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This study examined the association between Oxidative Balance Score (OBS), an integrated measure of both antioxidant and pro-oxidant exposures, and odds of psychological disorders. This cross-sectional analysis used baseline data from the Isfahan Functional Disorders (ISFUN) cohort. Dietary intakes were assessed using a self-administered, Willett-format, Dish-based, 106-item Semi-quantitative Food Frequency Questionnaire (DS-FFQ). OBS was calculated based on 16 dietary and 4 lifestyle factors. Depression and anxiety symptoms were evaluated using the Iranian-validated Hospital Anxiety and Depression Scale (HADS). After adjusting for confounding variables, higher OBS was significantly associated with reduced odds of depression (OR: 0.65; 95% CI: 0.49\u20130.86) and anxiety (OR: 0.70; 95% CI: 0.53\u20130.92). In sex-stratified analyses, a significant inverse association was found between OBS with depression (OR: 0.65; 95% CI: 0.45\u20130.93) and anxiety (OR: 0.64; 95% CI: 0.45\u20130.91) among women. However, there was no significant association between OBS with depression and anxiety among men. In conclusion, a higher OBS was associated with reduced odds of depression and anxiety in this population, with this inverse association being statistically significant only in women, highlighting the potential importance of a balanced antioxidant-pro-oxidant profile for mental health. Prospective studies are needed to confirm these findings.<\/jats:p>","DOI":"10.1038\/s41598-026-46301-7","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T09:54:20Z","timestamp":1781258060000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between oxidative balance score and psychological disorders in adults"],"prefix":"10.1038","volume":"16","author":[{"given":"Glareh","family":"Koochakpoor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma","family":"Salari-Moghaddam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Bagheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awat","family":"Feizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"K Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Hajihashemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Ani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamidreza","family":"Roohafza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peyman","family":"Adibi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"issue":"10","key":"46301_CR1","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1038\/s41562-021-01191-9","volume":"5","author":"AR Daros","year":"2021","unstructured":"Daros, A. 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