{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:51:56Z","timestamp":1781830316861,"version":"3.54.5"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":55,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"JSPS KAKENHI","award":["23K15513"],"award-info":[{"award-number":["23K15513"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-50084-2","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T06:15:28Z","timestamp":1777097728000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real-world survival benefit of chemotherapy in elderly patients with advanced gastric cancer: a population-based SEER analysis"],"prefix":"10.1038","volume":"16","author":[{"given":"Nobuhiro","family":"Nakazawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Kuriyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Kumakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiharu","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Sano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Shirabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Saeki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,25]]},"reference":[{"issue":"3","key":"50084_CR1","first-page":"209","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung, H. et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71(3), 209\u2013249 (2021).","journal-title":"CA Cancer J. Clin."},{"issue":"22","key":"50084_CR2","doi-asserted-by":"publisher","first-page":"6695","DOI":"10.7150\/jca.62734","volume":"12","author":"T Zhang","year":"2021","unstructured":"Zhang, T. et al. Global changing trends in incidence and mortality of gastric cancer by age and sex, 1990\u20132019: Findings from Global Burden of Disease Study. J. Cancer 12(22), 6695\u20136705 (2021).","journal-title":"J. Cancer"},{"issue":"1","key":"50084_CR3","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1097\/MCG.0000000000001811","volume":"58","author":"KS Liu","year":"2024","unstructured":"Liu, K. S., Raza, S. A., El-Serag, H. B. & Thrift, A. P. Recent trends in the incidence of gastric cancer in the United States. J. Clin. Gastroenterol. 58(1), 39\u201345 (2024).","journal-title":"J. Clin. Gastroenterol."},{"issue":"1","key":"50084_CR4","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1002\/cncr.34511","volume":"129","author":"Y Li","year":"2023","unstructured":"Li, Y. et al. Gastric cancer incidence trends in China and Japan from 1990 to 2019: Disentangling age-period-cohort patterns. Cancer 129(1), 98\u2013106 (2023).","journal-title":"Cancer"},{"issue":"10","key":"50084_CR5","doi-asserted-by":"publisher","first-page":"3845","DOI":"10.1111\/cas.14586","volume":"111","author":"M Asaka","year":"2020","unstructured":"Asaka, M. et al. Gastric cancer deaths by age group in Japan: Outlook on preventive measures for elderly adults. Cancer Sci. 111(10), 3845\u20133853 (2020).","journal-title":"Cancer Sci."},{"issue":"12","key":"50084_CR6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167615","volume":"11","author":"HJ Park","year":"2016","unstructured":"Park, H. J. et al. Clinical characteristics and outcomes of gastric cancer patients aged over 80 years: A retrospective case-control study. PLoS ONE 11(12), e0167615 (2016).","journal-title":"PLoS ONE"},{"key":"50084_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.972287","volume":"12","author":"X Wang","year":"2022","unstructured":"Wang, X. et al. Impact of frailty on survival and readmission in patients with gastric cancer undergoing gastrectomy: A meta-analysis. Front Oncol. 12, 972287 (2022).","journal-title":"Front Oncol."},{"issue":"1","key":"50084_CR8","doi-asserted-by":"publisher","first-page":"88","DOI":"10.7150\/jca.13248","volume":"7","author":"HS Kim","year":"2016","unstructured":"Kim, H. S., Kim, J. H., Kim, J. W. & Kim, B. C. Chemotherapy in elderly patients with gastric cancer. J. Cancer 7(1), 88\u201394 (2016).","journal-title":"J. Cancer"},{"issue":"1","key":"50084_CR9","first-page":"7","volume":"71","author":"RL Siegel","year":"2021","unstructured":"Siegel, R. L., Miller, K. D., Fuchs, H. E. & Jemal, A. Cancer statistics, 2021. CA Cancer J. Clin. 71(1), 7\u201333 (2021).","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"50084_CR10","doi-asserted-by":"publisher","first-page":"223","DOI":"10.4143\/crt.2018.073","volume":"51","author":"JW Kim","year":"2019","unstructured":"Kim, J. W. et al. Treatment patterns and changes in quality of life during first-line palliative chemotherapy in Korean patients with advanced gastric cancer. Cancer Res. Treat 51(1), 223\u2013239 (2019).","journal-title":"Cancer Res. Treat"},{"issue":"26","key":"50084_CR11","doi-asserted-by":"publisher","first-page":"4293","DOI":"10.1200\/JCO.23.00933","volume":"41","author":"W Dale","year":"2023","unstructured":"Dale, W. et al. Practical assessment and management of vulnerabilities in older patients receiving systemic cancer therapy: ASCO Guideline Update. J. Clin. Oncol. 41(26), 4293\u20134312 (2023).","journal-title":"J. Clin. Oncol."},{"issue":"9","key":"50084_CR12","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.6004\/jnccn.2021.0043","volume":"19","author":"E Dotan","year":"2021","unstructured":"Dotan, E. et al. NCCN Guidelines\u00ae Insights: Older Adult Oncology, Version 1.2021. J. Natl. Compr. Cancer Netw. 19(9), 1006\u20131019 (2021).","journal-title":"J. Natl. Compr. Cancer Netw."},{"issue":"8","key":"50084_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2024.103657","volume":"9","author":"KP Loh","year":"2024","unstructured":"Loh, K. P. et al. Adequate assessment yields appropriate care-the role of geriatric assessment and management in older adults with cancer: A position paper from the ESMO\/SIOG Cancer in the Elderly Working Group. ESMO Open 9(8), 103657 (2024).","journal-title":"ESMO Open"},{"issue":"2","key":"50084_CR14","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1200\/JCO.2002.20.2.494","volume":"20","author":"L Repetto","year":"2002","unstructured":"Repetto, L. et al. Comprehensive geriatric assessment adds information to Eastern Cooperative Oncology Group performance status in elderly cancer patients: an Italian Group for Geriatric Oncology Study. J. Clin. Oncol. 20(2), 494\u2013502 (2002).","journal-title":"J. Clin. Oncol."},{"issue":"1","key":"50084_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.critrevonc.2007.05.001","volume":"64","author":"U Wedding","year":"2007","unstructured":"Wedding, U., K\u00f6dding, D., Pientka, L., Steinmetz, H. T. & Schmitz, S. Physicians\u2019 judgement and comprehensive geriatric assessment (CGA) select different patients as fit for chemotherapy. Crit. Rev. Oncol. Hematol. 64(1), 1\u20139 (2007).","journal-title":"Crit. Rev. Oncol. Hematol."},{"issue":"5","key":"50084_CR16","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3390\/geriatrics7050107","volume":"7","author":"IV Zurlo","year":"2022","unstructured":"Zurlo, I. V. et al. Safety and efficacy of a first-line chemotherapy tailored by G8 score in elderly metastatic or locally advanced gastric and gastro- esophageal cancer patients: A real-world analysis. Geriatrics (Basel) 7(5), 107 (2022).","journal-title":"Geriatrics (Basel)"},{"key":"50084_CR17","doi-asserted-by":"publisher","first-page":"175883592513630","DOI":"10.1177\/17588359251363057","volume":"17","author":"Y Narita","year":"2025","unstructured":"Narita, Y. & Muro, K. Systemic therapy strategies for elderly patients with gastric cancer. Ther. Adv. Med. Oncol. 17, 17588359251363056 (2025).","journal-title":"Ther. Adv. Med. Oncol."},{"issue":"1","key":"50084_CR18","doi-asserted-by":"publisher","first-page":"5943","DOI":"10.1038\/s41598-019-42406-4","volume":"9","author":"W Liu","year":"2019","unstructured":"Liu, W., Quan, H., Chen, X., Ouyang, Y. & Xiao, H. Clinicopathological features and prognosis of young gastric cancer patients following radical gastrectomy: A propensity score matching analysis. Sci. Rep. 9(1), 5943 (2019).","journal-title":"Sci. Rep."},{"issue":"9","key":"50084_CR19","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.7150\/jca.82876","volume":"14","author":"IF Rompen","year":"2023","unstructured":"Rompen, I. F. et al. Clinical characteristics and oncological outcomes of surgically treated early-onset gastric adenocarcinoma\u2014A retrospective cohort study. J. Cancer 14(9), 1470\u20131478 (2023).","journal-title":"J. Cancer"},{"issue":"6","key":"50084_CR20","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1001\/jamaoncol.2021.0848","volume":"7","author":"PS Hall","year":"2021","unstructured":"Hall, P. S. et al. Efficacy of reduced- intensity chemotherapy with oxaliplatin and capecitabine on quality of life and cancer control among older and frail patients with advanced gastroesophageal cancer: The GO2 phase 3 randomized clinical trial. JAMA Oncol. 7(6), 869\u2013877 (2021).","journal-title":"JAMA Oncol."},{"issue":"8","key":"50084_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2024.102072","volume":"15","author":"J Skjoldbirk","year":"2024","unstructured":"Skjoldbirk, J. et al. Dose reduced preoperative chemotherapy in older patients with resectable gastroesophageal cancer: A real-world data study. J. Geriatr. Oncol. 15(8), 102072 (2024).","journal-title":"J. Geriatr. Oncol."},{"issue":"2","key":"50084_CR22","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.56106","volume":"7","author":"MR Mohamed","year":"2024","unstructured":"Mohamed, M. R. et al. Primary treatment modification and treatment tolerability among older chemotherapy recipients with advanced cancer. JAMA Netw. Open 7(2), e2356106 (2024).","journal-title":"JAMA Netw. Open"},{"issue":"7","key":"50084_CR23","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1007\/s11136-009-9493-z","volume":"18","author":"D Curran","year":"2009","unstructured":"Curran, D. et al. Quality of life of palliative chemotherapy naive patients with advanced adenocarcinoma of the stomach or esophagogastric junction treated with irinotecan combined with 5-fluorouracil and folinic acid: Results of a randomised phase III trial. Qual. Life Res. 18(7), 853\u2013861 (2009).","journal-title":"Qual. Life Res."},{"issue":"3","key":"50084_CR24","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s00280-005-0055-y","volume":"57","author":"SH Park","year":"2006","unstructured":"Park, S. H. et al. Quality of life in patients with advanced gastric cancer treated with second-line chemotherapy. Cancer Chemother. Pharmacol. 57(3), 289\u2013294 (2006).","journal-title":"Cancer Chemother. Pharmacol."},{"key":"50084_CR25","unstructured":"National Cancer Institute Surveillance. Epidemiology, and End Results Program. Overview of the SEER Program. https:\/\/seer.cancer.gov\/data-software\/documentation\/seerstat\/nov2022\/."},{"issue":"1","key":"50084_CR26","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41562-017-0189-z","volume":"2","author":"DJ Benjamin","year":"2018","unstructured":"Benjamin, D. J. et al. Redefine statistical significance. Nat. Hum. Behav. 2(1), 6\u201310 (2018).","journal-title":"Nat. Hum. Behav."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-50084-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-50084-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-50084-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:05:49Z","timestamp":1781827549000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-50084-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,25]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["50084"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-50084-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,25]]},"assertion":[{"value":"17 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study used publicly available, de-identified data from the SEER database. Institutional review board approval and informed consent were not required.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of Ethics"}}],"article-number":"19126"}}