{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:08:35Z","timestamp":1779232115748,"version":"3.51.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":49,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100013317","name":"Shanxi Provincial Key Research and Development Project","doi-asserted-by":"publisher","award":["202102130501013"],"award-info":[{"award-number":["202102130501013"]}],"id":[{"id":"10.13039\/501100013317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013317","name":"Shanxi Provincial Key Research and Development Project","doi-asserted-by":"publisher","award":["202102130501013"],"award-info":[{"award-number":["202102130501013"]}],"id":[{"id":"10.13039\/501100013317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013317","name":"Shanxi Provincial Key Research and Development Project","doi-asserted-by":"publisher","award":["202102130501013"],"award-info":[{"award-number":["202102130501013"]}],"id":[{"id":"10.13039\/501100013317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013317","name":"Shanxi Provincial Key Research and Development Project","doi-asserted-by":"publisher","award":["202102130501013"],"award-info":[{"award-number":["202102130501013"]}],"id":[{"id":"10.13039\/501100013317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013317","name":"Shanxi Provincial Key Research and Development Project","doi-asserted-by":"publisher","award":["202102130501013"],"award-info":[{"award-number":["202102130501013"]}],"id":[{"id":"10.13039\/501100013317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013317","name":"Shanxi Provincial Key Research and Development Project","doi-asserted-by":"publisher","award":["202102130501013"],"award-info":[{"award-number":["202102130501013"]}],"id":[{"id":"10.13039\/501100013317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013317","name":"Shanxi Provincial Key Research and Development Project","doi-asserted-by":"publisher","award":["202102130501013"],"award-info":[{"award-number":["202102130501013"]}],"id":[{"id":"10.13039\/501100013317","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-47111-7","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T19:23:21Z","timestamp":1775071401000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synergistic effects of platelet-rich plasma and teriparatide on osteoporotic fracture healing in OVX rats"],"prefix":"10.1038","volume":"16","author":[{"given":"Li","family":"Shuwei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu","family":"Kaidong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeng","family":"Lingyuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Qiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bai","family":"Xiaoyu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Xiaoqiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"issue":"Suppl 2","key":"47111_CR1","doi-asserted-by":"publisher","first-page":"S21","DOI":"10.1016\/S0020-1383(16)47004-X","volume":"47","author":"WH Cheung","year":"2016","unstructured":"Cheung, W. H., Miclau, T., Chow, S. K., Yang, F. F. & Alt, V. Fracture healing in osteoporotic bone. Injury 47 (Suppl 2), S21\u2013S26. https:\/\/doi.org\/10.1016\/S0020-1383(16)47004-X (2016).","journal-title":"Injury"},{"issue":"11","key":"47111_CR2","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1002\/ptr.2209","volume":"21","author":"M Mukherjee","year":"2007","unstructured":"Mukherjee, M. et al. Role of peritoneal macrophages and lymphocytes in the development of hypogonadal osteoporosis in an ovariectomized rat model: possible phytoestrogenic efficacy of oil extract of garlic to preserve skeletal health. Phytother Res. 21 (11), 1045\u20131054. https:\/\/doi.org\/10.1002\/ptr.2209 (2007).","journal-title":"Phytother Res."},{"issue":"14","key":"47111_CR3","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.2174\/1389450114666131216224003","volume":"14","author":"N Ibrahim","year":"2013","unstructured":"Ibrahim, N., Mohamad, S., Mohamed, N. & Shuid, A. N. Experimental fracture protocols in assessments of potential agents for osteoporotic fracture healing using rodent models. Curr. Drug Targets. 14 (14), 1642\u20131650. https:\/\/doi.org\/10.2174\/1389450114666131216224003 (2013).","journal-title":"Curr. Drug Targets"},{"issue":"9727","key":"47111_CR4","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1016\/S0140-6736(10)60320-0","volume":"375","author":"RM Zebaze","year":"2010","unstructured":"Zebaze, R. M. et al. Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study. Lancet 375 (9727), 1729\u20131736. https:\/\/doi.org\/10.1016\/S0140-6736(10)60320-0 (2010).","journal-title":"Lancet"},{"issue":"10","key":"47111_CR5","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1097\/GME.0000000000000899","volume":"24","author":"CJ Crandall","year":"2017","unstructured":"Crandall, C. J. et al. Comparison of clinical outcomes among users of oral and transdermal estrogen therapy in the Women\u2019s Health Initiative Observational Study. Menopause 24 (10), 1145\u20131153. https:\/\/doi.org\/10.1097\/GME.0000000000000899 (2017).","journal-title":"Menopause"},{"issue":"5","key":"47111_CR6","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1210\/jc.2019-00221","volume":"104","author":"R Eastell","year":"2019","unstructured":"Eastell, R. et al. Pharmacological management of osteoporosis in postmenopausal women: an endocrine society* clinical practice guideline. J. Clin. Endocrinol. Metab. 104 (5), 1595\u20131622. https:\/\/doi.org\/10.1210\/jc.2019-00221 (2019).","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"42","key":"47111_CR7","doi-asserted-by":"publisher","first-page":"49762","DOI":"10.1021\/acsami.1c17472","volume":"13","author":"A Gilarska","year":"2021","unstructured":"Gilarska, A. et al. Addressing the osteoporosis problem-multifunctional injectable hybrid materials for controlling local bone tissue remodeling. ACS Appl. Mater. Interfaces. 13 (42), 49762\u201349779. https:\/\/doi.org\/10.1021\/acsami.1c17472 (2021). Epub 2021 Oct 13.","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"5","key":"47111_CR8","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1089\/ten.TEB.2020.0168","volume":"27","author":"Z Zheng","year":"2021","unstructured":"Zheng, Z., Yu, C. & Wei, H. Injectable hydrogels as three-dimensional network reservoirs for osteoporosis treatment. Tissue Eng. Part. B Rev. 27 (5), 430\u2013454. https:\/\/doi.org\/10.1089\/ten.TEB.2020.0168 (2021). Epub 2020 Nov 25.","journal-title":"Tissue Eng. Part. B Rev."},{"issue":"5","key":"47111_CR9","doi-asserted-by":"publisher","first-page":"362","DOI":"10.2174\/1574888X13666180403163456","volume":"13","author":"Y Li","year":"2018","unstructured":"Li, Y. et al. Mesenchymal stem cells-derived exosomes: a possible therapeutic strategy for osteoporosis. Curr. Stem Cell. Res. Ther. 13 (5), 362\u2013368. https:\/\/doi.org\/10.2174\/1574888X13666180403163456 (2018).","journal-title":"Curr. Stem Cell. Res. Ther."},{"key":"47111_CR10","doi-asserted-by":"publisher","unstructured":"Sakata, M. et al. Bone regeneration of osteoporotic vertebral body defects using platelet-rich plasma and gelatin \u03b2-tricalcium phosphate sponges. Tissue Eng. Part A. 24(11\u201312), 1001\u20131010 (2018). https:\/\/doi.org\/10.1089\/ten.TEA.2017.0358. Epub 2018 Apr 12.","DOI":"10.1089\/ten.TEA.2017.0358"},{"issue":"1","key":"47111_CR11","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1186\/s12891-020-03549-y","volume":"21","author":"CC Wong","year":"2020","unstructured":"Wong, C. C. et al. Novel transplant of combined platelet-rich fibrin releasate and bone marrow stem cells prevent bone loss in Ovariectomized osteoporotic mice. BMC Musculoskelet. Disord. 21 (1), 527. https:\/\/doi.org\/10.1186\/s12891-020-03549-y (2020).","journal-title":"BMC Musculoskelet. Disord"},{"key":"47111_CR12","doi-asserted-by":"publisher","first-page":"963689720927398","DOI":"10.1177\/0963689720927398","volume":"29","author":"SY Sheu","year":"2020","unstructured":"Sheu, S. Y. et al. Enhanced bone formation in osteoporotic mice by a novel transplant combined with adipose-derived stem cells and platelet-rich fibrin releasates. Cell. Transpl. 29, 963689720927398. https:\/\/doi.org\/10.1177\/0963689720927398 (2020).","journal-title":"Cell. Transpl."},{"key":"47111_CR13","doi-asserted-by":"publisher","first-page":"252","DOI":"10.3389\/fnins.2018.00252","volume":"12","author":"NF Chen","year":"2018","unstructured":"Chen, N. F. et al. Therapeutic effect of platelet-rich plasma in rat spinal cord injuries. Front. Neurosci. 12, 252. https:\/\/doi.org\/10.3389\/fnins.2018.00252 (2018).","journal-title":"Front. Neurosci."},{"issue":"10","key":"47111_CR14","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.3390\/nu14102106","volume":"14","author":"Z Yang","year":"2022","unstructured":"Yang, Z. et al. Sesamin promotes osteoporotic fracture healing by activating chondrogenesis and angiogenesis pathways. Nutrients 14 (10), 2106. https:\/\/doi.org\/10.3390\/nu14102106 (2022).","journal-title":"Nutrients"},{"issue":"6","key":"47111_CR15","doi-asserted-by":"publisher","first-page":"e687","DOI":"10.3928\/01477447-20130523-10","volume":"36","author":"L Chen","year":"2013","unstructured":"Chen, L. et al. Platelet-rich plasma promotes healing of osteoporotic fractures. Orthopedics 36 (6), e687\u2013e694. https:\/\/doi.org\/10.3928\/01477447-20130523-10 (2013).","journal-title":"Orthopedics"},{"key":"47111_CR16","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1196\/annals.1346.041","volume":"1068","author":"TJ Martin","year":"2006","unstructured":"Martin, T. J. et al. Mechanisms involved in skeletal anabolic therapies. Ann. N Y Acad. Sci. 1068, 458\u2013470. https:\/\/doi.org\/10.1196\/annals.1346.041 (2006).","journal-title":"Ann. N Y Acad. Sci."},{"issue":"6","key":"47111_CR17","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1002\/jcb.20506","volume":"95","author":"NH Kulkarni","year":"2005","unstructured":"Kulkarni, N. H. et al. Effects of parathyroid hormone on Wnt signaling pathway in bone. J. Cell. Biochem. 95 (6), 1178\u20131190. https:\/\/doi.org\/10.1002\/jcb.20506 (2005).","journal-title":"J. Cell. Biochem."},{"issue":"4 Suppl B","key":"47111_CR18","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.18553\/jmcp.2012.18.s4-b.1","volume":"18","author":"S Levis","year":"2012","unstructured":"Levis, S. & Theodore, G. Summary of AHRQ\u2019s comparative effectiveness review of treatment to prevent fractures in men and women with low bone density or osteoporosis: update of the 2007 report. J. Manag Care Pharm. 18 (4 Suppl B), S1\u201315. https:\/\/doi.org\/10.18553\/jmcp.2012.18.s4-b.1 (2012). discussion S13.","journal-title":"J. Manag Care Pharm."},{"key":"47111_CR19","doi-asserted-by":"publisher","first-page":"89","DOI":"10.17179\/excli2019-1990","volume":"19","author":"N Yousefzadeh","year":"2020","unstructured":"Yousefzadeh, N., Kashfi, K., Jeddi, S. & Ghasemi, A. Ovariectomized rat model of osteoporosis: a practical guide. EXCLI J. 19, 89\u2013107. https:\/\/doi.org\/10.17179\/excli2019-1990 (2020).","journal-title":"EXCLI J."},{"issue":"3","key":"47111_CR20","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.tibtech.2008.11.009","volume":"27","author":"DM Dohan Ehrenfest","year":"2009","unstructured":"Dohan Ehrenfest, D. M., Rasmusson, L. & Albrektsson, T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol. 27 (3), 158\u2013167 (2009). Epub 2009 Jan 31.","journal-title":"Trends Biotechnol."},{"issue":"4","key":"47111_CR21","doi-asserted-by":"publisher","first-page":"731","DOI":"10.2106\/JBJS.D.02115","volume":"87","author":"YM Alkhiary","year":"2005","unstructured":"Alkhiary, Y. M. et al. Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1\u201334). J. Bone Joint Surg. Am. 87 (4), 731\u2013741. https:\/\/doi.org\/10.2106\/JBJS.D.02115 (2005).","journal-title":"J. Bone Joint Surg. Am."},{"key":"47111_CR22","doi-asserted-by":"publisher","first-page":"126599","DOI":"10.1016\/j.jtemb.2020.126599","volume":"62","author":"A \u00d6zmeri\u00e7","year":"2020","unstructured":"\u00d6zmeri\u00e7, A. et al. Intramedullary implants coated with cubic boron nitride enhance bone fracture healing in a rat model. J. Trace Elem. Med. Biol. 62, 126599. https:\/\/doi.org\/10.1016\/j.jtemb.2020.126599 (2020). Epub 2020 Jun 23.","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"5","key":"47111_CR23","doi-asserted-by":"publisher","first-page":"4376","DOI":"10.1021\/acs.chemrev.6b00654","volume":"117","author":"Y Li","year":"2017","unstructured":"Li, Y., Xiao, Y. & Liu, C. The horizon of materiobiology: a perspective on material-guided cell behaviors and tissue engineering. Chem. Rev. 117 (5), 4376\u20134421. https:\/\/doi.org\/10.1021\/acs.chemrev.6b00654 (2017). Epub 2017 Feb 6.","journal-title":"Chem. Rev."},{"issue":"1","key":"47111_CR24","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1186\/s12891-022-05265-1","volume":"23","author":"X Guo","year":"2022","unstructured":"Guo, X., Yu, X., Yao, Q. & Qin, J. Early effects of ovariectomy on bone microstructure, bone turnover markers and mechanical properties in rats. BMC Musculoskelet. Disord. 23 (1), 316. https:\/\/doi.org\/10.1186\/s12891-022-05265-1 (2022).","journal-title":"BMC Musculoskelet. Disord"},{"issue":"12","key":"47111_CR25","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1016\/j.phymed.2008.06.007","volume":"15","author":"DL French","year":"2008","unstructured":"French, D. L., Muir, J. M. & Webber, C. E. The ovariectomized, mature rat model of postmenopausal osteoporosis: an assessment of the bone sparing effects of curcumin. Phytomedicine 15 (12), 1069\u20131078. https:\/\/doi.org\/10.1016\/j.phymed.2008.06.007 (2008). Epub 2008 Aug 6.","journal-title":"Phytomedicine"},{"key":"47111_CR26","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.biomaterials.2018.10.037","volume":"196","author":"J Pajarinen","year":"2019","unstructured":"Pajarinen, J. et al. Mesenchymal stem cell-macrophage crosstalk and bone healing. Biomaterials 196, 80\u201389. https:\/\/doi.org\/10.1016\/j.biomaterials.2018.10.037 (2019). Epub 2018 Nov 1.","journal-title":"Biomaterials"},{"issue":"11","key":"47111_CR27","doi-asserted-by":"publisher","first-page":"e2108430","DOI":"10.1002\/adma.202108430","volume":"34","author":"D Li","year":"2022","unstructured":"Li, D. et al. A Logic-Based Diagnostic and Therapeutic Hydrogel with Multistimuli Responsiveness to Orchestrate Diabetic Bone Regeneration. Adv. Mater. 34 (11), e2108430. https:\/\/doi.org\/10.1002\/adma.202108430 (2022). Epub 2022 Feb 3.","journal-title":"Adv. Mater."},{"key":"47111_CR28","doi-asserted-by":"publisher","first-page":"4719","DOI":"10.2147\/IJN.S113460","volume":"11","author":"N Jiang","year":"2016","unstructured":"Jiang, N. et al. The synergistic effect of TiO2 nanoporous modification and platelet-rich plasma treatment on titanium-implant stability in ovariectomized rats. Int. J. Nanomed. 11, 4719\u20134733. https:\/\/doi.org\/10.2147\/IJN.S113460 (2016).","journal-title":"Int. J. Nanomed."},{"issue":"10","key":"47111_CR29","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1111\/clr.13503","volume":"30","author":"A Engler-Pinto","year":"2019","unstructured":"Engler-Pinto, A. et al. Effects of leukocyte- and platelet-rich fibrin associated or not with bovine bone graft on the healing of bone defects in rats with osteoporosis induced by ovariectomy. Clin. Oral Implants Res. 30 (10), 962\u2013976. https:\/\/doi.org\/10.1111\/clr.13503 (2019). Epub 2019 Aug 19.","journal-title":"Clin. Oral Implants Res."},{"issue":"9","key":"47111_CR30","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1590\/s0102-865020170090000010","volume":"32","author":"MAC Rocha","year":"2017","unstructured":"Rocha, M. A. C. et al. Allogeneic mesenchymal stem cells and xenogenic platelet rich plasma, associated or not, in the repair of bone failures in rabbits with secondary osteoporosis. Acta Cir. Bras. 32 (9), 767\u2013780. https:\/\/doi.org\/10.1590\/s0102-865020170090000010 (2017).","journal-title":"Acta Cir. Bras."},{"issue":"2","key":"47111_CR31","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1097\/SCS.0000000000007040","volume":"32","author":"P Sun","year":"2021","unstructured":"Sun, P., Wang, Y., Xu, D. & Gong, K. The calcium phosphate modified titanium implant combined with platelet-rich plasma treatment promotes implant stabilization in an osteoporotic model. J. Craniofac. Surg. 32 (2), 603\u2013608. https:\/\/doi.org\/10.1097\/SCS.0000000000007040 (2021).","journal-title":"J. Craniofac. Surg."},{"key":"47111_CR32","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/164_2019_336","volume":"262","author":"SK Ramchand","year":"2020","unstructured":"Ramchand, S. K. & Seeman, E. Reduced bone modeling and unbalanced bone remodeling: targets for antiresorptive and anabolic therapy. Handb. Exp. Pharmacol. 262, 423\u2013450. https:\/\/doi.org\/10.1007\/164_2019_336 (2020).","journal-title":"Handb. Exp. Pharmacol."},{"issue":"12","key":"47111_CR33","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1002\/pds.5119","volume":"29","author":"A Gilsenan","year":"2020","unstructured":"Gilsenan, A. et al. Assessing the incidence of osteosarcoma among teriparatide users based on Medicare Part D and US State Cancer Registry Data. Pharmacoepidemiol Drug Saf. 29 (12), 1616\u20131626. https:\/\/doi.org\/10.1002\/pds.5119 (2020). Epub 2020 Sep 1.","journal-title":"Pharmacoepidemiol Drug Saf."},{"key":"47111_CR34","doi-asserted-by":"publisher","first-page":"115525","DOI":"10.1016\/j.bone.2020.115525","volume":"139","author":"Y Etani","year":"2020","unstructured":"Etani, Y. et al. Combined effect of teriparatide and an anti-RANKL monoclonal antibody on bone defect regeneration in mice with glucocorticoid-induced osteoporosis. Bone 139, 115525. https:\/\/doi.org\/10.1016\/j.bone.2020.115525 (2020). Epub 2020 Jul 10.","journal-title":"Bone"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-47111-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-47111-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-47111-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:00:25Z","timestamp":1779231625000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-47111-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["47111"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-47111-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]},"assertion":[{"value":"10 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"15644"}}