{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:56:11Z","timestamp":1782863771426,"version":"3.54.5"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":76,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Fujian Province Natural Science Foundation","award":["No.2024J011511)"],"award-info":[{"award-number":["No.2024J011511)"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-47662-9","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T15:45:26Z","timestamp":1776354326000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["BMSC-derived exosomal ANTXR1 inhibits erythroid differentiation by suppressing the TLR4\/MyD88\/NF-\u03baB signaling pathway"],"prefix":"10.1038","volume":"16","author":[{"given":"Dengyun","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunbo","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanhui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"47662_CR1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1053\/j.seminhematol.2021.12.002","volume":"59","author":"V Giudice","year":"2022","unstructured":"Giudice, V. & Selleri, C. Aplastic anemia: Pathophysiology. Semin Hematol. 59, 13\u201320 (2022).","journal-title":"Semin Hematol."},{"key":"47662_CR2","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1002\/cbin.11689","volume":"45","author":"MR Javan","year":"2021","unstructured":"Javan, M. R., Saki, N. & Moghimian-Boroujeni, B. Aplastic anemia, cellular and molecular aspects. Cell. Biol. Int. 45, 2395\u20132402 (2021).","journal-title":"Cell. Biol. Int."},{"key":"47662_CR3","first-page":"1271","volume":"20","author":"N Dewarrat","year":"2024","unstructured":"Dewarrat, N. et al. Aplastic anemia. Rev. Med. Suisse. 20, 1271\u20131275 (2024).","journal-title":"Rev. Med. Suisse"},{"key":"47662_CR4","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s12185-024-03715-1","volume":"119","author":"Y Onishi","year":"2024","unstructured":"Onishi, Y. Aplastic anemia: History and recent developments in diagnosis and treatment. Int. J. Hematol. 119, 217\u2013219 (2024).","journal-title":"Int. J. Hematol."},{"key":"47662_CR5","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.hemonc.2020.10.001","volume":"15","author":"A Alshaibani","year":"2022","unstructured":"Alshaibani, A., Dufour, C., Risitano, A., de Latour, R. & Aljurf, M. Hepatitis-associated aplastic anemia. Hematol. Oncol. Stem Cell. Ther. 15, 8\u201312 (2022).","journal-title":"Hematol. Oncol. Stem Cell. Ther."},{"key":"47662_CR6","doi-asserted-by":"publisher","first-page":"1378432","DOI":"10.3389\/fimmu.2024.1378432","volume":"15","author":"A Piekarska","year":"2024","unstructured":"Piekarska, A., Pawelec, K., Szmigielska-Kap\u0142on, A. & Ussowicz, M. The state of the art in the treatment of severe aplastic anemia: Immunotherapy and hematopoietic cell transplantation in children and adults. Front. Immunol. 15, 1378432 (2024).","journal-title":"Front. Immunol."},{"key":"47662_CR7","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1053\/j.seminhematol.2022.08.001","volume":"59","author":"J Durrani","year":"2022","unstructured":"Durrani, J. & Groarke, E. M. Clonality in immune aplastic anemia: Mechanisms of immune escape or malignant transformation. Semin Hematol. 59, 137\u2013142 (2022).","journal-title":"Semin Hematol."},{"key":"47662_CR8","first-page":"1191","volume":"37","author":"RP Gale","year":"2023","unstructured":"Gale, R. P. et al. What causes aplastic anaemia? Leukemia 37, 1191\u20131193 (2023).","journal-title":"What causes aplastic anaemia? Leukemia"},{"key":"47662_CR9","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.jcmgh.2022.10.018","volume":"15","author":"M Fan","year":"2023","unstructured":"Fan, M. et al. BMSCs promote differentiation of enteric neural precursor cells to maintain neuronal homeostasis in mice with enteric nerve injury. Cell. Mol. Gastroenterol. Hepatol. 15, 511\u2013531 (2023).","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"47662_CR10","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1186\/s13287-022-03099-1","volume":"13","author":"Y Wang","year":"2022","unstructured":"Wang, Y. et al. Insufficient S-adenosylhomocysteine hydrolase compromises the beneficial effect of diabetic BMSCs on diabetic cardiomyopathy. Stem Cell. Res. Ther. 13, 418 (2022).","journal-title":"Stem Cell. Res. Ther."},{"key":"47662_CR11","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1186\/s13287-020-01781-w","volume":"11","author":"L He","year":"2020","unstructured":"He, L. et al. Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis. Stem Cell. Res. Ther. 11, 276 (2020).","journal-title":"Stem Cell. Res. Ther."},{"key":"47662_CR12","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1186\/s12951-022-01646-9","volume":"20","author":"Y Wang","year":"2022","unstructured":"Wang, Y. et al. BMSC exosome-enriched acellular fish scale scaffolds promote bone regeneration. J. Nanobiotechnol. 20, 444 (2022).","journal-title":"J. Nanobiotechnol."},{"key":"47662_CR13","doi-asserted-by":"publisher","first-page":"113700","DOI":"10.1016\/j.expneurol.2021.113700","volume":"341","author":"X Liu","year":"2021","unstructured":"Liu, X. et al. Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1\/M2 phenotypes. Exp. Neurol. 341, 113700 (2021).","journal-title":"Exp. Neurol."},{"key":"47662_CR14","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1186\/s13287-022-02975-0","volume":"13","author":"Z Li","year":"2022","unstructured":"Li, Z. et al. BMSC-derived exosomes promote tendon-bone healing after anterior cruciate ligament reconstruction by regulating M1\/M2 macrophage polarization in rats. Stem Cell. Res. Ther. 13, 295 (2022).","journal-title":"Stem Cell. Res. Ther."},{"key":"47662_CR15","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1146\/annurev-pathmechdis-051222-122724","volume":"19","author":"R Kanagal-Shamanna","year":"2024","unstructured":"Kanagal-Shamanna, R., Beck, D. B. & Calvo, K. R. Clonal hematopoiesis, inflammation, and hematologic malignancy. Annu. Rev. Pathol. 19, 479\u2013506 (2024).","journal-title":"Annu. Rev. Pathol."},{"key":"47662_CR16","doi-asserted-by":"publisher","first-page":"1378639","DOI":"10.1155\/2019\/1378639","volume":"2019","author":"S Alcal\u00e1","year":"2019","unstructured":"Alcal\u00e1, S., Martinelli, P., Hermann, P. C., Heeschen, C. & Sainz, B. The anthrax toxin receptor 1 (ANTXR1) is enriched in pancreatic cancer stem cells derived from primary tumor cultures. Stem Cells Int. 2019, 1378639 (2019).","journal-title":"Stem Cells Int."},{"key":"47662_CR17","first-page":"281","volume":"13","author":"MB Jahantab","year":"2024","unstructured":"Jahantab, M. B. et al. Modelling of miRNA-mRNA network to identify gene signatures with diagnostic and prognostic value in gastric cancer: Evidence from in-silico and in-vitro studies. Rep. Biochem. Mol. Biol. 13, 281\u2013300 (2024).","journal-title":"Rep. Biochem. Mol. Biol."},{"key":"47662_CR18","doi-asserted-by":"publisher","first-page":"598221","DOI":"10.3389\/fmolb.2020.598221","volume":"7","author":"X Huang","year":"2020","unstructured":"Huang, X., Zhang, J. & Zheng, Y. ANTXR1 is a prognostic biomarker and correlates with stromal and immune cell infiltration in gastric cancer. Front. Mol. Biosci. 7, 598221 (2020).","journal-title":"Front. Mol. Biosci."},{"key":"47662_CR19","doi-asserted-by":"publisher","first-page":"12642","DOI":"10.1038\/s41598-019-49100-5","volume":"9","author":"B Cheng","year":"2019","unstructured":"Cheng, B. et al. The role of anthrax toxin protein receptor 1 as a new mechanosensor molecule and its mechanotransduction in BMSCs under hydrostatic pressure. Sci. Rep. 9, 12642 (2019).","journal-title":"Sci. Rep."},{"key":"47662_CR20","doi-asserted-by":"crossref","unstructured":"Xu, Q. et al. Correlations between multiple SNPs and HbF Levels in \u03b2-Thalassemia carriers. Clin. Lab. 69, (2023).","DOI":"10.7754\/Clin.Lab.2023.230220"},{"key":"47662_CR21","doi-asserted-by":"publisher","first-page":"e202000737","DOI":"10.26508\/lsa.202000737","volume":"4","author":"W Jing","year":"2021","unstructured":"Jing, W. et al. G-CSF shifts erythropoiesis from bone marrow into spleen in the setting of systemic inflammation. Life Sci. Alliance. 4, e202000737 (2021).","journal-title":"Life Sci. Alliance"},{"key":"47662_CR22","doi-asserted-by":"publisher","first-page":"1123074","DOI":"10.3389\/fimmu.2023.1123074","volume":"14","author":"J Li","year":"2023","unstructured":"Li, J. et al. TLR7 modulates extramedullary splenic erythropoiesis in P. yoelii NSM-infected mice through the regulation of iron metabolism of macrophages with IFN-\u03b3. Front. Immunol. 14, 1123074 (2023).","journal-title":"Front. Immunol."},{"key":"47662_CR23","doi-asserted-by":"publisher","first-page":"563","DOI":"10.3390\/genes15050563","volume":"15","author":"G Myers","year":"2024","unstructured":"Myers, G., Sun, Y., Wang, Y., Benmhammed, H. & Cui, S. Roles of nuclear orphan receptors TR2 and TR4 during hematopoiesis. Genes (Basel). 15, 563 (2024).","journal-title":"Genes (Basel)"},{"key":"47662_CR24","doi-asserted-by":"publisher","first-page":"28943","DOI":"10.1074\/jbc.M111.306423","volume":"287","author":"DF Bishop","year":"2012","unstructured":"Bishop, D. F., Tchaikovskii, V., Hoffbrand, A. V., Fraser, M. E. & Margolis, S. X-linked sideroblastic anemia due to carboxyl-terminal ALAS2 mutations that cause loss of binding to the \u03b2-subunit of succinyl-CoA synthetase (SUCLA2). J. Biol. Chem. 287, 28943\u201328955 (2012).","journal-title":"J. Biol. Chem."},{"key":"47662_CR25","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1038\/s12276-020-00550-2","volume":"53","author":"P Azad","year":"2021","unstructured":"Azad, P., Villafuerte, F. C., Bermudez, D., Patel, G. & Haddad, G. G. Protective role of estrogen against excessive erythrocytosis in monge\u2019s disease. Exp. Mol. Med. 53, 125\u2013135 (2021).","journal-title":"Exp. Mol. Med."},{"key":"47662_CR26","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1007\/s11864-017-0511-z","volume":"18","author":"SA Peslak","year":"2017","unstructured":"Peslak, S. A., Olson, T. & Babushok, D. V. Diagnosis and treatment of aplastic anemia. Curr. Treat. Options Oncol. 18, 70 (2017).","journal-title":"Curr. Treat. Options Oncol."},{"key":"47662_CR27","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.3324\/haematol.2014.103580","volume":"99","author":"C Bueno","year":"2014","unstructured":"Bueno, C. et al. Bone marrow mesenchymal stem cells from patients with aplastic anemia maintain functional and immune properties and do not contribute to the pathogenesis of the disease. Haematologica 99, 1168\u20131175 (2014).","journal-title":"Haematologica"},{"key":"47662_CR28","doi-asserted-by":"publisher","first-page":"6055","DOI":"10.1002\/jcp.30291","volume":"236","author":"MA Gholampour","year":"2021","unstructured":"Gholampour, M. A., Abroun, S., Nieuwland, R., Mowla, S. J. & Soudi, S. Mesenchymal stem cell-derived extracellular vesicles conditionally ameliorate bone marrow failure symptoms in an immune-mediated aplastic anemia mouse model. J. Cell. Physiol. 236, 6055\u20136067 (2021).","journal-title":"J. Cell. Physiol."},{"key":"47662_CR29","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1186\/s13287-023-03496-0","volume":"14","author":"S Wang","year":"2023","unstructured":"Wang, S. et al. Impaired immunosuppressive effect of bone marrow mesenchymal stem cell-derived exosomes on T cells in aplastic anemia. Stem Cell. Res. Ther. 14, 285 (2023).","journal-title":"Stem Cell. Res. Ther."},{"key":"47662_CR30","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/ncb1596","volume":"9","author":"H Valadi","year":"2007","unstructured":"Valadi, H. et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell. Biol. 9, 654\u2013659 (2007).","journal-title":"Nat. Cell. Biol."},{"key":"47662_CR31","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1186\/s12951-024-03002-5","volume":"22","author":"L Liu","year":"2024","unstructured":"Liu, L. et al. Endothelial cell-derived exosomes trigger a positive feedback loop in osteogenesis-angiogenesis coupling via up-regulating zinc finger and BTB domain containing 16 in bone marrow mesenchymal stem cell. J. Nanobiotechnol. 22, 721 (2024).","journal-title":"J. Nanobiotechnol."},{"key":"47662_CR32","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1089\/152581600750062264","volume":"9","author":"MK Majumdar","year":"2000","unstructured":"Majumdar, M. K., Thiede, M. A., Haynesworth, S. E., Bruder, S. P. & Gerson, S. L. Human marrow-derived mesenchymal stem cells (MSCs) express hematopoietic cytokines and support long-term hematopoiesis when differentiated toward stromal and osteogenic lineages. J. Hematother Stem Cell. Res. 9, 841\u2013848 (2000).","journal-title":"J. Hematother Stem Cell. Res."},{"key":"47662_CR33","doi-asserted-by":"publisher","first-page":"8076529","DOI":"10.1155\/2017\/8076529","volume":"2017","author":"VF Gonzaga","year":"2017","unstructured":"Gonzaga, V. F., Wenceslau, C. V., Lisboa, G. S., Frare, E. O. & Kerkis, I. Mesenchymal stem cell benefits observed in bone marrow failure and acquired aplastic anemia. Stem Cells Int. 2017, 8076529 (2017).","journal-title":"Stem Cells Int."},{"key":"47662_CR34","doi-asserted-by":"publisher","first-page":"9321","DOI":"10.1038\/s41598-024-59901-y","volume":"14","author":"M Przyklenk","year":"2024","unstructured":"Przyklenk, M. et al. ANTXR1 deficiency promotes fibroblast senescence: implications for GAPO syndrome as a progeroid disorder. Sci. Rep. 14, 9321 (2024).","journal-title":"Sci. Rep."},{"key":"47662_CR35","doi-asserted-by":"publisher","first-page":"217917","DOI":"10.1016\/j.canlet.2025.217917","volume":"631","author":"J He","year":"2025","unstructured":"He, J. et al. Cancer associated fibroblasts-derived lactate induces oxaliplatin treatment resistance by promoting cancer stemness via ANTXR1 lactylation in colorectal cancer. Cancer Lett. 631, 217917 (2025).","journal-title":"Cancer Lett."},{"key":"47662_CR36","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/bjh.13938","volume":"173","author":"SK Nandakumar","year":"2016","unstructured":"Nandakumar, S. K., Ulirsch, J. C. & Sankaran, V. G. Advances in understanding erythropoiesis: Evolving perspectives. Br. J. Haematol. 173, 206\u2013218 (2016).","journal-title":"Br. J. Haematol."},{"key":"47662_CR37","doi-asserted-by":"publisher","first-page":"1226697","DOI":"10.1155\/2022\/1226697","volume":"2022","author":"T Jin","year":"2022","unstructured":"Jin, T. et al. ANTXR1 regulates erythroid cell proliferation and differentiation through wnt\/\u03b2-catenin signaling pathway in vitro and in hematopoietic stem cell. Dis. Markers. 2022, 1226697 (2022).","journal-title":"Dis. Markers"},{"key":"47662_CR38","doi-asserted-by":"publisher","first-page":"4848","DOI":"10.1182\/bloodadvances.2023010382","volume":"7","author":"RT Doty","year":"2023","unstructured":"Doty, R. T. et al. The transcriptomic landscape of normal and ineffective erythropoiesis at single-cell resolution. Blood Adv. 7, 4848\u20134868 (2023).","journal-title":"Blood Adv."},{"key":"47662_CR39","doi-asserted-by":"publisher","first-page":"17169","DOI":"10.3390\/ijms242417169","volume":"24","author":"O Perik-Zavodskaia","year":"2023","unstructured":"Perik-Zavodskaia, O. et al. Knockouts of TNFRSF1A and TNFRSF1B genes in K562 cell line lead to diverse long-lasting responses to TNF-\u03b1. Int. J. Mol. Sci. 24, 17169 (2023).","journal-title":"Int. J. Mol. Sci."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-47662-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-47662-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-47662-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:13:41Z","timestamp":1782861221000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-47662-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,16]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["47662"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-47662-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,16]]},"assertion":[{"value":"26 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"19999"}}