{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:56:28Z","timestamp":1787003788134,"version":"build-2736575974"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":56,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-47490-x","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T12:18:44Z","timestamp":1776860324000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dietary nutrient intake and nutritional status in women with infertility: a cross-sectional study"],"prefix":"10.1038","volume":"16","author":[{"given":"Laura","family":"Mart\u00edn-Manchado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"S\u00e1nchez-Sansegundo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Zaragoza-Mart\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Serrado De La Cruz-Delgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Antonio","family":"Hurtado-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"47490_CR1","unstructured":"World Health Organization. WHO news: 1 in 6 people globally affected by infertility. https:\/\/www.paho.org\/en\/news\/4-4-2023-1-6-people-globally%20affected-infertility-who. Accessed 3 December 2024. (2023)"},{"key":"47490_CR2","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1097\/01.AOG.0000287293.25465.e1","volume":"110","author":"JE Chavarro","year":"2007","unstructured":"Chavarro, J. E., Rich-Edwards, J. W., Rosner, B. A. & Willett, W. C. Diet and lifestyle in the prevention of ovulatory disorder infertility. Obstet. Gynecol. 110, 1050\u20131058. https:\/\/doi.org\/10.1097\/01.AOG.0000287293.25465.e1 (2007).","journal-title":"Obstet. Gynecol."},{"key":"47490_CR3","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3390\/nu8020087","volume":"8","author":"R Fontana","year":"2016","unstructured":"Fontana, R. & Della Torre, S. The Deep Correlation between Energy Metabolism and Reproduction: A View on the Effects of Nutrition for Women Fertility. Nutrients 8, 87. https:\/\/doi.org\/10.3390\/nu8020087 (2016).","journal-title":"Nutrients"},{"key":"47490_CR4","doi-asserted-by":"publisher","first-page":"e13804","DOI":"10.1111\/obr.13804","volume":"25","author":"J Zhou","year":"2024","unstructured":"Zhou, J. et al. Association between preconception body mass index and fertility in adult female: A systematic review and meta-analysis. Obes. Rev. 25, e13804. https:\/\/doi.org\/10.1111\/obr.13804 (2024).","journal-title":"Obes. Rev."},{"key":"47490_CR5","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1136\/bmj.306.6876.484","volume":"306","author":"BM Zaadstra","year":"1993","unstructured":"Zaadstra, B. M. et al. Fat and female fecundity: prospective study of effect of body fat distribution on conception rates. BMJ 306, 484\u2013487. https:\/\/doi.org\/10.1136\/bmj.306.6876.484 (1993).","journal-title":"BMJ"},{"key":"47490_CR6","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1093\/humrep\/dem035","volume":"22","author":"CH Ramlau-Hansen","year":"2007","unstructured":"Ramlau-Hansen, C. H. et al. Subfecundity in overweight and obese couples. Hum. Reprod. 22, 1634\u20131637. https:\/\/doi.org\/10.1093\/humrep\/dem035 (2007).","journal-title":"Hum. Reprod."},{"key":"47490_CR7","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1093\/humrep\/dem371","volume":"23","author":"JW Van der Steeg","year":"2008","unstructured":"Van der Steeg, J. W. et al. Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women. Hum. Reprod. 23, 324\u2013328. https:\/\/doi.org\/10.1093\/humrep\/dem371 (2008).","journal-title":"Hum. Reprod."},{"key":"47490_CR8","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.1016\/j.fertnstert.2009.01.100","volume":"93","author":"JE Chavarro","year":"2010","unstructured":"Chavarro, J. E., Toth, T. L., Wright, D. L., Meeker, J. D. & Hauser, R. Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic. Fertil. Steril. 93, 2222\u20132231. https:\/\/doi.org\/10.1016\/j.fertnstert.2009.01.100 (2010).","journal-title":"Fertil. Steril."},{"key":"47490_CR9","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1093\/humupd\/dmt033","volume":"20","author":"AN Comninos","year":"2014","unstructured":"Comninos, A. N., Jayasena, C. N. & Dhillo, W. S. The relationship between gut and adipose hormones, and reproduction. Hum. Reprod. Update. 20, 153\u2013174. https:\/\/doi.org\/10.1093\/humupd\/dmt033 (2014).","journal-title":"Hum. Reprod. Update"},{"key":"47490_CR10","doi-asserted-by":"publisher","first-page":"2285025","DOI":"10.1080\/01443615.2023.2285025","volume":"43","author":"X Ji","year":"2023","unstructured":"Ji, X., Ye, Y., Wang, L., Liu, S. & Dong, X. Association between nutrient intake and female infertility: a study based on NHANES database. J. Obstet. Gynaecol. 43, 2285025. https:\/\/doi.org\/10.1080\/01443615.2023.2285025 (2023).","journal-title":"J. Obstet. Gynaecol."},{"key":"47490_CR11","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/ejcn.2015.94","volume":"70","author":"HT Cueto","year":"2016","unstructured":"Cueto, H. T. et al. Folic acid supplementation and fecundability: a Danish prospective cohort study. Eur. J. Clin. Nutr. 70, 66\u201371. https:\/\/doi.org\/10.1038\/ejcn.2015.94 (2016).","journal-title":"Eur. J. Clin. Nutr."},{"key":"47490_CR12","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1097\/AOG.0000000000000477","volume":"124","author":"AJ Gaskins","year":"2014","unstructured":"Gaskins, A. J. et al. Dietary folate and reproductive success among women undergoing assisted reproduction. Obstet. Gynecol. 124, 801\u2013809. https:\/\/doi.org\/10.1097\/AOG.0000000000000477 (2014).","journal-title":"Obstet. Gynecol."},{"key":"47490_CR13","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.ajog.2017.08.010","volume":"218","author":"AJ Gaskins","year":"2018","unstructured":"Gaskins, A. J. & Chavarro, J. E. Diet and fertility: a review. Am. J. Obstet. Gynecol. 218, 379\u2013389. https:\/\/doi.org\/10.1016\/j.ajog.2017.08.010 (2018).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"47490_CR14","doi-asserted-by":"publisher","first-page":"1808","DOI":"10.1017\/S0007114509993837","volume":"103","author":"JD Fern\u00e1ndez-Ballart","year":"2010","unstructured":"Fern\u00e1ndez-Ballart, J. D. et al. Relative validity of a semi-quantitative food-frequency questionnaire in an elderly Mediterranean population of Spain. Br. J. Nutr. 103, 1808\u20131816. https:\/\/doi.org\/10.1017\/S0007114509993837 (2010).","journal-title":"Br. J. Nutr."},{"key":"47490_CR15","unstructured":"AESAN\/BEDCA. Base de Datos Espa\u00f1ola de Composici\u00f3n de Alimentos v1.0. Agencia Espa\u00f1ola de Seguridad Alimentaria y Nutrici\u00f3n (AESAN). https:\/\/www.bedca.net. Accessed 21 December 2024. (2010)."},{"key":"47490_CR16","unstructured":"Gallar, M. Nutrici\u00f3n cl\u00ednica del adulto Publicacions Universitat D\u2019Alacant. Universidad de Alicante (Servicio de Publicaciones, 2019)."},{"key":"47490_CR17","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1177\/039139889201501105","volume":"15","author":"M Yeksan","year":"1992","unstructured":"Yeksan, M. et al. Effect of vitamin E therapy on sexual functions of uremic patients in hemodialysis. Int. J. Artif. Organs. 15, 648\u2013652 (1992).","journal-title":"Int. J. Artif. Organs"},{"key":"47490_CR18","doi-asserted-by":"publisher","first-page":"1271521","DOI":"10.3389\/fendo.2023.1271521","volume":"14","author":"A Patani","year":"2023","unstructured":"Patani, A. et al. Harnessing the power of nutritional antioxidants against adrenal hormone imbalance-associated oxidative stress. Front. Endocrinol. (Lausanne). 14, 1271521. https:\/\/doi.org\/10.3389\/fendo.2023.1271521 (2023).","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"2","key":"47490_CR19","doi-asserted-by":"publisher","first-page":"207","DOI":"10.3164\/jcbn.09-33","volume":"45","author":"N Kobayashi","year":"2009","unstructured":"Kobayashi, N. et al. Elevation by oxidative stress and aging of hypothalamic-pituitary-adrenal activity in rats and its prevention by vitamin e. J. Clin. Biochem. Nutr. 45 (2), 207\u2013213. https:\/\/doi.org\/10.3164\/jcbn.09-33 (2009).","journal-title":"J. Clin. Biochem. Nutr."},{"key":"47490_CR20","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s12905-020-00930-w","volume":"20","author":"J Chen","year":"2020","unstructured":"Chen, J. et al. Effect of a short-term vitamin E supplementation on oxidative stress in infertile PCOS women under ovulation induction: a retrospective cohort study. BMC Womens Health. 20, 69. https:\/\/doi.org\/10.1186\/s12905-020-00930-w (2020).","journal-title":"BMC Womens Health"},{"issue":"1","key":"47490_CR21","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3390\/cells14010036","volume":"14","author":"E Moustakli","year":"2025","unstructured":"Moustakli, E. et al. Oxidative Stress and the NLRP3 Inflammasome: Focus on Female Fertility and Reproductive Health. Cells 14 (1), 36. https:\/\/doi.org\/10.3390\/cells14010036 (2025).","journal-title":"Cells"},{"issue":"3","key":"47490_CR22","doi-asserted-by":"publisher","first-page":"173","DOI":"10.2174\/0113892002357565250604075932","volume":"26","author":"DN Daraghmeh","year":"2025","unstructured":"Daraghmeh, D. N., Salameh, S., Zahdeh, M., Ghanem, R. & Karaman, R. Exploring the Effects of Oxidative Stress on Female Reproductive Function: The Role of Antioxidant Supplementation. Curr. Drug Metab. 26 (3), 173\u2013191. https:\/\/doi.org\/10.2174\/0113892002357565250604075932 (2025).","journal-title":"Curr. Drug Metab."},{"key":"47490_CR23","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1089\/109662004322984699","volume":"7","author":"S Ima-Nirwana","year":"2004","unstructured":"Ima-Nirwana, S. & Suhaniza, S. Effects of tocopherols and tocotrienols on body composition and bone calcium content in adrenalectomized rats replaced with dexamethasone. J. Med. Food. 7, 45\u201351. https:\/\/doi.org\/10.1089\/109662004322984699 (2004).","journal-title":"J. Med. Food"},{"key":"47490_CR24","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3945\/jn.108.096131","volume":"139","author":"H Uto-Kondo","year":"2009","unstructured":"Uto-Kondo, H. et al. Tocotrienol suppresses adipocyte differentiation and Akt phosphorylation in 3T3-L1 preadipocytes. J. Nutr. 139, 51\u201357. https:\/\/doi.org\/10.3945\/jn.108.096131 (2009).","journal-title":"J. Nutr."},{"key":"47490_CR25","doi-asserted-by":"publisher","first-page":"1368966","DOI":"10.3389\/fnut.2024.1368966","volume":"11","author":"M Alser","year":"2024","unstructured":"Alser, M., Naja, K. & Elrayess, M. A. Mechanisms of body fat distribution and gluteal-femoral fat protection against metabolic disorders. Front. Nutr. 11, 1368966. https:\/\/doi.org\/10.3389\/fnut.2024.1368966 (2024).","journal-title":"Front. Nutr."},{"key":"47490_CR26","doi-asserted-by":"publisher","first-page":"950","DOI":"10.3390\/ijms21030950","volume":"21","author":"N Suwannasom","year":"2020","unstructured":"Suwannasom, N., Kao, I., Pru\u00df, A., Georgieva, R. & B\u00e4umler, H. Riboflavin: The Health Benefits of a Forgotten Natural Vitamin. Int. J. Mol. Sci. 21, 950. https:\/\/doi.org\/10.3390\/ijms21030950 (2020).","journal-title":"Int. J. Mol. Sci."},{"key":"47490_CR27","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.3390\/antiox12081490","volume":"12","author":"A Kaltsas","year":"2023","unstructured":"Kaltsas, A. et al. The Silent Threat to Women\u2019s Fertility: Uncovering the Devastating Effects of Oxidative Stress. Antioxidants 12, 1490. https:\/\/doi.org\/10.3390\/antiox12081490 (2023).","journal-title":"Antioxidants"},{"key":"47490_CR28","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1017\/S0007114521005031","volume":"128","author":"N Olfat","year":"2022","unstructured":"Olfat, N., Ashoori, M. & Saedisomeolia, A. Riboflavin is an antioxidant: a review update. Br. J. Nutr. 128, 1887\u20131895. https:\/\/doi.org\/10.1017\/S0007114521005031 (2022).","journal-title":"Br. J. Nutr."},{"key":"47490_CR29","doi-asserted-by":"publisher","first-page":"1369331","DOI":"10.3389\/fnut.2024.1369331","volume":"11","author":"S Yang","year":"2024","unstructured":"Yang, S. et al. Association of vitamins B1 and B2 intake with early-onset sarcopenia in the general adult population of the US: a cross-sectional study of NHANES data from 2011 to 2018. Front. Nutr. 11, 1369331. https:\/\/doi.org\/10.3389\/fnut.2024.1369331 (2024).","journal-title":"Front. Nutr."},{"key":"47490_CR30","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.2147\/JMDH.S517307","volume":"18","author":"H Dong","year":"2025","unstructured":"Dong, H., Liu, Y., Wang, X. & Liu, P. Associations Between Total and Regional Fat-to-Muscle Mass Ratio with the Prevalence of Infertility: A Cross-Sectional Study. J. Multidiscip Healthc. 18, 2173\u20132184. https:\/\/doi.org\/10.2147\/JMDH.S517307 (2025).","journal-title":"J. Multidiscip Healthc."},{"issue":"2\u20133","key":"47490_CR31","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.ceca.2016.02.005","volume":"59","author":"MK Tu","year":"2016","unstructured":"Tu, M. K., Levin, J. B., Hamilton, A. M. & Borodinsky, L. N. Calcium signaling in skeletal muscle development, maintenance and regeneration. Cell. Calcium. 59 (2\u20133), 91\u201397. https:\/\/doi.org\/10.1016\/j.ceca.2016.02.005 (2016).","journal-title":"Cell. Calcium"},{"key":"47490_CR32","doi-asserted-by":"publisher","first-page":"1526879","DOI":"10.3389\/fnut.2025.1526879","volume":"12","author":"J Jiang","year":"2025","unstructured":"Jiang, J., Chen, G., Li, Y., Zhao, Q. & Chen, Z. Serum calcium levels and the risk of sarcopenia in young adults: insights from NHANES 2011\u20132018. Front. Nutr. 12, 1526879. https:\/\/doi.org\/10.3389\/fnut.2025.1526879 (2025).","journal-title":"Front. Nutr."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-47490-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-47490-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-47490-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:29:00Z","timestamp":1781648940000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-47490-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,22]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["47490"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-47490-x","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,22]]},"assertion":[{"value":"14 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of the Alicante Institute for Health and Biomedical Research (ISABIAL) [CEIm: PI2021\/113]. Participants were informed about the study\u2019s objectives and characteristics, emphasizing the voluntary nature of their participation and their right to withdraw at any time without consequence. After this explanation, their collaboration was requested, and informed consent was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"18726"}}