{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:04:35Z","timestamp":1780448675788,"version":"3.54.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":51,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HR22C1734"],"award-info":[{"award-number":["HR22C1734"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-47400-1","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T09:17:57Z","timestamp":1776071877000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of ultrasound predictors and development of a diagnostic scoring system for sarcopenia using LASSO regression: a cross-sectional study"],"prefix":"10.1038","volume":"16","author":[{"given":"Byung Chan","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang Hee","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4096-7470","authenticated-orcid":false,"given":"Changwon","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"47400_CR1","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1002\/jcsm.12483","volume":"10","author":"J Bauer","year":"2019","unstructured":"Bauer, J. et al. Sarcopenia: A time for action. An SCWD position paper. J. Cachexia Sarcopenia Muscle 10, 956\u2013961. https:\/\/doi.org\/10.1002\/jcsm.12483 (2019).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"47400_CR2","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1002\/jcsm.12783","volume":"13","author":"F Petermann-Rocha","year":"2022","unstructured":"Petermann-Rocha, F. et al. Global prevalence of sarcopenia and severe sarcopenia: A systematic review and meta-analysis. J. Cachexia Sarcopenia Muscle 13, 86\u201399. https:\/\/doi.org\/10.1002\/jcsm.12783 (2022).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"47400_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2021.111262","volume":"147","author":"N Veronese","year":"2021","unstructured":"Veronese, N. et al. Sarcopenia and fall-related injury among older adults in five low- and middle-income countries. Exp. Gerontol. 147, 111262. https:\/\/doi.org\/10.1016\/j.exger.2021.111262 (2021).","journal-title":"Exp. Gerontol."},{"key":"47400_CR4","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.clnu.2019.01.002","volume":"39","author":"X Zhang","year":"2020","unstructured":"Zhang, X. et al. Falls among older adults with sarcopenia dwelling in nursing home or community: A meta-analysis. Clin. Nutr. 39, 33\u201339. https:\/\/doi.org\/10.1016\/j.clnu.2019.01.002 (2020).","journal-title":"Clin. Nutr."},{"key":"47400_CR5","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1159\/000517099","volume":"68","author":"J Xu","year":"2022","unstructured":"Xu, J., Wan, C. S., Ktoris, K., Reijnierse, E. M. & Maier, A. B. Sarcopenia is associated with mortality in adults: A systematic review and meta-analysis. Gerontology 68, 361\u2013376. https:\/\/doi.org\/10.1159\/000517099 (2022).","journal-title":"Gerontology"},{"key":"47400_CR6","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1038\/s43587-025-01004-y","volume":"5","author":"LK Chen","year":"2025","unstructured":"Chen, L. K. et al. A focus shift from sarcopenia to muscle health in the Asian Working Group for Sarcopenia 2025 consensus update. Nat. Aging 5, 2164\u20132175. https:\/\/doi.org\/10.1038\/s43587-025-01004-y (2025).","journal-title":"Nat. Aging"},{"key":"47400_CR7","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/ageing\/afy169","volume":"48","author":"AJ Cruz-Jentoft","year":"2019","unstructured":"Cruz-Jentoft, A. J. et al. Sarcopenia: Revised European consensus on definition and diagnosis. Age Ageing 48, 16\u201331. https:\/\/doi.org\/10.1093\/ageing\/afy169 (2019).","journal-title":"Age Ageing"},{"key":"47400_CR8","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-015-9853-2","volume":"37","author":"T Abe","year":"2015","unstructured":"Abe, T., Thiebaud, R. S., Loenneke, J. P. & Young, K. C. Prediction and validation of DXA-derived appendicular lean soft tissue mass by ultrasound in older adults. Age 37, 114. https:\/\/doi.org\/10.1007\/s11357-015-9853-2 (2015).","journal-title":"Age"},{"key":"47400_CR9","doi-asserted-by":"publisher","first-page":"482","DOI":"10.4093\/dmj.2020.0277","volume":"45","author":"I Miljkovic","year":"2021","unstructured":"Miljkovic, I., Vella, C. A. & Allison, M. Computed tomography-derived myosteatosis and metabolic disorders. Diabetes Metab. J. 45, 482\u2013491. https:\/\/doi.org\/10.4093\/dmj.2020.0277 (2021).","journal-title":"Diabetes Metab. J."},{"key":"47400_CR10","doi-asserted-by":"publisher","first-page":"7937","DOI":"10.21037\/qims-24-365","volume":"14","author":"AI Garcia-Diez","year":"2024","unstructured":"Garcia-Diez, A. I. et al. Myosteatosis: Diagnostic significance and assessment by imaging approaches. Quant. Imaging Med. Surg. 14, 7937\u20137957 (2024).","journal-title":"Quant. Imaging Med. Surg."},{"key":"47400_CR11","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1002\/jcsm.13149","volume":"14","author":"H Fu","year":"2023","unstructured":"Fu, H., Wang, L., Zhang, W., Lu, J. & Yang, M. Diagnostic test accuracy of ultrasound for sarcopenia diagnosis: A systematic review and meta-analysis. J. Cachexia Sarcopenia Muscle 14, 57\u201370. https:\/\/doi.org\/10.1002\/jcsm.13149 (2023).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"47400_CR12","doi-asserted-by":"publisher","first-page":"519","DOI":"10.18999\/nagjms.80.4.519","volume":"80","author":"T Hida","year":"2018","unstructured":"Hida, T. et al. Ultrasound measurement of thigh muscle thickness for assessment of sarcopenia. Nagoya J. Med. Sci. 80, 519\u2013527. https:\/\/doi.org\/10.18999\/nagjms.80.4.519 (2018).","journal-title":"Nagoya J. Med. Sci."},{"key":"47400_CR13","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s41999-020-00433-9","volume":"12","author":"S Perkisas","year":"2021","unstructured":"Perkisas, S. et al. Application of ultrasound for muscle assessment in sarcopenia: 2020 SARCUS update. Eur. Geriatr. Med. 12, 45\u201359. https:\/\/doi.org\/10.1007\/s41999-020-00433-9 (2021).","journal-title":"Eur. Geriatr. Med."},{"key":"47400_CR14","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12532","author":"AM Burton","year":"2018","unstructured":"Burton, A. M. & Stock, M. S. Consistency of novel ultrasound equations for estimating percent intramuscular fat. Clin. Physiol. Funct. Imaging https:\/\/doi.org\/10.1111\/cpf.12532 (2018).","journal-title":"Clin. Physiol. Funct. Imaging"},{"key":"47400_CR15","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1519\/jsc.0000000000003455","volume":"36","author":"S Bartolomei","year":"2022","unstructured":"Bartolomei, S., Rovai, C., Lanzoni, I. M. & di Michele, R. Relationships between muscle architecture, deadlift performance, and maximal isometric force produced at the midthigh and midshin pull in resistance-trained individuals. J. Strength Cond. Res. 36, 299\u2013303. https:\/\/doi.org\/10.1519\/jsc.0000000000003455 (2022).","journal-title":"J. Strength Cond. Res."},{"key":"47400_CR16","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jbi.2014.02.013","volume":"48","author":"K Hajian-Tilaki","year":"2014","unstructured":"Hajian-Tilaki, K. Sample size estimation in diagnostic test studies of biomedical informatics. J. Biomed. Inform. 48, 193\u2013204. https:\/\/doi.org\/10.1016\/j.jbi.2014.02.013 (2014).","journal-title":"J. Biomed. Inform."},{"key":"47400_CR17","doi-asserted-by":"publisher","first-page":"993","DOI":"10.2147\/cia.S463917","volume":"19","author":"JS Staempfli","year":"2024","unstructured":"Staempfli, J. S., Kistler-Fischbacher, M., Gewiess, J., Bastian, J. D. & Eggimann, A. K. The validity of muscle ultrasound in the diagnostic workup of sarcopenia among older adults: A scoping review. Clin. Interv. Aging 19, 993\u20131003. https:\/\/doi.org\/10.2147\/cia.S463917 (2024).","journal-title":"Clin. Interv. Aging"},{"key":"47400_CR18","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/j.2517-6161.1996.tb02080.x","volume":"58","author":"R Tibshirani","year":"1996","unstructured":"Tibshirani, R. Regression shrinkage and selection via the lasso. J. R. Stat. Soc. B. 58, 267\u2013288. https:\/\/doi.org\/10.1111\/j.2517-6161.1996.tb02080.x (1996).","journal-title":"J. R. Stat. Soc. B."},{"key":"47400_CR19","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1002\/bimj.200410135","volume":"47","author":"R Fluss","year":"2005","unstructured":"Fluss, R., Faraggi, D. & Reiser, B. Estimation of the Youden index and its associated cutoff point. Biom. J. 47, 458\u2013472. https:\/\/doi.org\/10.1002\/bimj.200410135 (2005).","journal-title":"Biom. J."},{"key":"47400_CR20","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1002\/jcsm.13160","volume":"14","author":"LD Westbury","year":"2023","unstructured":"Westbury, L. D. et al. Recent sarcopenia definitions\u2014Prevalence, agreement and mortality associations among men: Findings from population-based cohorts. J. Cachexia Sarcopenia Muscle 14, 565\u2013575. https:\/\/doi.org\/10.1002\/jcsm.13160 (2023).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"47400_CR21","doi-asserted-by":"publisher","first-page":"9","DOI":"10.4235\/agmr.23.0009","volume":"27","author":"JY Baek","year":"2023","unstructured":"Baek, J. Y. et al. Korean working group on sarcopenia guideline: Expert consensus on sarcopenia screening and diagnosis by the Korean Society of Sarcopenia, the Korean Society for Bone and Mineral Research, and the Korean Geriatrics Society. Ann. Geriatr. Med. Res. 27, 9\u201321. https:\/\/doi.org\/10.4235\/agmr.23.0009 (2023).","journal-title":"Ann. Geriatr. Med. Res."},{"key":"47400_CR22","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1055\/s-2002-33145","volume":"23","author":"C O'Brien","year":"2002","unstructured":"O\u2019Brien, C., Young, A. J. & Sawka, M. N. Bioelectrical impedance to estimate changes in hydration status. Int. J. Sports Med. 23, 361\u2013366. https:\/\/doi.org\/10.1055\/s-2002-33145 (2002).","journal-title":"Int. J. Sports Med."},{"key":"47400_CR23","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1002\/mus.26819","volume":"61","author":"LD Hobson-Webb","year":"2020","unstructured":"Hobson-Webb, L. D. Emerging technologies in neuromuscular ultrasound. Muscle Nerve 61, 719\u2013725. https:\/\/doi.org\/10.1002\/mus.26819 (2020).","journal-title":"Muscle Nerve"},{"key":"47400_CR24","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1093\/ageing\/afaa163","volume":"50","author":"KM Madden","year":"2020","unstructured":"Madden, K. M., Feldman, B., Arishenkoff, S. & Meneilly, G. S. A rapid point-of-care ultrasound marker for muscle mass and muscle strength in older adults. Age Ageing 50, 505\u2013510. https:\/\/doi.org\/10.1093\/ageing\/afaa163 (2020).","journal-title":"Age Ageing"},{"key":"47400_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2022.111692","volume":"101","author":"Y Ozturk","year":"2022","unstructured":"Ozturk, Y. et al. The role of muscle ultrasound to predict sarcopenia. Nutrition 101, 111692. https:\/\/doi.org\/10.1016\/j.nut.2022.111692 (2022).","journal-title":"Nutrition"},{"key":"47400_CR26","doi-asserted-by":"publisher","first-page":"807.e9","DOI":"10.1016\/j.jamda.2017.05.011","volume":"18","author":"M Yamada","year":"2017","unstructured":"Yamada, M. et al. Differential characteristics of skeletal muscle in community-dwelling older adults. J. Am. Med. Dir. Assoc. 18, 807.e9-807.e16. https:\/\/doi.org\/10.1016\/j.jamda.2017.05.011 (2017).","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"47400_CR27","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1093\/mr\/roab049","volume":"32","author":"T Yoshida","year":"2022","unstructured":"Yoshida, T. et al. Ultrasound assessment of sarcopenia in patients with rheumatoid arthritis. Mod. Rheumatol. 32, 728\u2013735. https:\/\/doi.org\/10.1093\/mr\/roab049 (2022).","journal-title":"Mod. Rheumatol."},{"key":"47400_CR28","doi-asserted-by":"publisher","DOI":"10.3390\/app12189133","volume":"12","author":"P Spiliopoulou","year":"2022","unstructured":"Spiliopoulou, P. et al. Vastus lateralis and vastus intermedius as predictors of quadriceps femoris muscle hypertrophy after strength training. Appl. Sci. 12, 9133 (2022).","journal-title":"Appl. Sci."},{"key":"47400_CR29","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1007\/s40520-018-0958-1","volume":"30","author":"A Ticinesi","year":"2018","unstructured":"Ticinesi, A. et al. Assessing sarcopenia with vastus lateralis muscle ultrasound: An operative protocol. Aging Clin. Exp. Res. 30, 1437\u20131443. https:\/\/doi.org\/10.1007\/s40520-018-0958-1 (2018).","journal-title":"Aging Clin. Exp. Res."},{"key":"47400_CR30","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.archger.2019.03.014","volume":"83","author":"AM Ata","year":"2019","unstructured":"Ata, A. M. et al. Regional and total muscle mass, muscle strength and physical performance: The potential use of ultrasound imaging for sarcopenia. Arch. Gerontol. Geriatr. 83, 55\u201360. https:\/\/doi.org\/10.1016\/j.archger.2019.03.014 (2019).","journal-title":"Arch. Gerontol. Geriatr."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-47400-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-47400-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-47400-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:16:00Z","timestamp":1780445760000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-47400-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,13]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["47400"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-47400-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,13]]},"assertion":[{"value":"11 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The ethical validity of the trial was assessed and approved by the Institutional Review Board of Chungnam National University Hospital (CNUH-2022-12-026). All methods were performed in accordance with the relevant guidelines and regulations, including the Declaration of Helsinki. All the participants provided written informed consent before the trial and agreed to participate.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"17116"}}