{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:48:27Z","timestamp":1791244107295,"version":"4.1.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":56,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"a subsidy from the Ministry of Science and Higher Education obtained by the Faculty of Health Sciences of the Pomeranian Medical University in Szczecin","award":["WNoZ-318\/S\/2026"],"award-info":[{"award-number":["WNoZ-318\/S\/2026"]}]},{"name":"Minister of Science under the \"Regional Excellence Initiative\" Program","award":["RID\/SP\/0045\/2024\/01"],"award-info":[{"award-number":["RID\/SP\/0045\/2024\/01"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-48634-9","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T03:43:33Z","timestamp":1777347813000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hematological markers of proinflammatory and prothrombotic states in normal-weight obesity (NWO)."],"prefix":"10.1038","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6760-199X","authenticated-orcid":false,"given":"Waldemar","family":"Pluta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5378-5409","authenticated-orcid":false,"given":"Anna","family":"Lubkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1032-6349","authenticated-orcid":false,"given":"Wioleta","family":"Dudzi\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"48634_CR1","doi-asserted-by":"publisher","first-page":"33995","DOI":"10.1038\/s41598-025-12262-6","volume":"15","author":"W Pluta","year":"2025","unstructured":"Pluta, W., Lubkowska, A. & Dudzi\u0144ska, W. Diagnostic and prognostic value of adipose tissue content and distribution indicators for normal weight obesity in young women. Sci. Rep. 15, 33995 (2025).","journal-title":"Sci. Rep."},{"key":"48634_CR2","doi-asserted-by":"publisher","first-page":"3990","DOI":"10.1172\/JCI129187","volume":"129","author":"CR Kahn","year":"2019","unstructured":"Kahn, C. R., Wang, G. & Lee, K. Y. Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome. J. Clin. Invest. 129, 3990\u20134000 (2019).","journal-title":"J. Clin. Invest."},{"key":"48634_CR3","doi-asserted-by":"publisher","first-page":"111315","DOI":"10.1016\/j.biopha.2021.111315","volume":"137","author":"B Ahmed","year":"2021","unstructured":"Ahmed, B., Sultana, R. & Greene, M. W. Adipose tissue and insulin resistance in obese. Biomed. Pharmacother. 137, 111315 (2021).","journal-title":"Biomed. Pharmacother."},{"key":"48634_CR4","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1111\/ejh.13560","volume":"106","author":"JC Purdy","year":"2021","unstructured":"Purdy, J. C. & Shatzel, J. J. The Hematologic Consequences of Obesity. Eur. J. Haematol. 106, 306\u2013319 (2021).","journal-title":"Eur. J. Haematol."},{"key":"48634_CR5","doi-asserted-by":"publisher","first-page":"101052","DOI":"10.1016\/j.ajpc.2025.101052","volume":"23","author":"K Okada","year":"2025","unstructured":"Okada, K. et al. Association between baseline white blood cell count and future cardiovascular events in patients with stable coronary artery disease- Sub-analysis of the REAL-CAD trial. Am. J. Prev. Cardiol. 23, 101052 (2025).","journal-title":"Am. J. Prev. Cardiol."},{"key":"48634_CR6","doi-asserted-by":"publisher","first-page":"1358378","DOI":"10.3389\/fcvm.2024.1358378","volume":"11","author":"W Jiang","year":"2024","unstructured":"Jiang, W. et al. White blood cell counts can predict 4-year cardiovascular disease risk in patients with stable coronary heart disease: a prospective cohort study. Front. Cardiovasc. Med. 11, 1358378 (2024).","journal-title":"Front. Cardiovasc. Med."},{"key":"48634_CR7","doi-asserted-by":"publisher","first-page":"2697","DOI":"10.3390\/biomedicines10112697","volume":"10","author":"IH Seo","year":"2022","unstructured":"Seo, I. H. & Lee, Y. J. Usefulness of Complete Blood Count (CBC) to Assess Cardiovascular and Metabolic Diseases in Clinical Settings: A Comprehensive Literature Review. Biomedicines 10, 2697 (2022).","journal-title":"Biomedicines"},{"key":"48634_CR8","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.thromres.2022.10.008","volume":"231","author":"A Vauclard","year":"2023","unstructured":"Vauclard, A. et al. Obesity: Effects on bone marrow homeostasis and platelet activation. Thromb. Res. 231, 195\u2013205 (2023).","journal-title":"Thromb. Res."},{"key":"48634_CR9","first-page":"109","volume":"9","author":"HR Jeong","year":"2022","unstructured":"Jeong, H. R., Lee, H. S., Shim, Y. S. & Hwang, J. S. Positive Associations between Body Mass Index and Hematological Parameters, Including RBCs, WBCs, and Platelet Counts, in Korean Children and Adolescents. Child. (Basel). 9, 109 (2022).","journal-title":"Child. (Basel)"},{"key":"48634_CR10","doi-asserted-by":"crossref","unstructured":"Li, Z., Yao, Z. & Liu, Q. The association between white blood cell counts and metabolic health obesity among US adults. Front Nutr 12, (2025).","DOI":"10.3389\/fnut.2025.1458764"},{"key":"48634_CR11","doi-asserted-by":"publisher","first-page":"511","DOI":"10.3390\/nu18030511","volume":"18","author":"D Fonseca-P\u00e9rez","year":"2026","unstructured":"Fonseca-P\u00e9rez, D. et al. Dietary Diversity, Dietary Patterns, and Cardiometabolic Health in University Students: A Cross-Sectional Study. Nutrients 18, 511 (2026).","journal-title":"Nutrients"},{"key":"48634_CR12","doi-asserted-by":"publisher","first-page":"101662","DOI":"10.1016\/j.jocd.2025.101662","volume":"29","author":"S Bah\u00e7eba\u015f\u0131","year":"2026","unstructured":"Bah\u00e7eba\u015f\u0131, S., A\u00e7maz, B. & Savranlar, A. Metabolic and body composition alterations in normal-weight adults with prediabetes: A DEXA-based analysis. J. Clin. Densitom. 29, 101662 (2026).","journal-title":"J. Clin. Densitom"},{"key":"48634_CR13","doi-asserted-by":"publisher","first-page":"e58354","DOI":"10.1371\/journal.pone.0058354","volume":"8","author":"N Babio","year":"2013","unstructured":"Babio, N. et al. White blood cell counts as risk markers of developing metabolic syndrome and its components in the PREDIMED study. PLoS One. 8, e58354 (2013).","journal-title":"PLoS One"},{"key":"48634_CR14","doi-asserted-by":"publisher","first-page":"455","DOI":"10.2337\/diabetes.51.2.455","volume":"51","author":"B Vozarova","year":"2002","unstructured":"Vozarova, B. et al. High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes. Diabetes 51, 455\u2013461 (2002).","journal-title":"Diabetes"},{"key":"48634_CR15","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.jdiacomp.2016.10.029","volume":"31","author":"H Zhang","year":"2017","unstructured":"Zhang, H. et al. White blood cell subtypes and risk of type 2 diabetes. J. Diabetes Complications. 31, 31\u201337 (2017).","journal-title":"J. Diabetes Complications"},{"key":"48634_CR16","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1186\/s12944-018-0927-x","volume":"17","author":"Z Gu","year":"2018","unstructured":"Gu, Z. et al. Obesity and lipid-related parameters for predicting metabolic syndrome in Chinese elderly population. Lipids Health Dis. 17, 289 (2018).","journal-title":"Lipids Health Dis."},{"key":"48634_CR17","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/S0895-4356(00)00296-1","volume":"54","author":"DW Brown","year":"2001","unstructured":"Brown, D. W., Giles, W. H. & Croft, J. B. White blood cell count: an independent predictor of coronary heart disease mortality among a national cohort. J. Clin. Epidemiol. 54, 316\u2013322 (2001).","journal-title":"J. Clin. Epidemiol."},{"key":"48634_CR18","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1016\/j.jacc.2004.07.056","volume":"44","author":"M Madjid","year":"2004","unstructured":"Madjid, M., Awan, I., Willerson, J. T. & Casscells, S. W. Leukocyte count and coronary heart disease: implications for risk assessment. J. Am. Coll. Cardiol. 44, 1945\u20131956 (2004).","journal-title":"J. Am. Coll. Cardiol."},{"key":"48634_CR19","doi-asserted-by":"publisher","first-page":"1044178","DOI":"10.3389\/fimmu.2023.1044178","volume":"14","author":"N Mohammadian Khonsari","year":"2023","unstructured":"Mohammadian Khonsari, N. et al. Association of normal weight obesity phenotype with inflammatory markers: A systematic review and meta-analysis. Front. Immunol. 14, 1044178 (2023).","journal-title":"Front. Immunol."},{"key":"48634_CR20","doi-asserted-by":"publisher","first-page":"851","DOI":"10.5114\/aoms.2016.58928","volume":"13","author":"MS Ellulu","year":"2017","unstructured":"Ellulu, M. S., Patimah, I., Khaza\u2019ai, H., Rahmat, A. & Abed, Y. Obesity and inflammation: the linking mechanism and the complications. Arch. Med. Sci. 13, 851\u2013863 (2017).","journal-title":"Arch. Med. Sci."},{"key":"48634_CR21","doi-asserted-by":"publisher","first-page":"6184","DOI":"10.3390\/ijms15046184","volume":"15","author":"UJ Jung","year":"2014","unstructured":"Jung, U. J. & Choi, M. S. Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int. J. Mol. Sci. 15, 6184\u20136223 (2014).","journal-title":"Int. J. Mol. Sci."},{"key":"48634_CR22","doi-asserted-by":"publisher","first-page":"e002823","DOI":"10.1161\/JAHA.115.002823","volume":"5","author":"DF van Wijk","year":"2016","unstructured":"van Wijk, D. F. et al. C-Reactive Protein Identifies Low-Risk Metabolically Healthy Obese Persons: The European Prospective Investigation of Cancer-Norfolk Prospective Population Study. J. Am. Heart Assoc. 5, e002823 (2016).","journal-title":"J. Am. Heart Assoc."},{"key":"48634_CR23","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1161\/01.CIR.99.2.237","volume":"99","author":"W Koenig","year":"1999","unstructured":"Koenig, W. et al. C-Reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992. Circulation 99, 237\u2013242 (1999).","journal-title":"Circulation"},{"key":"48634_CR24","doi-asserted-by":"publisher","first-page":"e0172666","DOI":"10.1371\/journal.pone.0172666","volume":"12","author":"J Lee","year":"2017","unstructured":"Lee, J., Yoon, K., Ryu, S., Chang, Y. & Kim, H. R. High-normal levels of hs-CRP predict the development of nonalcoholic fatty liver in healthy men. PLOS ONE. 12, e0172666 (2017).","journal-title":"PLOS ONE"},{"key":"48634_CR25","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1056\/NEJM200003233421202","volume":"342","author":"PM Ridker","year":"2000","unstructured":"Ridker, P. M., Hennekens, C. H., Buring, J. E. & Rifai, N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl. J. Med. 342, 836\u2013843 (2000).","journal-title":"N Engl. J. Med."},{"key":"48634_CR26","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1093\/oxfordjournals.aje.a008963","volume":"144","author":"LH Kuller","year":"1996","unstructured":"Kuller, L. H., Tracy, R. P., Shaten, J. & Meilahn, E. N. Relation of C-reactive protein and coronary heart disease in the MRFIT nested case-control study. Multiple Risk Factor Intervention Trial. Am. J. Epidemiol. 144, 537\u2013547 (1996).","journal-title":"Am. J. Epidemiol."},{"key":"48634_CR27","doi-asserted-by":"publisher","first-page":"2750","DOI":"10.1161\/01.STR.0000044168.00485.02","volume":"33","author":"IM Van Der Meer","year":"2002","unstructured":"Van Der Meer, I. M. et al. C-reactive protein predicts progression of atherosclerosis measured at various sites in the arterial tree: the Rotterdam Study. Stroke 33, 2750\u20132755 (2002).","journal-title":"Stroke"},{"key":"48634_CR28","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1161\/01.CIR.0000033116.22237.F9","volume":"106","author":"SK Venugopal","year":"2002","unstructured":"Venugopal, S. K., Devaraj, S., Yuhanna, I., Shaul, P. & Jialal, I. Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells. Circulation 106, 1439\u20131441 (2002).","journal-title":"Circulation"},{"key":"48634_CR29","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1161\/01.CIR.0000029802.88087.5E","volume":"106","author":"S Verma","year":"2002","unstructured":"Verma, S. et al. A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis. Circulation 106, 913\u2013919 (2002).","journal-title":"Circulation"},{"key":"48634_CR30","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1161\/01.CIR.0000134965.73212.A6","volume":"110","author":"AD Pradhan","year":"2004","unstructured":"Pradhan, A. D. et al. Tissue plasminogen activator antigen and D-dimer as markers for atherothrombotic risk among healthy postmenopausal women. Circulation 110, 292\u2013300 (2004).","journal-title":"Circulation"},{"key":"48634_CR31","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1080\/13813450802181047","volume":"114","author":"I Nieto-Vazquez","year":"2008","unstructured":"Nieto-Vazquez, I. et al. Insulin resistance associated to obesity: the link TNF-alpha. Arch. Physiol. Biochem. 114, 183\u2013194 (2008).","journal-title":"Arch. Physiol. Biochem."},{"key":"48634_CR32","doi-asserted-by":"publisher","first-page":"491","DOI":"10.2337\/diacare.27.2.491","volume":"27","author":"K Ohshita","year":"2004","unstructured":"Ohshita, K. et al. Elevated white blood cell count in subjects with impaired glucose tolerance. Diabetes Care. 27, 491\u2013496 (2004).","journal-title":"Diabetes Care"},{"key":"48634_CR33","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3109\/09537104.2011.589014","volume":"23","author":"BJ Park","year":"2012","unstructured":"Park, B. J. et al. The relationship of platelet count, mean platelet volume with metabolic syndrome according to the criteria of the American Association of Clinical Endocrinologists: a focus on gender differences. Platelets 23, 45\u201350 (2012).","journal-title":"Platelets"},{"key":"48634_CR34","first-page":"291","volume":"2014","author":"RJ Widmer","year":"2014","unstructured":"Widmer, R. J. & Lerman, A. Endothelial dysfunction and cardiovascular disease. Glob Cardiol. Sci. Pract. 2014, 291\u2013308 (2014).","journal-title":"Glob Cardiol. Sci. Pract."},{"key":"48634_CR35","doi-asserted-by":"publisher","first-page":"e13651","DOI":"10.7717\/peerj.13651","volume":"10","author":"K Solanki","year":"2022","unstructured":"Solanki, K. et al. The expanding roles of neuronal nitric oxide synthase (NOS1). PeerJ 10, e13651 (2022).","journal-title":"PeerJ"},{"key":"48634_CR36","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1046\/j.1365-2796.1996.815000.x","volume":"239","author":"G Targher","year":"1996","unstructured":"Targher, G. et al. The white blood cell count: its relationship to plasma insulin and other cardiovascular risk factors in healthy male individuals. J. Intern. Med. 239, 435\u2013441 (1996).","journal-title":"J. Intern. Med."},{"key":"48634_CR37","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1161\/CIR.0b013e3182160726","volume":"123","author":"M Miller","year":"2011","unstructured":"Miller, M. et al. Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation 123, 2292\u20132333 (2011).","journal-title":"Circulation"},{"key":"48634_CR38","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.atherosclerosis.2006.04.029","volume":"192","author":"A Shankar","year":"2007","unstructured":"Shankar, A., Mitchell, P., Rochtchina, E. & Wang, J. J. The association between circulating white blood cell count, triglyceride level and cardiovascular and all-cause mortality: population-based cohort study. Atherosclerosis 192, 177\u2013183 (2007).","journal-title":"Atherosclerosis"},{"key":"48634_CR39","doi-asserted-by":"publisher","first-page":"100662","DOI":"10.1016\/j.jlr.2024.100662","volume":"65","author":"JX Fang","year":"2024","unstructured":"Fang, J. X. et al. Potential causal and temporal relationship between plasma triglyceride levels and circulating leukocyte. J. Lipid Res. 65, 100662 (2024).","journal-title":"J. Lipid Res."},{"key":"48634_CR40","doi-asserted-by":"publisher","first-page":"62","DOI":"10.2174\/1573399814666180119143026","volume":"15","author":"A Mahdiani","year":"2019","unstructured":"Mahdiani, A., Kheirandish, M. & Bonakdaran, S. Correlation Between White Blood Cell Count and Insulin Resistance in Type 2 Diabetes. Curr. Diabetes Rev. 15, 62\u201366 (2019).","journal-title":"Curr. Diabetes Rev."},{"key":"48634_CR41","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1186\/s12902-021-00788-5","volume":"21","author":"F Ahmed","year":"2021","unstructured":"Ahmed, F., Al-Habori, M., Al-Zabedi, E. & Saif-Ali, R. Impact of triglycerides and waist circumference on insulin resistance and \u03b2-cell function in non-diabetic first-degree relatives of type 2 diabetes. BMC Endocr. Disord. 21, 124 (2021).","journal-title":"BMC Endocr. Disord"},{"key":"48634_CR42","doi-asserted-by":"crossref","first-page":"EC11","DOI":"10.1111\/crj.12171","volume":"10","author":"V Raghavan","year":"2016","unstructured":"Raghavan, V., Gunasekar, D. & Rao, K. R. Relevance of Haematologic Parameters in Obese Women with or without Metabolic Syndrome. J. Clin. Diagn. Res. 10, EC11\u2013EC16 (2016).","journal-title":"J. Clin. Diagn. Res."},{"key":"48634_CR43","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.diabres.2018.07.033","volume":"143","author":"JY Hwang","year":"2018","unstructured":"Hwang, J. Y., Kwon, Y. J., Choi, W. J. & Jung, D. H. Platelet count and 8-year incidence of diabetes: The Korean Genome and Epidemiology Study. Diabetes Res. Clin. Pract. 143, 301\u2013309 (2018).","journal-title":"Diabetes Res. Clin. Pract."},{"key":"48634_CR44","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1002\/oby.22294","volume":"26","author":"S Han","year":"2018","unstructured":"Han, S. et al. Associations of Platelet Indices with Body Fat Mass and Fat Distribution. Obes. (Silver Spring). 26, 1637\u20131643 (2018).","journal-title":"Obes. (Silver Spring)"},{"key":"48634_CR45","first-page":"785","volume":"38","author":"M Koupenova","year":"2017","unstructured":"Koupenova, M., Kehrel, B. E., Corkrey, H. A. & Freedman, J. E. Thrombosis and platelets: an update. Eur. Heart J. 38, 785\u2013791 (2017).","journal-title":"Eur. Heart J."},{"key":"48634_CR46","doi-asserted-by":"publisher","first-page":"294","DOI":"10.3389\/fendo.2020.00294","volume":"11","author":"A Benova","year":"2020","unstructured":"Benova, A. & Tencerova, M. Obesity-Induced Changes in Bone Marrow Homeostasis. Front. Endocrinol. (Lausanne). 11, 294 (2020).","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"48634_CR47","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.thromres.2019.05.008","volume":"179","author":"G Couldwell","year":"2019","unstructured":"Couldwell, G. & Machlus, K. R. Modulation of megakaryopoiesis and platelet production during inflammation. Thromb. Res. 179, 114\u2013120 (2019).","journal-title":"Thromb. Res."},{"key":"48634_CR48","doi-asserted-by":"publisher","first-page":"313","DOI":"10.31083\/j.fbl2711313","volume":"27","author":"L Li","year":"2022","unstructured":"Li, L. et al. Insights into Regulatory Factors in Megakaryocyte Development and Function: Basic Mechanisms and Potential Targets. Front. Biosci. (Landmark Ed). 27, 313 (2022).","journal-title":"Front. Biosci. (Landmark Ed)"},{"key":"48634_CR49","doi-asserted-by":"publisher","first-page":"3111","DOI":"10.3390\/ijms20123111","volume":"20","author":"M Dupuis","year":"2019","unstructured":"Dupuis, M. et al. Effects of Estrogens on Platelets and Megakaryocytes. Int. J. Mol. Sci. 20, 3111 (2019).","journal-title":"Int. J. Mol. Sci."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-48634-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-48634-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-48634-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T02:02:28Z","timestamp":1782180148000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-48634-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["48634"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-48634-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-8481327\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"assertion":[{"value":"30 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki and was approved by the Institutional Review Board (the Bioethics Committee of the Pomeranian Medical University; Ref. KB-0012\/13\/2021).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional Review Board Statement"}}],"article-number":"19508"}}