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To address the cell type-specific contribution of Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.2 to endophenotypes related to psychiatric disorders, we generated mice with a conditional\n                    <jats:italic>Cacna1c<\/jats:italic>\n                    deletion in PV\n                    <jats:sup>+<\/jats:sup>\n                    neurons (Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.2-PV). Male knockout mice exhibited increased anxiety-like behavior, and a more passive stress-coping strategy in the forced swim test, while locomotion, social behavior, and cognitive performance were unaffected. In contrast, mice lacking Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.2 in forebrain glutamatergic neurons (Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.2-Nex) displayed enhanced active stress-coping, revealing a bidirectional, cell type-specific role of Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.2 in stress-induced behaviors. cFos mapping following stress exposure identified distinct activation patterns in stress-responsive brain regions, suggesting distinct circuit mechanisms underlying these opposing behavioral phenotypes. Together, these findings identify Ca\n                    <jats:sub>v<\/jats:sub>\n                    1.2 in PV\n                    <jats:sup>+<\/jats:sup>\n                    neurons as a critical regulator of anxiety and stress-coping behavior and highlight complementary contributions of inhibitory and excitatory circuits to stress adaptation, with implications for targeted therapeutic strategies in psychiatric disorders.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-48841-4","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T08:39:26Z","timestamp":1776674366000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cacna1c deficiency in parvalbumin-expressing neurons promotes anxiety and passive stress-coping behavior"],"prefix":"10.1038","volume":"16","author":[{"given":"Srivaishnavi","family":"Loganathan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan M.","family":"Deussing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"48841_CR1","doi-asserted-by":"publisher","first-page":"1255263","DOI":"10.1126\/science.1255263","volume":"345","author":"H Hu","year":"2014","unstructured":"Hu, H., Gan, J. & Jonas, P. 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