{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T07:57:15Z","timestamp":1793779035396,"version":"4.6.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":54,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-47034-3","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T11:04:52Z","timestamp":1776510292000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Safety outcomes in 602 GERD patients treated by RefluxStop: a multi-center real-world study from 22 centers across six European countries"],"prefix":"10.1038","volume":"16","author":[{"given":"Sebastian F.","family":"Schoppmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Zehetner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moustafa","family":"Elshafei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naim","family":"Fakih-Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Feka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fergus","family":"Noble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Eugenia","family":"Barrios Carvajal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Hern\u00e1ndez Matias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Daniel","family":"S\u00e1nchez L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Cuadrado Ayuso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Guil Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Miliani Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Moreno Sanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Pozzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Pavanello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Renzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Bona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Vincenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Bonavina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Borbely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Lipham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,18]]},"reference":[{"key":"47034_CR1","doi-asserted-by":"crossref","unstructured":"Boulton, K. H. A. & Dettmar, P. W. A narrative review of the prevalence of gastroesophageal reflux disease (GERD). Ann. Esophagus. 5 (2021).","DOI":"10.21037\/aoe-20-80"},{"key":"47034_CR2","unstructured":"Antunes, C., Aleem, A., Curtis, S. A. & Gastroesophageal Reflux, D. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing Copyright \u00a9 2023, StatPearls Publishing LLC. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK441938\/ (2023)."},{"issue":"Suppl 8","key":"47034_CR3","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1365-2036.2004.02219.x","volume":"20","author":"BC Delaney","year":"2004","unstructured":"Delaney, B. C. Review article: Prevalence and epidemiology of gastro-oesophageal reflux disease. Aliment. Pharmacol. Ther. 20(Suppl 8), 2\u20134 (2004).","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"9","key":"47034_CR4","doi-asserted-by":"publisher","first-page":"4903","DOI":"10.1007\/s00464-021-08625-5","volume":"35","author":"BJ Slater","year":"2021","unstructured":"Slater, B. J. et al. SAGES guidelines for the surgical treatment of gastroesophageal reflux (GERD). Surg. Endosc. 35(9), 4903\u20134917 (2021).","journal-title":"Surg. Endosc."},{"issue":"5","key":"47034_CR5","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1053\/j.gastro.2019.12.014","volume":"158","author":"SD Delshad","year":"2020","unstructured":"Delshad, S. D., Almario, C. V., Chey, W. D. & Spiegel, B. M. R. Prevalence of gastroesophageal reflux disease and proton pump inhibitor-refractory symptoms. Gastroenterology 158(5), 1250\u201361e2 (2020).","journal-title":"Gastroenterology"},{"key":"47034_CR6","doi-asserted-by":"publisher","first-page":"l1580","DOI":"10.1136\/bmj.l1580","volume":"365","author":"Y Xie","year":"2019","unstructured":"Xie, Y. et al. Estimates of all cause mortality and cause specific mortality associated with proton pump inhibitors among US veterans: Cohort study. BMJ 365, l1580 (2019).","journal-title":"BMJ"},{"key":"47034_CR7","doi-asserted-by":"publisher","unstructured":"Zehetner, J., Hoffsten, J., Das, S., Schoppmann, S. F. & Lipham, J. C. Looking back on a gold standard: A systematic literature review of laparoscopic Nissen fundoplication as an anti-reflux treatment option. Eur. Surg. 56, 143\u2013171. https:\/\/doi.org\/10.1007\/s10353-024-00836-z (2024).","DOI":"10.1007\/s10353-024-00836-z"},{"issue":"2","key":"47034_CR8","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1007\/s00464-019-07208-9","volume":"34","author":"A Andreou","year":"2020","unstructured":"Andreou, A., Watson, D. I., Mavridis, D., Francis, N. K. & Antoniou, S. A. Assessing the efficacy and safety of laparoscopic antireflux procedures for the management of gastroesophageal reflux disease: A systematic review with network meta-analysis. Surg. Endosc. 34(2), 510\u2013520 (2020).","journal-title":"Surg. Endosc"},{"issue":"4","key":"47034_CR9","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1007\/s11605-018-04073-0","volume":"23","author":"PR Armijo","year":"2019","unstructured":"Armijo, P. R., Pokala, B., Misfeldt, M., Pagkratis, S. & Oleynikov, D. Predictors of hiatal hernia recurrence after laparoscopic anti-reflux surgery with hiatal hernia repair: A prospective database analysis. J. Gastrointest. Surg. 23(4), 696\u2013701 (2019).","journal-title":"J. Gastrointest. Surg."},{"key":"47034_CR10","doi-asserted-by":"publisher","unstructured":"DeMarchi, J., Schwiers, M., Soberman, M. & Tokarski, A. Evolution of a novel technology for gastroesophageal reflux disease: a safety perspective of magnetic sphincter augmentation. Dis. Esophagus. 34 (11), doab036. https:\/\/doi.org\/10.1093\/dote\/doab036(2021).","DOI":"10.1093\/dote\/doab036"},{"key":"47034_CR11","doi-asserted-by":"publisher","first-page":"1293270","DOI":"10.3389\/fsurg.2023.1293270","volume":"10","author":"C Froiio","year":"2023","unstructured":"Froiio, C., Aiolfi, A., Bona, D. & Bonavina, L. Safety profile of magnetic sphincter augmentation for gastroesophageal reflux disease. Front. Surg. 10, 1293270 (2023).","journal-title":"Front. Surg."},{"issue":"8","key":"47034_CR12","doi-asserted-by":"publisher","first-page":"3078","DOI":"10.1007\/s00464-016-5370-3","volume":"31","author":"D Skubleny","year":"2017","unstructured":"Skubleny, D. et al. LINX(\u00ae) magnetic esophageal sphincter augmentation versus Nissen fundoplication for gastroesophageal reflux disease: A systematic review and meta-analysis. Surg. Endosc. 31(8), 3078\u20133084 (2017).","journal-title":"Surg. Endosc"},{"issue":"3","key":"47034_CR13","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s00464-014-3704-6","volume":"29","author":"EG Sheu","year":"2015","unstructured":"Sheu, E. G., Nau, P., Nath, B., Kuo, B. & Rattner, D. W. A comparative trial of laparoscopic magnetic sphincter augmentation and Nissen fundoplication. Surg. Endosc. 29(3), 505\u2013509 (2015).","journal-title":"Surg. Endosc"},{"issue":"1","key":"47034_CR14","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s12893-020-00794-9","volume":"20","author":"M Bjelovi\u0107","year":"2020","unstructured":"Bjelovi\u0107, M., Hars\u00e1nyi, L., Altorjay, \u00c1., Kincses, Z. & Forsell, P. Non-active implantable device treating acid reflux with a new dynamic treatment approach: 1-year results. BMC Surg. 20(1), 159 (2020).","journal-title":"BMC Surg."},{"issue":"2","key":"47034_CR15","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s10620-024-08788-w","volume":"70","author":"L Hars\u00e1nyi","year":"2025","unstructured":"Hars\u00e1nyi, L., Kincses, Z. & Altorjay, \u00c1. Acid reflux management with the RefluxStop implant: A prospective multicenter trial with 3-year outcomes. Dig. Dis. Sci. 70(2), 665\u2013674 (2025).","journal-title":"Dig. Dis. Sci."},{"issue":"7","key":"47034_CR16","doi-asserted-by":"publisher","first-page":"4615","DOI":"10.1007\/s00464-025-11818-x","volume":"39","author":"L Hars\u00e1nyi","year":"2025","unstructured":"Hars\u00e1nyi, L., Kincses, Z., Veselinovi\u0107, M., Zehetner, J. & Altorjay, \u00c1. Food passageway-related sequelae in the RefluxStop prospective multicenter trial: patient-centric outcomes of dysphagia, odynophagia, gas-bloating, and inability to belch and\/or vomit at 5 years. Surg. Endosc. 39(7), 4615\u20134627 (2025).","journal-title":"Surg. Endosc."},{"key":"47034_CR17","doi-asserted-by":"publisher","unstructured":"Hars\u00e1nyi, L., Kincses, Z., Veselinovi\u0107, M., Zehetner, J. & Altorjay, \u00c1. Five-year clinical outcomes of RefluxStop surgery in the treatment of acid reflux: a prospective multicenter trial of safety and effectiveness. Surg. Endosc. 39 (9), 6163\u20136179. https:\/\/doi.org\/10.1007\/s00464-025-11979-9(2025).","DOI":"10.1007\/s00464-025-11979-9"},{"issue":"10","key":"47034_CR18","doi-asserted-by":"publisher","first-page":"6060","DOI":"10.1007\/s00464-024-11114-0","volume":"38","author":"L Hars\u00e1nyi","year":"2024","unstructured":"Hars\u00e1nyi, L., Kincses, Z., Zehetner, J. & Altorjay, \u00c1. Treating acid reflux without compressing the food passageway: 4-year safety and clinical outcomes with the RefluxStop device in a prospective multicenter study. Surg. Endosc. 38(10), 6060\u20136069 (2024).","journal-title":"Surg. Endosc"},{"issue":"1","key":"47034_CR19","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1007\/s10029-025-03339-2","volume":"29","author":"Y Borb\u00e9ly","year":"2025","unstructured":"Borb\u00e9ly, Y. et al. A safety and effectiveness evaluation of RefluxStop in the treatment of acid reflux comparing large and small hiatal hernia groups: Results from 99 patients in Switzerland with up to 4-years follow-up. Hernia 29(1), 156 (2025).","journal-title":"Hernia"},{"key":"47034_CR20","unstructured":"Borb\u00e9ly, Y. et al. RefluxStop: 3-year results of a novel procedure to address gastroesophageal reflux disease. Surg. Endosc. (2025)."},{"key":"47034_CR21","doi-asserted-by":"publisher","unstructured":"Elshafei, M. Experience with an innovative surgical treatment for gastroesophageal reflux disease: Results of 28 patients in a retrospective analysis. J. Laparoendosc. Adv. Surg. Tech. 35 (5), 357\u2013364. https:\/\/doi.org\/10.1089\/lap.2024.0390.(2025).","DOI":"10.1089\/lap.2024.0390."},{"issue":"1","key":"47034_CR22","doi-asserted-by":"publisher","first-page":"15425","DOI":"10.1038\/s41598-024-65751-5","volume":"14","author":"J Feka","year":"2024","unstructured":"Feka, J. et al. Multicentric short term and safety study of ineffective esophageal motility patients treated with RefluxStop device. Sci. Rep. 14(1), 15425 (2024).","journal-title":"Sci. Rep."},{"issue":"1","key":"47034_CR23","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/s00423-024-03264-5","volume":"409","author":"Y Fringeli","year":"2024","unstructured":"Fringeli, Y., Linas, I., Kessler, U. & Zehetner, J. Short-term results of laparoscopic anti-reflux surgery with the RefluxStop device in patients with gastro-esophageal reflux disease and ineffective esophageal motility. Langenbecks Arch. Surg. 409(1), 78 (2024).","journal-title":"Langenbecks Arch. Surg."},{"issue":"2","key":"47034_CR24","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1097\/SLE.0000000000001256","volume":"34","author":"Y Fringeli","year":"2024","unstructured":"Fringeli, Y., Linas, I., Kessler, U. & Zehetner, J. Laparoscopic large hiatal hernia repair With RefluxStop: Outcomes of six months follow-up in thirty patients. Surg. Laparosc. Endosc. Percutan. Tech. 34(2), 143\u2013149 (2024).","journal-title":"Surg. Laparosc. Endosc. Percutan. Tech."},{"key":"47034_CR25","doi-asserted-by":"publisher","first-page":"3365","DOI":"10.57187\/s.3365","volume":"154","author":"Y Fringeli","year":"2024","unstructured":"Fringeli, Y., Linas, I., Kessler, U. & Zehetner, J. Exploring the feasibility and safety of laparoscopic anti-reflux surgery with the new RefluxStop\u2122 device: A retrospective cohort study of 40 patients. Swiss Med. Wkly. 154, 3365 (2024).","journal-title":"Swiss Med. Wkly."},{"key":"47034_CR26","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.sopen.2024.12.003","volume":"23","author":"T Lehmann","year":"2025","unstructured":"Lehmann, T., \u0160imkus, M. & Oehler, C. A retrospective study assessing RefluxStop surgery for gastroesophageal reflux disease: Clinical outcomes in 79 patients from Germany. Surg. Open. Sci. 23, 9\u201315 (2025).","journal-title":"Surg. Open. Sci."},{"key":"47034_CR27","doi-asserted-by":"crossref","unstructured":"Zehetner, J. et al. Dysphagia, safety, and effectivenss of the RefluxStop procedure in GERD patients with ineffective esophageal motility (IEM): Multicenter results in Swtizerland for up to 3 years. In process of journal submission (2025).","DOI":"10.2139\/ssrn.5938819"},{"key":"47034_CR28","unstructured":"Regulation (EU) 2017\/745 of the European Parliament and of the Council of 5 April 2017 on medical devices, amending Directive 2001\/83\/EC, Regulation (EC) No 178\/2002 and Regulation (EC) No 1223\/2009 and repealing Council Directives 90\/385\/EEC and 93\/42\/EEC (Text with EEA relevance. ). Sect. article 2, paragraphs 57, 58, 59."},{"key":"47034_CR29","doi-asserted-by":"publisher","unstructured":"Nguyen, N., Abu Dayyeh, B. & Chang, K. et al. American Foregut Society cooperative white paper on mechanisms of pathologic reflux and antireflux surgery. Foregut: J. Am. Foregut Soc. 5 (1), 16\u201326. https:\/\/doi.org\/10.1177\/26345161241276454 (2024).","DOI":"10.1177\/26345161241276454"},{"key":"47034_CR30","doi-asserted-by":"publisher","first-page":"263451612211269","DOI":"10.1177\/26345161221126961","volume":"2","author":"N Nguyen","year":"2022","unstructured":"Nguyen, N. et al. The American Foregut Society White paper on the endoscopic classification of esophagogastric junction integrity. Foregut: J. Am. Foregut Soc. 2, 263451612211269 (2022).","journal-title":"Foregut: J. Am. Foregut Soc."},{"key":"47034_CR31","doi-asserted-by":"publisher","unstructured":"Bonavina, L. Individualizing the choice of surgical therapy for gastroesophageal reflux disease. Curr. Opin. Gastroenterol. 41 (4), 245\u2013250. https:\/\/doi.org\/10.1097\/MOG.0000000000001082(2025).","DOI":"10.1097\/MOG.0000000000001082"},{"issue":"1","key":"47034_CR32","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s11605-019-04331-9","volume":"24","author":"S Ayazi","year":"2020","unstructured":"Ayazi, S. et al. Magnetic sphincter augmentation and postoperative dysphagia: Characterization, clinical risk factors, and management. J. Gastrointest. Surg. 24(1), 39\u201349 (2020).","journal-title":"J. Gastrointest. Surg."},{"key":"47034_CR33","unstructured":"InformedHealth.org [Internet]. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG). Hernias: Learn more\u2014How are incisional hernias treated? [Updated 2023 Dec 13]. (2006). Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK395550\/."},{"issue":"Suppl 20","key":"47034_CR34","first-page":"590","volume":"86","author":"R Nissen","year":"1956","unstructured":"Nissen, R. A simple operation for control of reflux esophagitis. Schweiz. Med. Wochenschr. 86(Suppl 20), 590\u2013592 (1956).","journal-title":"Schweiz. Med. Wochenschr"},{"issue":"6","key":"47034_CR35","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1016\/j.athoracsur.2024.09.010","volume":"118","author":"KE Daus","year":"2024","unstructured":"Daus, K. E. et al. Long-term outcomes of magnetic sphincter augmentation: A comparative study to Nissen fundoplication. Ann. Thorac. Surg. 118(6), 1207\u20131214 (2024).","journal-title":"Ann. Thorac. Surg."},{"issue":"11","key":"47034_CR36","doi-asserted-by":"publisher","first-page":"E1785","DOI":"10.1055\/a-1547-6599","volume":"9","author":"M Dbouk","year":"2021","unstructured":"Dbouk, M. et al. The learning curve for transoral incisionless fundoplication. Endosc Int. Open. 9(11), E1785\u2013e91 (2021).","journal-title":"Endosc Int. Open."},{"issue":"8","key":"47034_CR37","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1007\/s00464-006-9156-x","volume":"21","author":"P Salminen","year":"2007","unstructured":"Salminen, P., Hiekkanen, H., Laine, S. & Ovaska, J. Surgeons\u2019 experience with laparoscopic fundoplication after the early personal experience: Does it have an impact on the outcome? Surg. Endosc. 21(8), 1377\u20131382 (2007).","journal-title":"Surg. Endosc"},{"issue":"4","key":"47034_CR38","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/S1072-7515(01)00992-9","volume":"193","author":"MA Carlson","year":"2001","unstructured":"Carlson, M. A. & Frantzides, C. T. Complications and results of primary minimally invasive antireflux procedures: A review of 10,735 reported cases. J. Am. Coll. Surg. 193(4), 428\u2013439 (2001).","journal-title":"J. Am. Coll. Surg."},{"issue":"5","key":"47034_CR39","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1007\/s00464-009-0718-6","volume":"24","author":"CT Frantzides","year":"2010","unstructured":"Frantzides, C. T. et al. Hiatal hernia repair with mesh: A survey of SAGES members. Surg. Endosc. 24(5), 1017\u20131024 (2010).","journal-title":"Surg. Endosc"},{"issue":"4","key":"47034_CR40","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.jamcollsurg.2011.05.017","volume":"213","author":"BK Oelschlager","year":"2011","unstructured":"Oelschlager, B. K. et al. Biologic prosthesis to prevent recurrence after laparoscopic paraesophageal hernia repair: Long-term follow-up from a multicenter, prospective, randomized trial. J. Am. Coll. Surg. 213(4), 461\u2013468 (2011).","journal-title":"J. Am. Coll. Surg."},{"issue":"2","key":"47034_CR41","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1097\/SLA.0000000000003734","volume":"272","author":"DI Watson","year":"2020","unstructured":"Watson, D. I. et al. Five year follow-up of a randomized controlled trial of laparoscopic repair of very large hiatus hernia with sutures versus absorbable versus nonabsorbable mesh. Ann. Surg. 272(2), 241\u2013247 (2020).","journal-title":"Ann. Surg."},{"issue":"7","key":"47034_CR42","doi-asserted-by":"publisher","first-page":"5451","DOI":"10.1007\/s00464-021-08887-z","volume":"36","author":"ME Linnaus","year":"2022","unstructured":"Linnaus, M. E., Garren, A. & Gould, J. C. Anatomic location and mechanism of hiatal hernia recurrence: A video-based assessment. Surg. Endosc. 36(7), 5451\u20135455 (2022).","journal-title":"Surg. Endosc"},{"key":"47034_CR43","doi-asserted-by":"publisher","unstructured":"Buniak, N., Buniuak, B. & Maini, A. et al. GERD symptoms often improve after magnetic sphincter augmentation (MSA) device removal\u2014an observation study, 23 March 2023, PREPRINT (Version 1) available at Research Square [https:\/\/doi.org\/10.21203\/rs.3.rs-2628818\/v1.","DOI":"10.21203\/rs.3.rs-2628818\/v1"},{"issue":"2","key":"47034_CR44","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1067\/mge.2002.121226","volume":"55","author":"N Malhi-Chowla","year":"2002","unstructured":"Malhi-Chowla, N. et al. Dilation after fundoplication: timing, frequency, indications, and outcome. Gastrointest. Endosc. 55(2), 219\u2013223 (2002).","journal-title":"Gastrointest. Endosc"},{"issue":"1","key":"47034_CR45","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.jamcollsurg.2015.02.025","volume":"221","author":"JL Reynolds","year":"2015","unstructured":"Reynolds, J. L. et al. Laparoscopic magnetic sphincter augmentation vs laparoscopic Nissen fundoplication: A matched-pair analysis of 100 patients. J. Am. Coll. Surg. 221(1), 123\u2013128 (2015).","journal-title":"J. Am. Coll. Surg."},{"issue":"9","key":"47034_CR46","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1002\/bjs.7174","volume":"97","author":"JA Broeders","year":"2010","unstructured":"Broeders, J. A. et al. Systematic review and meta-analysis of laparoscopic Nissen (posterior total) versus Toupet (posterior partial) fundoplication for gastro-oesophageal reflux disease. Br. J. Surg. 97(9), 1318\u20131330 (2010).","journal-title":"Br. J. Surg."},{"issue":"3","key":"47034_CR47","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1097\/SLA.0000000000006249","volume":"281","author":"IS Sarici","year":"2025","unstructured":"Sarici, I. S. et al. Impact of change in sizing protocol on outcome of magnetic sphincter augmentation. Ann. Surg. 281(3), 454\u2013461 (2025).","journal-title":"Ann. Surg."},{"issue":"1","key":"47034_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.36469\/jheor.2024.90924","volume":"11","author":"S Harper","year":"2024","unstructured":"Harper, S. et al. Budget impact of RefluxStop\u2122 as a treatment for patients with refractory gastro-oesophageal reflux disease in the United Kingdom. J. Health Econ. Outcomes Res. 11(1), 1\u20137 (2024).","journal-title":"J. Health Econ. Outcomes Res."},{"issue":"1","key":"47034_CR49","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1080\/13696998.2024.2362564","volume":"27","author":"S Harper","year":"2024","unstructured":"Harper, S., Kartha, M., Mealing, S., Borb\u00e9ly, Y. M. & Zehetner, J. Cost-effectiveness of the RefluxStop device for management of refractory gastroesophageal reflux disease in Switzerland. J. Med. Econ. 27(1), 805\u2013815 (2024).","journal-title":"J. Med. Econ."},{"key":"47034_CR50","doi-asserted-by":"publisher","unstructured":"Harper, S., Kartha, M., Mealing, S. & Lundell, L. A cost-effectiveness analysis of RefluxStop against relevant therapeutic alternatives for chronic gastroesophageal reflux disease in Sweden. Expert Rev. Pharmacoecon. Outcomes Res. 25 (3), 353\u2013365. https:\/\/doi.org\/10.1080\/14737167.2024.2417774 (2025).","DOI":"10.1080\/14737167.2024.2417774"},{"issue":"6","key":"47034_CR51","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1007\/s41669-024-00521-7","volume":"8","author":"S Harper","year":"2024","unstructured":"Harper, S., Kartha, M., Mealing, S., Pavanello, M. & Bonavina, L. The economic impact of introducing RefluxStop for Refractory gastroesophageal reflux disease on the Italian healthcare system. PharmacoEconomics - Open. 8(6), 935\u2013943 (2024).","journal-title":"PharmacoEconomics - Open."},{"key":"47034_CR52","doi-asserted-by":"crossref","unstructured":"Harper, H., Bui, K., Mealing, S., L\u00f3pez, D. & Jim\u00e9nez, P. Budget impact modeling of RefluxStop surgery for refractory gastroesophageal reflux disease in Spain. In peer review (2025).","DOI":"10.1016\/j.jval.2024.10.887"},{"issue":"1","key":"47034_CR53","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1080\/13696998.2023.2201063","volume":"26","author":"S Harper","year":"2023","unstructured":"Harper, S. et al. Cost-effectiveness of a novel, non-active implantable device as a treatment for refractory gastro-esophageal reflux disease. J. Med. Econ. 26 (1), 603\u2013613 (2023).","journal-title":"J. Med. Econ."},{"key":"47034_CR54","doi-asserted-by":"crossref","unstructured":"Katz, P. O. et al. ACG Clinical guideline for the diagnosis and management of gastroesophageal reflux disease. Official J. Am. Coll. Gastroenterol. | ACG. 117(1) (2022).","DOI":"10.14309\/ajg.0000000000001538"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-47034-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-47034-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-47034-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T22:55:52Z","timestamp":1781132152000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-47034-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,18]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["47034"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-47034-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,18]]},"assertion":[{"value":"17 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"SFS declares receiving travel grants from Implantica (Zug, Switzerland). ME, TL, YB, SFS, JZ, and JCL receive travel and conference presentation honoraria for education activities from Implantica (Zug, Switzerland). AA, NFG, MEBC, AHM, JDSL, MCA, BGO, CMM, CMS, LV, and GP declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"18071"}}