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The study received approval from the Ethics Committee of the Third Xiangya Hospital of Central South University for the use of patient tissue samples (approval number F-24714), and separately for the collection of healthy donor blood (approval number F-24055). All subjects provided written informed consent following the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The manuscript can be published with the consent of all authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"16403"}}