{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:44:57Z","timestamp":1782780297878,"version":"3.54.5"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":62,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004492","name":"National Youth Foundation of China","doi-asserted-by":"publisher","award":["82000388"],"award-info":[{"award-number":["82000388"]}],"id":[{"id":"10.13039\/501100004492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004492","name":"National Youth Foundation of China","doi-asserted-by":"publisher","award":["82200324"],"award-info":[{"award-number":["82200324"]}],"id":[{"id":"10.13039\/501100004492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2020JJ4900"],"award-info":[{"award-number":["2020JJ4900"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ40926"],"award-info":[{"award-number":["2023JJ40926"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873508"],"award-info":[{"award-number":["81873508"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-50545-8","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:33:04Z","timestamp":1777455184000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["TCONS_00052110 is associated with prolonged PTBP1 half-life and mitochondrial injury in PAH-associated right ventricular stress"],"prefix":"10.1038","volume":"16","author":[{"given":"Xiaowei","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhe","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"50545_CR1","doi-asserted-by":"publisher","unstructured":"Garcia, M. V. F., Nanah, A. & Caruso, P. Acute decompensated pulmonary hypertension outcomes in pulmonary arterial hypertension patients: Systematic review and meta-analysis of proportions. Heart Lung 70, 57\u201364. https:\/\/doi.org\/10.1016\/j.hrtlng.2024.11.009 (2025).","DOI":"10.1016\/j.hrtlng.2024.11.009"},{"key":"50545_CR2","doi-asserted-by":"publisher","unstructured":"Giannakoulas, G. et al. Acute right ventricular failure: Pathophysiology, aetiology, assessment, and management. Eur. Heart J. https:\/\/doi.org\/10.1093\/eurheartj\/ehaf215 (2025).","DOI":"10.1093\/eurheartj\/ehaf215"},{"key":"50545_CR3","doi-asserted-by":"publisher","unstructured":"Olsson, K. M. et al. Right heart function during and after pregnancy in women with pulmonary arterial hypertension. Eur. Respir. J. https:\/\/doi.org\/10.1183\/13993003.00179-2024 (2024).","DOI":"10.1183\/13993003.00179-2024"},{"key":"50545_CR4","doi-asserted-by":"publisher","unstructured":"Vasudeva, R., Challa, A., Tuck, N., Pothuru, S. & Vindhyal, M. Hospital outcomes for patients with pulmonary arterial hypertension in sepsis and septic shock. BMC Pulm. Med. 22, 374. https:\/\/doi.org\/10.1186\/s12890-022-02145-1 (2022).","DOI":"10.1186\/s12890-022-02145-1"},{"key":"50545_CR5","doi-asserted-by":"publisher","unstructured":"Riou, M., Enache, I., Sauer, F., Charles, A. L. & Geny, B. Targeting mitochondrial metabolic dysfunction in pulmonary hypertension: Toward new therapeutic approaches?. Int. J. Mol. Sci. https:\/\/doi.org\/10.3390\/ijms24119572 (2023).","DOI":"10.3390\/ijms24119572"},{"key":"50545_CR6","doi-asserted-by":"publisher","unstructured":"Esparza-Molt\u00f3, P. B. & Cuezva, J. M. Reprogramming oxidative phosphorylation in cancer: A role for RNA-binding proteins. Antioxid. Redox Signal. 33, 927\u2013945. https:\/\/doi.org\/10.1089\/ars.2019.7988 (2020).","DOI":"10.1089\/ars.2019.7988"},{"key":"50545_CR7","doi-asserted-by":"publisher","unstructured":"Zhou, R., Yazdi, A. S., Menu, P. & Tschopp, J. A role for mitochondria in NLRP3 inflammasome activation. Nature 469, 221\u2013225. https:\/\/doi.org\/10.1038\/nature09663 (2011).","DOI":"10.1038\/nature09663"},{"key":"50545_CR8","doi-asserted-by":"publisher","unstructured":"Zorov, D. B., Juhaszova, M. & Sollott, S. J. Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol. Rev. 94, 909\u2013950. https:\/\/doi.org\/10.1152\/physrev.00026.2013 (2014).","DOI":"10.1152\/physrev.00026.2013"},{"key":"50545_CR9","doi-asserted-by":"publisher","unstructured":"Zecchini, V. et al. Fumarate induces vesicular release of mtDNA to drive innate immunity. Nature 615, 499\u2013506. https:\/\/doi.org\/10.1038\/s41586-023-05770-w (2023).","DOI":"10.1038\/s41586-023-05770-w"},{"key":"50545_CR10","doi-asserted-by":"publisher","unstructured":"Xu, W., Janocha, A. J. & Erzurum, S. C. Metabolism in pulmonary hypertension. Annu. Rev. Physiol. 83, 551\u2013576. https:\/\/doi.org\/10.1146\/annurev-physiol-031620-123956 (2021).","DOI":"10.1146\/annurev-physiol-031620-123956"},{"key":"50545_CR11","doi-asserted-by":"publisher","unstructured":"Bornstein, M. R., Tian, R. & Arany, Z. Human cardiac metabolism. Cell Metab. 36, 1456\u20131481. https:\/\/doi.org\/10.1016\/j.cmet.2024.06.003 (2024).","DOI":"10.1016\/j.cmet.2024.06.003"},{"key":"50545_CR12","doi-asserted-by":"publisher","unstructured":"Caruso, P. et al. Identification of MicroRNA-124 as a major regulator of enhanced endothelial cell glycolysis in pulmonary arterial hypertension via PTBP1 (polypyrimidine tract binding protein) and pyruvate kinase M2. Circulation 136, 2451\u20132467. https:\/\/doi.org\/10.1161\/circulationaha.117.028034 (2017).","DOI":"10.1161\/circulationaha.117.028034"},{"key":"50545_CR13","doi-asserted-by":"publisher","unstructured":"Glisovic, T., Bachorik, J. L., Yong, J. & Dreyfuss, G. RNA-binding proteins and post-transcriptional gene regulation. FEBS Lett. 582, 1977\u20131986. https:\/\/doi.org\/10.1016\/j.febslet.2008.03.004 (2008).","DOI":"10.1016\/j.febslet.2008.03.004"},{"key":"50545_CR14","doi-asserted-by":"publisher","unstructured":"Guo, L. et al. M-type pyruvate kinase 2 (PKM2) tetramerization alleviates the progression of right ventricle failure by regulating oxidative stress and mitochondrial dynamics. J. Transl. Med. 21, 888. https:\/\/doi.org\/10.1186\/s12967-023-04780-6 (2023).","DOI":"10.1186\/s12967-023-04780-6"},{"key":"50545_CR15","doi-asserted-by":"publisher","unstructured":"Guo, L. et al. Regulation of the immune microenvironment by an NLRP3 inhibitor contributes to attenuation of acute right ventricular failure in rats with pulmonary arterial hypertension. J. Inflamm. Res. 14, 5699\u20135711. https:\/\/doi.org\/10.2147\/jir.S336964 (2021).","DOI":"10.2147\/jir.S336964"},{"key":"50545_CR16","doi-asserted-by":"publisher","unstructured":"Zhang, J. et al. Lipopolysaccharide acutely suppresses right-ventricular strain in rats with pulmonary artery hypertension. Pulm. Circ. 8, 2045893217744504. https:\/\/doi.org\/10.1177\/2045893217744504 (2018).","DOI":"10.1177\/2045893217744504"},{"key":"50545_CR17","doi-asserted-by":"publisher","unstructured":"Yang, Y. et al. Long non-coding RNA expression profiling in the lungs of pulmonary arterial hypertension rats with acute inflammation. Pulm. Circ. 9, 2045894019879393. https:\/\/doi.org\/10.1177\/2045894019879393 (2019).","DOI":"10.1177\/2045894019879393"},{"key":"50545_CR18","doi-asserted-by":"publisher","unstructured":"Cao, Y. et al. Analyses of long non-coding RNA and mRNA profiles in right ventricle myocardium of acute right heart failure in pulmonary arterial hypertension rats. Biomed. Pharmacother. 106, 1108\u20131115. https:\/\/doi.org\/10.1016\/j.biopha.2018.07.057 (2018).","DOI":"10.1016\/j.biopha.2018.07.057"},{"key":"50545_CR19","doi-asserted-by":"publisher","unstructured":"Zahid, K. R., Raza, U., Chen, J., Raj, U. J. & Gou, D. Pathobiology of pulmonary artery hypertension: Role of long non-coding RNAs. Cardiovasc. Res. 116, 1937\u20131947. https:\/\/doi.org\/10.1093\/cvr\/cvaa050 (2020).","DOI":"10.1093\/cvr\/cvaa050"},{"key":"50545_CR20","doi-asserted-by":"publisher","unstructured":"Han, D., Gao, Q. & Cao, F. Long noncoding RNAs (LncRNAs) - The dawning of a new treatment for cardiac hypertrophy and heart failure. Biochim. Biophys. Acta (BBA) Mol. Basis Dis. 1863, 2078\u20132084. https:\/\/doi.org\/10.1016\/j.bbadis.2017.02.024 (2017).","DOI":"10.1016\/j.bbadis.2017.02.024"},{"key":"50545_CR21","doi-asserted-by":"publisher","unstructured":"Yang, Y. et al. Plasma MIR-212-3p as a biomarker for acute right heart failure with pulmonary artery hypertension. Ann. Transl. Med. 8, 1571. https:\/\/doi.org\/10.21037\/atm-20-1653a (2020).","DOI":"10.21037\/atm-20-1653a"},{"key":"50545_CR22","doi-asserted-by":"publisher","unstructured":"Klein, M. et al. Combined tyrosine and serine\/threonine kinase inhibition by sorafenib prevents progression of experimental pulmonary hypertension and myocardial remodeling. Circulation 118, 2081\u20132090. https:\/\/doi.org\/10.1161\/circulationaha.108.779751 (2008).","DOI":"10.1161\/circulationaha.108.779751"},{"key":"50545_CR23","doi-asserted-by":"publisher","unstructured":"Prasad, K. M., Xu, Y., Yang, Z., Acton, S. T. & French, B. A. Robust cardiomyocyte-specific gene expression following systemic injection of AAV: In vivo gene delivery follows a Poisson distribution. Gene Ther. 18, 43\u201352. https:\/\/doi.org\/10.1038\/gt.2010.105 (2011).","DOI":"10.1038\/gt.2010.105"},{"key":"50545_CR24","doi-asserted-by":"publisher","unstructured":"Werfel, S. et al. Rapid and highly efficient inducible cardiac gene knockout in adult mice using AAV-mediated expression of Cre recombinase. Cardiovasc. Res. 104, 15\u201323. https:\/\/doi.org\/10.1093\/cvr\/cvu174 (2014).","DOI":"10.1093\/cvr\/cvu174"},{"key":"50545_CR25","doi-asserted-by":"publisher","unstructured":"Shimauchi, T. et al. PARP1-PKM2 axis mediates right ventricular failure associated with pulmonary arterial hypertension. JACC. Basic Transl. Sci. 7, 384\u2013403. https:\/\/doi.org\/10.1016\/j.jacbts.2022.01.005 (2022).","DOI":"10.1016\/j.jacbts.2022.01.005"},{"key":"50545_CR26","doi-asserted-by":"publisher","unstructured":"Savale, L. et al. Acute decompensated pulmonary hypertension. Eur. Respir. Rev. 26, 170092. https:\/\/doi.org\/10.1183\/16000617.0092-2017 (2017).","DOI":"10.1183\/16000617.0092-2017"},{"key":"50545_CR27","doi-asserted-by":"publisher","unstructured":"Arici, M. et al. Selective SERCA2a activator as a candidate for chronic heart failure therapy. J. Transl. Med. 22, 77. https:\/\/doi.org\/10.1186\/s12967-024-04874-9 (2024).","DOI":"10.1186\/s12967-024-04874-9"},{"key":"50545_CR28","doi-asserted-by":"publisher","unstructured":"Khassafi, F. et al. Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension. Nat. Cardiovasc. Res. 2, 917\u2013936. https:\/\/doi.org\/10.1038\/s44161-023-00338-3 (2023).","DOI":"10.1038\/s44161-023-00338-3"},{"key":"50545_CR29","doi-asserted-by":"publisher","unstructured":"Lajoie, A. C. et al. Combination therapy versus monotherapy for pulmonary arterial hypertension: A meta-analysis. Lancet Respir. Med. 4, 291\u2013305. https:\/\/doi.org\/10.1016\/s2213-2600(16)00027-8 (2016).","DOI":"10.1016\/s2213-2600(16)00027-8"},{"key":"50545_CR30","doi-asserted-by":"publisher","unstructured":"Reddy, S. & Bernstein, D. Molecular mechanisms of right ventricular failure. Circulation 132, 1734\u20131742. https:\/\/doi.org\/10.1161\/circulationaha.114.012975 (2015).","DOI":"10.1161\/circulationaha.114.012975"},{"key":"50545_CR31","doi-asserted-by":"publisher","unstructured":"Guttman, M. & Rinn, J. L. Modular regulatory principles of large non-coding RNAs. Nature 482, 339\u2013346. https:\/\/doi.org\/10.1038\/nature10887 (2012).","DOI":"10.1038\/nature10887"},{"key":"50545_CR32","doi-asserted-by":"publisher","unstructured":"Li, J. et al. Long noncoding RNA NRON contributes to HIV-1 latency by specifically inducing tat protein degradation. Nat. Commun. 7, 11730. https:\/\/doi.org\/10.1038\/ncomms11730 (2016).","DOI":"10.1038\/ncomms11730"},{"key":"50545_CR33","doi-asserted-by":"publisher","unstructured":"Mongelli, A., Martelli, F., Farsetti, A. & Gaetano, C. The dark that matters: Long non-coding RNAs as master regulators of cellular metabolism in non-communicable diseases. Front. Physiol. 10, 369. https:\/\/doi.org\/10.3389\/fphys.2019.00369 (2019).","DOI":"10.3389\/fphys.2019.00369"},{"key":"50545_CR34","doi-asserted-by":"publisher","unstructured":"Du, H. et al. LncRNA DCRT protects against dilated cardiomyopathy by preventing NDUFS2 alternative splicing by binding to PTBP1. Circulation 150, 1030\u20131049. https:\/\/doi.org\/10.1161\/circulationaha.123.067861 (2024).","DOI":"10.1161\/circulationaha.123.067861"},{"key":"50545_CR35","doi-asserted-by":"publisher","unstructured":"Lee, R. G., Crosby, J., Baker, B. F., Graham, M. J. & Crooke, R. M. Antisense technology: An emerging platform for cardiovascular disease therapeutics. J. Cardiovasc. Transl. Res. 6, 969\u2013980. https:\/\/doi.org\/10.1007\/s12265-013-9495-7 (2013).","DOI":"10.1007\/s12265-013-9495-7"},{"key":"50545_CR36","doi-asserted-by":"publisher","unstructured":"Ma, C. et al. Super enhancer-associated circular RNA-CircKrt4 regulates hypoxic pulmonary artery endothelial cell dysfunction in mice. Arterioscler. Thromb. Vasc. Biol. 43, 1179\u20131198. https:\/\/doi.org\/10.1161\/atvbaha.122.318842 (2023).","DOI":"10.1161\/atvbaha.122.318842"},{"key":"50545_CR37","doi-asserted-by":"publisher","unstructured":"Chiao, Y. A. et al. Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice. Elifehttps:\/\/doi.org\/10.7554\/eLife.55513 (2020).","DOI":"10.7554\/eLife.55513"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-50545-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-50545-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-50545-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:57:38Z","timestamp":1782777458000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-50545-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,29]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["50545"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-50545-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,29]]},"assertion":[{"value":"26 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"19892"}}