{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T01:14:14Z","timestamp":1783300454852,"version":"3.54.6"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":62,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Samjinpharm","award":["SJ-IIT-99-01"],"award-info":[{"award-number":["SJ-IIT-99-01"]}]},{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","award":["0323240410"],"award-info":[{"award-number":["0323240410"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-51953-6","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:29:57Z","timestamp":1777951797000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clopidogrel bisulfate modulates metabolic activity and ERK-associated signaling in human endothelial progenitor cells under oxidative stress: an in vitro study"],"prefix":"10.1038","volume":"16","author":[{"given":"Seoho","family":"Jahng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mijung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manho","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,5]]},"reference":[{"key":"51953_CR1","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1126\/science.275.5302.964","volume":"275","author":"T Asahara","year":"1997","unstructured":"Asahara, T. et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 275, 964\u2013967. https:\/\/doi.org\/10.1126\/science.275.5302.964 (1997).","journal-title":"Science"},{"key":"51953_CR2","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1161\/01.Res.0000137877.89448.78","volume":"95","author":"C Urbich","year":"2004","unstructured":"Urbich, C. & Dimmeler, S. Endothelial progenitor cells: characterization and role in vascular biology. Circ. Res. 95, 343\u2013353. https:\/\/doi.org\/10.1161\/01.Res.0000137877.89448.78 (2004).","journal-title":"Circ. Res."},{"key":"51953_CR3","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1161\/circresaha.111.243386","volume":"110","author":"GP Fadini","year":"2012","unstructured":"Fadini, G. P., Losordo, D. & Dimmeler, S. Critical reevaluation of endothelial progenitor cell phenotypes for therapeutic and diagnostic use. Circ. Res. 110, 624\u2013637. https:\/\/doi.org\/10.1161\/circresaha.111.243386 (2012).","journal-title":"Circ. Res."},{"key":"51953_CR4","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1055\/s-0037-1614133","volume":"84","author":"P Savi","year":"2000","unstructured":"Savi, P. et al. Identification and biological activity of the active metabolite of clopidogrel. Thromb. Haemost. 84, 891\u2013896 (2000).","journal-title":"Thromb. Haemost"},{"key":"51953_CR5","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1159\/000108274","volume":"7","author":"AT Nurden","year":"2007","unstructured":"Nurden, A. T., Duperat, G., Nurden, P. & V. & Platelet Function and Pharmacology of Antiplatelet Drugs. Cerebrovasc. Dis. 7, 2\u20139. https:\/\/doi.org\/10.1159\/000108274 (2007).","journal-title":"Cerebrovasc. Dis."},{"key":"51953_CR6","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.hfc.2008.01.010","volume":"4","author":"A Kumar","year":"2008","unstructured":"Kumar, A. & Cannon, C. P. The Role of Statins in the Prevention of Heart Failure After Acute Coronary Syndrome. Heart Fail. Clin. 4, 129\u2013139. https:\/\/doi.org\/10.1016\/j.hfc.2008.01.010 (2008).","journal-title":"Heart Fail. Clin."},{"key":"51953_CR7","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1182\/blood.V95.3.952.003k27_952_958","volume":"95","author":"M Peichev","year":"2000","unstructured":"Peichev, M. et al. Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors. Blood 95, 952\u2013958 (2000).","journal-title":"Blood"},{"key":"51953_CR8","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1369\/jhc.2009.954446","volume":"57","author":"C Gao","year":"2009","unstructured":"Gao, C. & Wang, A. Y. Significance of increased apoptosis and Bax expression in human small intestinal adenocarcinoma. J. Histochem. Cytochem. 57, 1139\u20131148. https:\/\/doi.org\/10.1369\/jhc.2009.954446 (2009).","journal-title":"J. Histochem. Cytochem."},{"key":"51953_CR9","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1002\/cncr.10876","volume":"95","author":"TE Vaskivuo","year":"2002","unstructured":"Vaskivuo, T. E., Stenb\u00e4ck, F. & Tapanainen, J. S. Apoptosis and apoptosis-related factors Bcl-2, Bax, tumor necrosis factor-alpha, and NF-kappaB in human endometrial hyperplasia and carcinoma. Cancer 95, 1463\u20131471. https:\/\/doi.org\/10.1002\/cncr.10876 (2002).","journal-title":"Cancer"},{"key":"51953_CR10","doi-asserted-by":"publisher","first-page":"2567","DOI":"10.1172\/jci1560","volume":"101","author":"T Murohara","year":"1998","unstructured":"Murohara, T. et al. Nitric oxide synthase modulates angiogenesis in response to tissue ischemia. J. Clin. Invest. 101, 2567\u20132578. https:\/\/doi.org\/10.1172\/jci1560 (1998).","journal-title":"J. Clin. Invest."},{"key":"51953_CR11","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1042\/cs20100429","volume":"120","author":"S Sen","year":"2011","unstructured":"Sen, S., McDonald, S. P., Coates, P. T. & Bonder, C. S. Endothelial progenitor cells: novel biomarker and promising cell therapy for cardiovascular disease. Clin. Sci. (Lond). 120, 263\u2013283. https:\/\/doi.org\/10.1042\/cs20100429 (2011).","journal-title":"Clin. Sci. (Lond)"},{"key":"51953_CR12","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1111\/j.1476-5381.2010.00951.x","volume":"161","author":"J Lecka","year":"2010","unstructured":"Lecka, J., Rana, M. S. & S\u00e9vigny, J. Inhibition of vascular ectonucleotidase activities by the pro-drugs ticlopidine and clopidogrel favours platelet aggregation. Br. J. Pharmacol. 161, 1150\u20131160. https:\/\/doi.org\/10.1111\/j.1476-5381.2010.00951.x (2010).","journal-title":"Br. J. Pharmacol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-51953-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-51953-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-51953-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:15:46Z","timestamp":1783296946000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-51953-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,5]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["51953"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-51953-6","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,5]]},"assertion":[{"value":"20 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was conducted in accordance with the principles of the Declaration of Helsinki and was approved by the Institutional Review Board (IRB) of Seoul National University Hospital (Approval No. H-2101-194-1194). Written informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics declarations"}}],"article-number":"20616"}}