{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:18:58Z","timestamp":1783948738903,"version":"3.55.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":62,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-50528-9","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T18:23:30Z","timestamp":1778610210000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hyaluronic acid\/kaempferol-functionalized Fe\u2083O\u2084 nanoparticles promote ROS-associated apoptosis and modulate caspase-8\/BCRT1 axis in triple-negative breast cancer"],"prefix":"10.1038","volume":"16","author":[{"given":"Deniz","family":"Kazemzadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Salehzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahab","family":"Shariati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Ataollah Sadat","family":"Shandiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"issue":"3","key":"50528_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung, H. et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Cancer J. Clin. 71 (3), 209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660 (2021).","journal-title":"Cancer J. Clin."},{"key":"50528_CR2","doi-asserted-by":"publisher","first-page":"681476","DOI":"10.3389\/fonc.2021.681476","volume":"11","author":"M Ensenyat-Mendez","year":"2021","unstructured":"Ensenyat-Mendez, M. et al. Current triple-negative breast cancer subtypes: dissecting the most aggressive form of breast cancer. Front. Oncol. 11, 681476. https:\/\/doi.org\/10.3389\/fonc.2021.681476 (2021).","journal-title":"Front. Oncol."},{"key":"50528_CR3","doi-asserted-by":"publisher","unstructured":"Collignon, J., Lousberg, L., Schroeder, H. & Jerusalem, G. Triple-negative breast cancer: treatment challenges and solutions. Breast Cancer: Targets Therapy. 93\u2013107. https:\/\/doi.org\/10.2147\/BCTT.S69488 (2016).","DOI":"10.2147\/BCTT.S69488"},{"key":"50528_CR4","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1007\/s13346-018-0551-3","volume":"8","author":"S Al-Mahmood","year":"2018","unstructured":"Al-Mahmood, S., Sapiezynski, J., Garbuzenko, O. B. & Minko, T. Metastatic and triple-negative breast cancer: challenges and treatment options. Drug delivery translational Res. 8, 1483\u20131507. https:\/\/doi.org\/10.1007\/s13346-018-0551-3 (2018).","journal-title":"Drug delivery translational Res."},{"key":"50528_CR5","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.mattod.2021.08.002","volume":"50","author":"Q Mu","year":"2021","unstructured":"Mu, Q. et al. Iron oxide nanoparticle targeted chemo-immunotherapy for triple negative breast cancer. Mater. Today. 50, 149\u2013169. https:\/\/doi.org\/10.1016\/j.mattod.2021.08.002 (2021).","journal-title":"Mater. Today"},{"issue":"1","key":"50528_CR6","doi-asserted-by":"publisher","first-page":"236","DOI":"10.3390\/pharmaceutics15010236","volume":"15","author":"T Vangijzegem","year":"2023","unstructured":"Vangijzegem, T. et al. Superparamagnetic iron oxide nanoparticles (SPION): From fundamentals to state-of-the-art innovative applications for cancer therapy. Pharmaceutics 15 (1), 236. https:\/\/doi.org\/10.3390\/pharmaceutics15010236 (2023).","journal-title":"Pharmaceutics"},{"issue":"1","key":"50528_CR7","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3390\/ijms24010103","volume":"24","author":"M Michalczyk","year":"2022","unstructured":"Michalczyk, M., Humeniuk, E., Adamczuk, G. & Korga-Plewko, A. Hyaluronic acid as a modern approach in anticancer therapy-review. Int. J. Mol. Sci. 24 (1), 103. https:\/\/doi.org\/10.3390\/ijms24010103 (2022).","journal-title":"Int. J. Mol. Sci."},{"issue":"77","key":"50528_CR8","doi-asserted-by":"publisher","first-page":"73083","DOI":"10.1039\/C6RA11260A","volume":"6","author":"S Sharma","year":"2016","unstructured":"Sharma, S. et al. Hyaluronic acid anchored paclitaxel nanocrystals improves chemotherapeutic efficacy and inhibits lung metastasis in tumor-bearing rat model. RSC Adv. 6 (77), 73083\u201373095 (2016).","journal-title":"RSC Adv."},{"issue":"12","key":"50528_CR9","doi-asserted-by":"publisher","first-page":"482","DOI":"10.3390\/cancers10120482","volume":"10","author":"ZK Price","year":"2018","unstructured":"Price, Z. K., Lokman, N. A. & Ricciardelli, C. Differing roles of hyaluronan molecular weight on cancer cell behavior and chemotherapy resistance. Cancers 10 (12), 482 (2018).","journal-title":"Cancers"},{"key":"50528_CR10","doi-asserted-by":"publisher","unstructured":"Zeng, X. et al. pH-responsive hyaluronic acid nanoparticles for enhanced triple negative breast cancer therapy. Int. J. Nanomed. 1437\u20131457. https:\/\/doi.org\/10.2147\/IJN.S360500 (2022).","DOI":"10.2147\/IJN.S360500"},{"issue":"6","key":"50528_CR11","doi-asserted-by":"publisher","first-page":"843","DOI":"10.3390\/polym16060843","volume":"16","author":"L Ding","year":"2024","unstructured":"Ding, L. et al. Polymer-Based Drug Delivery Systems for Cancer Therapeutics. Polym. (Basel). 16 (6), 843. https:\/\/doi.org\/10.3390\/polym16060843 (2024).","journal-title":"Polym. (Basel)"},{"key":"50528_CR12","doi-asserted-by":"publisher","first-page":"585","DOI":"10.3390\/cancers16030585","volume":"16","author":"EF De Morais","year":"2024","unstructured":"De Morais, E. F. et al. The Anticancer Potential of Kaempferol: A Systematic Review Based on. Vitro Stud. Cancers. 16, 585. https:\/\/doi.org\/10.3390\/ cancers16030585 (2024).","journal-title":"Vitro Stud. Cancers"},{"issue":"4","key":"50528_CR13","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1016\/j.foodchem.2012.11.139","volume":"138","author":"AY Chen","year":"2013","unstructured":"Chen, A. Y. & Chen, Y. C. A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention. Food Chem. 138 (4), 2099\u20132107. https:\/\/doi.org\/10.1016\/j.foodchem.2012.11.139 (2013).","journal-title":"Food Chem."},{"issue":"10","key":"50528_CR14","doi-asserted-by":"publisher","first-page":"8630","DOI":"10.3390\/ijms24108630","volume":"24","author":"A Almatroudi","year":"2023","unstructured":"Almatroudi, A. et al. Effects and mechanisms of kaempferol in the management of cancers through modulation of inflammation and signal transduction pathways. Int. J. Mol. Sci. 24 (10), 8630. https:\/\/doi.org\/10.3390\/ijms24108630 (2023).","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"50528_CR15","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1007\/s10534-023-00516-7","volume":"36","author":"S Fekri Kohan","year":"2023","unstructured":"Fekri Kohan, S., Zamani, H. & Salehzadeh, A. Antibacterial potential and cytotoxic activity of iron oxide nanoparticles conjugated with thymol (Fe3O4@ Glu-Thymol) on breast cancer cells and investigating the expression of BAX, CASP8, and BCL-2 genes. Biometals 36 (6), 1273\u20131284. https:\/\/doi.org\/10.1007\/s10534-023-00516-7 (2023).","journal-title":"Biometals"},{"key":"50528_CR16","doi-asserted-by":"publisher","unstructured":"Hosseinkhah, M. et al. Cytotoxic Potential of Nickel Oxide Nanoparticles Functionalized with Glutamic Acid and Conjugated with Thiosemicarbazide (NiO@ Glu\/TSC) Against Human Gastric Cancer Cells. J. Cluster Sci. 1\u20139. https:\/\/doi.org\/10.1007\/s10876-021-02124-2 (2021).","DOI":"10.1007\/s10876-021-02124-2"},{"issue":"1","key":"50528_CR17","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s00775-019-01729-3","volume":"25","author":"R Kumari","year":"2020","unstructured":"Kumari, R., Saini, A. K., Kumar, A. & Saini, R. V. Apoptosis induction in lung and prostate cancer cells through silver nanoparticles synthesized from Pinus roxburghii bioactive fraction. J. Biol. Inorg. Chem. 25 (1), 23\u201337. https:\/\/doi.org\/10.1007\/s00775-019-01729-3 (2020).","journal-title":"J. Biol. Inorg. Chem."},{"issue":"1","key":"50528_CR18","first-page":"222","volume":"18","author":"T Ramezani","year":"2019","unstructured":"Ramezani, T., Nabiuni, M., Baharara, J., Parivar, K. & Namvar, F. Sensitization of resistance ovarian cancer cells to cisplatin by biogenic synthesized silver nanoparticles through p53 activation. Iran. J. Pharm. research: IJPR. 18 (1), 222 (2019).","journal-title":"Iran. J. Pharm. research: IJPR"},{"key":"50528_CR19","doi-asserted-by":"publisher","unstructured":"Shameli, K. et al. Green biosynthesis of silver nanoparticles using Curcuma longa tuber powder. Int. J. Nanomed. 5603\u20135610. https:\/\/doi.org\/10.2147\/IJN.S36786 (2012).","DOI":"10.2147\/IJN.S36786"},{"issue":"6","key":"50528_CR20","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1007\/s00289-024-05595-1","volume":"82","author":"WR de Souza","year":"2025","unstructured":"de Souza, W. R. et al. Synthesis and physical\u2013chemical characterization of chitosan grafted with hyaluronic acid as potential application in biomaterials. Polym. Bull. 82 (6), 1915\u20131933. https:\/\/doi.org\/10.1007\/s00289-024-05595-1 (2025).","journal-title":"Polym. Bull."},{"key":"50528_CR21","doi-asserted-by":"publisher","first-page":"108659","DOI":"10.1016\/j.polymertesting.2024.108659","volume":"142","author":"I Najafipour","year":"2025","unstructured":"Najafipour, I. et al. Synthesis of Fe3O4@ MIL-101-OH\/Chitosan for adsorption and release of doxorubicin. Polym. Test. 142, 108659. https:\/\/doi.org\/10.1016\/j.polymertesting.2024.108659 (2025).","journal-title":"Polym. Test."},{"issue":"5","key":"50528_CR22","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.1039\/D3NJ05411J","volume":"48","author":"MD Yilmaz","year":"2024","unstructured":"Yilmaz, M. D., Ozsamur, N. G. & Erbas-Cakmak, S. Catalytic investigation of hyaluronic acid-stabilized Ag nanoparticles as non-toxic nanocatalysts in the oxidation of morin. New J. Chem. 48 (5), 2341\u20132347. https:\/\/doi.org\/10.1039\/D3NJ05411J (2024).","journal-title":"New J. Chem."},{"issue":"2","key":"50528_CR23","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1007\/s13762-022-04679-7","volume":"20","author":"N Emami","year":"2023","unstructured":"Emami, N., Farhadian, M., Solaimany Nazar, A. R. & Tangestaninejad, S. Adsorption of cefixime and lamotrigine on HKUST-1\/ZIF-8 nanocomposite: isotherms, kinetics models and mechanism. Int. J. Environ. Sci. Technol. 20 (2), 1645\u20131672. https:\/\/doi.org\/10.1007\/s13762-022-04679-7 (2023).","journal-title":"Int. J. Environ. Sci. Technol."},{"issue":"2","key":"50528_CR24","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1080\/24701556.2021.2025074","volume":"53","author":"SZ Habibzadeh","year":"2023","unstructured":"Habibzadeh, S. Z., Salehzadeh, A., Moradi-Shoeili, Z. & Shandiz, S. A. S. Iron oxide nanoparticles functionalized with 3-chloropropyltrimethoxysilane and conjugated with thiazole alter the expression of BAX, BCL2, and p53 genes in AGS cell line. Inorg. Nano-Metal Chem. 53 (2), 191\u2013198. https:\/\/doi.org\/10.1080\/24701556.2021.2025074 (2023).","journal-title":"Inorg. Nano-Metal Chem."},{"issue":"3","key":"50528_CR25","doi-asserted-by":"publisher","first-page":"585","DOI":"10.3390\/cancers16030585","volume":"16","author":"EF De Morais","year":"2024","unstructured":"De Morais, E. F. et al. The anticancer potential of kaempferol: a systematic review based on in vitro studies. Cancers 16 (3), 585. https:\/\/doi.org\/10.3390\/cancers16030585 (2024).","journal-title":"Cancers"},{"issue":"15","key":"50528_CR26","doi-asserted-by":"publisher","first-page":"2392","DOI":"10.3390\/nu16152392","volume":"16","author":"S Kaur","year":"2024","unstructured":"Kaur, S., Mendonca, P. & Soliman, K. F. The Anticancer Effects and Therapeutic Potential of Kaempferol in Triple-Negative Breast Cancer. Nutrients 16 (15), 2392. https:\/\/doi.org\/10.3390\/nu16152392 (2024).","journal-title":"Nutrients"},{"issue":"4","key":"50528_CR27","doi-asserted-by":"publisher","first-page":"322","DOI":"10.4162\/nrp.2008.2.4.322","volume":"2","author":"EJ Choi","year":"2008","unstructured":"Choi, E. J. & Ahn, W. S. Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells. Nutr. Res. Pract. 2 (4), 322\u2013325. https:\/\/doi.org\/10.4162\/nrp.2008.2.4.322 (2008).","journal-title":"Nutr. Res. Pract."},{"issue":"6","key":"50528_CR28","doi-asserted-by":"publisher","first-page":"629","DOI":"10.3727\/096504018X15228018559434","volume":"27","author":"L Zhu","year":"2019","unstructured":"Zhu, L. & Xue, L. Kaempferol suppresses proliferation and induces cell cycle arrest, apoptosis, and DNA damage in breast cancer cells. Oncol. Res. 27 (6), 629. https:\/\/doi.org\/10.3727\/096504018X15228018559434 (2019).","journal-title":"Oncol. Res."},{"issue":"1","key":"50528_CR29","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/nrm3722","volume":"15","author":"PE Czabotar","year":"2014","unstructured":"Czabotar, P. E., Lessene, G., Strasser, A. & Adams, J. M. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat. Rev. Mol. Cell Biol. 15 (1), 49\u201363. https:\/\/doi.org\/10.1038\/nrm3722 (2014).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"50528_CR30","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s13205-023-03863-x","volume":"14","author":"X Wang","year":"2024","unstructured":"Wang, X., Li, H., Li, N., Yang, H. & Bai, X. LncRNA BCRT1 depletion suppresses cervical cancer cell growth via sponging miR-432-5p\/CCR7 axis. 3 Biotech. 14 (1), 17. https:\/\/doi.org\/10.1007\/s13205-023-03863-x (2024).","journal-title":"3 Biotech."},{"issue":"11","key":"50528_CR31","doi-asserted-by":"publisher","first-page":"15501","DOI":"10.18632\/aging.203106","volume":"13","author":"G Han","year":"2021","unstructured":"Han, G. et al. LncRNA BCRT1 facilitates osteosarcoma progression via regulating miR-1303\/FGF7 axis. Aging (Albany NY). 13 (11), 15501. https:\/\/doi.org\/10.18632\/aging.203106 (2021).","journal-title":"Aging (Albany NY)"},{"issue":"7","key":"50528_CR32","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.4161\/cbt.7.7.6164","volume":"7","author":"BW Kim","year":"2008","unstructured":"Kim, B. W. et al. Sustained ERK activation is involved in the kaempferol-induced apoptosis of breast cancer cells and is more evident under 3-D culture condition. Cancer Biol. Ther. 7 (7), 1080\u20131089. https:\/\/doi.org\/10.4161\/cbt.7.7.6164 (2008).","journal-title":"Cancer Biol. Ther."},{"issue":"8","key":"50528_CR33","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1093\/carcin\/bgq102","volume":"31","author":"KM Lee","year":"2010","unstructured":"Lee, K. M. et al. Phosphatidylinositol 3-kinase, a novel target molecule for the inhibitory effects of kaempferol on neoplastic cell transformation. Carcinogenesis 31 (8), 1338\u20131343. https:\/\/doi.org\/10.1093\/carcin\/bgq102 (2010).","journal-title":"Carcinogenesis"},{"issue":"6","key":"50528_CR34","doi-asserted-by":"publisher","first-page":"3155","DOI":"10.3390\/app12063155","volume":"12","author":"N Afroze","year":"2022","unstructured":"Afroze, N. et al. Kaempferol regresses carcinogenesis through a molecular cross talk involved in proliferation, apoptosis and inflammation on human cervical cancer cells, HeLa. Appl. Sci. 12 (6), 3155. https:\/\/doi.org\/10.3390\/app12063155 (2022).","journal-title":"Appl. Sci."},{"key":"50528_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12885-021-08158-z","volume":"21","author":"F Wang","year":"2021","unstructured":"Wang, F. et al. Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt\/mTOR signaling. BMC cancer. 21, 1\u201311. https:\/\/doi.org\/10.1186\/s12885-021-08158-z (2021).","journal-title":"BMC cancer"},{"key":"50528_CR36","doi-asserted-by":"publisher","first-page":"108700","DOI":"10.1016\/j.abb.2020.108700","volume":"697","author":"C Fouzder","year":"2021","unstructured":"Fouzder, C., Mukhuty, A. & Kundu, R. Kaempferol inhibits Nrf2 signalling pathway via downregulation of Nrf2 mRNA and induces apoptosis in NSCLC cells. Arch. Biochem. Biophys. 697, 108700. https:\/\/doi.org\/10.1016\/j.abb.2020.108700 (2021).","journal-title":"Arch. Biochem. Biophys."},{"key":"50528_CR37","doi-asserted-by":"publisher","first-page":"154689","DOI":"10.1016\/j.phymed.2023.154689","volume":"113","author":"SK Nandi","year":"2023","unstructured":"Nandi, S. K. et al. Kaempferol with Verapamil impeded panoramic chemoevasion pathways in breast cancer through ROS overproduction and disruption of lysosomal biogenesis. Phytomedicine 113, 154689. https:\/\/doi.org\/10.1016\/j.phymed.2023.154689 (2023).","journal-title":"Phytomedicine"},{"issue":"4","key":"50528_CR38","doi-asserted-by":"publisher","first-page":"1692","DOI":"10.1021\/acsabm.2c00068","volume":"5","author":"X Tian","year":"2022","unstructured":"Tian, X. et al. Appropriate size of Fe3O4 nanoparticles for cancer therapy by ferroptosis. ACS Appl. Bio Mater. 5 (4), 1692\u20131699. https:\/\/doi.org\/10.1021\/acsabm.2c00068 (2022).","journal-title":"ACS Appl. Bio Mater."},{"key":"50528_CR39","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1007\/s12011-014-9972-0","volume":"159","author":"S Alarifi","year":"2014","unstructured":"Alarifi, S., Ali, D., Alkahtani, S. & Alhader, M. S. Iron oxide nanoparticles induce oxidative stress, DNA damage, and caspase activation in the human breast cancer cell line. Biol. Trace Elem. Res. 159, 416\u2013424. https:\/\/doi.org\/10.1007\/s12011-014-9972-0 (2014).","journal-title":"Biol. Trace Elem. Res."},{"issue":"10","key":"50528_CR40","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.3390\/polym15102317","volume":"15","author":"CP Fu","year":"2023","unstructured":"Fu, C. P. et al. Hyaluronic acid-based nanocarriers for anticancer drug delivery. Polymers 15 (10), 2317. https:\/\/doi.org\/10.3390\/polym15102317 (2023).","journal-title":"Polymers"},{"key":"50528_CR41","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1007\/s00432-017-2464-9","volume":"143","author":"MH Raza","year":"2017","unstructured":"Raza, M. H. et al. ROS-modulated therapeutic approaches in cancer treatment. J. Cancer Res. Clin. Oncol. 143, 1789\u20131809. https:\/\/doi.org\/10.1007\/s00432-017-2464-9 (2017).","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"50528_CR42","doi-asserted-by":"publisher","first-page":"101818","DOI":"10.1016\/j.genrep.2023.101818","volume":"33","author":"F Shokrollahi","year":"2023","unstructured":"Shokrollahi, F., Salehzadeh, A., Kafilzadeh, F. & Zaefizadeh, M. Evaluation of the effect of iron oxide nanoparticles functionalized by glucose and conjugated with coumarin (Fe3O4@ Glu-Coumarin NPs) on the expression of CASP8, CASP9, p53, mTOR1, and MAPK1 genes in liver cancer cell line. Gene Rep. 33, 101818. https:\/\/doi.org\/10.1016\/j.genrep.2023.101818 (2023).","journal-title":"Gene Rep."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-50528-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-50528-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-50528-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:01:20Z","timestamp":1783947680000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-50528-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,12]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["50528"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-50528-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,12]]},"assertion":[{"value":"13 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"21797"}}