{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T19:24:53Z","timestamp":1794079493666,"version":"4.8.0"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":63,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Sociedad Chilena de Nutrici\u00f3n and Consorcio Lechero","id":[{"id":"https:\/\/ror.org\/04j3qhq62","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["FONDECYT 11230186"],"award-info":[{"award-number":["FONDECYT 11230186"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["FONDECYT 1241959"],"award-info":[{"award-number":["FONDECYT 1241959"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fund for Research Centers in Priority Areas","award":["ACT210006"],"award-info":[{"award-number":["ACT210006"]}]},{"DOI":"10.13039\/501100018735","name":"Fondo de Financiamiento de Centros de Investigaci\u00f3n en \u00c1reas Prioritarias","doi-asserted-by":"publisher","award":["15150012"],"award-info":[{"award-number":["15150012"]}],"id":[{"id":"10.13039\/501100018735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018735","name":"Fondo de Financiamiento de Centros de Investigaci\u00f3n en \u00c1reas Prioritarias","doi-asserted-by":"publisher","award":["FONDAP-15150012"],"award-info":[{"award-number":["FONDAP-15150012"]}],"id":[{"id":"10.13039\/501100018735","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Financiamiento Basal para Centros Cient\u00edficos y Tecnol\u00f3gicos de Excelencia Centro Ciencia and Vida","award":["FB210008"],"award-info":[{"award-number":["FB210008"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-51209-3","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T20:27:59Z","timestamp":1779136079000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Protein yogurt and whey protein produce comparable muscle gains, but divergent microbiome shifts during strength training in older adults"],"prefix":"10.1038","volume":"16","author":[{"given":"Mat\u00edas","family":"Monsalves-\u00c1lvarez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Calder\u00f3n-Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hayes-Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sof\u00eda","family":"Bobadilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio P\u00e9rez","family":"de Tudela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yildy","family":"Utreras-Mendoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Badir","family":"Zara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Sep\u00falveda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Troncoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Correa-Burrows","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gonz\u00e1lez-Billault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe A","family":"Court","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Flores-Opazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denisse","family":"Valladares-Ide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"issue":"12","key":"51209_CR1","doi-asserted-by":"publisher","first-page":"M716","DOI":"10.1093\/gerona\/55.12.M716","volume":"55","author":"R Roubenoff","year":"2000","unstructured":"Roubenoff, R. & Hughes, V. A. Sarcopenia: Current concepts. J. Gerontol. A Biol. Sci. Med. Sci. 55(12), M716-24. https:\/\/doi.org\/10.1093\/gerona\/55.12.M716 (2000).","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"3","key":"51209_CR2","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1096\/fj.04-2640fje","volume":"19","author":"D Cuthbertson","year":"2005","unstructured":"Cuthbertson, D. et al. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB J. 19(3), 422\u20134. https:\/\/doi.org\/10.1096\/fj.04-2640fje (2005).","journal-title":"FASEB J."},{"issue":"7","key":"51209_CR3","doi-asserted-by":"publisher","first-page":"R561","DOI":"10.1152\/ajpregu.00198.2015","volume":"310","author":"DA Rivas","year":"2016","unstructured":"Rivas, D. A. et al. Diminished anabolic signaling response to insulin induced by intramuscular lipid accumulation is associated with inflammation in aging but not obesity. Am. J. Physiol. Regul. Integr. Comp. Physiol. 310(7), R561-9. https:\/\/doi.org\/10.1152\/ajpregu.00198.2015 (2016).","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"7","key":"51209_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/nu11071633","volume":"11","author":"A Ticinesi","year":"2019","unstructured":"Ticinesi, A. et al. Gut microbiota, muscle mass and function in aging: A focus on physical frailty and sarcopenia. Nutrients 11(7), 7. https:\/\/doi.org\/10.3390\/nu11071633 (2019).","journal-title":"Nutrients"},{"issue":"11","key":"51209_CR5","doi-asserted-by":"publisher","first-page":"2751","DOI":"10.1113\/jphysiol.2012.228833","volume":"590","author":"TA Churchward-Venne","year":"2012","unstructured":"Churchward-Venne, T. A. et al. Supplementation of a suboptimal protein dose with leucine or essential amino acids: Effects on myofibrillar protein synthesis at rest and following resistance exercise in men. J. Physiol. 590(11), 2751\u201365. https:\/\/doi.org\/10.1113\/jphysiol.2012.228833 (2012).","journal-title":"J. Physiol."},{"key":"51209_CR6","doi-asserted-by":"publisher","unstructured":"Sedentary behaviour, physical activity, and sarcopenia among older adults in the TSHA: isotemporal substitution model - S\u00e1nchez-S\u00e1nchez\u2009\u2013\u20092019 - Journal of Cachexia, Sarcopenia and Muscle - Wiley Online Library [Internet]. [citado 26 de febrero de 2025]. Disponible en: https:\/\/onlinelibrary.wiley.com\/doi\/full\/https:\/\/doi.org\/10.1002\/jcsm.12369","DOI":"10.1002\/jcsm.12369"},{"issue":"6","key":"51209_CR7","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1136\/bjsports-2017-098970","volume":"54","author":"RE Ashton","year":"2020","unstructured":"Ashton, R. E. et al. Effects of short-term, medium-term and long-term resistance exercise training on cardiometabolic health outcomes in adults: Systematic review with meta-analysis. Br. J. Sports Med. 54(6), 341\u20138. https:\/\/doi.org\/10.1136\/bjsports-2017-098970 (2020).","journal-title":"Br. J. Sports Med."},{"key":"51209_CR8","doi-asserted-by":"crossref","unstructured":"Marzuca-Nassr, G. N. et al. Muscle Mass and Strength Gains Following Resistance Exercise Training in Older Adults 65\u201375 Years and Older Adults Above 85 Years [Internet]. 24 de octubre de 2023 [citado 26 de febrero de 2025]. Disponible en: https:\/\/journals.humankinetics.com\/view\/journals\/ijsnem\/34\/1\/article-p11.xml","DOI":"10.1123\/ijsnem.2023-0087"},{"issue":"8","key":"51209_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10081630","volume":"10","author":"K Talar","year":"2021","unstructured":"Talar, K. et al. Benefits of resistance training in early and late stages of frailty and sarcopenia: A systematic review and meta-analysis of randomized controlled studies. J. Clin. Med. 10(8), 8. https:\/\/doi.org\/10.3390\/jcm10081630 (2021).","journal-title":"J. Clin. Med."},{"key":"51209_CR10","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.exger.2017.08.011","volume":"97","author":"PRP Nunes","year":"2017","unstructured":"Nunes, P. R. P., Oliveira, A. A., Martins, F. M., Souza, A. P. & Orsatti, F. L. Effect of resistance training volume on walking speed performance in postmenopausal women: A randomized controlled trial. Exp. Gerontol. 97, 80\u20138. https:\/\/doi.org\/10.1016\/j.exger.2017.08.011 (2017).","journal-title":"Exp. Gerontol."},{"issue":"8","key":"51209_CR11","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1007\/s40520-017-0863-z","volume":"30","author":"P Lopez","year":"2018","unstructured":"Lopez, P. et al. Benefits of resistance training in physically frail elderly: A systematic review. Aging Clin. Exp. Res. 30(8), 889\u201399. https:\/\/doi.org\/10.1007\/s40520-017-0863-z (2018).","journal-title":"Aging Clin. Exp. Res."},{"issue":"1","key":"51209_CR12","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jamda.2018.09.011","volume":"20","author":"S Vikberg","year":"2019","unstructured":"Vikberg, S. et al. Effects of resistance training on functional strength and muscle mass in 70-year-old individuals with pre-sarcopenia: A randomized controlled trial. J. Am. Med. Dir. Assoc. 20(1), 28\u201334. https:\/\/doi.org\/10.1016\/j.jamda.2018.09.011 (2019).","journal-title":"J. Am. Med. Dir. Assoc."},{"issue":"1","key":"51209_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.advnut.2024.100347","volume":"16","author":"JW Carbone","year":"2025","unstructured":"Carbone, J. W., Phillips, S. M., Weaver, C. M., Hughes, J. M. & Pasiakos, S. M. Exploring opportunities to better characterize the effects of dietary protein on health across the lifespan. Adv. Nutr. 16(1), 100347. https:\/\/doi.org\/10.1016\/j.advnut.2024.100347 (2025).","journal-title":"Adv. Nutr."},{"issue":"12","key":"51209_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/nu12123704","volume":"12","author":"SR Hertzler","year":"2020","unstructured":"Hertzler, S. R., Lieblein-Boff, J. C., Weiler, M. & Allgeier, C. Plant proteins: Assessing their nutritional quality and effects on health and physical function. Nutrients 12(12), E3704. https:\/\/doi.org\/10.3390\/nu12123704 (2020).","journal-title":"Nutrients"},{"key":"51209_CR15","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1159\/000382000","volume":"82","author":"DR Moore","year":"2015","unstructured":"Moore, D. R. & Soeters, P. B. The Biological Value of Protein. Nestle Nutr. Inst. Workshop Ser. 82, 39\u201351 (2015).","journal-title":"Nestle Nutr. Inst. Workshop Ser."},{"key":"51209_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjnut.2025.07.005","author":"JJ Matthews","year":"2025","unstructured":"Matthews, J. J. et al. Understanding dietary protein quality: Digestible indispensable amino acid scores and beyond. J. Nutr. https:\/\/doi.org\/10.1016\/j.tjnut.2025.07.005 (2025).","journal-title":"J. Nutr."},{"issue":"9","key":"51209_CR17","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.3945\/jn.114.204305","volume":"145","author":"S van Vliet","year":"2015","unstructured":"van Vliet, S., Burd, N. A. & van Loon, L. J. The skeletal muscle anabolic response to plant- versus animal-based protein consumption. J. Nutr. 145(9), 1981\u201391. https:\/\/doi.org\/10.3945\/jn.114.204305 (2015).","journal-title":"J. Nutr."},{"issue":"1","key":"51209_CR18","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1177\/0884533617724759","volume":"33","author":"P Savino","year":"2018","unstructured":"Savino, P. Knowledge of constituent ingredients in enteral nutrition formulas can make a difference in patient response to enteral feeding. Nutr. Clin. Pract. 33(1), 90\u20138. https:\/\/doi.org\/10.1177\/0884533617724759 (2018).","journal-title":"Nutr. Clin. Pract."},{"issue":"2","key":"51209_CR19","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1080\/07315724.2013.875365","volume":"33","author":"PE Miller","year":"2014","unstructured":"Miller, P. E., Alexander, D. D. & Perez, V. Effects of whey protein and resistance exercise on body composition: A meta-analysis of randomized controlled trials. J. Am. Coll. Nutr. 33(2), 163\u201375. https:\/\/doi.org\/10.1080\/07315724.2013.875365 (2014).","journal-title":"J. Am. Coll. Nutr."},{"issue":"26","key":"51209_CR20","doi-asserted-by":"publisher","first-page":"14930","DOI":"10.1073\/pnas.94.26.14930","volume":"94","author":"Y Boirie","year":"1997","unstructured":"Boirie, Y. et al. Slow and fast dietary proteins differently modulate postprandial protein accretion. Proc. Natl. Acad. Sci. U. S. A. 94(26), 14930\u20135. https:\/\/doi.org\/10.1073\/pnas.94.26.14930 (1997).","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"51209_CR21","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1080\/15502783.2022.2090828","volume":"19","author":"A Zapata-Muriel","year":"2022","unstructured":"Zapata-Muriel, A., Echeverry, P., Van Dusseldorp, T. A., Kurtz, J. & Monsalves-Alvarez, M. Measured versus label declared macronutrient and calorie content in Colombian commercially available whey proteins. J. Int. Soc. Sports Nutr. 19(1), 258\u201366. https:\/\/doi.org\/10.1080\/15502783.2022.2090828 (2022).","journal-title":"J. Int. Soc. Sports Nutr."},{"issue":"3","key":"51209_CR22","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3109\/19390211.2015.1036187","volume":"13","author":"CC Almeida","year":"2016","unstructured":"Almeida, C. C., Alvares, T. S., Costa, M. P. & Conte-Junior, C. A. Protein and amino acid profiles of different whey protein supplements. J. Diet. Suppl. 13(3), 313\u2013323. https:\/\/doi.org\/10.3109\/19390211.2015.1036187 (2016).","journal-title":"J. Diet. Suppl."},{"issue":"1","key":"51209_CR23","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s40279-018-1009-y","volume":"49","author":"NA Burd","year":"2019","unstructured":"Burd, N. A., Beals, J. W., Martinez, I. G., Salvador, A. F. & Skinner, S. K. Food-first approach to enhance the regulation of post-exercise skeletal muscle protein synthesis and remodeling. Sports Med. 49(1), 59\u201368. https:\/\/doi.org\/10.1007\/s40279-018-1009-y (2019).","journal-title":"Sports Med."},{"key":"51209_CR24","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3389\/fnut.2019.00055","volume":"6","author":"A Bridge","year":"2019","unstructured":"Bridge, A. et al. Greek yogurt and 12 weeks of exercise training on strength, muscle thickness and body composition in lean, untrained, university-aged males. Front. Nutr. 6, 55. https:\/\/doi.org\/10.3389\/fnut.2019.00055 (2019).","journal-title":"Front. Nutr."},{"issue":"9","key":"51209_CR25","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1017\/S0007114521002166","volume":"127","author":"R Bagheri","year":"2022","unstructured":"Bagheri, R. et al. Effects of Icelandic yogurt consumption and resistance training in healthy untrained older males. Br. J. Nutr. 127(9), 1334\u201342. https:\/\/doi.org\/10.1017\/S0007114521002166 (2022).","journal-title":"Br. J. Nutr."},{"key":"51209_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2020.126419","volume":"317","author":"HTH Nguyen","year":"2020","unstructured":"Nguyen, H. T. H., Gathercole, J. L., Day, L. & Dalziel, J. E. Differences in peptide generation following in vitro gastrointestinal digestion of yogurt and milk from cow, sheep and goat. Food Chem. 317, 126419. https:\/\/doi.org\/10.1016\/j.foodchem.2020.126419 (2020).","journal-title":"Food Chem."},{"issue":"1","key":"51209_CR27","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2020.1799533","volume":"12","author":"H Aslam","year":"2020","unstructured":"Aslam, H. et al. The effects of dairy and dairy derivatives on the gut microbiota: A systematic literature review. Gut Microbes 12(1), 1799533. https:\/\/doi.org\/10.1080\/19490976.2020.1799533 (2020).","journal-title":"Gut Microbes"},{"issue":"1","key":"51209_CR28","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms5010006","volume":"5","author":"DJ Lisko","year":"2017","unstructured":"Lisko, D. J., Johnston, G. P. & Johnston, C. G. Effects of dietary yogurt on the healthy human gastrointestinal (GI) microbiome. Microorganisms 5(1), 6. https:\/\/doi.org\/10.3390\/microorganisms5010006 (2017).","journal-title":"Microorganisms"},{"key":"51209_CR29","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.jnutbio.2017.08.014","volume":"51","author":"M Masarwi","year":"2018","unstructured":"Masarwi, M. et al. Food restriction followed by refeeding with a casein- or whey-based diet differentially affects the gut microbiota of pre-pubertal male rats. J. Nutr. Biochem. 51, 27\u201339. https:\/\/doi.org\/10.1016\/j.jnutbio.2017.08.014 (2018).","journal-title":"J. Nutr. Biochem."},{"issue":"17","key":"51209_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/foods11172691","volume":"11","author":"E Hadjimbei","year":"2022","unstructured":"Hadjimbei, E., Botsaris, G. & Chrysostomou, S. Beneficial effects of yoghurts and probiotic fermented milks and their functional food potential. Foods 11(17), 17. https:\/\/doi.org\/10.3390\/foods11172691 (2022).","journal-title":"Foods"},{"issue":"5","key":"51209_CR31","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.20960\/nh.03632","volume":"38","author":"AG Behrmann","year":"2021","unstructured":"Behrmann, A. G. et al. Etiquetado nutricional y perfil de amino\u00e1cidos en l\u00e1cteos chilenos altos en prote\u00edna: nueva alternativa para la salud y el deporte. Nutr. Hosp. 38(5), 1075\u201381. https:\/\/doi.org\/10.20960\/nh.03632 (2021).","journal-title":"Nutr. Hosp."},{"issue":"3","key":"51209_CR32","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.numecd.2018.11.007","volume":"29","author":"HCG Nabuco","year":"2019","unstructured":"Nabuco, H. C. G. et al. Effects of pre- or post-exercise whey protein supplementation on body fat and metabolic and inflammatory profile in pre-conditioned older women: A randomized, double-blind, placebo-controlled trial. Nutr. Metab. Cardiovasc. Dis. 29(3), 290\u2013300. https:\/\/doi.org\/10.1016\/j.numecd.2018.11.007 (2019).","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"issue":"8","key":"51209_CR33","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1519\/JSC.0000000000003230","volume":"33","author":"MS Fragala","year":"2019","unstructured":"Fragala, M. S. et al. Resistance training for older adults: Position statement from the National Strength and Conditioning Association. J. Strength Cond. Res. 33(8), 2019\u201352. https:\/\/doi.org\/10.1519\/JSC.0000000000003230 (2019).","journal-title":"J. Strength Cond. Res."},{"issue":"11","key":"51209_CR34","doi-asserted-by":"publisher","first-page":"2955","DOI":"10.1519\/JSC.0000000000002089","volume":"31","author":"S Henr\u00edquez","year":"2017","unstructured":"Henr\u00edquez, S. et al. Effects of two training modalities on body fat and insulin resistance in postmenopausal women. J. Strength Cond. Res. 31(11), 2955\u201364. https:\/\/doi.org\/10.1519\/JSC.0000000000002089 (2017).","journal-title":"J. Strength Cond. Res."},{"key":"51209_CR35","unstructured":"Evidence Analysis Library Review of Best Practices for Performing Indirect Calorimetry in Healthy. and Non\u2013Critically Ill Individuals - ScienceDirect [Internet]. [citado 24 de julio de 2024]. Disponible en: https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2212267215003949"},{"issue":"1","key":"51209_CR36","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-022-03293-z","volume":"22","author":"JH Sung","year":"2022","unstructured":"Sung, J. H., Son, S. R., Baek, S. H. & Kim, B. J. The association of aerobic, resistance, and combined exercises with the handgrip strength of middle-aged and elderly Korean adults: A nationwide cross-sectional study. BMC Geriatr. 22(1), 676. https:\/\/doi.org\/10.1186\/s12877-022-03293-z (2022).","journal-title":"BMC Geriatr."},{"key":"51209_CR37","doi-asserted-by":"publisher","DOI":"10.53520\/jen2022.103123","author":"J Perez","year":"2022","unstructured":"Perez, J. et al. Training and Nutritional Habits Before and During COVID-19 Quarantine on Physically Active Women. J. Exerc. Nutr. 22 de abril de https:\/\/doi.org\/10.53520\/jen2022.103123 (2022).","journal-title":"J. Exerc. Nutr. 22 de abril de"},{"key":"51209_CR38","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00850","author":"TL Burrows","year":"2019","unstructured":"Burrows, T. L., Ho, Y. Y., Rollo, M. E. & Collins, C. E. Validity of dietary assessment methods when compared to the method of doubly labeled water: A systematic review in adults. Front. Endocrinol. https:\/\/doi.org\/10.3389\/fendo.2019.00850 (2019).","journal-title":"Front. Endocrinol."},{"key":"51209_CR39","unstructured":"Cerda, R., Barrera, C., Arena, M., Bascu\u00f1\u00e1n, K. & Jimenez, G. Atlas fotogr\u00e1fico de alimentos y preparaciones t\u00edpicas chilenas. Encuesta Nac. Consumo Aliment. ;143. (2010)."},{"issue":"1","key":"51209_CR40","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s13102-020-00178-9","volume":"12","author":"PP Abdalla","year":"2020","unstructured":"Abdalla, P. P. et al. One-repetition submaximal protocol to measure knee extensor muscle strength among older adults with and without sarcopenia: A validation study. BMC Sports Sci. Med. Rehabil. 12(1), 29. https:\/\/doi.org\/10.1186\/s13102-020-00178-9 (2020).","journal-title":"BMC Sports Sci. Med. Rehabil."},{"issue":"1","key":"51209_CR41","first-page":"152","volume":"19","author":"R Sim\u00e3o","year":"2005","unstructured":"Sim\u00e3o, R., Farinatti, P., Polito, M. D., Maior, A. S. & Fleck, S. J. Influence of exercise order on the number of repetitions performed and perceived exertion during resistance exercises. J. Strength Cond. Res. 19(1), 152\u20136 (2005).","journal-title":"J. Strength Cond. Res."},{"issue":"3","key":"51209_CR42","first-page":"242","volume":"13","author":"KM Knutzen","year":"1999","unstructured":"Knutzen, K. M., Brilla, L. R. & Caine, D. Validity of 1RM Prediction Equations for Older Adults. J. Strength. Cond Res. agosto de. 13 (3), 242 (1999).","journal-title":"J. Strength. Cond Res. agosto de"},{"issue":"3","key":"51209_CR43","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1002\/jcsm.12181","volume":"8","author":"EM Reijnierse","year":"2017","unstructured":"Reijnierse, E. M. et al. Assessment of maximal handgrip strength: How many attempts are needed?. J. Cachexia Sarcopenia Muscle 8(3), 466\u201374. https:\/\/doi.org\/10.1002\/jcsm.12181 (2017).","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"51209_CR44","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.archger.2017.02.007","volume":"70","author":"GA Maranhao Neto","year":"2017","unstructured":"Maranhao Neto, G. A. et al. Normalizing handgrip strength in older adults: An allometric approach. Arch. Gerontol. Geriatr. 70, 230\u20134. https:\/\/doi.org\/10.1016\/j.archger.2017.02.007 (2017).","journal-title":"Arch. Gerontol. Geriatr."},{"issue":"3","key":"51209_CR45","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s40520-019-01220-8","volume":"32","author":"O Dokuzlar","year":"2020","unstructured":"Dokuzlar, O. et al. Assessment of factors that increase risk of falling in older women by four different clinical methods. Aging Clin. Exp. Res. 32(3), 483\u201390. https:\/\/doi.org\/10.1007\/s40520-019-01220-8 (2020).","journal-title":"Aging Clin. Exp. Res."},{"issue":"1","key":"51209_CR46","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-022-03032-4","volume":"22","author":"P Correa-Burrows","year":"2022","unstructured":"Correa-Burrows, P. et al. Multiple events case\u2013control study in a prospective cohort to identify systemic, cellular, and molecular biomarkers of obesity-induced accelerated aging in 30-years-olds: The ObAGE study protocol. BMC Geriatr. 22(1), 387. https:\/\/doi.org\/10.1186\/s12877-022-03032-4 (2022).","journal-title":"BMC Geriatr."},{"issue":"1","key":"51209_CR47","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28(1), 27\u201330. https:\/\/doi.org\/10.1093\/nar\/28.1.27 (2000).","journal-title":"Nucleic Acids Res."},{"key":"51209_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2023.105182","volume":"117","author":"A Silva","year":"2024","unstructured":"Silva, A. et al. Progressive strength training can reverse sarcopenia stage in middle-aged and older adults regardless of their genetic profile. Arch. Gerontol. Geriatr. 117, 105182. https:\/\/doi.org\/10.1016\/j.archger.2023.105182 (2024).","journal-title":"Arch. Gerontol. Geriatr."},{"issue":"1","key":"51209_CR49","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-79958-z","volume":"14","author":"F Cheng","year":"2024","unstructured":"Cheng, F. et al. The effect of resistance training on patients with secondary sarcopenia: A systematic review and meta-analysis. Sci. Rep. 14(1), 1. https:\/\/doi.org\/10.1038\/s41598-024-79958-z (2024).","journal-title":"Sci. Rep."},{"key":"51209_CR50","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.759677","volume":"12","author":"DA de Santana","year":"2021","unstructured":"de Santana, D. A., Castro, A. & Cavaglieri, C. R. Strength training volume to increase muscle mass responsiveness in older individuals: Weekly sets based approach. Front. Physiol. 12, 759677. https:\/\/doi.org\/10.3389\/fphys.2021.759677 (2021).","journal-title":"Front. Physiol."},{"issue":"3","key":"51209_CR51","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s12603-018-1151-0","volume":"23","author":"M Yamada","year":"2019","unstructured":"Yamada, M. et al. Phase angle is a useful indicator for muscle function in older adults. J. Nutr. Health Aging 23(3), 251\u20135. https:\/\/doi.org\/10.1007\/s12603-018-1151-0 (2019).","journal-title":"J. Nutr. Health Aging"},{"issue":"6","key":"51209_CR52","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1007\/s41999-022-00706-5","volume":"13","author":"PM Cawthon","year":"2022","unstructured":"Cawthon, P. M. et al. Defining terms commonly used in sarcopenia research: A glossary proposed by the Global Leadership in Sarcopenia (GLIS) Steering Committee. Eur. Geriatr. Med. 13(6), 1239\u201344. https:\/\/doi.org\/10.1007\/s41999-022-00706-5 (2022).","journal-title":"Eur. Geriatr. Med."},{"issue":"6","key":"51209_CR53","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1016\/j.clnu.2022.04.026","volume":"41","author":"LCC Lopes","year":"2022","unstructured":"Lopes, L. C. C. et al. Sex and population-specific cutoff values of muscle quality index: Results from NHANES 2011\u20132014. Clin Nutr 41(6), 1328\u201334. https:\/\/doi.org\/10.1016\/j.clnu.2022.04.026 (2022).","journal-title":"Clin Nutr"},{"key":"51209_CR54","unstructured":"Pre- versus. post-exercise protein intake has similar effects on muscular adaptations [PeerJ] [Internet]. [citado 30 de abril de 2025]. Disponible en: https:\/\/peerj.com\/articles\/2825\/?fbclid=IwAR3n0u8bEK4HPqYdfXhdR7Uu-O7yILCLGZZwGLnHKlZz48INmg-pgenZXJE"},{"issue":"1","key":"51209_CR55","doi-asserted-by":"publisher","DOI":"10.1186\/s12970-018-0228-9","volume":"15","author":"JM Joy","year":"2018","unstructured":"Joy, J. M. et al. Daytime and nighttime casein supplements similarly increase muscle size and strength in response to resistance training earlier in the day: A preliminary investigation. J. Int. Soc. Sports Nutr. 15(1), 24. https:\/\/doi.org\/10.1186\/s12970-018-0228-9 (2018).","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"51209_CR56","doi-asserted-by":"publisher","DOI":"10.20960\/nh.03632","author":"A Glaves Berhmann","year":"2021","unstructured":"Glaves Berhmann, A., G\u00f3mez-L\u00f3pez, J. & Monsalves \u00c1lvarez, M. Nutritional labeling and amino acid profile in high protein Chilean dairy products: a new alternative for health and sports. Nutr Hosp. https:\/\/doi.org\/10.20960\/nh.03632 (2021) (PubMed PMID: 34044575.).","journal-title":"Nutr Hosp."},{"issue":"4","key":"51209_CR57","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1080\/07315724.2009.10718096","volume":"28","author":"SM Phillips","year":"2009","unstructured":"Phillips, S. M., Tang, J. E. & Moore, D. R. The role of milk- and soy-based protein in support of muscle protein synthesis and muscle protein accretion in young and elderly persons. J. Am. Coll. Nutr. 28(4), 343\u201354. https:\/\/doi.org\/10.1080\/07315724.2009.10718096 (2009).","journal-title":"J. Am. Coll. Nutr."},{"issue":"5","key":"51209_CR58","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1093\/ajcn\/nqy214","volume":"108","author":"Y Park","year":"2018","unstructured":"Park, Y., Choi, J. E. & Hwang, H. S. Protein supplementation improves muscle mass and physical performance in undernourished prefrail and frail elderly subjects: A randomized, double-blind, placebo-controlled trial. Am. J. Clin. Nutr. 108(5), 1026\u201333. https:\/\/doi.org\/10.1093\/ajcn\/nqy214 (2018).","journal-title":"Am. J. Clin. Nutr."},{"issue":"3","key":"51209_CR59","doi-asserted-by":"publisher","DOI":"10.3390\/dairy5030034","volume":"5","author":"EC Pappa","year":"2024","unstructured":"Pappa, E. C. et al. Physicochemical characteristics of commercially available Greek yoghurts. Dairy 5(3), 3. https:\/\/doi.org\/10.3390\/dairy5030034 (2024).","journal-title":"Dairy"},{"key":"51209_CR60","doi-asserted-by":"publisher","DOI":"10.5601\/jelem.2023.28.4.2398","author":"T Daszkiewicz","year":"2023","unstructured":"Daszkiewicz, T. & Ankiewicz, W. A comparison of the quality of plain yogurt and icelandic yogurt (skyr). J. Elem. https:\/\/doi.org\/10.5601\/jelem.2023.28.4.2398 (2023).","journal-title":"J. Elem."},{"key":"51209_CR61","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.cofs.2020.02.003","volume":"32","author":"B Chugh","year":"2020","unstructured":"Chugh, B. & Kamal-Eldin, A. Bioactive compounds produced by probiotics in food products. Curr. Opin. Food Sci. 32, 76\u201382. https:\/\/doi.org\/10.1016\/j.cofs.2020.02.003 (2020).","journal-title":"Curr. Opin. Food Sci."},{"issue":"1","key":"51209_CR62","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-84031-0","volume":"11","author":"L Kang","year":"2021","unstructured":"Kang, L. et al. Alterations in intestinal microbiota diversity, composition, and function in patients with sarcopenia. Sci. Rep. 11(1), 4628. https:\/\/doi.org\/10.1038\/s41598-021-84031-0 (2021).","journal-title":"Sci. Rep."},{"key":"51209_CR63","doi-asserted-by":"publisher","unstructured":"The Firmicutes\/Bacteroidetes. ratio of the human microbiota changes with age | BMC Microbiology | Full Text [Internet]. [citado 2 de mayo de 2025]. Disponible en: https:\/\/bmcmicrobiol.biomedcentral.com\/articles\/https:\/\/doi.org\/10.1186\/1471-2180-9-123","DOI":"10.1186\/1471-2180-9-123"},{"issue":"6","key":"51209_CR64","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1111\/acel.12387","volume":"14","author":"ME Walsh","year":"2015","unstructured":"Walsh, M. E. et al. The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging. Aging Cell 14(6), 957\u201370. https:\/\/doi.org\/10.1111\/acel.12387 (2015).","journal-title":"Aging Cell"},{"key":"51209_CR65","doi-asserted-by":"crossref","unstructured":"Differential Adaptation of Human Gut. Microbiota to Bariatric Surgery\u2013Induced Weight Loss | Diabetes | American Diabetes Association [Internet]. [citado 2 de mayo de 2025]. Disponible en: https:\/\/diabetesjournals.org\/diabetes\/article\/59\/12\/3049\/26331\/Differential-Adaptation-of-Human-Gut-Microbiota-to","DOI":"10.2337\/db10-0253"},{"issue":"7122","key":"51209_CR66","doi-asserted-by":"publisher","first-page":"1022a","DOI":"10.1038\/4441022aa","volume":"444","author":"RE Ley","year":"2006","unstructured":"Ley, R. E., Turnbaugh, P. J., Klein, S. & Gordon, J. I. Human gut microbes associated with obesity. Nature 444(7122), 1022a\u20133. https:\/\/doi.org\/10.1038\/4441022aa (2006).","journal-title":"Nature"},{"issue":"3","key":"51209_CR67","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1123\/ijsnem.2018-0024","volume":"29","author":"RP Durk","year":"2019","unstructured":"Durk, R. P. et al. Gut microbiota composition is related to cardiorespiratory fitness in healthy young adults. Int. J. Sport Nutr. Exerc. Metab. 29(3), 249\u201353. https:\/\/doi.org\/10.1123\/ijsnem.2018-0024 (2019).","journal-title":"Int. J. Sport Nutr. Exerc. Metab."},{"key":"51209_CR68","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2024.1343219","author":"R Duan","year":"2024","unstructured":"Duan, R. et al. The impact of exercise on the gut microbiota in middle-aged amateur serious runners: A comparative study. Front. Physiol. https:\/\/doi.org\/10.3389\/fphys.2024.1343219 (2024).","journal-title":"Front. Physiol."},{"issue":"1","key":"51209_CR69","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-71684-w","volume":"14","author":"S Urban","year":"2024","unstructured":"Urban, S., Chmura, O., W\u0105tor, J., Panek, P. & Zapa\u0142a, B. The intensive physical activity causes changes in the composition of gut and oral microbiota. Sci. Rep. 14(1), 20858. https:\/\/doi.org\/10.1038\/s41598-024-71684-w (2024).","journal-title":"Sci. Rep."},{"key":"51209_CR70","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.01047","volume":"8","author":"L Madsen","year":"2017","unstructured":"Madsen, L., Myrmel, L. S., Fj\u00e6re, E., Liaset, B. & Kristiansen, K. Links between dietary protein sources, the gut microbiota, and obesity. Front. Physiol. 8, 1047. https:\/\/doi.org\/10.3389\/fphys.2017.01047 (2017).","journal-title":"Front. Physiol."},{"key":"51209_CR71","doi-asserted-by":"crossref","unstructured":"Milk and resistance exercise intervention to improve muscle function in community-dwelling older adults at risk of sarcopenia (MIlkMAN): protocol for a pilot study | BMJ Open [Internet]. [citado 30 de abril de 2025]. Disponible en: https:\/\/bmjopen.bmj.com\/content\/9\/10\/e031048","DOI":"10.1136\/bmjopen-2019-031048"},{"key":"51209_CR72","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00398","author":"S Verdi","year":"2018","unstructured":"Verdi, S. et al. An investigation into physical frailty as a link between the gut microbiome and cognitive health. Front. Aging Neurosci. https:\/\/doi.org\/10.3389\/fnagi.2018.00398 (2018).","journal-title":"Front. Aging Neurosci."},{"issue":"1","key":"51209_CR73","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-016-0262-7","volume":"8","author":"MA Jackson","year":"2016","unstructured":"Jackson, M. A. et al. Signatures of early frailty in the gut microbiota. Genome Med. 8(1), 8. https:\/\/doi.org\/10.1186\/s13073-016-0262-7 (2016).","journal-title":"Genome Med."},{"key":"51209_CR74","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-025-01605-w","author":"C Ramos","year":"2025","unstructured":"Ramos, C. et al. Assessing the gut microbiota composition in older adults: Connections to physical activity and healthy ageing. GeroScience https:\/\/doi.org\/10.1007\/s11357-025-01605-w (2025).","journal-title":"GeroScience"},{"issue":"3","key":"51209_CR75","doi-asserted-by":"publisher","first-page":"219","DOI":"10.11005\/jbm.2024.31.3.219","volume":"31","author":"YC Ha","year":"2024","unstructured":"Ha, Y. C., Kim, S. & Yoo, J. I. Open, active-controlled clinical study to evaluate the correlation between whole body DEXA and BIA muscle measurements. J. Bone Metab. 31(3), 219\u201327. https:\/\/doi.org\/10.11005\/jbm.2024.31.3.219 (2024).","journal-title":"J. Bone Metab."}],"updated-by":[{"DOI":"10.1038\/s41598-026-79071-3","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:00:00Z","timestamp":1793750400000}}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-51209-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-51209-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-51209-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T19:03:11Z","timestamp":1794078191000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-51209-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,18]]},"references-count":75,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["51209"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-51209-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-8098210\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,18]]},"assertion":[{"value":"12 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2026","order":6,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":7,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41598-026-79071-3","URL":"https:\/\/doi.org\/10.1038\/s41598-026-79071-3","order":9,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"22592"}}