"81","author":"RK Sterling","year":"2025","unstructured":"Sterling, R. K. et al. AASLD Practice Guideline on imaging-based noninvasive liver disease assessment of hepatic fibrosis and steatosis. Hepatology 81(2), 672\u2013724. https:\/\/doi.org\/10.1097\/HEP.0000000000000843 (2025).","journal-title":"Hepatology"},{"key":"45880_CR7","doi-asserted-by":"publisher","DOI":"10.1177\/17562848221140657","volume":"15","author":"G Ferraioli","year":"2022","unstructured":"Ferraioli, G. & Roccarina, D. Update on the role of elastography in liver disease. Ther. Adv. Gastroenterol. 15, 17562848221140657. https:\/\/doi.org\/10.1177\/17562848221140657 (2022).","journal-title":"Ther. Adv. Gastroenterol."},{"issue":"1","key":"45880_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2021.101761","volume":"46","author":"J Boursier","year":"2022","unstructured":"Boursier, J. et al. Quality criteria for the measurement of liver stiffness. Clin. Res. Hepatol. Gastroenterol. 46(1), 101761. https:\/\/doi.org\/10.1016\/j.clinre.2021.101761 (2022).","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"issue":"4","key":"45880_CR9","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.jhep.2021.12.022","volume":"76","author":"R de Franchis","year":"2022","unstructured":"de Franchis, R. et al. Baveno VII\u2014Renewing consensus in portal hypertension. J. Hepatol. 76(4), 959\u2013974. https:\/\/doi.org\/10.1016\/j.jhep.2021.12.022 (2022).","journal-title":"J. Hepatol."},{"key":"45880_CR10","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ijid.2016.08.017","volume":"51","author":"C Leroi","year":"2016","unstructured":"Leroi, C. et al. Prevalence of chronic hepatitis B virus infection in Thailand: A systematic review and meta-analysis. Int. J. Infect. Dis. 51, 36\u201343. https:\/\/doi.org\/10.1016\/j.ijid.2016.08.017 (2016).","journal-title":"Int. J. Infect. Dis."},{"issue":"6","key":"45880_CR11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0270458","volume":"17","author":"S Sono","year":"2022","unstructured":"Sono, S., Sae-Chan, J., Kaewdech, A., Chamroonkul, N. & Sripongpun, P. HBV seroprevalence and liver fibrosis status among population born before national immunization in Southern Thailand: Findings from a health check-up program. PLoS ONE 17(6), e0270458. https:\/\/doi.org\/10.1371\/journal.pone.0270458 (2022).","journal-title":"PLoS ONE"},{"key":"45880_CR12","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14113946","author":"Y Poovorawan","year":"2025","unstructured":"Poovorawan, Y. et al. Microelimination of Hepatitis C in Thailand, phetchabun model: Progress, challenges, and future directions. J. Clin. Med. https:\/\/doi.org\/10.3390\/jcm14113946 (2025).","journal-title":"J. Clin. Med."},{"issue":"1","key":"45880_CR13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-06874-1","volume":"15","author":"S Sono","year":"2025","unstructured":"Sono, S. et al. Metabolic dysfunction-associated fatty liver disease (MAFLD) in the adult population attending a health check-up program in Thailand: Prevalence and fibrosis status. Sci. Rep. 15(1), 21429. https:\/\/doi.org\/10.1038\/s41598-025-06874-1 (2025).","journal-title":"Sci. Rep."},{"issue":"1","key":"45880_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-70526-z","volume":"14","author":"P Danpanichkul","year":"2024","unstructured":"Danpanichkul, P. et al. Changes in the epidemiological trends of primary liver cancer in the Asia-Pacific region. Sci. Rep. 14(1), 19544. https:\/\/doi.org\/10.1038\/s41598-024-70526-z (2024).","journal-title":"Sci. Rep."},{"issue":"2","key":"45880_CR15","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000310","volume":"12","author":"A Kaewdech","year":"2021","unstructured":"Kaewdech, A. et al. Validation of the \u201csix-and-twelve\u201d prognostic score in transarterial chemoembolization-treated hepatocellular carcinoma patients. Clin. Transl. Gastroenterol. 12(2), e00310. https:\/\/doi.org\/10.14309\/ctg.0000000000000310 (2021).","journal-title":"Clin. Transl. Gastroenterol."},{"key":"45880_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1077842","volume":"10","author":"A Kaewdech","year":"2023","unstructured":"Kaewdech, A. et al. FAIL-T (AFP, AST, tumor size, ALT, and tumor number): A model to predict intermediate-stage HCC patients who are not good candidates for TACE. Front. Med. 10, 1077842. https:\/\/doi.org\/10.3389\/fmed.2023.1077842 (2023).","journal-title":"Front. Med."},{"issue":"12","key":"45880_CR17","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/s41575-024-00967-4","volume":"21","author":"LY Mak","year":"2024","unstructured":"Mak, L. Y. et al. Liver diseases and hepatocellular carcinoma in the Asia-Pacific region: Burden, trends, challenges and future directions. Nat. Rev. Gastroenterol. Hepatol. 21(12), 834\u2013851. https:\/\/doi.org\/10.1038\/s41575-024-00967-4 (2024).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"2","key":"45880_CR18","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.jhep.2024.07.017","volume":"82","author":"G Lau","year":"2025","unstructured":"Lau, G. et al. Outcomes in the Asian subgroup of the phase III randomised HIMALAYA study of tremelimumab plus durvalumab in unresectable hepatocellular carcinoma. J. Hepatol. 82(2), 258\u2013267. https:\/\/doi.org\/10.1016\/j.jhep.2024.07.017 (2025).","journal-title":"J. Hepatol."},{"key":"45880_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/v15030724","author":"T Geeratragool","year":"2023","unstructured":"Geeratragool, T. et al. A novel and simplified score for determining treatment eligibility for patients with chronic Hepatitis B. Viruses https:\/\/doi.org\/10.3390\/v15030724 (2023).","journal-title":"Viruses"},{"key":"45880_CR20","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/goaf013","volume":"13","author":"N Uman","year":"2025","unstructured":"Uman, N., Kaewdech, A., Sripongpun, P., Chamroonkul, N. & Piratvisuth, T. Coexisting steatotic liver disease is not associated with long-term liver-related events in patients with chronic hepatitis B. Gastroenterol. Rep. 13, goaf013. https:\/\/doi.org\/10.1093\/gastro\/goaf013 (2025).","journal-title":"Gastroenterol. Rep."},{"issue":"1","key":"45880_CR21","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.jhep.2022.03.024","volume":"77","author":"R de Franchis","year":"2022","unstructured":"de Franchis, R. et al. Corrigendum to \u2019Baveno VII\u2014Renewing consensus in portal hypertension. J Hepatol. 77(1), 271. https:\/\/doi.org\/10.1016\/j.jhep.2022.03.024 (2022).","journal-title":"J Hepatol."},{"issue":"5","key":"45880_CR22","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.jhep.2024.12.004","volume":"82","author":"GL Wong","year":"2025","unstructured":"Wong, G. L. & Lemoine, M. The 2024 updated WHO guidelines for the prevention and management of chronic hepatitis B: Main changes and potential implications for the next major liver society clinical practice guidelines. J. Hepatol. 82(5), 918\u2013925. https:\/\/doi.org\/10.1016\/j.jhep.2024.12.004 (2025).","journal-title":"J. Hepatol."},{"issue":"4","key":"45880_CR23","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1002\/hep.29800","volume":"67","author":"NA Terrault","year":"2018","unstructured":"Terrault, N. A. et al. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance. Hepatology 67(4), 1560\u20131599. https:\/\/doi.org\/10.1002\/hep.29800 (2018).","journal-title":"Hepatology"},{"issue":"2","key":"45880_CR24","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.jhep.2025.03.018","volume":"83","author":"Liver EAftSot.","year":"2025","unstructured":"Liver EAftSot. EASL clinical practice guidelines on the management of hepatitis B virus infection. J. Hepatol. 83(2), 502\u2013583. https:\/\/doi.org\/10.1016\/j.jhep.2025.03.018 (2025).","journal-title":"J. Hepatol."},{"issue":"5","key":"45880_CR25","doi-asserted-by":"publisher","first-page":"232","DOI":"10.14740\/gr1557","volume":"15","author":"P Malik","year":"2022","unstructured":"Malik, P. et al. Diagnostic accuracy of elastography and liver disease: A meta-analysis. Gastroenterol. Res. 15(5), 232\u2013239. https:\/\/doi.org\/10.14740\/gr1557 (2022).","journal-title":"Gastroenterol. Res."},{"issue":"6","key":"45880_CR26","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1053\/j.gastro.2017.03.016","volume":"152","author":"S Singh","year":"2017","unstructured":"Singh, S., Muir, A. J., Dieterich, D. T. & Falck-Ytter, Y. T. American gastroenterological association Institute technical review on the role of elastography in chronic liver diseases. Gastroenterology 152(6), 1544\u20131577. https:\/\/doi.org\/10.1053\/j.gastro.2017.03.016 (2017).","journal-title":"Gastroenterology"},{"issue":"4","key":"45880_CR27","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/S2468-1253(24)00437-0","volume":"10","author":"A Liguori","year":"2025","unstructured":"Liguori, A., Zoncap\u00e8, M., Casazza, G., Easterbrook, P. & Tsochatzis, E. A. Staging liver fibrosis and cirrhosis using non-invasive tests in people with chronic hepatitis B to inform WHO 2024 guidelines: A systematic review and meta-analysis. Lancet. Gastroenterol. Hepatol. 10(4), 332\u2013349. https:\/\/doi.org\/10.1016\/S2468-1253(24)00437-0 (2025).","journal-title":"Lancet. Gastroenterol. Hepatol."},{"issue":"3","key":"45880_CR28","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.jhep.2015.05.022","volume":"63","author":"R de Franchis","year":"2015","unstructured":"de Franchis, R. & Faculty, B. V. Expanding consensus in portal hypertension: Report of the Baveno VI consensus workshop: stratifying risk and individualizing care for portal hypertension. J. Hepatol. 63(3), 743\u2013752. https:\/\/doi.org\/10.1016\/j.jhep.2015.05.022 (2015).","journal-title":"J. Hepatol."},{"key":"45880_CR29","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000231","author":"LE Hetland","year":"2023","unstructured":"Hetland, L. E. et al. Suboptimal diagnostic accuracy of ultrasound and CT for compensated cirrhosis: Evidence from prospective cohort studies. Hepatol. Commun. https:\/\/doi.org\/10.1097\/HC9.0000000000000231 (2023).","journal-title":"Hepatol. Commun."},{"issue":"6","key":"45880_CR30","first-page":"367","volume":"14","author":"EMM Kelly","year":"2018","unstructured":"Kelly, E. M. M. et al. An assessment of the clinical accuracy of ultrasound in diagnosing cirrhosis in the absence of portal hypertension. Gastroenterol. Hepatol. 14(6), 367\u2013373 (2018).","journal-title":"Gastroenterol. Hepatol."},{"issue":"28","key":"45880_CR31","doi-asserted-by":"publisher","first-page":"3510","DOI":"10.3748\/wjg.v16.i28.3510","volume":"16","author":"R Allan","year":"2010","unstructured":"Allan, R., Thoirs, K. & Phillips, M. Accuracy of ultrasound to identify chronic liver disease. World J. Gastroenterol. 16(28), 3510\u20133520. https:\/\/doi.org\/10.3748\/wjg.v16.i28.3510 (2010).","journal-title":"World J. Gastroenterol."},{"issue":"23","key":"45880_CR32","doi-asserted-by":"publisher","first-page":"7231","DOI":"10.3748\/wjg.v20.i23.7231","volume":"20","author":"R De Robertis","year":"2014","unstructured":"De Robertis, R. et al. Noninvasive diagnosis of cirrhosis: A review of different imaging modalities. World J. Gastroenterol. 20(23), 7231\u20137241. https:\/\/doi.org\/10.3748\/wjg.v20.i23.7231 (2014).","journal-title":"World J. Gastroenterol."},{"issue":"10","key":"45880_CR33","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1111\/jvh.13560","volume":"28","author":"SH Yoo","year":"2021","unstructured":"Yoo, S. H. et al. Risk assessment of hepatocellular carcinoma and liver-related events using ultrasonography and transient elastography in patients with chronic hepatitis B. J. Viral Hepat. 28(10), 1362\u20131372. https:\/\/doi.org\/10.1111\/jvh.13560 (2021).","journal-title":"J. Viral Hepat."},{"issue":"1","key":"45880_CR34","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.jhep.2015.04.006","volume":"63","author":"EASL-ALEH","year":"2015","unstructured":"EASL-ALEH. EASL-ALEH clinical practice guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. J Hepatol 63(1), 237\u2013264. https:\/\/doi.org\/10.1016\/j.jhep.2015.04.006 (2015).","journal-title":"J Hepatol"},{"key":"45880_CR35","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000001342","author":"E Dajti","year":"2025","unstructured":"Dajti, E., Huber, A. T., Ferraioli, G. & Berzigotti, A. Advances in imaging-elastography. Hepatology https:\/\/doi.org\/10.1097\/HEP.0000000000001342 (2025).","journal-title":"Hepatology"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-45880-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-45880-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-45880-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T11:02:29Z","timestamp":1779274949000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-45880-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,2]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["45880"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-45880-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,2]]},"assertion":[{"value":"30 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This is a secondary analysis of a retrospective cohort study that was published earlier. The study protocol was approved by the Human Research Ethics Committee (HREC), Faculty of Medicine, Prince of Songkla University, Thailand (REC.65-382-14-1). The study was conducted under the good clinical practice and the ethical guidelines of the 1975 Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The retrospective nature of the study resulted in the waiver of obtaining informed consent, and this was granted by the HREC at the protocol approval.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"15645"}}