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Hyperspectral Imaging (HSI) may be such a tool, but the current limited availability of data from COVID-19 positive individuals hinders traditional supervised learning approaches. To overcome this, we designed a novel framework that integrates HSI with Artificial Intelligence (AI) analysis for detecting COVID-19 status from images of fingertips, thereby demonstrating infection detection through biometric data. By analyzing high-dimensional spectral signatures from the fingertip, the approach identifies distinctive patterns linked to physiological changes caused by the virus. In this pilot study, a Support Vector Machine (SVM) and a Logistic Regression classification algorithm demonstrated high accuracy in classifying HSI images, underscoring the potential of hyperspectral features for non-invasive, real-time health monitoring, even with the limitations of a small dataset. We introduced the first publicly available dataset of HSI images from COVID-19-positive individuals. This contribution sets a foundation for advancing biometric spectral imaging in biomedical research and AI-powered diagnostics. The datasets used during this study is available from the corresponding author upon reasonable request.<\/jats:p>","DOI":"10.1038\/s41598-026-47056-x","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:07:34Z","timestamp":1777536454000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["HyperHealth: a pilot study on AI-driven COVID-19 detection using hyperspectral fingertip images"],"prefix":"10.1038","volume":"16","author":[{"given":"Emanuela","family":"Marasco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Wagle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mason","family":"Rule","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Lee-Wisdom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maheen H.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Deeken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghavendra","family":"Ramachandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Karzai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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