{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T12:04:51Z","timestamp":1779883491742,"version":"3.53.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:00:00Z","timestamp":1775260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":53,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-45935-x","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T10:18:19Z","timestamp":1775297899000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Focused ultrasound thalamotomy improves voice tremor in essential tremor: objective insight from artificial intelligence"],"prefix":"10.1038","volume":"16","author":[{"given":"Francesca","family":"Pistoia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Sucapane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Asci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"Saporito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Costantini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Cesarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Saggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Sacco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Suppa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,4]]},"reference":[{"key":"45935_CR1","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1056\/NEJMoa1600159","volume":"375","author":"WJ Elias","year":"2016","unstructured":"Elias, W. J. et al. A randomized trial of focused ultrasound thalamotomy for essential tremor. N Engl. J. Med. 375, 730\u2013739 (2016).","journal-title":"N Engl. J. Med."},{"key":"45935_CR2","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1056\/NEJMoa1300962","volume":"369","author":"WJ Elias","year":"2013","unstructured":"Elias, W. J. et al. A pilot study of focused ultrasound thalamotomy for essential tremor. N. Engl. J. Med. 369, 640\u2013648 (2013).","journal-title":"N. Engl. J. Med."},{"key":"45935_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2022.120193","volume":"435","author":"DK Binder","year":"2022","unstructured":"Binder, D. K., Shah, B. B. & Elias, W. J. Focused ultrasound and other lesioning in the treatment of tremor. J. Neurol. Sci. 435, 120193 (2022).","journal-title":"J. Neurol. Sci."},{"key":"45935_CR4","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.mric.2015.05.013","volume":"23","author":"T Kobus","year":"2015","unstructured":"Kobus, T. & McDannold, N. Update on clinical magnetic resonance\u2013guided focused ultrasound applications. Magn. Reson. Imaging Clin. N. Am. 23, 657\u2013667 (2015).","journal-title":"Magn. Reson. Imaging Clin. N. Am."},{"key":"45935_CR5","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s11910-022-01185-8","volume":"22","author":"N Shetty","year":"2022","unstructured":"Shetty, N. Essential tremor-Do we have better therapeutics? A review of recent advances and future directions. Curr. Neurol. Neurosci. Rep. 22, 197\u2013208 (2022).","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"45935_CR6","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1002\/lary.30884","volume":"134","author":"P Larner","year":"2024","unstructured":"Larner, P. et al. Voice improvement after essential tremor treatment via focused ultrasound and deep brain stimulation. Laryngoscope 134, 367\u2013373 (2024).","journal-title":"Laryngoscope"},{"key":"45935_CR7","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.2295","volume":"81","author":"MG Kaplitt","year":"2024","unstructured":"Kaplitt, M. G. et al. Safety and efficacy of staged, bilateral focused ultrasound thalamotomy in essential tremor: An open-label clinical trial. JAMA Neurol. 81, 939 (2024).","journal-title":"JAMA Neurol."},{"key":"45935_CR8","doi-asserted-by":"publisher","DOI":"10.3171\/CASE2351","volume":"5","author":"JJ Pearce","year":"2023","unstructured":"Pearce, J. J., Thoma, J., Vinson, K. & Sani, S. Treatment of vocal tremor with bilateral magnetic resonance imaging-guided focused ultrasound of the ventral intermediate thalamic nucleus: Illustrative case. J. Neurosurg. Case Lessons 5, CASE2351 (2023).","journal-title":"J. Neurosurg. Case Lessons"},{"key":"45935_CR9","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1002\/mds.29801","volume":"39","author":"A Arcadi","year":"2024","unstructured":"Arcadi, A. et al. Magnetic resonance-guided focused ultrasound (MRgFUS)-thalamotomy for Essential Tremor: Lesion location and clinical outcomes. Mov. Disord. 39, 1015\u20131025 (2024).","journal-title":"Mov. Disord."},{"key":"45935_CR10","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.clineuro.2017.04.025","volume":"158","author":"J Alshaikh","year":"2017","unstructured":"Alshaikh, J. & Fishman, P. S. Revisiting bilateral thalamotomy for tremor. Clin. Neurol. Neurosurg. 158, 103\u2013107 (2017).","journal-title":"Clin. Neurol. Neurosurg."},{"key":"45935_CR11","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1002\/mds.26890","volume":"32","author":"P Krack","year":"2017","unstructured":"Krack, P., Martinez-Fernandez, R., del Alamo, M. & Obeso, J. A. Current applications and limitations of surgical treatments for movement disorders: Surgical treatments for movement disorders. Mov. Disord. 32, 36\u201352 (2017).","journal-title":"Mov. Disord."},{"key":"45935_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1169707","volume":"14","author":"F Asci","year":"2023","unstructured":"Asci, F. et al. Acoustic analysis in stuttering: A machine-learning study. Front. Neurol. 14, 1169707 (2023).","journal-title":"Front. Neurol."},{"key":"45935_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/s20185022","volume":"20","author":"F Asci","year":"2020","unstructured":"Asci, F. et al. Machine-learning analysis of voice samples recorded through smartphones: The combined effect of ageing and gender. Sensors 20, E5022 (2020).","journal-title":"Sensors"},{"key":"45935_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1267360","volume":"14","author":"A Suppa","year":"2023","unstructured":"Suppa, A. et al. Effects of deep brain stimulation of the subthalamic nucleus on patients with Parkinson\u2019s disease: A machine-learning voice analysis. Front. Neurol. 14, 1267360 (2023).","journal-title":"Front. Neurol."},{"key":"45935_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.831428","volume":"13","author":"A Suppa","year":"2022","unstructured":"Suppa, A. et al. Voice in Parkinson\u2019s Disease: A machine learning study. Front. Neurol. 13, 831428 (2022).","journal-title":"Front. Neurol."},{"key":"45935_CR16","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28508","author":"A Suppa","year":"2021","unstructured":"Suppa, A. et al. Voice analysis with machine learning: One step closer to an objective diagnosis of Essential Tremor. Mov. Disord. https:\/\/doi.org\/10.1002\/mds.28508 (2021).","journal-title":"Mov. Disord."},{"key":"45935_CR17","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.parkreldis.2020.03.012","volume":"73","author":"A Suppa","year":"2020","unstructured":"Suppa, A. et al. Voice analysis in adductor spasmodic dysphonia: Objective diagnosis and response to botulinum toxin. Parkinsonism Relat. Disord. 73, 23\u201330 (2020).","journal-title":"Parkinsonism Relat. Disord"},{"key":"45935_CR18","doi-asserted-by":"publisher","first-page":"04028","DOI":"10.7189\/jogh.11.04028","volume":"11","author":"P Song","year":"2021","unstructured":"Song, P. et al. The global prevalence of essential tremor, with emphasis on age and sex: A meta-analysis. J. Glob Health. 11, 04028 (2021).","journal-title":"J. Glob Health"},{"key":"45935_CR19","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/j.clinph.2020.02.005","volume":"131","author":"J Hlavni\u010dka","year":"2020","unstructured":"Hlavni\u010dka, J. et al. Characterizing vocal tremor in progressive neurological diseases via automated acoustic analyses. Clin. Neurophysiol. 131, 1155\u20131165 (2020).","journal-title":"Clin. Neurophysiol."},{"key":"45935_CR20","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1016\/j.clinph.2020.02.017","volume":"131","author":"E Tripoliti","year":"2020","unstructured":"Tripoliti, E. Voice tremor and acoustic analysis: Finding harmony through the waves. Clin. Neurophysiol. 131, 1144\u20131145 (2020).","journal-title":"Clin. Neurophysiol."},{"key":"45935_CR21","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29658","author":"J Peters","year":"2023","unstructured":"Peters, J. et al. Outcomes of focused ultrasound thalamotomy in tremor syndromes. Mov. Disord. https:\/\/doi.org\/10.1002\/mds.29658 (2023).","journal-title":"Mov. Disord."},{"key":"45935_CR22","doi-asserted-by":"publisher","first-page":"E7","DOI":"10.3171\/2017.11.FOCUS17614","volume":"44","author":"DG Iacopino","year":"2018","unstructured":"Iacopino, D. G. et al. Preliminary experience with a transcranial magnetic resonance\u2013guided focused ultrasound surgery system integrated with a 1.5-T MRI unit in a series of patients with essential tremor and Parkinson\u2019s disease. NeuroSurg. Focus. 44, E7 (2018).","journal-title":"NeuroSurg. Focus"},{"key":"45935_CR23","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1136\/jnnp-2020-325278","volume":"92","author":"R Mart\u00ednez-Fern\u00e1ndez","year":"2021","unstructured":"Mart\u00ednez-Fern\u00e1ndez, R. et al. Bilateral staged magnetic resonance-guided focused ultrasound thalamotomy for the treatment of essential tremor: a case series study. J. Neurol. Neurosurg. Psychiatry. 92, 927\u2013931 (2021).","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"45935_CR24","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.procs.2018.03.007","volume":"128","author":"M Br\u00fcckl","year":"2018","unstructured":"Br\u00fcckl, M., Ghio, A. & Viallet, F. Measurement of Tremor in the Voices of Speakers with Parkinson\u2019s Disease. Procedia Comput. Sci. 128, 47\u201354 (2018).","journal-title":"Procedia Comput. Sci."},{"key":"45935_CR25","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1002\/mdc3.13882","volume":"10","author":"N Scantlebury","year":"2023","unstructured":"Scantlebury, N. et al. Safety of bilateral staged magnetic resonance-guided focused ultrasound thalamotomy for essential tremor. Mov. Disord. Clin. Pract. 10, 1559\u20131561 (2023).","journal-title":"Mov. Disord. Clin. Pract."},{"key":"45935_CR26","first-page":"154","volume":"2010","author":"M Muthuraman","year":"2010","unstructured":"Muthuraman, M., Heute, U., Deuschl, G. & Raethjen, J. The central oscillatory network of essential tremor. Annu. Int. Conf. IEEE Eng. Med. Biol. Soc. 2010, 154\u2013157 (2010).","journal-title":"Annu. Int. Conf. IEEE Eng. Med. Biol. Soc."},{"key":"45935_CR27","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.clinph.2011.09.024","volume":"123","author":"J Raethjen","year":"2012","unstructured":"Raethjen, J. & Deuschl, G. The oscillating central network of essential tremor. Clin. Neurophysiol. 123, 61\u201364 (2012).","journal-title":"Clin. Neurophysiol."},{"key":"45935_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-023-00543-8","volume":"9","author":"L Dahmani","year":"2023","unstructured":"Dahmani, L. et al. Focused ultrasound thalamotomy for tremor treatment impacts the cerebello-thalamo-cortical network. npj Parkinsons Dis 9, 90 (2023).","journal-title":"npj Parkinsons Dis"},{"key":"45935_CR29","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.cortex.2018.05.015","volume":"112","author":"AD Baddeley","year":"2019","unstructured":"Baddeley, A. D. & Hitch, G. J. The phonological loop as a buffer store: An update. Cortex 112, 91\u2013106 (2019).","journal-title":"Cortex"},{"key":"45935_CR30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002209","volume":"13","author":"S Fuertinger","year":"2015","unstructured":"Fuertinger, S., Horwitz, B. & Simonyan, K. The functional connectome of speech control. PLoS Biol 13, e1002209 (2015).","journal-title":"PLoS Biol"},{"key":"45935_CR31","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2020.0256","volume":"376","author":"D Valeriani","year":"2021","unstructured":"Valeriani, D. & Simonyan, K. The dynamic connectome of speech control. Philos Trans R Soc Lond B Biol Sci 376, 20200256 (2021).","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"45935_CR32","doi-asserted-by":"publisher","DOI":"10.7916\/D8KD1WN3","author":"ED Louis","year":"2013","unstructured":"Louis, E. D. & Gerbin, M. Voice handicap in essential tremor: A comparison with normal controls and Parkinson\u2019s disease.. Tremor Other Hyperkinet Mov (N Y) https:\/\/doi.org\/10.7916\/D8KD1WN3 (2013).","journal-title":"Tremor Other Hyperkinet Mov (N Y)"},{"key":"45935_CR33","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/mds.27121","volume":"33","author":"KP Bhatia","year":"2018","unstructured":"Bhatia, K. P. et al. Consensus Statement on the classification of tremors. from the task force on tremor of the International Parkinson and Movement Disorder Society: IPMDS Task Force on Tremor Consensus Statement. Mov. Disord. 33, 75\u201387 (2018).","journal-title":"Mov. Disord"},{"key":"45935_CR34","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/mds.870131303","volume":"13","author":"G Deuschl","year":"2008","unstructured":"Deuschl, G., Bain, P. & Brin, M. Consensus statement of the Movement Disorder Society on tremor. Mov. Disord. 13, 2\u201323 (2008).","journal-title":"Mov. Disord."},{"key":"45935_CR35","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1212\/WNL.54.1.2","volume":"54","author":"RJ Elble","year":"2000","unstructured":"Elble, R. J. Diagnostic criteria for essential tremor and differential diagnosis. Neurology 54, S2-6 (2000).","journal-title":"Neurology"},{"key":"45935_CR36","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1002\/mds.25648","volume":"28","author":"R Elble","year":"2013","unstructured":"Elble, R. et al. Task force report: Scales for screening and evaluating tremor: Critique and recommendations. Mov. Disord. 28, 1793\u20131800 (2013).","journal-title":"Mov. Disord."},{"key":"45935_CR37","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1002\/mdc3.12560","volume":"5","author":"W Ondo","year":"2018","unstructured":"Ondo, W. et al. Comparison of the Fahn-Tolosa-Marin Clinical Rating Scale and the Essential Tremor Rating Assessment Scale. Mov Disord Clin Pract 5, 60\u201365 (2018).","journal-title":"Mov Disord Clin Pract"},{"key":"45935_CR38","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1044\/1058-0360.0603.66","volume":"6","author":"BH Jacobson","year":"1997","unstructured":"Jacobson, B. H. et al. The Voice Handicap Index (VHI): Development and validation. Am. J. Speech Lang. Pathol. 6, 66\u201370 (1997).","journal-title":"Am. J. Speech Lang. Pathol."},{"key":"45935_CR39","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.jvoice.2009.05.006","volume":"24","author":"A Schindler","year":"2010","unstructured":"Schindler, A. et al. Cross-cultural adaptation and validation of the Voice Handicap Index into Italian. J Voice 24, 708\u2013714 (2010).","journal-title":"J Voice"},{"key":"45935_CR40","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"MF Folstein","year":"1975","unstructured":"Folstein, M. F., Folstein, S. E. & McHugh, P. R. \u2018Mini-mental state\u2019. A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12, 189\u2013198 (1975).","journal-title":"J. Psychiatr. Res."},{"key":"45935_CR41","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1212\/WNL.55.11.1621","volume":"55","author":"B Dubois","year":"2000","unstructured":"Dubois, B., Slachevsky, A., Litvan, I. & Pillon, B. The FAB: A Frontal Assessment Battery at bedside. Neurology 55, 1621\u20131626 (2000).","journal-title":"Neurology"},{"key":"45935_CR42","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1961.01710120031004","volume":"4","author":"AT Beck","year":"1961","unstructured":"Beck, A. T. An inventory for measuring depression. Arch. Gen. Psychiatry 4, 561 (1961).","journal-title":"Arch. Gen. Psychiatry"},{"key":"45935_CR43","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1002\/mds.27700","volume":"34","author":"JJ Ferreira","year":"2019","unstructured":"Ferreira, J. J. et al. MDS evidence-based review of treatments for essential tremor. Mov. Disord. 34, 950\u2013958 (2019).","journal-title":"Mov. Disord."},{"key":"45935_CR44","unstructured":"REAPER | Audio Production Without Limits. https:\/\/www.reaper.fm\/"},{"key":"45935_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bspc.2021.103006","volume":"70","author":"MB Er","year":"2021","unstructured":"Er, M. B., Isik, E. & Isik, I. Parkinson\u2019s detection based on combined CNN and LSTM using enhanced speech signals with variational mode decomposition. Biomed. Signal Process. Control 70, 103006 (2021).","journal-title":"Biomed. Signal Process. Control"},{"key":"45935_CR46","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.procs.2015.06.066","volume":"54","author":"N Upadhyay","year":"2015","unstructured":"Upadhyay, N. & Karmakar, A. Speech enhancement using spectral subtraction-type algorithms: A comparison and simulation study. Procedia Comput. Sci. 54, 574\u2013584 (2015).","journal-title":"Procedia Comput. Sci."},{"key":"45935_CR47","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1145\/2729095.2729097","volume":"6","author":"F Eyben","year":"2015","unstructured":"Eyben, F. & Schuller, B. openSMILE:): The Munich open-source large-scale multimedia feature extractor. SIGMultimedia Rec 6, 4\u201313 (2015).","journal-title":"SIGMultimedia Rec"},{"key":"45935_CR48","doi-asserted-by":"crossref","unstructured":"Schuller, B. The INTERSPEECH 2016 computational paralinguistics challenge: 17th Annual Conference of the International Speech Communication Association, INTERSPEECH 2016. In\u00a0Proceedings of the Annual Conference of the International Speech Communication Association, INTERSPEECH 08-12-September-2016, 2001\u20132005 (2016).","DOI":"10.21437\/Interspeech.2016-129"},{"key":"45935_CR49","unstructured":"Bogert, B. P. The quefrency alanysis of time series for echoes; Cepstrum, pseudo-autocovariance, cross-cepstrum and saphe cracking.\u00a0Time Series Analysis,\u00a0209\u2013243 (1963)."},{"key":"45935_CR50","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1109\/89.326616","volume":"2","author":"H Hermansky","year":"1994","unstructured":"Hermansky, H. & Morgan, N. RASTA processing of speech. IEEE Trans. Speech Audio Process. 2, 578\u2013589 (1994).","journal-title":"IEEE Trans. Speech Audio Process."},{"key":"45935_CR51","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/978-3-540-49127-9_10","volume-title":"Pitch and Voicing Determination of Speech with an Extension Toward Music Signals","author":"W Hess","year":"2008","unstructured":"Hess, W. Pitch and Voicing Determination of Speech with an Extension Toward Music Signals 181\u2013212 (2008). https:\/\/doi.org\/10.1007\/978-3-540-49127-9_10."},{"key":"45935_CR52","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.cogsys.2018.12.004","volume":"54","author":"SA Mostafa","year":"2019","unstructured":"Mostafa, S. A. et al. Examining multiple feature evaluation and classification methods for improving the diagnosis of Parkinson\u2019s disease. Cogn. Syst. Res. 54, 90\u201399 (2019).","journal-title":"Cogn. Syst. Res."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-45935-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-45935-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-45935-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T11:03:16Z","timestamp":1779879796000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-45935-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,4]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["45935"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-45935-x","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,4]]},"assertion":[{"value":"9 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Authors VC, GC, and GSag are advisory members of VoiceWise S.r.l., spin-off company of University of Rome Tor Vergata (Rome, Italy) developing voice analysis solutions for diagnostic purposes. The other authors declare they received no funding from any institution, including personal relationships, interests, grants, employment, affiliations, patents, inventions, honoraria, consultancies, royalties, stock options\/ownership, or expert testimony for the last 12 months.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"16354"}}