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Seventy\u2011five patients with long\u2011COVID symptoms completed a six\u2011week programme comprising three weekly outpatient sessions. Participants were randomly assigned to two groups following an identical comprehensive protocol, incorporating aerobic training, respiratory exercises, strength and general fitness training, stretching, and respiratory resistance training with a respiratory muscle trainer, with the control group receiving placebo IMT. The study evaluated the programme\u2019s effectiveness by assessing respiratory function (spirometry, muscle strength, chest expansion, and DTF), voice and speech quality, and symptom persistence. The six-month follow-up analysis demonstrated statistically significant retention of improvements in functional and qualitative parameters compared with post-rehabilitation values, with further gains relative to baseline. Our findings indicate that the multi\u2011component rehabilitation programme is broadly beneficial, with the greatest functional gains in patients with lower baseline capacity, while offering equitable, low\u2011cost support across age and sex groups and enabling targeted allocation of intensive monitoring to those with the highest potential for clinically meaningful improvement. The study is the first comprehensive analysis of the relationship between long\u2011COVID and voice and speech\u2011related disabilities, while also validating the clinical efficacy of the intervention.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Clinical trials registration<\/jats:bold>\n                    : NCT05449379; 08\/07\/2022.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-51787-2","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T09:13:51Z","timestamp":1777972431000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of comprehensive rehabilitation for functional recovery and symptom reduction in long COVID: results from a six\u2011month randomised controlled trial"],"prefix":"10.1038","volume":"16","clinical-trial-number":[{"clinical-trial-number":"nct05449379","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5286-9002","authenticated-orcid":false,"given":"Katarzyna Anna","family":"Pietranis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5287-0401","authenticated-orcid":false,"given":"Anna","family":"Kuryliszyn-Moskal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8110-3586","authenticated-orcid":false,"given":"Diana","family":"Moskal-Jasi\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2313-7125","authenticated-orcid":false,"given":"Mariusz","family":"Wojciuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1609-3793","authenticated-orcid":false,"given":"Mariusz","family":"Cio\u0142kiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4036-3952","authenticated-orcid":false,"given":"Katarzyna","family":"Kaniewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"issue":"10","key":"51787_CR1","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1016\/j.apmr.2022.06.007","volume":"103","author":"I Ahmed","year":"2022","unstructured":"Ahmed, I., Mustafaoglu, R., Yeldan, I., Yasaci, Z. & Erhan, B. 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