{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:28:55Z","timestamp":1791599335651,"version":"4.3.4"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:00:00Z","timestamp":1775260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":51,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Emergence agitation (EA) is a common complication during recovery from pediatric anesthesia, particularly in children with obstructive sleep apnea syndrome (OSAS) undergoing tonsillectomy and adenoidectomy (T&amp;A). This study aimed to compare the effects of dexmedetomidine-assisted deep extubation and awake extubation strategies on the incidence of EA in this high-risk population. In this prospective randomized trial, 100 children aged 3\u201310 years scheduled for T&amp;A were allocated to either a dexmedetomidine-assisted deep extubation group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200950) or an awake extubation group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200950). The primary outcome was the incidence of EA, assessed using the Pediatric Anesthesia Emergence Delirium (PAED) scale with a diagnostic threshold\u2009&gt;\u200910. Secondary outcomes included extubation time and post-anesthesia care unit (PACU) length of stay. The dexmedetomidine-assisted deep extubation group demonstrated a significantly lower incidence of EA compared to the awake extubation group (21.3% vs. 54%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002; relative risk [95% confidence interval]\u2009=\u20090.394 [0.215\u20130.722]; NNT [number needed to treat]\u2009=\u20093.06). Extubation time was also significantly shorter in the deep extubation group (5.5\u2009\u00b1\u20092.02 vs. 11.7\u2009\u00b1\u20092.39\u00a0min;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). No significant difference was observed in PACU length of stay between the two groups (60.4\u2009\u00b1\u20092.92 vs. 60.6\u2009\u00b1\u20093.14\u00a0min;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.78). In this single-center randomized controlled trial, dexmedetomidine-assisted deep extubation was associated with a reduced incidence of EA and a shorter extubation time, without prolonging PACU stay or increasing observed adverse events.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial registration:<\/jats:bold>\n                    Chictr.org.cn; Identifier: ChiCTR2300075947; registered 20 September 2023.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-46227-0","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T23:33:22Z","timestamp":1775259202000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The effect of deep extubation on the emergence agitation in pediatric patients undergoing obstructive sleep apnea syndrome surgery: a randomized controlled study"],"prefix":"10.1038","volume":"16","author":[{"given":"Yuanyuan","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,4]]},"reference":[{"key":"46227_CR1","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1046\/j.1460-9592.2002.00868.x","volume":"12","author":"JW Cole","year":"2002","unstructured":"Cole, J. 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