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Ethanolic leaf extract of\n                    <jats:italic>Camellia sinensis<\/jats:italic>\n                    was profiled by HR-LCMS\/MS, and 11 abundant phytocompounds were taken forward for network pharmacology analysis against ERPBC targets. Hub genes and pathways were validated by molecular docking and 200 ns molecular dynamics simulations, focusing on Theacitrin C\u2013CTNNB1 and Plathymenin\u2013ESR1 complexes. A phospholipid phytosome of the extract was then formulated and characterised for particle size, zeta potential and morphology, followed by in vitro cytotoxicity on MCF-7 and L929 cells using the MTT assay. 36 overlapping targets and 8 hub genes were identified. Theacitrin C and Plathymenin showed strong, dynamically stable binding to CTNNB1 and ESR1. The phytosome exhibited a mean size of 519\u00a0nm, zeta potential of \u2212\u200923.0\u2009\u00b1\u20091.1 mV and mainly spherical particles. It was highly biocompatible toward L929 cells (84.31% viability at 1000\u00a0\u00b5g\/mL) and showed dose-dependent cytotoxicity in MCF-7 cells (IC\u2085\u2080 445.55\u00a0\u00b5g\/mL).\n                    <jats:italic>Camellia sinensis-derived<\/jats:italic>\n                    phytochemicals, particularly Theacitrin C and Plathymenin, appear to modulate CTNNB1- and ESR1-centred networks in ERPBC, and their phytosomal delivery offers a stable, selectively cytotoxic formulation. These findings justify further preclinical evaluation of\n                    <jats:italic>Camellia sinensis<\/jats:italic>\n                    phytosomes as multi-target adjuncts for ERPBC.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-48243-6","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T13:47:40Z","timestamp":1776088060000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrated in silico and in vitro evaluation of Camellia sinensis phytosomes in estrogen receptor-positive breast cancer"],"prefix":"10.1038","volume":"16","author":[{"given":"Kunal","family":"Bhattacharya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meher Rijwana","family":"Afrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj Ghritakousik","family":"Upadhyaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. 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