{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:21:02Z","timestamp":1789420862835,"version":"build-2803163510"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":63,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-45913-3","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:06:16Z","timestamp":1777485976000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Designing a molecularly imprinted polymer sensor for sensitive and selective detection of the prostate cancer drug Abiraterone acetate"],"prefix":"10.1038","volume":"16","author":[{"given":"Abdullah Al","family":"Faysal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taner","family":"Erdo\u011fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015feg\u00fcl","family":"G\u00f6lc\u00fc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"45913_CR1","doi-asserted-by":"publisher","first-page":"843110","DOI":"10.3389\/fphar.2022.843110","volume":"13","author":"M Chen","year":"2022","unstructured":"Chen, M. et al. Abiraterone, orteronel, enzalutamide and docetaxel: sequential or combined therapy?. Front. Pharmacol. 13, 843110 (2022).","journal-title":"Front. Pharmacol."},{"key":"45913_CR2","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.euo.2021.09.006","volume":"4","author":"G Gandaglia","year":"2021","unstructured":"Gandaglia, G. et al. Epidemiology and prevention of prostate cancer. Eur. Urol. Oncol. 4, 877\u2013892 (2021).","journal-title":"Eur. Urol. Oncol."},{"key":"45913_CR3","doi-asserted-by":"publisher","first-page":"732599","DOI":"10.3389\/fonc.2021.732599","volume":"11","author":"Z Wei","year":"2021","unstructured":"Wei, Z., Chen, C., Li, B., Li, Y. & Gu, H. Efficacy and safety of abiraterone acetate and enzalutamide for the treatment of metastatic castration-resistant prostate cancer: a systematic review and meta-analysis. Front. Oncol. 11, 732599 (2021).","journal-title":"Front. Oncol."},{"key":"45913_CR4","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/s41391-020-00275-3","volume":"24","author":"HY Lee","year":"2021","unstructured":"Lee, H. Y. et al. Abiraterone and enzalutamide had different adverse effects on the cardiovascular system: a systematic review with pairwise and network meta-analyses. Prostate Cancer Prostatic Dis. 24, 244\u2013252 (2021).","journal-title":"Prostate Cancer Prostatic Dis."},{"key":"45913_CR5","doi-asserted-by":"publisher","first-page":"1006101","DOI":"10.3389\/fendo.2022.1006101","volume":"13","author":"AE Harris","year":"2022","unstructured":"Harris, A. E. et al. Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer. Front. Endocrinol. (Lausanne) 13, 1006101 (2022).","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"45913_CR6","first-page":"457","volume":"13","author":"F Crowley","year":"2021","unstructured":"Crowley, F. et al. A Review of the Pathophysiological Mechanisms Underlying Castration-resistant Prostate Cancer. Res. Rep. Urol. 13, 457\u2013472 (2021).","journal-title":"Res. Rep. Urol."},{"key":"45913_CR7","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.eururo.2018.03.028","volume":"75","author":"P Nuhn","year":"2019","unstructured":"Nuhn, P. et al. Update on systemic prostate cancer therapies: Management of metastatic castration-resistant prostate cancer in the era of precision oncology. Eur. Urol. 75, 88\u201399 (2019).","journal-title":"Eur. Urol."},{"key":"45913_CR8","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0140-6736(21)00580-8","volume":"398","author":"C Sweeney","year":"2021","unstructured":"Sweeney, C. et al. Ipatasertib plus abiraterone and prednisolone in metastatic castration-resistant prostate cancer (IPATential150): a multicentre, randomised, double-blind, phase 3 trial. Lancet 398, 131\u2013142 (2021).","journal-title":"Lancet"},{"key":"45913_CR9","doi-asserted-by":"publisher","first-page":"EVIDoa2200043","DOI":"10.1056\/EVIDoa2200043","volume":"1","author":"NW Clarke","year":"2022","unstructured":"Clarke, N. W. et al. Abiraterone and Olaparib for Metastatic Castration-Resistant Prostate Cancer. NEJM Evid. 1, EVIDoa2200043 (2022).","journal-title":"NEJM Evid."},{"key":"45913_CR10","first-page":"87","volume":"14","author":"E Choi","year":"2022","unstructured":"Choi, E., Buie, J. D., Camacho, J., Sharma, P. & de Riese, W. T. Evolution of androgen deprivation therapy (ADT) and its new emerging modalities in prostate cancer: An update for practicing urologists, clinicians and medical providers. Res. Rep. Urol. 14, 87\u2013108 (2022).","journal-title":"Res. Rep. Urol."},{"key":"45913_CR11","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.28444","volume":"7","author":"J La","year":"2024","unstructured":"La, J. et al. Abiraterone or Enzalutamide for patients with metastatic castration-resistant prostate cancer. JAMA Netw. Open 7, e2428444 (2024).","journal-title":"JAMA Netw. Open"},{"key":"45913_CR12","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1056\/NEJMoa1209096","volume":"368","author":"CJ Ryan","year":"2013","unstructured":"Ryan, C. J. et al. Abiraterone in Metastatic Prostate Cancer without Previous Chemotherapy. New Engl. J. Med. 368, 138\u2013148 (2013).","journal-title":"New Engl. J. Med."},{"key":"45913_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/separations11100290","volume":"11","author":"E Akbel","year":"2024","unstructured":"Akbel, E. Development, validation, and greenness assessment of eco-friendly analytical methods for the determination of Abiraterone Acetate in pure form and pharmaceutical formulations. Separations 11, 290 (2024).","journal-title":"Separations"},{"key":"45913_CR14","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1007\/s10895-013-1261-3","volume":"23","author":"A Gong","year":"2013","unstructured":"Gong, A. & Zhu, X. \u03b2-cyclodextrin sensitized spectrofluorimetry for the determination of Abiraterone Acetate and Abiraterone. J. Fluoresc. 23, 1279\u20131286 (2013).","journal-title":"J. Fluoresc."},{"key":"45913_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2023.115568","volume":"234","author":"DK Mhaske","year":"2023","unstructured":"Mhaske, D. K. & Kumbhar, A. S. The first RP-UHPLC method for simultaneous quantification of Abiraterone Acetate, its four degradants, and six specified process impurities and correct identification of all analytes based on molecular weight. J. Pharm. Biomed. Anal. 234, 115568 (2023).","journal-title":"J. Pharm. Biomed. Anal."},{"key":"45913_CR16","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1093\/chromsci\/bmaa080","volume":"59","author":"S Beg","year":"2021","unstructured":"Beg, S. et al. Systematic development and validation of a RP-HPLC method for estimation of Abiraterone Acetate and its degradation products. J. Chromatogr. Sci. 59, 79\u201387 (2021).","journal-title":"J. Chromatogr. Sci."},{"key":"45913_CR17","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.matpr.2020.02.665","volume":"34","author":"D Kavitapu","year":"2021","unstructured":"Kavitapu, D., Maruthapillai, A., Mahapatra, S. & Arockia Selvi, J. New stability indicating RP-HPLC method for the determination of Abiraterone acetate, its related substances and degradation products in bulk and dosage form. Mater. Today Proc. 34, 469\u2013478 (2021).","journal-title":"Mater. Today Proc."},{"key":"45913_CR18","doi-asserted-by":"publisher","first-page":"233","DOI":"10.2174\/1573412913666170213152002","volume":"14","author":"J Rodriguez","year":"2018","unstructured":"Rodriguez, J., Castaneda, G., Lizcano, I. & Villa, J. C. A rapid, direct and validated HPLC-fluorescence method for the quantification of Abiraterone and Abiraterone Acetate in urine and serum samples from patients with Castration-resistant Prostate Cancer. Curr. Pharm. Anal. 14, 233\u2013238 (2018).","journal-title":"Curr. Pharm. Anal."},{"key":"45913_CR19","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.jchromb.2015.03.001","volume":"989","author":"T Belleville","year":"2015","unstructured":"Belleville, T. et al. A HPLC-fluorescence method for the quantification of Abiraterone in plasma from patients with metastatic castration-resistant Prostate Cancer. J. Chromatogr. B Biomed. Sci. Appl. 989, 86\u201390 (2015).","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"45913_CR20","doi-asserted-by":"publisher","DOI":"10.1039\/c3ay26611g","volume":"5","author":"TA Wani","year":"2013","unstructured":"Wani, T. A. Highly sensitive ultra-performance liquid chromatography\u2013tandem mass spectrometry method for the determination of Abiraterone in human plasma. Anal. Methods 5, 3693 (2013).","journal-title":"Anal. Methods"},{"key":"45913_CR21","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1097\/FTD.0000000000000387","volume":"39","author":"M van Nuland","year":"2017","unstructured":"van Nuland, M., Hillebrand, M. J. X., Rosing, H., Schellens, J. H. M. & Beijnen, J. H. Development and validation of an LC-MS\/MS method for the simultaneous quantification of Abiraterone, Enzalutamide, and their major metabolites in human plasma. Ther. Drug Monit. 39, 243\u2013251 (2017).","journal-title":"Ther. Drug Monit."},{"key":"45913_CR22","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jchromb.2017.10.033","volume":"1068\u20131069","author":"M van Nuland","year":"2017","unstructured":"van Nuland, M. et al. An LC\u2013MS\/MS method for quantification of the active Abiraterone metabolite \u0394(4)-Abiraterone (D4A) in human plasma. J. Chromatogr. B Biomed. Sci. Appl. 1068\u20131069, 119\u2013124 (2017).","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"45913_CR23","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.jsbmb.2016.04.002","volume":"172","author":"M Alyamani","year":"2017","unstructured":"Alyamani, M. et al. Development and validation of a novel LC\u2013MS\/MS method for simultaneous determination of Abiraterone and its seven steroidal metabolites in human serum: Innovation in separation of diastereoisomers without use of a chiral column. J. Steroid Biochem. Mol. Biol. 172, 231\u2013239 (2017).","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"45913_CR24","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.jchromb.2018.12.003","volume":"1104","author":"P Caron","year":"2019","unstructured":"Caron, P., Turcotte, V., L\u00e9vesque, E. & Guillemette, C. An LC-MS\/MS method for quantification of Abiraterone, its active metabolites D(4)-Abiraterone (D4A) and 5\u03b1-Abiraterone, and their inactive glucuronide derivatives. J. Chromatogr. B Biomed. Sci. Appl. 1104, 249\u2013255 (2019).","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"45913_CR25","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1007\/s12668-017-0393-3","volume":"8","author":"N Aliakbarinodehi","year":"2018","unstructured":"Aliakbarinodehi, N., De Micheli, G. & Carrara, S. Highly sensitive enzymatic MWCNTs-based biosensors for detection of Abiraterone in human serum. Bionanoscience 8, 675\u2013679 (2018).","journal-title":"Bionanoscience"},{"key":"45913_CR26","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1002\/tcr.201900092","volume":"20","author":"H Karimi\u2010Maleh","year":"2020","unstructured":"Karimi\u2010Maleh, H., Karimi, F., Alizadeh, M. & Sanati, A. L. Electrochemical sensors, a bright future in the fabrication of portable kits in analytical systems. Chem. Rec. 20, 682\u2013692 (2020).","journal-title":"Chem. Rec."},{"key":"45913_CR27","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.aca.2019.11.020","volume":"1097","author":"A Motaharian","year":"2020","unstructured":"Motaharian, A., Naseri, K., Mehrpour, O. & Shoeibi, S. Electrochemical determination of atypical antipsychotic drug quetiapine using nano-molecularly imprinted polymer modified carbon paste electrode. Anal. Chim. Acta 1097, 214\u2013221 (2020).","journal-title":"Anal. Chim. Acta"},{"key":"45913_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2022.109074","volume":"139","author":"S Basak","year":"2022","unstructured":"Basak, S., Venkatram, R. & Singhal, R. S. Recent advances in the application of molecularly imprinted polymers (MIPs) in food analysis. Food Control 139, 109074 (2022).","journal-title":"Food Control"},{"key":"45913_CR29","doi-asserted-by":"publisher","DOI":"10.3390\/jfb13010012","volume":"13","author":"OI Parisi","year":"2022","unstructured":"Parisi, O. I. et al. The evolution of molecular recognition: From antibodies to molecularly imprinted polymers (MIPs) as artificial counterpart. J. Funct. Biomater. 13, 12 (2022).","journal-title":"J. Funct. Biomater."},{"key":"45913_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2020.116041","volume":"132","author":"W Wang","year":"2020","unstructured":"Wang, W. et al. Recent advances in nanomaterials-based electrochemical (bio)sensors for pesticides detection. TrAC Trends Anal. Chem. 132, 116041 (2020).","journal-title":"TrAC Trends Anal. Chem."},{"key":"45913_CR31","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1021\/acsomega.1c05985","volume":"7","author":"K Murugan","year":"2022","unstructured":"Murugan, K., Jothi, V. K., Rajaram, A. & Natarajan, A. Novel metal-free fluorescent sensor based on molecularly imprinted polymer N-CDs@MIP for highly selective detection of TNP. ACS Omega 7, 1368\u20131379 (2022).","journal-title":"ACS Omega"},{"key":"45913_CR32","doi-asserted-by":"publisher","first-page":"N1272","DOI":"10.1111\/1750-3841.13283","volume":"81","author":"Y Hu","year":"2016","unstructured":"Hu, Y. & Lu, X. Rapid Detection of Melamine in Tap Water and Milk Using Conjugated \u201cOne-Step\u201d Molecularly Imprinted Polymers-Surface Enhanced Raman Spectroscopic Sensor. J. Food Sci. 81, N1272\u2013N1280 (2016).","journal-title":"J. Food Sci."},{"key":"45913_CR33","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1021\/acssensors.8b01642","volume":"4","author":"G Ert\u00fcrk Bergdahl","year":"2019","unstructured":"Ert\u00fcrk Bergdahl, G. et al. In Vivo Detection and Absolute Quantification of a Secreted Bacterial Factor from Skin Using Molecularly Imprinted Polymers in a Surface Plasmon Resonance Biosensor for Improved Diagnostic Abilities. ACS Sens 4, 717\u2013725 (2019).","journal-title":"ACS Sens"},{"key":"45913_CR34","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-15637-1","volume":"12","author":"MM El-Wekil","year":"2022","unstructured":"El-Wekil, M. M., Halby, H. M., Darweesh, M., Ali, M. E. & Ali, R. An innovative dual recognition aptasensor for specific detection of Staphylococcus aureus based on Au\/Fe3O4 binary hybrid. Sci. Rep. 12, 12502 (2022).","journal-title":"Sci. Rep."},{"key":"45913_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.snr.2023.100153","volume":"5","author":"L Wang","year":"2023","unstructured":"Wang, L., Pagett, M. & Zhang, W. Molecularly imprinted polymer (MIP) based electrochemical sensors and their recent advances in health applications. Sens. Actuators Rep. 5, 100153 (2023).","journal-title":"Sens. Actuators Rep."},{"key":"45913_CR36","doi-asserted-by":"publisher","first-page":"B286","DOI":"10.1149\/2.0501607jes","volume":"163","author":"KK Tadi","year":"2016","unstructured":"Tadi, K. K. & Motghare, R. V. Voltammetric determination of pindolol in biological fluids using molecularly imprinted polymer based biomimetic sensor. J. Electrochem. Soc. 163, B286\u2013B292 (2016).","journal-title":"J. Electrochem. Soc."},{"key":"45913_CR37","doi-asserted-by":"publisher","first-page":"99115","DOI":"10.1039\/C5RA16636E","volume":"5","author":"KK Tadi","year":"2015","unstructured":"Tadi, K. K., Motghare, R. V. & Ganesh, V. Electrochemical detection of epinephrine using a biomimic made up of hemin modified molecularly imprinted microspheres. RSC Adv. 5, 99115\u201399124 (2015).","journal-title":"RSC Adv."},{"key":"45913_CR38","doi-asserted-by":"publisher","first-page":"9564","DOI":"10.1021\/acsomega.3c09399","volume":"9","author":"A Al Faysal","year":"2024","unstructured":"Al Faysal, A. et al. Development and fabrication of a molecularly imprinted polymer-based electroanalytical sensor for the determination of Acyclovir. ACS Omega 9, 9564\u20139576 (2024).","journal-title":"ACS Omega"},{"key":"45913_CR39","doi-asserted-by":"publisher","first-page":"3385","DOI":"10.1007\/s00894-013-1856-2","volume":"19","author":"KK Tadi","year":"2013","unstructured":"Tadi, K. K. & Motghare, R. V. Rational synthesis of pindolol imprinted polymer by non-covalent protocol based on computational approach. J. Mol. Model. 19, 3385\u20133396 (2013).","journal-title":"J. Mol. Model."},{"key":"45913_CR40","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1002\/jcc.10325","volume":"24","author":"C-E Chang","year":"2003","unstructured":"Chang, C.-E. & Gilson, M. K. Tork: Conformational analysis method for molecules and complexes. J. Comput. Chem. 24, 1987\u20131998 (2003).","journal-title":"J. Comput. Chem."},{"key":"45913_CR41","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"30","author":"GM Morris","year":"2009","unstructured":"Morris, G. M. et al. AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. J. Comput. Chem. 30, 2785\u20132791 (2009).","journal-title":"J. Comput. Chem."},{"key":"45913_CR42","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"O Trott","year":"2010","unstructured":"Trott, O. & Olson, A. J. AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J. Comput. Chem. 31, 455\u2013461 (2010).","journal-title":"J. Comput. Chem."},{"key":"45913_CR43","unstructured":"Frisch, M. J. et al. Gaussian 16 Revision C.01. Preprint at (2016)."},{"key":"45913_CR44","unstructured":"Dennington, R., Keith, T. A & Millam, J. M. GaussView 6. Preprint at (2016)."},{"key":"45913_CR45","unstructured":"BIOVIA, Discovery Studio Visualizer. Preprint at (2023)."},{"key":"45913_CR46","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-47138-8","volume-title":"Electroanalysis in Biomedical and Pharmaceutical Sciences","author":"SA Ozkan","year":"2015","unstructured":"Ozkan, S. A., Kauffmann, J.-M. & Zuman, P. Electroanalysis in Biomedical and Pharmaceutical Sciences (Springer Berlin Heidelberg, 2015). https:\/\/doi.org\/10.1007\/978-3-662-47138-8."},{"key":"45913_CR47","doi-asserted-by":"publisher","first-page":"7598","DOI":"10.1039\/D3GC02347H","volume":"25","author":"N Manousi","year":"2023","unstructured":"Manousi, N., Wojnowski, W., P\u0142otka-Wasylka, J. & Samanidou, V. Blue applicability grade index (BAGI) and software: A new tool for the evaluation of method practicality. Green Chem. 25, 7598\u20137604 (2023).","journal-title":"Green Chem."},{"key":"45913_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2022.116553","volume":"149","author":"W Wojnowski","year":"2022","unstructured":"Wojnowski, W., Tobiszewski, M., Pena-Pereira, F. & Psillakis, E. AGREEprep \u2013 Analytical greenness metric for sample preparation. TrAC Trends Anal. Chem. 149, 116553 (2022).","journal-title":"TrAC Trends Anal. Chem."},{"key":"45913_CR49","doi-asserted-by":"publisher","first-page":"10076","DOI":"10.1021\/acs.analchem.0c01887","volume":"92","author":"F Pena-Pereira","year":"2020","unstructured":"Pena-Pereira, F., Wojnowski, W. & Tobiszewski, M. AGREE\u2014Analytical GREEnness metric approach and software. Anal. Chem. 92, 10076\u201310082 (2020).","journal-title":"Anal. Chem."},{"key":"45913_CR50","doi-asserted-by":"publisher","first-page":"12516","DOI":"10.1021\/acssuschemeng.4c03874","volume":"12","author":"M Mar\u0107","year":"2024","unstructured":"Mar\u0107, M., Wojnowski, W., Pena-Pereira, F., Tobiszewski, M. & Mart\u00edn-Esteban, A. AGREEMIP: The Analytical Greenness Assessment Tool for molecularly imprinted polymers synthesis. ACS Sustain. Chem. Eng. 12, 12516\u201312524 (2024).","journal-title":"ACS Sustain. Chem. Eng."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-45913-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-45913-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-45913-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T01:04:25Z","timestamp":1782867865000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-45913-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,29]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["45913"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-45913-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7774003\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,29]]},"assertion":[{"value":"3 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study does not require any ethical approval.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"20020"}}