{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T20:43:00Z","timestamp":1776372180167,"version":"3.51.2"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007653","name":"Universit\u00e4tsklinikum Jena","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007653","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In a previous cross-sectional study using the tablet-based Oxford Cognitive Screen-Plus (OCS-Plus), deficits in delayed memory, attention, and executive functioning were identified in working-age patients with post-COVID-19 syndrome (PCS) following infection in 2020 or early 2021. Initial assessment occurred approximately five months after infection. To examine short-term longitudinal trajectories, patients were reassessed several months later. Eighty-one patients with PCS (mean age 46.6 years, 64% female) completed OCS-Plus assessments at baseline and after a median follow-up of 4.4 months. Cognitive change was analysed using Wilcoxon signed-rank tests and equivalence testing (\u00b1\u20091 SD of reference scores) to assess clinical relevance. Associations between cognitive change and changes in depression and fatigue were examined using bootstrap-corrected multiple regression. No significant change in cognitive performance was observed between baseline and follow-up across any cognitive domain (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.3). Equivalence testing indicated that observed differences fell within predefined bounds of clinical insignificance (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Changes in depressive symptoms and fatigue were not associated with changes in cognitive performance. Across the observed follow-up period, domain-level cognitive performance remained stable, with no evidence of short-term spontaneous improvement. These findings suggest short-term longitudinal stability of cognitive impairments in PCS within the limits of screening-based assessment and the follow-up interval studied, supporting the value of continued cognitive monitoring in affected individuals.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-48476-5","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T19:35:01Z","timestamp":1776368101000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal stability of cognitive impairments in post-COVID-19 syndrome assessed with the tablet-based Oxford Cognitive Screen-Plus"],"prefix":"10.1038","volume":"16","author":[{"given":"Valeska","family":"Kozik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp A.","family":"Reuken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katzer","family":"Katrin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoe","family":"Stallmach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Utech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nele","family":"Demeyere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Stallmach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"Finke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"48476_CR1","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/s41591-021-01283-z","volume":"27","author":"A Nalbandian","year":"2021","unstructured":"Nalbandian, A. et al. Post-acute COVID-19 syndrome. Nat. Med. 27, 601\u2013615 (2021).","journal-title":"Nat. Med."},{"key":"48476_CR2","doi-asserted-by":"crossref","unstructured":"Wahlgren, C. et al. Two-year follow-up of patients with post-COVID-19 condition in Sweden: a prospective cohort study. The Lancet Reg. Health\u2013Europe 28, 100595 (2023).","DOI":"10.1016\/j.lanepe.2023.100595"},{"key":"48476_CR3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.jinf.2023.12.004","volume":"88","author":"C Fernandez-de-Las-Pe\u00f1as","year":"2024","unstructured":"Fernandez-de-Las-Pe\u00f1as, C. et al. Persistence of post-COVID symptoms in the general population two years after SARS-CoV-2 infection: A systematic review and meta-analysis. J. Infect. 88, 77\u201388 (2024).","journal-title":"J. Infect."},{"key":"48476_CR4","doi-asserted-by":"crossref","unstructured":"Davis, H. E. et al. 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