{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:20:18Z","timestamp":1791645618188,"version":"4.3.4"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-48112-2","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T04:18:16Z","timestamp":1776226696000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antimicrobial use at the end of life: a retrospective cohort study"],"prefix":"10.1038","volume":"16","author":[{"given":"Klara","family":"Sandqvist","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Ekstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"issue":"10325","key":"48112_CR1","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","volume":"399","author":"CJL Murray","year":"2022","unstructured":"Murray, C. J. L. et al. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. The Lancet. 399(10325), 629\u2013655 (2022).","journal-title":"The Lancet."},{"key":"48112_CR2","unstructured":"Socialstyrelsen. Statistik om sjukdomar behandlade i sluten v\u00e5rd 2022. 2023\u201306\u201320 [Internet]. 2023 [citerad 24 oktober 2023]; Tillg\u00e4nglig vid: https:\/\/www.scb.se\/hitta-statistik\/statistik-efter-amne\/halso--och-sjukvard\/halsa-och-sjukdomar\/sjukdomar-i-sluten-vard\/"},{"issue":"5","key":"48112_CR3","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1111\/jgs.14868","volume":"65","author":"D Rizzuto","year":"2017","unstructured":"Rizzuto, D., Melis, R. J. F., Angleman, S., Qiu, C. & Marengoni, A. Effect of chronic diseases and multimorbidity on survival and functioning in elderly adults. J. Am. Geriatr. Soc. 65(5), 1056\u20131060 (2017).","journal-title":"J. Am. Geriatr. Soc."},{"key":"48112_CR4","doi-asserted-by":"publisher","first-page":"263235242412382","DOI":"10.1177\/26323524241238232","volume":"18","author":"C Larsdotter","year":"2024","unstructured":"Larsdotter, C. et al. Trends in the place of death in Sweden from 2013 to 2019\u2014disclosing prerequisites for palliative care. Palliat. Care Soc. Pract. 18, 26323524241238230 (2024).","journal-title":"Palliat. Care Soc. Pract."},{"issue":"5","key":"48112_CR5","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/S0885-3924(00)00189-5","volume":"20","author":"L Vitetta","year":"2000","unstructured":"Vitetta, L., Kenner, D. & Sali, A. Bacterial infections in terminally ill hospice patients. J. Pain Symptom Manag. 20(5), 326\u2013334 (2000).","journal-title":"J. Pain Symptom Manag."},{"issue":"2","key":"48112_CR6","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jpainsymman.2005.03.006","volume":"30","author":"RE Reinbolt","year":"2005","unstructured":"Reinbolt, R. E., Shenk, A. M., White, P. H. & Navari, R. M. Symptomatic treatment of infections in patients with advanced cancer receiving hospice care. J. Pain Symptom Manag. 30(2), 175\u2013182 (2005).","journal-title":"J. Pain Symptom Manag."},{"issue":"4","key":"48112_CR7","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1017\/ice.2018.6","volume":"39","author":"CE Gaw","year":"2018","unstructured":"Gaw, C. E., Hamilton, K. W., Gerber, J. S. & Szymczak, J. E. Physician perceptions regarding antimicrobial use in end-of-life care. Infect. Control Hosp. Epidemiol. 39(4), 383\u2013390 (2018).","journal-title":"Infect. Control Hosp. Epidemiol."},{"issue":"4","key":"48112_CR8","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.jpainsymman.2012.09.010","volume":"46","author":"JS Albrecht","year":"2013","unstructured":"Albrecht, J. S., McGregor, J. C., Fromme, E. K., Bearden, D. T. & Furuno, J. P. A nationwide analysis of antibiotic use in hospice care in the final week of life. J. Pain Symptom Manag. 46(4), 483\u2013490 (2013).","journal-title":"J. Pain Symptom Manag."},{"issue":"10","key":"48112_CR9","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1086\/323757","volume":"33","author":"EL Marcus","year":"2001","unstructured":"Marcus, E. L., Clarfield, A. M. & Moses, A. E. Ethical issues relating to the use of antimicrobial therapy in older adults. Clin. Infect. Dis. 33(10), 1697\u20131705 (2001).","journal-title":"Clin. Infect. Dis."},{"issue":"4","key":"48112_CR10","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1001\/archinternmed.2007.104","volume":"168","author":"E D\u2019Agata","year":"2008","unstructured":"D\u2019Agata, E. & Mitchell, S. L. Patterns of antimicrobial use among nursing home residents with advanced dementia. Arch Intern Med. 168(4), 357\u2013362 (2008).","journal-title":"Arch Intern Med."},{"issue":"5","key":"48112_CR11","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1017\/ice.2020.1241","volume":"42","author":"AR Marra","year":"2021","unstructured":"Marra, A. R. et al. Antibiotic use during end-of-life care: A systematic literature review and meta-analysis. Infect. Control Hosp. Epidemiol. maj 42(5), 523\u2013529 (2021).","journal-title":"Infect. Control Hosp. Epidemiol. maj"},{"key":"48112_CR12","doi-asserted-by":"publisher","unstructured":"Lopez m. fl. A Retrospective Study Analyzing the Lack of Symptom Benefit With Antimicrobials at the End of Life [Internet]. [citerad 25 oktober 2023]. Tillg\u00e4nglig vid: https:\/\/journals.sagepub.com\/doi\/epub\/https:\/\/doi.org\/10.1177\/1049909120951748","DOI":"10.1177\/1049909120951748"},{"issue":"13","key":"48112_CR13","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1001\/archinternmed.2010.181","volume":"170","author":"JL Givens","year":"2010","unstructured":"Givens, J. L., Jones, R. N., Shaffer, M. L., Kiely, D. K. & Mitchell, S. L. Survival and comfort after treatment of pneumonia in advanced dementia. Arch. Intern. Med. 170(13), 1102\u20131107 (2010).","journal-title":"Arch. Intern. Med."},{"issue":"9","key":"48112_CR14","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1017\/ice.2018.167","volume":"39","author":"Y Tagashira","year":"2018","unstructured":"Tagashira, Y., Kawahara, K., Takamatsu, A. & Honda, H. Antimicrobial prescribing in patients with advanced-stage illness in the antimicrobial stewardship era. Infect. Control Hosp. Epidemiol. 39(9), 1023\u20131029 (2018).","journal-title":"Infect. Control Hosp. Epidemiol."},{"issue":"12","key":"48112_CR15","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1089\/jpm.2013.0276","volume":"16","author":"JH Rosenberg","year":"2013","unstructured":"Rosenberg, J. H. et al. Antimicrobial use for symptom management in patients receiving hospice and palliative care: A systematic review. J. Palliat. Med. 16(12), 1568\u20131574 (2013).","journal-title":"J. Palliat. Med."},{"issue":"2","key":"48112_CR16","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.idh.2018.12.001","volume":"24","author":"J Dyer","year":"2019","unstructured":"Dyer, J., Vaux, L., Broom, A. & Broom, J. Antimicrobial use in patients at the end of life in an Australian hospital. Infect. Dis Health. maj 24(2), 92\u201397 (2019).","journal-title":"Infect. Dis Health. maj"},{"issue":"2","key":"48112_CR17","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1046\/j.1525-1497.2002.10711.x","volume":"17","author":"JP Metlay","year":"2002","unstructured":"Metlay, J. P., Shea, J. A., Crossette, L. B. & Asch, D. A. Tensions in antibiotic prescribing. J. Gen. Intern. Med. februari 17(2), 87\u201394 (2002).","journal-title":"J. Gen. Intern. Med. februari"},{"key":"48112_CR18","unstructured":"Infektionsl\u00e4karf\u00f6reningen. CDI V\u00e5rdprogram 2023. 2023\u201305\u201323. 2023;"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-48112-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-48112-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-48112-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T04:47:31Z","timestamp":1776228451000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-48112-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,15]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["48112"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-48112-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-8345712\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,15]]},"assertion":[{"value":"12 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Ethical approval was granted by the Swedish Ethical Review Authority on 2023-12-14 (Dnr: 2023-07647-01).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"12371"}}