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To address this, we developed a daily replaceable chitosan\u2013hyaluronic acid (CS\u2013HA) bandage contact lens co-loaded with levofloxacin and betamethasone using a soaking-based drug-loading approach. In a rabbit 8-mm mechanical corneal debridement model (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200915\/group), the dual-drug CS\u2013HA lens was compared with a chitosan-only drug-loaded lens, a commercial silicone-hydrogel bandage lens plus drops, and drops alone. The CS\u2013HA lens maintained adequate optical transparency, water content, and oxygen permeability suitable for short-term wear. In vitro assays showed that the dual-drug CS\u2013HA lens retained antibacterial inhibitory activity in agar diffusion tests and reduced TNF-\u03b1 secretion in an LPS-stimulated THP-1 assay. Re-epithelialization was significantly faster with the CS\u2013HA lens, achieving complete closure at a median of 3 days versus 5, 6, and 8 days in the respective control groups. Day-10 histology showed a well-stratified epithelium with no evidence of stromal inflammatory infiltration in the CS\u2013HA group, whereas controls exhibited greater stromal disorganization. This biocompatible dual-drug platform may accelerate ocular surface restoration and reduce reliance on frequent topical dosing in settings such as post-refractive surgery care and persistent epithelial defects.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-51386-1","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:58:33Z","timestamp":1778155113000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A dual-drug chitosan\u2013hyaluronic acid bandage contact lens accelerates corneal re-epithelialization in a rabbit mechanical debridement model"],"prefix":"10.1038","volume":"16","author":[{"given":"Mohamadreza","family":"Aghamirsalim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erfan","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood","family":"Jabbarvand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farshad","family":"Famildardashti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzad","family":"Famildardashti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1832-1094","authenticated-orcid":false,"given":"Alireza","family":"Sahraian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"51386_CR1","doi-asserted-by":"crossref","unstructured":"Ong, J., Thanitcul, C., Fotovat-Ahmadi, N., Reinhardt, C. & Aakalu, V. 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