{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:27:12Z","timestamp":1785522432826,"version":"3.56.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":67,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The \u201cweekend effect\u201d has been variably associated with outcomes in acute pulmonary embolism (PE), but its relevance in cancer-associated PE remains uncertain. Among U.S. hospitalizations for cancer-associated PE, is weekend admission independently associated with in-hospital mortality, and do PE-related interventions differ by day of admission? Retrospective cross-sectional study using the HCUP National Inpatient Sample (2016\u20132022). Adults (\u2265\u200918 years) hospitalized with a principal diagnosis of PE and concomitant malignancy were included. Weekend admission was Saturday\u2013Sunday. Survey-weighted analyses in R generated national estimates. Survey-weighted logistic regression estimated adjusted odds ratios (ORs) for in-hospital mortality. We compared PE-related therapies\/procedures (mechanical ventilation, vasopressors, systemic thrombolysis, and inferior vena cava [IVC] filter placement), including hospital-day-1 use (0 days to procedure). We identified 37,491 unweighted cancer-associated PE hospitalizations, representing approximately 187,455 weighted national hospitalizations, of which 7,804 unweighted hospitalizations (20.8%) were weekend admissions. Weekend admissions had higher acuity, with the administrative marker of high-acuity PE more frequent on weekends (29.1% vs. 26.3%), and higher unadjusted mortality (6.6% vs. 5.9%). In the fully adjusted model (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200936,408; deaths\u2009=\u20092,210), weekend admission was not associated with mortality (adjusted OR 1.04, 95% CI 0.93\u20131.16). Mechanical ventilation was more frequent on weekends (4.7% vs. 3.6%). Thrombolysis and overall IVC filter use were similar, but hospital-day-1 IVC filter placement was less common on weekends (14.7% vs. 18.9%). Higher unadjusted weekend mortality in cancer-associated PE appears largely explained by case mix and severity rather than weekend admission itself.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-50298-4","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T10:15:50Z","timestamp":1779444950000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Weekend admission and outcomes in cancer-associated pulmonary embolism: a cross-sectional national inpatient sample study, 2016\u20132022"],"prefix":"10.1038","volume":"16","author":[{"given":"Xiaoyi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boon Jian","family":"San","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simo","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zizhuo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cho-Hao","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"50298_CR1","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.ijcard.2022.09.049","volume":"371","author":"AS Mai","year":"2023","unstructured":"Mai, A. S. et al. The association between cancer diagnosis, care, and outcomes in 1 million patients hospitalized for acute pulmonary embolism. Int. J. Cardiol. 371, 354\u2013362 (2023).","journal-title":"Int. J. Cardiol."},{"key":"50298_CR2","doi-asserted-by":"publisher","unstructured":"Font, C. et al. Clinical features and short-term outcomes of cancer patients with suspected and unsuspected pulmonary embolism: the EPIPHANY study. Eur. Respir J., 49(1), 1600282. https:\/\/doi.org\/10.1183\/13993003.00282-2016 (2017).","DOI":"10.1183\/13993003.00282-2016"},{"key":"50298_CR3","doi-asserted-by":"publisher","unstructured":"Shalaby, K. et al. Outcomes of acute pulmonary embolism in hospitalized patients with cancer. BMC Pulm. 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Due to the retrospective nature of the study, the Einstein Institutional Review Board (IRB), Albert Einstein College of Medicine, waived the need for obtaining informed consent.","order":3,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"23392"}}