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S.L.Q., A.Q.T., L.N.-C., and J.Q.-S. have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All experiments were performed in accordance with relevant guidelines and regulations. All research involving human research participants was also performed in accordance with the Declaration of Helsinki, and accomplished the law 3\/2.018, of December 5, 2008, on the Protection of Personal Data and was accordance with the Regulation (EU) 2016\/679 of the European Parliament and of the Council of April 27, 2016 on Data Protection. All patients and controls provided informed consents allowing us to include their data in a database for research purposes including this study. That research database was approved by the local Ethics Committee from Hospital Universitario Ram\u00f3n y Cajal (Date of approval: 7-March-2002; Reference number: 12\/02). The informed consent was revised and again approved by the same local Institutional Review Board on 2022, March 10.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"17401"}}