{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T01:01:40Z","timestamp":1784509300915,"version":"3.55.0"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:00:00Z","timestamp":1784505600000},"content-version":"vor","delay-in-days":63,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004230","name":"Korea Polar Research Institute","doi-asserted-by":"publisher","award":["PM24030 and PE26150"],"award-info":[{"award-number":["PM24030 and PE26150"]}],"id":[{"id":"10.13039\/501100004230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-52595-4","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T20:59:43Z","timestamp":1779137983000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative genomic and physiological characterization of a lichen-associated Streptacidiphilus strain from Antarctica"],"prefix":"10.1038","volume":"16","author":[{"given":"Yun Ho","family":"Roh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehyun","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woohyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Jong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Chul","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo Young","family":"Byun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Hyuck","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung Mi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"52595_CR1","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1023\/A:1023397724023","volume":"83","author":"SB Kim","year":"2003","unstructured":"Kim, S. B. et al. Streptacidiphilus gen. nov., acidophilic actinomycetes with wall chemotype I and emendation of the family Streptomycetaceae (Waksman and Henrici (1943)AL) emend. Rainey et al. 1997. Antonie Van Leeuwenhoek 83, 107\u2013116 (2003).","journal-title":"Antonie Van Leeuwenhoek"},{"key":"52595_CR2","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1099\/ijs.0.65480-0","volume":"58","author":"SH Cho","year":"2008","unstructured":"Cho, S. H. et al. Streptacidiphilus anmyonensis sp. nov., Streptacidiphilus rugosus sp. nov. and Streptacidiphilus melanogenes sp. nov., acidophilic actinobacteria isolated from Pinus soils. Int. J. Syst. Evol. Microbiol. 58, 1566\u20131570 (2008).","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"52595_CR3","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s10482-013-9938-9","volume":"104","author":"P Golinska","year":"2013","unstructured":"Golinska, P. et al. Streptacidiphilus durhamensis sp. nov., isolated from a spruce forest soil. Antonie Van Leeuwenhoek 104, 199\u2013206 (2013).","journal-title":"Antonie Van Leeuwenhoek"},{"key":"52595_CR4","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1023\/B:ANTO.0000036124.18820.ae","volume":"86","author":"Y Huang","year":"2004","unstructured":"Huang, Y. et al. Streptacidiphilus jiangxiensis sp. nov., a novel actinomycete isolated from acidic rhizosphere soil in China. Antonie Van Leeuwenhoek 86, 159\u2013165 (2004).","journal-title":"Antonie Van Leeuwenhoek"},{"key":"52595_CR5","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1099\/ijsem.0.002751","volume":"68","author":"W Song","year":"2018","unstructured":"Song, W. et al. Streptacidiphilus monticola sp. nov., a novel actinomycete isolated from soil. Int. J. Syst. Evol. Microbiol. 68, 1757\u20131761 (2018).","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"52595_CR6","doi-asserted-by":"publisher","first-page":"3149","DOI":"10.1099\/ijsem.0.002957","volume":"68","author":"SG Roh","year":"2018","unstructured":"Roh, S. G. et al. Streptacidiphilus pinicola sp. nov., isolated from pine grove soil. Int. J. Syst. Evol. Microbiol. 68, 3149\u20133155 (2018).","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"52595_CR7","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1007\/s10482-016-0759-5","volume":"109","author":"P Golinska","year":"2016","unstructured":"Golinska, P. et al. Streptacidiphilus toruniensis sp. nov., isolated from a pine forest soil. Antonie Van Leeuwenhoek 109, 1583\u20131591 (2016).","journal-title":"Antonie Van Leeuwenhoek"},{"key":"52595_CR8","doi-asserted-by":"crossref","unstructured":"Lee, S. D. et al. (2025) Streptacidiphilus alkalitolerans sp., Streptacidiphilus cavernicola sp. and Streptacidiphilus jeojiensis sp. isolated from a cave, and an emended description of the genus Streptacidiphilus. Int. J. Syst. Evol. Microbiol. 75: 006652.","DOI":"10.1099\/ijsem.0.006652"},{"key":"52595_CR9","doi-asserted-by":"crossref","unstructured":"Yu, B. et al. (2021) Streptacidiphilus fuscans sp., a novel actinobacterium isolated from the root of pumpkin (Cucurbita moschata). Int. J. Syst. Evol. Microbiol. 71: 004824.","DOI":"10.1099\/ijsem.0.004824"},{"key":"52595_CR10","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/ja.2012.27","volume":"65","author":"J B\u00e9rdy","year":"2012","unstructured":"B\u00e9rdy, J. Thoughts and facts about antibiotics: Where we are now and where we are heading. J. Antibiot. 65, 385\u2013395 (2012).","journal-title":"J. Antibiot."},{"key":"52595_CR11","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1021\/acs.jnatprod.8b00828","volume":"82","author":"S Hwang","year":"2019","unstructured":"Hwang, S. et al. Acidiphilamides A-E, modified peptides as autophagy inhibitors from an acidophilic actinobacterium. Streptacidiphilus rugosus. J. Nat. Prod. 82, 341\u2013348 (2019).","journal-title":"J. Nat. Prod."},{"key":"52595_CR12","doi-asserted-by":"publisher","first-page":"10648","DOI":"10.1021\/acs.joc.0c01210","volume":"85","author":"SS Elsayed","year":"2020","unstructured":"Elsayed, S. S. et al. Atypical spirotetronate polyketides identified in the underexplored genus Streptacidiphilus. J. Org. Chem. 85, 10648\u201310657 (2020).","journal-title":"J. Org. Chem."},{"key":"52595_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2023.104709","volume":"110","author":"MH Koo","year":"2023","unstructured":"Koo, M. H. et al. Cyclic dipeptides and alkaloids from the rare actinobacteria Streptacidiphilus carbonis isolated from Sphaerophorus globosus (Huds.) Vain. Biochem. Syst. Ecol. 110, 104709 (2023).","journal-title":"Biochem. Syst. Ecol."},{"key":"52595_CR14","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.3390\/genes11101166","volume":"11","author":"A Malik","year":"2020","unstructured":"Malik, A. et al. Genome mining of the genus Streptacidiphilus for biosynthetic and biodegradation potential. Genes 11, 1166 (2020).","journal-title":"Genes"},{"key":"52595_CR15","unstructured":"Nash, T. H. Lichen Biology. (Cambridge University Press, 1996)."},{"key":"52595_CR16","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1038\/ismej.2014.138","volume":"9","author":"M Grube","year":"2015","unstructured":"Grube, M. et al. Exploring functional contexts of symbiotic sustain within lichen-associated bacteria by comparative omics. ISME J. 9, 412\u2013424 (2015).","journal-title":"ISME J."},{"key":"52595_CR17","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1111\/j.1365-2672.2006.03010.x","volume":"101","author":"C Liba","year":"2006","unstructured":"Liba, C. et al. Nitrogen-fixing chemo-organotrophic bacteria isolated from cyanobacteria-deprived lichens and their ability to solubilize phosphate and to release amino acids and phytohormones. J. Appl. Microbiol. 101, 1076\u20131086 (2006).","journal-title":"J. Appl. Microbiol."},{"key":"52595_CR18","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.1007\/s11274-014-1695-z","volume":"30","author":"YM Lee","year":"2014","unstructured":"Lee, Y. M. et al. Biodiversity and physiological characteristics of Antarctic and Arctic lichens-associated bacteria. World J. Microbiol. Biotechnol. 30, 2711\u20132721 (2014).","journal-title":"World J. Microbiol. Biotechnol."},{"key":"52595_CR19","doi-asserted-by":"publisher","first-page":"607","DOI":"10.3390\/microorganisms9030607","volume":"9","author":"HJ Noh","year":"2021","unstructured":"Noh, H. J. et al. Diversity and physiological characteristics of Antarctic lichens-associated bacteria. Microorganisms 9, 607 (2021).","journal-title":"Microorganisms"},{"key":"52595_CR20","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1111\/nph.16630","volume":"227","author":"DL Hawksworth","year":"2020","unstructured":"Hawksworth, D. L. & Grube, M. Lichens redefined as complex ecosystems. New Phytol. 227, 1281\u20131283 (2020).","journal-title":"New Phytol."},{"key":"52595_CR21","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1128\/AEM.02257-10","volume":"77","author":"ST Bates","year":"2011","unstructured":"Bates, S. T. et al. Bacterial communities associated with the lichen symbiosis. Appl. Environ. Microbiol. 77, 1309\u20131314 (2011).","journal-title":"Appl. Environ. Microbiol."},{"key":"52595_CR22","doi-asserted-by":"publisher","first-page":"398","DOI":"10.3389\/fmicb.2020.00398","volume":"11","author":"MA Sierra","year":"2020","unstructured":"Sierra, M. A. et al. The microbiomes of seven lichen genera reveal host specificity, a reduced core community and potential as source of antimicrobials. Front. Microbiol. 11, 398 (2020).","journal-title":"Front. Microbiol."},{"key":"52595_CR23","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.femsec.2005.05.004","volume":"54","author":"I Gonz\u00e1lez","year":"2005","unstructured":"Gonz\u00e1lez, I. et al. Actinomycetes isolated from lichens: Evaluation of their diversity and detection of biosynthetic gene sequences. FEMS Microbiol. Ecol. 54, 401\u2013415 (2005).","journal-title":"FEMS Microbiol. Ecol."},{"key":"52595_CR24","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1111\/j.1574-6941.2006.00133.x","volume":"57","author":"M Cardinale","year":"2006","unstructured":"Cardinale, M. et al. Molecular analysis of lichen-associated bacterial communities. FEMS Microbiol. Ecol. 57, 484\u2013495 (2006).","journal-title":"FEMS Microbiol. Ecol."},{"key":"52595_CR25","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1007\/s00248-017-0972-4","volume":"74","author":"C Liu","year":"2017","unstructured":"Liu, C. et al. Diversity, antimicrobial activity, and biosynthetic potential of cultivable actinomycetes associated with lichen symbiosis. Microb. Ecol. 74, 570\u2013584 (2017).","journal-title":"Microb. Ecol."},{"key":"52595_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/srep15839","volume":"5","author":"D Parrot","year":"2015","unstructured":"Parrot, D. et al. Littoral lichens as a novel source of potentially bioactive Actinobacteria. Sci. Rep. 5, 15839 (2015).","journal-title":"Sci. Rep."},{"key":"52595_CR27","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00620","volume":"6","author":"T Cernava","year":"2015","unstructured":"Cernava, T. et al. Analyzing the antagonistic potential of the lichen microbiome against pathogens by bridging metagenomic with culture studies. Front. Microbiol. 6, 620 (2015).","journal-title":"Front. Microbiol."},{"key":"52595_CR28","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1038\/ismej.2009.63","volume":"3","author":"M Grube","year":"2009","unstructured":"Grube, M. et al. Species-specific structural and functional diversity of bacterial communities in lichen symbioses. ISME J. 3, 1105\u20131115 (2009).","journal-title":"ISME J."},{"key":"52595_CR29","doi-asserted-by":"publisher","first-page":"317","DOI":"10.33073\/pjm-2014-042","volume":"63","author":"MK Kim","year":"2014","unstructured":"Kim, M. K. et al. Antibacterial and antioxidant capacity of polar microorganisms isolated from Arctic lichen Ochrolechia sp.. Pol. J. Microbiol. 63, 317\u2013322 (2014).","journal-title":"Pol. J. Microbiol."},{"key":"52595_CR30","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/ja.2010.94","volume":"63","author":"K Motohashi","year":"2010","unstructured":"Motohashi, K. et al. A new angucycline and a new butenolide isolated from lichen-derived Streptomyces spp. J. Antibiot. 63, 545\u2013548 (2010).","journal-title":"J. Antibiot."},{"key":"52595_CR31","doi-asserted-by":"publisher","first-page":"5233","DOI":"10.1021\/ol052081f","volume":"7","author":"J Davies","year":"2005","unstructured":"Davies, J. et al. Uncialamycin, a new enediyne antibiotic. Org. Lett. 7, 5233\u20135236 (2005).","journal-title":"Org. Lett."},{"key":"52595_CR32","doi-asserted-by":"publisher","first-page":"3501","DOI":"10.1021\/ol801274c","volume":"10","author":"DE Williams","year":"2008","unstructured":"Williams, D. E. et al. Cladoniamides A\u2212G, tryptophan-derived alkaloids produced in culture by Streptomyces uncialis. Org. Lett. 10, 3501\u20133504 (2008).","journal-title":"Org. Lett."},{"key":"52595_CR33","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1017\/S0024282917000044","volume":"49","author":"DF Jiang","year":"2017","unstructured":"Jiang, D. F. et al. Isolation and culture of lichen bacteriobionts. Lichenologist 49, 175\u2013181 (2017).","journal-title":"Lichenologist"},{"key":"52595_CR34","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1007\/s00300-012-1182-7","volume":"35","author":"YM Lee","year":"2012","unstructured":"Lee, Y. M. et al. Polar and Alpine Microbial Collection (PAMC): A culture collection dedicated to polar and alpine microorganisms. Polar Biol. 35, 1433\u20131438 (2012).","journal-title":"Polar Biol."},{"key":"52595_CR35","doi-asserted-by":"publisher","first-page":"6421","DOI":"10.1099\/ijsem.0.006421","volume":"74","author":"M Chalita","year":"2024","unstructured":"Chalita, M. et al. EzBioCloud: a genome-driven database and platform for microbiome identification and discovery. Int. J. Syst. Evol. Microbiol. 74, 6421 (2024).","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"52595_CR36","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1093\/molbev\/mst197","volume":"30","author":"K Tamura","year":"2013","unstructured":"Tamura, K. et al. MEGA6: molecular evolutionary genetics analysis version 6.0. Mol. Biol. Evol. 30, 2725\u20132729 (2013).","journal-title":"Mol. Biol. Evol."},{"key":"52595_CR37","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s13059-024-03252-4","volume":"25","author":"J Hu","year":"2024","unstructured":"Hu, J. et al. NextDenovo: an efficient error correction and accurate assembly tool for noisy long reads. Genome Biol. 25, 107 (2024).","journal-title":"Genome Biol."},{"key":"52595_CR38","doi-asserted-by":"publisher","first-page":"R12","DOI":"10.1186\/gb-2004-5-2-r12","volume":"5","author":"S Kurtz","year":"2004","unstructured":"Kurtz, S. et al. Versatile and open software for comparing large genomes. Genome Biol. 5, R12 (2004).","journal-title":"Genome Biol."},{"key":"52595_CR39","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1099\/ijsem.0.000760","volume":"66","author":"I Lee","year":"2016","unstructured":"Lee, I. et al. OrthoANI: An improved algorithm and software for calculating average nucleotide identity. Int. J. Syst. Evol. Microbiol. 66, 1100\u20131103 (2016).","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"52595_CR40","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/1471-2105-14-60","volume":"14","author":"JP Meier-Kolthoff","year":"2013","unstructured":"Meier-Kolthoff, J. P. et al. Genome sequence-based species delimitation with confidence intervals and improved distance functions. BMC Bioinformatics 14, 60 (2013).","journal-title":"BMC Bioinformatics"},{"key":"52595_CR41","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1093\/bioinformatics\/btz848","volume":"36","author":"P-A Chaumeil","year":"2020","unstructured":"Chaumeil, P.-A. et al. GTDB-Tk: a toolkit to classify genomes with the Genome Taxonomy Database. Bioinformatics 36, 1925\u20131927 (2020).","journal-title":"Bioinformatics"},{"key":"52595_CR42","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/1471-2164-9-75","volume":"9","author":"RK Aziz","year":"2008","unstructured":"Aziz, R. K. et al. The RAST server: Rapid annotations using subsystems technology. BMC Genomics 9, 75 (2008).","journal-title":"BMC Genomics"},{"key":"52595_CR43","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1093\/nar\/gkaf334","volume":"53","author":"K Blin","year":"2025","unstructured":"Blin, K. et al. antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation. Nucleic Acids Res. 53, 32\u201338 (2025).","journal-title":"Nucleic Acids Res."},{"key":"52595_CR44","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1093\/bioinformatics\/btl158","volume":"22","author":"W Li","year":"2006","unstructured":"Li, W. & Godzik, A. Cd-hit: A fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics 22, 1658\u20131659 (2006).","journal-title":"Bioinformatics"},{"key":"52595_CR45","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1109\/TVCG.2014.2346248","volume":"20","author":"A Lex","year":"2014","unstructured":"Lex, A. et al. UpSet: Visualization of intersecting sets. IEEE Trans. Vis. Comput. Graph. 20, 1983\u20131992 (2014).","journal-title":"IEEE Trans. Vis. Comput. Graph."},{"key":"52595_CR46","first-page":"607","volume-title":"Methods for General and Molecular Bacteriology","author":"R Smibert","year":"1994","unstructured":"Smibert, R. Phenotypic characterization. In Methods for General and Molecular Bacteriology (eds Gerhardt, P. et al.) 607\u2013654 (ASM Press, 1994)."},{"key":"52595_CR47","doi-asserted-by":"publisher","first-page":"19126","DOI":"10.1073\/pnas.0906412106","volume":"106","author":"M Richter","year":"2009","unstructured":"Richter, M. & Rossell\u00f3-M\u00f3ra, R. Shifting the genomic gold standard for the prokaryotic species definition. Proc. Natl. Acad. Sci. U. S. A. 106, 19126\u201319131 (2009).","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"52595_CR48","doi-asserted-by":"publisher","first-page":"709","DOI":"10.7745\/KJSSF.2011.44.5.709","volume":"44","author":"I-W Choi","year":"2011","unstructured":"Choi, I.-W. et al. Physico-chemical characteristics of soil in the vicinity of King Sejong Station, King George Island. Antarctica. Korean J. Soil Sci. Fert. 44, 709\u2013716 (2011).","journal-title":"Antarctica. Korean J. Soil Sci. Fert."},{"key":"52595_CR49","doi-asserted-by":"crossref","unstructured":"Bockheim, J. Antarctic soil properties and soilscapes. In Antarctic Terrestrial Microbiology: Physical and Biological Properties of Antarctic Soils (ed. Cowan, D. A.) 63\u201384 (Springer, 2014).","DOI":"10.1007\/978-3-642-45213-0_16"},{"key":"52595_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.xgen.2022.100213","volume":"2","author":"R Seshadri","year":"2022","unstructured":"Seshadri, R. et al. Expanding the genomic encyclopedia of Actinobacteria with 824 isolate reference genomes. Cell Genom. 2, 100213 (2022).","journal-title":"Cell Genom."},{"key":"52595_CR51","doi-asserted-by":"publisher","first-page":"180","DOI":"10.3389\/fmicb.2016.00180","volume":"7","author":"IA Aschenbrenner","year":"2016","unstructured":"Aschenbrenner, I. A. et al. Understanding microbial multi-species symbioses. Front. Microbiol. 7, 180 (2016).","journal-title":"Front. Microbiol."},{"key":"52595_CR52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3002862","volume":"22","author":"G Tagirdzhanova","year":"2024","unstructured":"Tagirdzhanova, G. et al. Microbial occurrence and symbiont detection in a global sample of lichen metagenomes. PLoS Biol. 22, e3002862 (2024).","journal-title":"PLoS Biol."},{"key":"52595_CR53","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.843490","volume":"13","author":"C Muster","year":"2022","unstructured":"Muster, C. et al. Lichens and their substrates reduce the influence of forest cover change on phosphate solubilizing bacteria. Front. Microbiol. 13, 843490 (2022).","journal-title":"Front. Microbiol."},{"key":"52595_CR54","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1548894","volume":"16","author":"V Pattapulavar","year":"2025","unstructured":"Pattapulavar, V. et al. Biosynthetic pathway of psi, psi-carotene from Streptomyces sp. VITGV38 (MCC 4869). Front. Microbiol. 16, 1548894 (2025).","journal-title":"Front. Microbiol."},{"key":"52595_CR55","doi-asserted-by":"publisher","first-page":"2300080","DOI":"10.1002\/anbr.202300080","volume":"3","author":"E Lebaudy","year":"2023","unstructured":"Lebaudy, E. et al. The high potential of \u03b5-poly-L-lysine for the development of antimicrobial biomaterials. Adv. Nanobiomed Res. 3, 2300080 (2023).","journal-title":"Adv. Nanobiomed Res."},{"key":"52595_CR56","doi-asserted-by":"publisher","first-page":"e00453","DOI":"10.1128\/aem.00453-23","volume":"89","author":"C Blanco Nouche","year":"2023","unstructured":"Blanco Nouche, C. et al. The non-ribosomal peptide synthetase-independent siderophore (NIS) rhizobactin produced by Caballeronia mineralivorans PML1(12) confers the ability to weather minerals. Appl. Environ. Microbiol. 89, e00453-e523 (2023).","journal-title":"Appl. Environ. Microbiol."},{"key":"52595_CR57","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1128\/am.18.1.35-40.1969","volume":"18","author":"D Gottlieb","year":"1969","unstructured":"Gottlieb, D. & Nicolas, G. Mode of action of lomofungin. Appl. Microbiol. 18, 321\u2013327 (1969).","journal-title":"Appl. Microbiol."},{"key":"52595_CR58","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1128\/AAC.3.6.716","volume":"3","author":"S-C Kuo","year":"1973","unstructured":"Kuo, S.-C. et al. Lomofungin, an inhibitor of ribonucleic acid synthesis in yeast protoplasts: Its effect on enzyme formation. Antimicrob. Agents Chemother. 3, 716\u2013722 (1973).","journal-title":"Antimicrob. Agents Chemother."},{"key":"52595_CR59","doi-asserted-by":"publisher","first-page":"396","DOI":"10.7164\/antibiotics.35.396","volume":"35","author":"H Sasaki","year":"1982","unstructured":"Sasaki, H. et al. Thiolactomycin, a new antibiotic: II. structure elucidation. J. Antibiot. 35, 396\u2013400 (1982).","journal-title":"J. Antibiot."},{"key":"52595_CR60","doi-asserted-by":"publisher","first-page":"10166","DOI":"10.1021\/ja034540i","volume":"125","author":"MS Brown","year":"2003","unstructured":"Brown, M. S. et al. Biosynthetic origins of the natural product, thiolactomycin: A unique and selective inhibitor of type II dissociated fatty acid synthases. J. Am. Chem. Soc. 125, 10166\u201310167 (2003).","journal-title":"J. Am. Chem. Soc."},{"key":"52595_CR61","doi-asserted-by":"publisher","first-page":"2634","DOI":"10.1021\/acs.orglett.0c00601","volume":"22","author":"H Guo","year":"2020","unstructured":"Guo, H. et al. Gene cluster activation in a bacterial symbiont leads to halogenated angucyclic maduralactomycins and spirocyclic actinospirols. Org. Lett. 22, 2634\u20132638 (2020).","journal-title":"Org. Lett."},{"key":"52595_CR62","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2023.1183073","volume":"10","author":"M Shoaib","year":"2023","unstructured":"Shoaib, M. et al. Identification of fungus-growing termite-associated halogenated-PKS maduralactomycin A as a potential inhibitor of MurF protein of multidrug-resistant Acinetobacter baumannii. Front. Mol. Biosci. 10, 1183073 (2023).","journal-title":"Front. Mol. Biosci."},{"key":"52595_CR63","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/j.funbio.2013.05.003","volume":"117","author":"R Honegger","year":"2013","unstructured":"Honegger, R. et al. Bacterial epibionts and endolichenic actinobacteria and fungi in the lower devonian lichen Chlorolichenomycites salopensis. Fungal Biol. 117, 512\u2013518 (2013).","journal-title":"Fungal Biol."},{"key":"52595_CR64","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00268","volume":"11","author":"H-J Noh","year":"2020","unstructured":"Noh, H.-J. et al. Microbiome in Cladonia squamosa is vertically stratified according to microclimatic conditions. Front. Microbiol. 11, 268 (2020).","journal-title":"Front. Microbiol."},{"key":"52595_CR65","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/j.1574-6968.2012.02508.x","volume":"329","author":"M Cardinale","year":"2012","unstructured":"Cardinale, M. et al. Bacterial taxa associated with the lung lichen Lobaria pulmonaria are differentially shaped by geography and habitat. FEMS Microbiol. Lett. 329, 111\u2013115 (2012).","journal-title":"FEMS Microbiol. Lett."},{"key":"52595_CR66","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1111\/j.1574-6941.2012.01420.x","volume":"82","author":"M Kuffner","year":"2012","unstructured":"Kuffner, M. et al. Effects of season and experimental warming on the bacterial community in a temperate mountain forest soil assessed by 16S rRNA gene pyrosequencing. FEMS Microbiol. Ecol. 82, 551\u2013562 (2012).","journal-title":"FEMS Microbiol. Ecol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-52595-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-52595-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-52595-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T00:02:32Z","timestamp":1784505752000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-52595-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,18]]},"references-count":66,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["52595"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-52595-4","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,18]]},"assertion":[{"value":"8 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"22598"}}