{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:56Z","timestamp":1784851256837,"version":"3.55.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":74,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270692"],"award-info":[{"award-number":["32270692"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-52051-3","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T05:04:27Z","timestamp":1778475867000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrative multi-omics analysis identifies ATAD1 as a potential regulator of metastasis in pancreatic cancer"],"prefix":"10.1038","volume":"16","author":[{"given":"Yi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangbo","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelin","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"issue":"10485","key":"52051_CR1","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1016\/S0140-6736(25)00261-2","volume":"405","author":"FS Thomas","year":"2025","unstructured":"Thomas, F. S. et al. Pancreatic cancer. Lancet 405(10485), 1182\u20131202. https:\/\/doi.org\/10.1016\/S0140-6736(25)00261-2 (2025).","journal-title":"Lancet"},{"issue":"3","key":"52051_CR2","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray, F. et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 74(3), 229\u2013263. https:\/\/doi.org\/10.3322\/caac.21834 (2024).","journal-title":"CA Cancer J. Clin."},{"issue":"96","key":"52051_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2021.102193","volume":"5","author":"J Ferlay","year":"2021","unstructured":"Ferlay, J., Partensky, C. & Bray, F. Blood biomarkers for differential diagnosis and early detection of pancreatic cancer. Cancer Treat. Rev. 5(96), 102193. https:\/\/doi.org\/10.1016\/j.ctrv.2021.102193 (2021).","journal-title":"Cancer Treat. Rev."},{"issue":"5","key":"52051_CR4","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1053\/j.gastro.2023.02.012","volume":"164","author":"EM Stoffel","year":"2023","unstructured":"Stoffel, E. M., Brand, R. E. & Goggins, M. Pancreatic cancer: Changing epidemiology and new approaches to risk assessment, early detection, and prevention. Gastroenterology 164(5), 752\u2013765. https:\/\/doi.org\/10.1053\/j.gastro.2023.02.012 (2023).","journal-title":"Gastroenterology"},{"issue":"1","key":"52051_CR5","doi-asserted-by":"publisher","first-page":"10","DOI":"10.14740\/wjon1166","volume":"10","author":"P Rawla","year":"2019","unstructured":"Rawla, P., Sunkara, T. & Gaduputi, V. Epidemiology of pancreatic cancer: Global trends, etiology and risk factors. World J. Oncol. 10(1), 10\u201327. https:\/\/doi.org\/10.14740\/wjon1166 (2019).","journal-title":"World J. Oncol."},{"issue":"10242","key":"52051_CR6","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1016\/S0140-6736(20)30974-0","volume":"395","author":"JD Mizrahi","year":"2020","unstructured":"Mizrahi, J. D. et al. Pancreatic cancer. Lancet 395(10242), 2008\u20132020. https:\/\/doi.org\/10.1016\/S0140-6736(20)30974-0 (2020).","journal-title":"Lancet"},{"key":"52051_CR7","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.semcancer.2017.03.008","volume":"44","author":"TYS Le Large","year":"2017","unstructured":"Le Large, T. Y. S. et al. Key biological processes driving metastatic spread of pancreatic cancer as identified by multi-omics studies. Semin. Cancer Biol. 44, 153\u2013169. https:\/\/doi.org\/10.1016\/j.semcancer.2017.03.008 (2017).","journal-title":"Semin. Cancer Biol."},{"issue":"4","key":"52051_CR8","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1038\/s43018-023-00526-x","volume":"4","author":"S B\u00e4rthel","year":"2016","unstructured":"B\u00e4rthel, S. et al. Single-cell profiling to explore pancreatic cancer heterogeneity, plasticity and response to therapy. Nat. Cancer. 4 (4), 454\u2013467. https:\/\/doi.org\/10.1038\/s43018-023-00526-x (2016).","journal-title":"Nat. Cancer"},{"issue":"1","key":"52051_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-025-07164-0","volume":"23","author":"QY Zhang","year":"2025","unstructured":"Zhang, Q. Y. et al. Metabolic and immune crosstalk between cancer-associated fibroblasts and pancreatic cancer cells. J. Transl. Med. 23(1), 1118. https:\/\/doi.org\/10.1186\/s12967-025-07164-0 (2025).","journal-title":"J. Transl. Med."},{"issue":"6","key":"52051_CR10","doi-asserted-by":"publisher","first-page":"507","DOI":"10.2217\/epi-2019-0374","volume":"12","author":"L Kong","year":"2020","unstructured":"Kong, L. et al. Multi-omics analysis based on integrated genomics, epigenomics and transcriptomics in pancreatic cancer. Epigenomics 12(6), 507\u2013524. https:\/\/doi.org\/10.2217\/epi-2019-0374 (2020).","journal-title":"Epigenomics"},{"issue":"1","key":"52051_CR11","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-76025-1","volume":"10","author":"B Baek","year":"2020","unstructured":"Baek, B. & Lee, H. Prediction of survival and recurrence in patients with pancreatic cancer by integrating multi-omics data. Sci. Rep. 10(1), 18951. https:\/\/doi.org\/10.1038\/s41598-020-76025-1 (2020).","journal-title":"Sci. Rep."},{"issue":"4","key":"52051_CR12","doi-asserted-by":"publisher","first-page":"501","DOI":"10.18388\/abp.2020_5225","volume":"67","author":"Y Jia","year":"2020","unstructured":"Jia, Y. et al. Development of a 12-biomarkers-based prognostic model for pancreatic cancer using multi-omics integrated analysis. Acta Biochim. Pol. 67(4), 501\u2013508. https:\/\/doi.org\/10.18388\/abp.2020_5225 (2020).","journal-title":"Acta Biochim. Pol."},{"issue":"1","key":"52051_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-025-06711-z","volume":"23","author":"JC Ge","year":"2025","unstructured":"Ge, J. C. et al. Multi-omics integration and machine learning uncover molecular basal-like subtype of pancreatic cancer and implicate A2ML1 in promoting tumor epithelial-mesenchymal transition. J. Transl. Med. 23(1), 741. https:\/\/doi.org\/10.1186\/s12967-025-06711-z (2025).","journal-title":"J. Transl. Med."},{"issue":"1","key":"52051_CR14","doi-asserted-by":"publisher","first-page":"101696","DOI":"10.1016\/j.gendis.2025.101696","volume":"13","author":"ZW Cai","year":"2025","unstructured":"Cai, Z. W. et al. LINC00431 modulates KRAS and p53 stability to drive pancreatic cancer progression under hypoxia. Genes Dis. 13 (1), 101696. https:\/\/doi.org\/10.1016\/j.gendis.2025.101696 (2025).","journal-title":"Genes Dis."},{"issue":"14","key":"52051_CR15","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","volume":"25","author":"H Li","year":"2009","unstructured":"Li, H. & Durbin, R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25 (14), 1754\u20131760. https:\/\/doi.org\/10.1093\/bioinformatics\/btp324 (2009).","journal-title":"Bioinformatics"},{"key":"52051_CR16","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giab008","author":"P Danecek","year":"2021","unstructured":"Danecek, P. et al. Twelve years of SAMtools and BCFtools. GigaScience https:\/\/doi.org\/10.1093\/gigascience\/giab008 (2021).","journal-title":"GigaScience"},{"issue":"9","key":"52051_CR17","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1101\/gr.107524.110","volume":"20","author":"A McKenna","year":"2010","unstructured":"McKenna, A. et al. The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res. 20(9), 1297\u20131303. https:\/\/doi.org\/10.1101\/gr.107524.110 (2010).","journal-title":"Genome Res."},{"key":"52051_CR18","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1101\/gr.129684.111","volume":"22","author":"D Koboldt","year":"2012","unstructured":"Koboldt, D. et al. VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing. Genome Res. 22, 568\u2013576. https:\/\/doi.org\/10.1101\/gr.129684.111 (2012).","journal-title":"Genome Res."},{"key":"52051_CR19","unstructured":"Garrison, E. & Marth, G. Haplotype-based variant detection from short-read sequencing. ArXiv\u00a0https:\/\/abs\/arXiv.org\/12073907 (2012)."},{"key":"52051_CR20","doi-asserted-by":"publisher","DOI":"10.1002\/0471250953.bi1112s47","volume":"47","author":"AR Quinlan","year":"2014","unstructured":"Quinlan, A. R. BEDTools: The Swiss-Army tool for genome feature analysis. Curr. Protoc. Bioinformatics 47, 11.12.1\u201334. https:\/\/doi.org\/10.1002\/0471250953.bi1112s47 (2014).","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"52051_CR21","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq603","volume":"38","author":"K Wang","year":"2010","unstructured":"Wang, K., Li, M. & Hakonarson, H. ANNOVAR: Functional annotation of genetic variants from next-generation sequencing data. Nucleic Acids Res. 38, e164. https:\/\/doi.org\/10.1093\/nar\/gkq603 (2010).","journal-title":"Nucleic Acids Res."},{"issue":"7319","key":"52051_CR22","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1038\/nature09534","volume":"467","author":"D Altshuler","year":"2010","unstructured":"Altshuler, D. et al. A map of human genome variation from population-scale sequencing. Nature 467 (7319), 1061\u20131073. https:\/\/doi.org\/10.1038\/nature09534 (2010).","journal-title":"Nature"},{"issue":"1","key":"52051_CR23","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/nbt.1754","volume":"29","author":"JT Robinson","year":"2011","unstructured":"Robinson, J. T. et al. Integrative Genomics Viewer. Nat. Biotechnol. 29(1), 24\u201326. https:\/\/doi.org\/10.1038\/nbt.1754 (2011).","journal-title":"Nat. Biotechnol."},{"issue":"3","key":"52051_CR24","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1093\/bioinformatics\/btr670","volume":"28","author":"V Boeva","year":"2012","unstructured":"Boeva, V. et al. Control-FREEC: A tool for assessing copy number and allelic content using next-generation sequencing data. Bioinformatics 28(3), 423\u2013425. https:\/\/doi.org\/10.1093\/bioinformatics\/btr670 (2012).","journal-title":"Bioinformatics"},{"issue":"1","key":"52051_CR25","doi-asserted-by":"publisher","first-page":"10","DOI":"10.14806\/ej.17.1.200","volume":"17","author":"M Martin","year":"2011","unstructured":"Martin, M. Cutadapt removes adapter sequences from high-throughput sequencing reads. EMBnet.J. 17(1), 10\u201312. https:\/\/doi.org\/10.14806\/ej.17.1.200 (2011).","journal-title":"EMBnet.J."},{"key":"52051_CR26","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","volume":"37","author":"D Kim","year":"2019","unstructured":"Kim, D. et al. Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. Nat. Biotechnol. 37, 907\u2013915. https:\/\/doi.org\/10.1038\/s41587-019-0201-4 (2019).","journal-title":"Nat. Biotechnol."},{"issue":"16","key":"52051_CR27","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1093\/bioinformatics\/bts356","volume":"28","author":"L Wang","year":"2012","unstructured":"Wang, L., Wang, S. & Li, W. RSeQC: Quality control of RNA-seq experiments. Bioinformatics 28(16), 2184\u20132185. https:\/\/doi.org\/10.1093\/bioinformatics\/bts356 (2012).","journal-title":"Bioinformatics"},{"issue":"7","key":"52051_CR28","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","volume":"30","author":"Y Liao","year":"2014","unstructured":"Liao, Y., Smyth, G. K. & Shi, W. featureCounts: An efficient general-purpose program for assigning sequence reads to genomic features. Bioinformatics 30(7), 923\u2013930. https:\/\/doi.org\/10.1093\/bioinformatics\/btt656 (2014).","journal-title":"Bioinformatics"},{"issue":"12","key":"52051_CR29","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15 (12), 550. https:\/\/doi.org\/10.1186\/s13059-014-0550-8 (2014).","journal-title":"Genome Biol."},{"issue":"D1","key":"52051_CR30","doi-asserted-by":"publisher","first-page":"D672","DOI":"10.1093\/nar\/gkae909","volume":"53","author":"M Kanehisa","year":"2025","unstructured":"Kanehisa, M. et al. KEGG: Biological systems database as a model of the real world. Nucleic Acids Res. 53(D1), D672\u2013D677. https:\/\/doi.org\/10.1093\/nar\/gkae909 (2025).","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"52051_CR31","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa, M. Toward understanding the origin and evolution of cellular organisms. Protein Sci. 28(11), 1947\u20131951. https:\/\/doi.org\/10.1002\/pro.3715 (2019).","journal-title":"Protein Sci."},{"issue":"3","key":"52051_CR32","doi-asserted-by":"publisher","first-page":"772","DOI":"10.20892\/j.issn.2095-3941.2020.0568","volume":"18","author":"GB Kang","year":"2021","unstructured":"Kang, G. B. et al. VHH212 nanobody targeting the hypoxia-inducible factor 1\u03b1 suppresses angiogenesis and potentiates gemcitabine therapy in pancreatic cancer in vivo. Cancer Biol. Med. 18(3), 772\u2013787. https:\/\/doi.org\/10.20892\/j.issn.2095-3941.2020.0568 (2021).","journal-title":"Cancer Biol. Med."},{"key":"52051_CR33","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1101\/gr.176601","volume":"11","author":"PC Ng","year":"2001","unstructured":"Ng, P. C. & Henikoff, S. Predicting deleterious amino acid substitutions. Genome Res. 11, 863\u2013874. https:\/\/doi.org\/10.1101\/gr.176601 (2001).","journal-title":"Genome Res."},{"key":"52051_CR34","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1038\/nmeth0410-248","volume":"7","author":"IA Adzhubei","year":"2010","unstructured":"Adzhubei, I. A. et al. A method and server for predicting damaging missense mutations. Nat. Methods 7, 248\u2013249. https:\/\/doi.org\/10.1038\/nmeth0410-248 (2010).","journal-title":"Nat. Methods"},{"key":"52051_CR35","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/nmeth0810-575","volume":"7","author":"JM Schwarz","year":"2010","unstructured":"Schwarz, J. M. et al. MutationTaster evaluates disease-causing potential of sequence alterations. Nat. Methods 7, 575\u2013576. https:\/\/doi.org\/10.1038\/nmeth0810-575 (2010).","journal-title":"Nat. Methods"},{"key":"52051_CR36","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr407","volume":"39","author":"B Reva","year":"2011","unstructured":"Reva, B., Antipin, Y. & Sander, C. Predicting the functional impact of protein mutations: Application to cancer genomics. Nucleic Acids Res. 39, e118. https:\/\/doi.org\/10.1093\/nar\/gkr407 (2011).","journal-title":"Nucleic Acids Res."},{"key":"52051_CR37","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2021-0495","author":"Z Wang","year":"2021","unstructured":"Wang, Z. et al. Identification of the immune cell infiltration landscape in pancreatic cancer to assist immunotherapy. Future Oncol. https:\/\/doi.org\/10.2217\/fon-2021-0495 (2021).","journal-title":"Future Oncol."},{"key":"52051_CR38","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.canlet.2019.11.020","volume":"469","author":"S Pan","year":"2020","unstructured":"Pan, S., Brentnall, T. A. & Chen, R. Proteome alterations in pancreatic ductal adenocarcinoma. Cancer Lett. 469, 429\u2013436. https:\/\/doi.org\/10.1016\/j.canlet.2019.11.020 (2020).","journal-title":"Cancer Lett."},{"issue":"1","key":"52051_CR39","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1002\/(SICI)1096-9896(199809)186:1<41::AID-PATH172>3.0.CO;2-L","volume":"186","author":"S Beghelli","year":"1998","unstructured":"Beghelli, S. et al. Pancreatic endocrine tumours: evidence for a tumour suppressor pathogenesis and for a tumour suppressor gene on chromosome 17p. J. Pathol. 186 (1), 41\u201350. https:\/\/doi.org\/10.1002\/(SICI)1096-9896(199809)186:1%3C41::AID-PATH172%3E3.0.CO;2-L (1998).","journal-title":"J. Pathol."},{"issue":"1","key":"52051_CR40","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.annonc.2020.10.470","volume":"32","author":"L Tobalina","year":"2021","unstructured":"Tobalina, L. et al. A meta-analysis of reversion mutations in BRCA genes identifies signatures of DNA end-joining repair mechanisms driving therapy resistance. Ann. Oncol. 32(1), 103\u2013112. https:\/\/doi.org\/10.1016\/j.annonc.2020.10.470 (2021).","journal-title":"Ann. Oncol."},{"key":"52051_CR41","unstructured":"Wild, C. P., Weiderpass, E. & editors Stewart, B. W. World Cancer Report: Cancer Research for Cancer Prevention. Lyon, France: International Agency for Research on Cancer.\u00a0Licence: CC BY-NC-ND 3.0 IGO.\u00a0http:\/\/publications.iarc.fr\/586 (2020).\u00a0"},{"key":"52051_CR42","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00728","volume":"10","author":"S Tachibana","year":"2020","unstructured":"Tachibana, S. et al. Genetic tracing of clonal expansion and progression of pancreatic ductal adenocarcinoma: A case report and multi-region sequencing analysis. Front. Oncol. 10, 728. https:\/\/doi.org\/10.3389\/fonc.2020.00728 (2020).","journal-title":"Front. Oncol."},{"issue":"1","key":"52051_CR43","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1093\/carcin\/bgz086","volume":"41","author":"Z Li","year":"2020","unstructured":"Li, Z. et al. Oncogenic ERBB2 aberrations and KRAS mutations cooperate to promote pancreatic ductal adenocarcinoma progression. Carcinogenesis 41(1), 44\u201355. https:\/\/doi.org\/10.1093\/carcin\/bgz086 (2020).","journal-title":"Carcinogenesis"},{"issue":"4","key":"52051_CR44","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1002\/ijc.22871","volume":"121","author":"J Kleeff","year":"2007","unstructured":"Kleeff, J. et al. Pancreatic cancer microenvironment. Int. J. Cancer. 121(4), 699\u2013705. https:\/\/doi.org\/10.1002\/ijc.22871 (2007).","journal-title":"Int. J. Cancer."},{"issue":"1","key":"52051_CR45","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23904-4","volume":"12","author":"XD Huang","year":"2021","unstructured":"Huang, X. D. et al. LINC00842 inactivates transcription co-regulator PGC-1\u03b1 to promote pancreatic cancer malignancy through metabolic remodelling. Nat. Commun. 12(1), 3830. https:\/\/doi.org\/10.1038\/s41467-021-23904-4 (2021).","journal-title":"Nat. Commun."},{"issue":"W1","key":"52051_CR46","doi-asserted-by":"publisher","first-page":"W556","DOI":"10.1093\/nar\/gkz430","volume":"47","author":"Z Tang","year":"2019","unstructured":"Tang, Z. et al. GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis. Nucleic Acids Res., 47(1): 556\u2013560. (2019). https:\/\/doi.org\/10.1093\/nar\/gkz430","journal-title":"Nucleic Acids Res."},{"key":"52051_CR47","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.neo.2022.01.001","volume":"25","author":"DS Chandrashekar","year":"2022","unstructured":"Chandrashekar, D. S. et al. UALCAN: An update to the integrated cancer data analysis platform. Neoplasia 25, 18\u201327. https:\/\/doi.org\/10.1016\/j.neo.2022.01.001 (2022).","journal-title":"Neoplasia"},{"issue":"1","key":"52051_CR48","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.pan.2011.11.001","volume":"12","author":"AM Luebke","year":"2012","unstructured":"Luebke, A. M. et al. Losses at chromosome 4q are associated with poor survival in operable ductal pancreatic adenocarcinoma. Pancreatology 12(1), 16\u201322. https:\/\/doi.org\/10.1016\/j.pan.2011.11.001 (2012).","journal-title":"Pancreatology"},{"issue":"4","key":"52051_CR49","doi-asserted-by":"publisher","first-page":"509","DOI":"10.5009\/gnl19087","volume":"14","author":"CS Lim","year":"2020","unstructured":"Lim, C. S. et al. The implication of cytogenetic alterations in pancreatic ductal adenocarcinoma and intraductal papillary mucinous neoplasm identified by fluorescence in situ hybridization and their potential diagnostic utility. Gut Liver 14(4), 509\u2013520. https:\/\/doi.org\/10.5009\/gnl19087 (2020).","journal-title":"Gut Liver"},{"issue":"49","key":"52051_CR50","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc4517","volume":"6","author":"A Hsieh","year":"2020","unstructured":"Hsieh, A. et al. Growth of pancreatic cancers with hemizygous chromosomal 17p loss of MYBBP1A can be preferentially targeted by PARP inhibitors. Sci. Adv. 6(49), eabc4517. https:\/\/doi.org\/10.1126\/sciadv.abc4517 (2020).","journal-title":"Sci. Adv."},{"issue":"4","key":"52051_CR51","doi-asserted-by":"publisher","first-page":"605","DOI":"10.3727\/096504016X14767450526417","volume":"25","author":"Y Yang","year":"2017","unstructured":"Yang, Y., Bai, Y. S. & Wang, Q. CDGSH Iron Sulfur Domain 2 activates proliferation and EMT of Pancreatic Cancer Cells via Wnt\/\u03b2-Catenin Pathway and has prognostic value in Human Pancreatic Cancer. Oncol. Res. 25(4), 605\u2013615. https:\/\/doi.org\/10.3727\/096504016X14767450526417 (2017).","journal-title":"Oncol. Res."},{"issue":"3","key":"52051_CR52","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1080\/15384101.2015.1127468","volume":"15","author":"M Tao","year":"2016","unstructured":"Tao, M. et al. Inflammatory stimuli promote growth and invasion of pancreatic cancer cells through NF-\u03baB pathway dependent repression of PP2Ac. Cell Cycle 15(3), 381\u2013393. https:\/\/doi.org\/10.1080\/15384101.2015.1127468 (2016).","journal-title":"Cell Cycle"},{"issue":"10","key":"52051_CR53","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1593\/neo.12878","volume":"14","author":"C Moser","year":"2012","unstructured":"Moser, C. et al. STAT5b as molecular target in Pancreatic Cancer\u2014Inhibition of tumor growth, angiogenesis, and metastases. Neoplasia 14(10), 915\u2013925. https:\/\/doi.org\/10.1593\/neo.12878 (2012).","journal-title":"Neoplasia"},{"issue":"1","key":"52051_CR54","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-025-02503-y","volume":"11","author":"DM Xu","year":"2025","unstructured":"Xu, D. M. et al. Decoding the impact of MMP1\u2009+\u2009malignant subsets on tumor-immune interactions: Insights from single-cell and spatial transcriptomics. Cell Death Discov. 11(1), 244. https:\/\/doi.org\/10.1038\/s41420-025-02503-y (2025).","journal-title":"Cell Death Discov."},{"issue":"1","key":"52051_CR55","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-025-02536-3","volume":"11","author":"ZZ Wang","year":"2025","unstructured":"Wang, Z. Z. et al. RGS3 acts as a tumor promoter by facilitating the regulation of the TGF-\u03b2 signaling pathway and promoting EMT in ovarian cancer. Cell Death Discov. 11(1), 262. https:\/\/doi.org\/10.1038\/s41420-025-02536-3 (2025).","journal-title":"Cell Death Discov."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-52051-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-52051-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-52051-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T23:05:11Z","timestamp":1784847911000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-52051-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,11]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["52051"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-52051-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,11]]},"assertion":[{"value":"27 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The human pancreatic ductal adenocarcinoma cell line, BxPC-3 (RRID: CVCL_0186) was obtained from the Cell Culture Center, Peking Union Medical College (Beijing, China). MIA PaCa-2 (RRID: CVCL_0428), HPAF-\u2161 (RRID: CVCL_0313), CFPAC-1 (RRID: CVCL_1119), SW1990 (RRID: CVCL_1723) were obtained from the American Type Culture Collection (Manassas, VA, USA).","order":2,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"23136"}}