{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:57:50Z","timestamp":1788501470312,"version":"build-2803163510"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/R003971\/1"],"award-info":[{"award-number":["BB\/R003971\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chemotherapy induced peripheral neuropathy (CIPN) is a frequent side effect of a number of chemotherapeutic agents which are widely used in the treatment of common cancers. Sensory symptoms primarily affect the fingers and toes and include numbness, tingling and pain. However, there is limited understanding of how these touch impairments may impact manipulation skills. Questionnaire and focus group methods were used to describe the experience of CIPN side effects impacting manual activities in 25 self-selected participants recruited from a cancer charity web site advertisement. Participants\u2019 responses demonstrated varying degrees of impact of touch impairment associated with CIPN on the performance of manual activities involving bimanual, unimanual and directed touch. Examination of the components of the affected activities, together with participants\u2019 reports of alterations in their experience of touch, were used to generate theory-informed hypotheses about why some manual tasks are more affected than others. In future research it is proposed that quantitative objective measures should be used to complement patient reported outcome measures in evaluating the mechanisms underlying issues in sensory motor control of manual activities caused by the effects of CIPN.<\/jats:p>","DOI":"10.1038\/s41598-026-46039-2","type":"journal-article","created":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T07:05:37Z","timestamp":1774767937000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Touch and manual action in chemotherapy-induced peripheral neuropathy: a mixed-methods study"],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9420-0676","authenticated-orcid":false,"given":"Roberta D.","family":"Roberts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6747-8813","authenticated-orcid":false,"given":"Winnie","family":"Chua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0679-0499","authenticated-orcid":false,"given":"Ali","family":"Khatibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9268-4179","authenticated-orcid":false,"given":"Nicholas P.","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9670-2263","authenticated-orcid":false,"given":"Claire","family":"Palles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4836-7624","authenticated-orcid":false,"given":"Racha","family":"Kussaibati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2623-3801","authenticated-orcid":false,"given":"Alan M.","family":"Wing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,29]]},"reference":[{"key":"46039_CR1","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s40487-021-00168-y","volume":"9","author":"J Burgess","year":"2021","unstructured":"Burgess, J. et al. Chemotherapy-induced peripheral neuropathy: Epidemiology, pathomechanisms and treatment. Oncol. Ther. 9, 385\u2013450. https:\/\/doi.org\/10.1007\/s40487-021-00168-y (2021).","journal-title":"Oncol. Ther."},{"key":"46039_CR2","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.critrevonc.2011.04.012","volume":"82","author":"AA Argyriou","year":"2012","unstructured":"Argyriou, A. A., Bruna, J., Marmiroli, P. & Cavaletti, G. Chemotherapy-induced peripheral neurotoxicity (CIPN): an update. Crit. Rev. Oncol. Hematol. 82, 51\u201377. https:\/\/doi.org\/10.1016\/j.critrevonc.2011.04.012 (2012).","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"46039_CR3","doi-asserted-by":"publisher","unstructured":"Tanay, M. A. L., Armes, J. & Ream, E. The experience of chemotherapy-induced peripheral neuropathy in adult cancer patients: A qualitative thematic synthesis. Eur. J. Cancer Care (Engl). 26 https:\/\/doi.org\/10.1111\/ecc.12443 (2017).","DOI":"10.1111\/ecc.12443"},{"key":"46039_CR4","doi-asserted-by":"publisher","first-page":"2261","DOI":"10.1007\/s00520-014-2255-7","volume":"22","author":"F Mols","year":"2014","unstructured":"Mols, F., Beijers, T., Vreugdenhil, G. & van de Poll-Franse, L. Chemotherapy-induced peripheral neuropathy and its association with quality of life: A systematic review. Support Care Cancer. 22, 2261\u20132269. https:\/\/doi.org\/10.1007\/s00520-014-2255-7 (2014).","journal-title":"Support Care Cancer"},{"key":"46039_CR5","doi-asserted-by":"publisher","first-page":"160940692412448","DOI":"10.1177\/16094069241244856","volume":"23","author":"ST Fife","year":"2024","unstructured":"Fife, S. T. & Gossner, J. D. Deductive qualitative analysis: Evaluating, expanding, and refining theory. Int. J. Qual. Methods. 23, 16094069241244856. https:\/\/doi.org\/10.1177\/16094069241244856 (2024).","journal-title":"Int. J. Qualitative Methods"},{"key":"46039_CR6","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkaf119","author":"K Chen","year":"2025","unstructured":"Chen, K., Antonen, E., Nadler, M. B., Mauti, E. & Jones, J. M. Assessment tools for chemotherapy-induced peripheral neuropathy: A narrative review of clinician, patient-reported, and objective measures. JNCI Cancer Spectr. https:\/\/doi.org\/10.1093\/jncics\/pkaf119 (2025).","journal-title":"JNCI Cancer Spectr."},{"key":"46039_CR7","doi-asserted-by":"publisher","first-page":"e13517","DOI":"10.1111\/ecc.13517","volume":"31","author":"MAL Tanay","year":"2022","unstructured":"Tanay, M. A. L., Robert, G., Rafferty, A. M., Moss-Morris, R. & Armes, J. Clinician and patient experiences when providing and receiving information and support for managing chemotherapy-induced peripheral neuropathy: A qualitative multiple methods study. Eur. J. Cancer Care (Engl). 31, e13517. https:\/\/doi.org\/10.1111\/ecc.13517 (2022).","journal-title":"Eur. J. Cancer Care (Engl)"},{"key":"46039_CR8","doi-asserted-by":"publisher","unstructured":"Amarelo, A., Amarelo, B., Ferreira, M. C. & Fernandes, C. S. Living with chemotherapy-induced peripheral neuropathy: A qualitative meta-synthesis of patient experiences. Eur. J. Oncol. Nurs. 77 https:\/\/doi.org\/10.1016\/j.ejon.2025.102921 (2025).","DOI":"10.1016\/j.ejon.2025.102921"},{"key":"46039_CR9","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1016\/j.ejca.2005.02.012","volume":"41","author":"TJ Postma","year":"2005","unstructured":"Postma, T. J. et al. The development of an EORTC quality of life questionnaire to assess chemotherapy-induced peripheral neuropathy: The QLQ-CIPN20. Eur. J. Cancer. 41, 1135\u20131139. https:\/\/doi.org\/10.1016\/j.ejca.2005.02.012 (2005).","journal-title":"Eur. J. Cancer"},{"key":"46039_CR10","doi-asserted-by":"publisher","first-page":"3091","DOI":"10.1007\/s11136-022-03154-7","volume":"31","author":"T Li","year":"2022","unstructured":"Li, T. et al. Assessing chemotherapy-induced peripheral neuropathy with patient reported outcome measures: a systematic review of measurement properties and considerations for future use. Qual. Life Res. 31, 3091\u20133107. https:\/\/doi.org\/10.1007\/s11136-022-03154-7 (2022).","journal-title":"Qual. Life Res."},{"key":"46039_CR11","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1053\/j.seminoncol.2005.12.010","volume":"33","author":"FH Hausheer","year":"2006","unstructured":"Hausheer, F. H., Schilsky, R. L., Bain, S., Berghorn, E. J. & Lieberman, F. Diagnosis, management, and evaluation of chemotherapy-induced peripheral neuropathy. Semin. Oncol. 33, 15\u201349. https:\/\/doi.org\/10.1053\/j.seminoncol.2005.12.010 (2006).","journal-title":"Semin. Oncol."},{"key":"46039_CR12","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.tins.2004.08.006","volume":"27","author":"AG Witney","year":"2004","unstructured":"Witney, A. G., Wing, A., Thonnard, J. L. & Smith, A. M. The cutaneous contribution to adaptive precision grip. Trends Neurosci. 27, 637\u2013643. https:\/\/doi.org\/10.1016\/j.tins.2004.08.006 (2004).","journal-title":"Trends Neurosci."},{"key":"46039_CR13","doi-asserted-by":"publisher","unstructured":"Anderson, C. Presenting and evaluating qualitative research. Am. J. Pharm. Educ. 74 https:\/\/doi.org\/10.5688\/aj7408141 (2010).","DOI":"10.5688\/aj7408141"},{"key":"46039_CR14","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1684\/ejd.2016.2833","volume":"26","author":"V Sibaud","year":"2016","unstructured":"Sibaud, V. et al. Dermatological adverse events with taxane chemotherapy. Eur. J. Dermatol. 26, 427\u2013443. https:\/\/doi.org\/10.1684\/ejd.2016.2833 (2016).","journal-title":"Eur. J. Dermatol."},{"key":"46039_CR15","doi-asserted-by":"publisher","unstructured":"Hertz, D. L. et al. Patient perceptions of altering chemotherapy treatment due to peripheral neuropathy. Support. Care Cancer 32, ARTN 48. https:\/\/doi.org\/10.1007\/s00520-023-08209-0 (2024).","DOI":"10.1007\/s00520-023-08209-0"},{"key":"46039_CR16","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s10549-016-3939-0","volume":"159","author":"T Bao","year":"2016","unstructured":"Bao, T. et al. Long-term chemotherapy-induced peripheral neuropathy among breast cancer survivors: prevalence, risk factors, and fall risk. Breast Cancer Res. Treat. 159, 327\u2013333. https:\/\/doi.org\/10.1007\/s10549-016-3939-0 (2016).","journal-title":"Breast Cancer Res. Treat."},{"key":"46039_CR17","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/S1470-2045(18)30093-7","volume":"19","author":"TJ Iveson","year":"2018","unstructured":"Iveson, T. J. et al. 3 versus 6 months of adjuvant oxaliplatin-fluoropyrimidine combination therapy for colorectal cancer (SCOT): An international, randomised, phase 3, non-inferiority trial. Lancet Oncol. 19, 562\u2013578. https:\/\/doi.org\/10.1016\/S1470-2045(18)30093-7 (2018).","journal-title":"Lancet Oncol."},{"key":"46039_CR18","doi-asserted-by":"publisher","first-page":"2604","DOI":"10.1200\/JCO.2016.71.3552","volume":"35","author":"KM Winters-Stone","year":"2017","unstructured":"Winters-Stone, K. M. et al. Falls, functioning, and disability among women with persistent symptoms of chemotherapy-induced peripheral neuropathy. J. Clin. Oncol. 35, 2604\u20132612. https:\/\/doi.org\/10.1200\/JCO.2016.71.3552 (2017).","journal-title":"J. Clin. Oncol."},{"key":"46039_CR19","doi-asserted-by":"publisher","unstructured":"Wang, A. B. et al. A review of movement disorders in chemotherapy-induced neurotoxicity. J. Neuroeng. Rehabil. 18 https:\/\/doi.org\/10.1186\/s12984-021-00818-2 (2021).","DOI":"10.1186\/s12984-021-00818-2"},{"key":"46039_CR20","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.neuroscience.2021.02.015","volume":"464","author":"S McIntyre","year":"2021","unstructured":"McIntyre, S., Nagi, S. S., McGlone, F. & Olausson, H. The effects of ageing on tactile function in humans. Neuroscience 464, 53\u201358. https:\/\/doi.org\/10.1016\/j.neuroscience.2021.02.015 (2021).","journal-title":"Neuroscience"},{"key":"46039_CR21","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1093\/gerona\/58.2.m146","volume":"58","author":"E Carmeli","year":"2003","unstructured":"Carmeli, E., Patish, H. & Coleman, R. The aging hand. J. Gerontol. Biol. Sci. Med. Sci. 58, 146\u2013152. https:\/\/doi.org\/10.1093\/gerona\/58.2.m146 (2003).","journal-title":"J. Gerontol. Biol. Sci. Med. Sci."},{"key":"46039_CR22","doi-asserted-by":"crossref","unstructured":"Jones, L. A. & Lederman, S. J. Human Hand Function (Oxford University Press, 2006).","DOI":"10.1093\/acprof:oso\/9780195173154.001.0001"},{"key":"46039_CR23","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1113\/JP283174","volume":"601","author":"D Deflorio","year":"2023","unstructured":"Deflorio, D., Di Luca, M. & Wing, A. M. Skin properties and afferent density in the deterioration of tactile spatial acuity with age. J. Physiol. 601, 517\u2013533. https:\/\/doi.org\/10.1113\/JP283174 (2023).","journal-title":"J. Physiol."},{"key":"46039_CR24","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1080\/0899022031000105154","volume":"20","author":"F Tremblay","year":"2003","unstructured":"Tremblay, F., Wong, K., Sanderson, R. & Cote, L. Tactile spatial acuity in elderly persons: Assessment with grating domes and relationship with manual dexterity. Somatosens Mot Res. 20, 127\u2013132. https:\/\/doi.org\/10.1080\/0899022031000105154 (2003).","journal-title":"Somatosens Mot Res."},{"key":"46039_CR25","doi-asserted-by":"publisher","first-page":"3238","DOI":"10.1523\/JNEUROSCI.19-08-03238.1999","volume":"19","author":"KJ Cole","year":"1999","unstructured":"Cole, K. J., Rotella, D. L. & Harper, J. G. Mechanisms for age-related changes of fingertip forces during precision gripping and lifting in adults. J. Neurosci. 19, 3238\u20133247. https:\/\/doi.org\/10.1523\/JNEUROSCI.19-08-03238.1999 (1999).","journal-title":"J. Neurosci."},{"key":"46039_CR26","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.ejca.2016.09.020","volume":"69","author":"F Mols","year":"2016","unstructured":"Mols, F. et al. Reference data of the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-CIPN20 Questionnaire in the general Dutch population. Eur. J. Cancer. 69, 28\u201338. https:\/\/doi.org\/10.1016\/j.ejca.2016.09.020 (2016).","journal-title":"Eur. J. Cancer"},{"key":"46039_CR27","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1007\/s11135-017-0574-8","volume":"52","author":"B Saunders","year":"2018","unstructured":"Saunders, B. et al. Saturation in qualitative research: Exploring its conceptualization and operationalization. Qual. Quant. 52, 1893\u20131907. https:\/\/doi.org\/10.1007\/s11135-017-0574-8 (2018).","journal-title":"Qual. Quant."},{"key":"46039_CR28","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/s12885-019-5302-4","volume":"19","author":"A Molassiotis","year":"2019","unstructured":"Molassiotis, A. et al. Are we mis-estimating chemotherapy-induced peripheral neuropathy? Analysis of assessment methodologies from a prospective, multinational, longitudinal cohort study of patients receiving neurotoxic chemotherapy. BMC Cancer. 19, 132. https:\/\/doi.org\/10.1186\/s12885-019-5302-4 (2019).","journal-title":"BMC Cancer"},{"key":"46039_CR29","doi-asserted-by":"publisher","unstructured":"Nielsen, S. W., Lindberg, S., Ruhlmann, C. H. B., Eckhoff, L. & Herrstedt, J. Addressing chemotherapy-induced peripheral neuropathy using multi-frequency vibrometry and patient-reported outcomes. J. Clin. Med. 11 https:\/\/doi.org\/10.3390\/jcm11071862 (2022).","DOI":"10.3390\/jcm11071862"},{"key":"46039_CR30","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1136\/jnnp-2019-320969","volume":"90","author":"AA Argyriou","year":"2019","unstructured":"Argyriou, A. A. et al. Neurophysiological, nerve imaging and other techniques to assess chemotherapy-induced peripheral neurotoxicity in the clinical and research settings. J. Neurol. Neurosurg. Psychiatry. 90, 1361\u20131369. https:\/\/doi.org\/10.1136\/jnnp-2019-320969 (2019).","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"46039_CR31","doi-asserted-by":"publisher","first-page":"102196","DOI":"10.1016\/j.ejon.2022.102196","volume":"60","author":"M Wang","year":"2022","unstructured":"Wang, M., Bandla, A., Sundar, R. & Molassiotis, A. The phenotype and value of nerve conduction studies in measuring chemotherapy-induced peripheral neuropathy: A secondary analysis of pooled data. Eur. J. Oncol. Nurs. 60, 102196. https:\/\/doi.org\/10.1016\/j.ejon.2022.102196 (2022).","journal-title":"Eur. J. Oncol. Nurs."},{"key":"46039_CR32","doi-asserted-by":"publisher","unstructured":"Roberts, R. D., Loomes, A. R., Allen, H. A., Di Luca, M. & Wing, A. M. Contact forces in roughness discrimination. Sci. Rep.-Uk 10, ARTN 5108. https:\/\/doi.org\/10.1038\/s41598-020-61943-x (2020).","DOI":"10.1038\/s41598-020-61943-x"},{"key":"46039_CR33","doi-asserted-by":"publisher","first-page":"421","DOI":"10.3758\/App.71.2.421","volume":"71","author":"MA Plaisier","year":"2009","unstructured":"Plaisier, M. A., Tiest, W. M. B. & Kappers, A. M. L. Salient features in 3-D haptic shape perception. Atten. Percept. Psychol. 71, 421\u2013430. https:\/\/doi.org\/10.3758\/App.71.2.421 (2009).","journal-title":"Atten. Percept. Psychol"},{"key":"46039_CR34","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1037\/h0061266","volume":"32","author":"J Tiffin","year":"1948","unstructured":"Tiffin, J. & Asher, E. J. The purdue pegboard: Norms and studies of reliability and validity. J. Appl. Psychol. 32, 234\u2013247. https:\/\/doi.org\/10.1037\/h0061266 (1948).","journal-title":"J. Appl. Psychol."},{"key":"46039_CR35","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1002\/dev.21619","volume":"60","author":"O Vasylenko","year":"2018","unstructured":"Vasylenko, O., Gorecka, M. M. & Rodriguez-Aranda, C. Manual dexterity in young and healthy older adults. 1. Age- and gender-related differences in unimanual and bimanual performance. Dev. Psychobiol. 60, 407\u2013427. https:\/\/doi.org\/10.1002\/dev.21619 (2018).","journal-title":"Dev. Psychobiol."},{"key":"46039_CR36","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/BF00229662","volume":"95","author":"JR Flanagan","year":"1993","unstructured":"Flanagan, J. R. & Wing, A. M. Modulation of grip force with load force during point-to-point arm movements. Exp. Brain Res. 95, 131\u2013143 (1993).","journal-title":"Exp. Brain Res."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-46039-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-46039-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-46039-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:06:01Z","timestamp":1781643961000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-46039-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,29]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["46039"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-46039-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,29]]},"assertion":[{"value":"10 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors RDR, WC, AK, NPH, CP and AMW declare no competing interests. Author RK has received speaker honoraria from: Novartis, AstraZeneca, Roche, Bristol Myers Squibb, Lilly, Pfizer, Exact Sciences and Menarini Stemline.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"10689"}}