{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T01:20:13Z","timestamp":1783905613636,"version":"3.55.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":61,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82560576, 32260186"],"award-info":[{"award-number":["82560576, 32260186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-026-52775-2","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:27:42Z","timestamp":1778646462000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated pan cancer analysis with breast cancer validation identifies SEC13 homolog as prognostic biomarker and immunotherapy target"],"prefix":"10.1038","volume":"16","author":[{"given":"Haojie","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haocong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyima","family":"Geni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenming","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"52775_CR1","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1016\/S0140-6736(25)01635-6","volume":"406","author":"GBDC Collaborators","year":"2025","unstructured":"Collaborators, G. B. D. C. The global, regional, and national burden of cancer, 1990\u20132023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023. Lancet 406, 1565\u20131586. https:\/\/doi.org\/10.1016\/S0140-6736(25)01635-6 (2025).","journal-title":"Lancet"},{"key":"52775_CR2","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray, F. et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 74, 229\u2013263. https:\/\/doi.org\/10.3322\/caac.21834 (2024).","journal-title":"CA Cancer J. Clin."},{"key":"52775_CR3","doi-asserted-by":"publisher","first-page":"1660125","DOI":"10.3389\/fonc.2025.1660125","volume":"15","author":"L Zhu","year":"2025","unstructured":"Zhu, L. et al. Global, regional, and national burden of 34 cancer groups across 204 countries and territories, 1990\u20132021, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. Front. Oncol. 15, 1660125. https:\/\/doi.org\/10.3389\/fonc.2025.1660125 (2025).","journal-title":"Front. Oncol."},{"key":"52775_CR4","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","volume":"69","author":"RL Siegel","year":"2019","unstructured":"Siegel, R. L., Miller, K. D. & Jemal, A. Cancer statistics, 2019. CA Cancer J. Clin. 69, 7\u201334. https:\/\/doi.org\/10.3322\/caac.21551 (2019).","journal-title":"CA Cancer J. Clin."},{"key":"52775_CR5","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1016\/j.cell.2024.02.041","volume":"187","author":"A Passaro","year":"2024","unstructured":"Passaro, A. et al. Cancer biomarkers: Emerging trends and clinical implications for personalized treatment. Cell 187, 1617\u20131635. https:\/\/doi.org\/10.1016\/j.cell.2024.02.041 (2024).","journal-title":"Cell"},{"key":"52775_CR6","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.molcel.2022.12.011","volume":"83","author":"U Sahu","year":"2023","unstructured":"Sahu, U. & Ben-Sahra, I. GATOR2 rings GATOR1 to speak to mTORC1. Mol. Cell. 83, 6\u20138. https:\/\/doi.org\/10.1016\/j.molcel.2022.12.011 (2023).","journal-title":"Mol. Cell."},{"key":"52775_CR7","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1038\/s41586-022-04939-z","volume":"607","author":"ML Valenstein","year":"2022","unstructured":"Valenstein, M. L. et al. Structure of the nutrient-sensing hub GATOR2. Nature 607, 610\u2013616. https:\/\/doi.org\/10.1038\/s41586-022-04939-z (2022).","journal-title":"Nature"},{"key":"52775_CR8","doi-asserted-by":"publisher","first-page":"111060","DOI":"10.1016\/j.cellsig.2024.111060","volume":"116","author":"Y Yang","year":"2024","unstructured":"Yang, Y. et al. SPOP negatively regulates mTORC1 activity by ubiquitinating SEC13. Cell. Signal. 116, 111060. https:\/\/doi.org\/10.1016\/j.cellsig.2024.111060 (2024).","journal-title":"Cell. Signal."},{"key":"52775_CR9","doi-asserted-by":"publisher","first-page":"167475","DOI":"10.1016\/j.bbadis.2024.167475","volume":"1870","author":"D Wu","year":"2024","unstructured":"Wu, D. et al. SEC13 promotes glycolysis by inhibiting Ubqln1 mediated Pgm1 ubiquitination in ALI. Biochim. Biophys. Acta Mol. Basis Dis. 1870, 167475. https:\/\/doi.org\/10.1016\/j.bbadis.2024.167475 (2024).","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"52775_CR10","doi-asserted-by":"publisher","first-page":"8700","DOI":"10.18632\/aging.204226","volume":"14","author":"G Liu","year":"2022","unstructured":"Liu, G., Wu, X. & Chen, J. Identification and validation of a glycolysis-related gene signature for depicting clinical characteristics and its relationship with tumor immunity in patients with colon cancer. Aging (Albany NY). 14, 8700\u20138718. https:\/\/doi.org\/10.18632\/aging.204226 (2022).","journal-title":"Aging (Albany NY)"},{"key":"52775_CR11","doi-asserted-by":"publisher","unstructured":"Sun, Y. et al. V-ATPase recruitment to ER exit sites switches COPII-mediated transport to lysosomal degradation. Dev. Cell 58, 2761\u20132775 e2765. https:\/\/doi.org\/10.1016\/j.devcel.2023.10.007 (2023).","DOI":"10.1016\/j.devcel.2023.10.007"},{"key":"52775_CR12","doi-asserted-by":"publisher","first-page":"10160","DOI":"10.1038\/s41598-024-60687-2","volume":"14","author":"F Angles","year":"2024","unstructured":"Angles, F., Gupta, V., Wang, C. & Balch, W. E. COPII cage assembly factor SEC13 integrates information flow regulating endomembrane function in response to human variation. Sci. Rep. 14, 10160. https:\/\/doi.org\/10.1038\/s41598-024-60687-2 (2024).","journal-title":"Sci. Rep."},{"key":"52775_CR13","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-025-04205-4","author":"Y Gu","year":"2026","unstructured":"Gu, Y., Yu, Y., Liu, K., Jin, L. & Jiang, G. Integrative analysis of SEC13: a prognostic predictor and immunotherapeutic target. Clin. Transl. Oncol.. https:\/\/doi.org\/10.1007\/s12094-025-04205-4 (2026).","journal-title":"Clin. Transl. Oncol."},{"key":"52775_CR14","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/s41587-020-0546-8","volume":"38","author":"MJ Goldman","year":"2020","unstructured":"Goldman, M. J. et al. Visualizing and interpreting cancer genomics data via the Xena platform. Nat. Biotechnol. 38, 675\u2013678. https:\/\/doi.org\/10.1038\/s41587-020-0546-8 (2020).","journal-title":"Nat. Biotechnol."},{"key":"52775_CR15","doi-asserted-by":"publisher","unstructured":"Shaohua, Y. et al. The role of PLIN3 in prognosis and tumor-associated macrophage infiltration: A pan-cancer analysis. J. Inflamm. Res. 18 https:\/\/doi.org\/10.2147\/jir.S509245 (2025).","DOI":"10.2147\/jir.S509245"},{"key":"52775_CR16","doi-asserted-by":"publisher","first-page":"4200","DOI":"10.1093\/bioinformatics\/btz210","volume":"35","author":"B Ru","year":"2019","unstructured":"Ru, B. et al. TISIDB: an integrated repository portal for tumor-immune system interactions. Bioinformatics 35, 4200\u20134202. https:\/\/doi.org\/10.1093\/bioinformatics\/btz210 (2019).","journal-title":"Bioinformatics"},{"key":"52775_CR17","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/pro.3307","volume":"27","author":"PJ Thul","year":"2018","unstructured":"Thul, P. J. & Lindskog, C. The human protein atlas: A spatial map of the human proteome. Protein Sci. 27, 233\u2013244. https:\/\/doi.org\/10.1002\/pro.3307 (2018).","journal-title":"Protein Sci."},{"key":"52775_CR18","doi-asserted-by":"publisher","first-page":"4101","DOI":"10.1016\/j.csbj.2021.07.014","volume":"19","author":"B Gyorffy","year":"2021","unstructured":"Gyorffy, B. Survival analysis across the entire transcriptome identifies biomarkers with the highest prognostic power in breast cancer. Comput. Struct. Biotechnol. J. 19, 4101\u20134109. https:\/\/doi.org\/10.1016\/j.csbj.2021.07.014 (2021).","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"52775_CR19","doi-asserted-by":"publisher","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","volume":"6","author":"J Gao","year":"2013","unstructured":"Gao, J. et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci. Signal. 6, pl1. https:\/\/doi.org\/10.1126\/scisignal.2004088 (2013).","journal-title":"Sci. Signal."},{"key":"52775_CR20","doi-asserted-by":"publisher","unstructured":"Liu, C. J. et al. GSCA: an integrated platform for gene set cancer analysis at genomic, pharmacogenomic and immunogenomic levels. Brief. Bioinform. 24 https:\/\/doi.org\/10.1093\/bib\/bbac558 (2023).","DOI":"10.1093\/bib\/bbac558"},{"key":"52775_CR21","doi-asserted-by":"publisher","first-page":"3771","DOI":"10.1093\/bioinformatics\/bty411","volume":"34","author":"CJ Liu","year":"2018","unstructured":"Liu, C. J. et al. GSCALite: a web server for gene set cancer analysis. Bioinformatics 34, 3771\u20133772. https:\/\/doi.org\/10.1093\/bioinformatics\/bty411 (2018).","journal-title":"Bioinformatics"},{"key":"52775_CR22","doi-asserted-by":"publisher","first-page":"e238","DOI":"10.1002\/imt2.238","volume":"3","author":"D Chen","year":"2024","unstructured":"Chen, D. et al. Sangerbox 2: Enhanced functionalities and update for a comprehensive clinical bioinformatics data analysis platform. Imeta 3, e238. https:\/\/doi.org\/10.1002\/imt2.238 (2024).","journal-title":"Imeta"},{"key":"52775_CR23","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.1038\/ncomms3612","volume":"4","author":"K Yoshihara","year":"2013","unstructured":"Yoshihara, K. et al. Inferring tumour purity and stromal and immune cell admixture from expression data. Nat. Commun. 4, 2612. https:\/\/doi.org\/10.1038\/ncomms3612 (2013).","journal-title":"Nat. Commun."},{"key":"52775_CR24","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.immuni.2013.10.003","volume":"39","author":"G Bindea","year":"2013","unstructured":"Bindea, G. et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity 39, 782\u2013795. https:\/\/doi.org\/10.1016\/j.immuni.2013.10.003 (2013).","journal-title":"Immunity"},{"key":"52775_CR25","doi-asserted-by":"publisher","first-page":"W509","DOI":"10.1093\/nar\/gkaa407","volume":"48","author":"T Li","year":"2020","unstructured":"Li, T. et al. TIMER2.0 for analysis of tumor-infiltrating immune cells. Nucleic Acids Res. 48, W509\u2013W514. https:\/\/doi.org\/10.1093\/nar\/gkaa407 (2020).","journal-title":"Nucleic Acids Res."},{"key":"52775_CR26","doi-asserted-by":"publisher","first-page":"W556","DOI":"10.1093\/nar\/gkz430","volume":"47","author":"Z Tang","year":"2019","unstructured":"Tang, Z., Kang, B., Li, C., Chen, T. & Zhang, Z. GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis. Nucleic Acids Res. 47, W556\u2013W560. https:\/\/doi.org\/10.1093\/nar\/gkz430 (2019).","journal-title":"Nucleic Acids Res."},{"key":"52775_CR27","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27\u201330. https:\/\/doi.org\/10.1093\/nar\/28.1.27 (2000).","journal-title":"Nucleic Acids Res."},{"key":"52775_CR28","doi-asserted-by":"publisher","first-page":"D457","DOI":"10.1093\/nar\/gkv1070","volume":"44","author":"M Kanehisa","year":"2016","unstructured":"Kanehisa, M., Sato, Y., Kawashima, M., Furumichi, M. & Tanabe, M. KEGG as a reference resource for gene and protein annotation. Nucleic Acids Res. 44, D457\u2013462. https:\/\/doi.org\/10.1093\/nar\/gkv1070 (2016).","journal-title":"Nucleic Acids Res."},{"key":"52775_CR29","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. U S A. 102, 15545\u201315550. https:\/\/doi.org\/10.1073\/pnas.0506580102 (2005).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"52775_CR30","doi-asserted-by":"publisher","unstructured":"Shengshan, X. et al. Interplay of disulfidptosis and the tumor microenvironment across cancers: implications for prognosis and therapeutic responses. BMC Cancer. 25 https:\/\/doi.org\/10.1186\/s12885-025-14246-1 (2025).","DOI":"10.1186\/s12885-025-14246-1"},{"key":"52775_CR31","doi-asserted-by":"publisher","unstructured":"Garnis, C., Buys, T. P. & Lam, W. L. Genetic alteration and gene expression modulation during cancer progression. Mol. Cancer. 3 https:\/\/doi.org\/10.1186\/1476-4598-3-9 (2004).","DOI":"10.1186\/1476-4598-3-9"},{"key":"52775_CR32","doi-asserted-by":"publisher","first-page":"e1006658","DOI":"10.1371\/journal.pcbi.1006658","volume":"15","author":"R Nussinov","year":"2019","unstructured":"Nussinov, R., Jang, H., Tsai, C. J. & Cheng, F. Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers. PLoS Comput. Biol. 15, e1006658. https:\/\/doi.org\/10.1371\/journal.pcbi.1006658 (2019).","journal-title":"PLoS Comput. Biol."},{"key":"52775_CR33","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1016\/j.cell.2012.05.003","volume":"149","author":"KD Meyer","year":"2012","unstructured":"Meyer, K. D. et al. Comprehensive analysis of mRNA methylation reveals enrichment in 3\u2019 UTRs and near stop codons. Cell 149, 1635\u20131646. https:\/\/doi.org\/10.1016\/j.cell.2012.05.003 (2012).","journal-title":"Cell"},{"key":"52775_CR34","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/s41568-025-00889-6","volume":"26","author":"H Luo","year":"2026","unstructured":"Luo, H., Kharas, M. G. & Jaffrey, S. R. N(6)-Methyladenosine: an RNA modification as a central regulator of cancer. Nat. Rev. Cancer. 26, 118\u2013136. https:\/\/doi.org\/10.1038\/s41568-025-00889-6 (2026).","journal-title":"Nat. Rev. Cancer"},{"key":"52775_CR35","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1001\/jamaoncol.2019.1549","volume":"5","author":"S Lu","year":"2019","unstructured":"Lu, S. et al. Comparison of biomarker modalities for predicting response to PD-1\/PD-L1 checkpoint blockade: A systematic review and meta-analysis. JAMA Oncol. 5, 1195\u20131204. https:\/\/doi.org\/10.1001\/jamaoncol.2019.1549 (2019).","journal-title":"JAMA Oncol."},{"key":"52775_CR36","doi-asserted-by":"publisher","first-page":"14597","DOI":"10.1007\/s00432-023-05268-y","volume":"149","author":"P Ma","year":"2023","unstructured":"Ma, P. & Sun, W. Integrated single-cell and bulk sequencing analyses with experimental validation identify the prognostic and immunological implications of CD226 in pan-cancer. J. Cancer Res. Clin. Oncol. 149, 14597\u201314617. https:\/\/doi.org\/10.1007\/s00432-023-05268-y (2023).","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"52775_CR37","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","volume":"168","author":"RA Saxton","year":"2017","unstructured":"Saxton, R. A. & Sabatini, D. M. mTOR signaling in growth, metabolism, and disease. Cell 168, 960\u2013976. https:\/\/doi.org\/10.1016\/j.cell.2017.02.004 (2017).","journal-title":"Cell"},{"key":"52775_CR38","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.3892\/ijo.2016.3395","volume":"48","author":"Y Togo","year":"2016","unstructured":"Togo, Y. et al. Genomic profiling of the genes on chromosome 3p in sporadic clear cell renal cell carcinoma. Int. J. Oncol. 48, 1571\u20131580. https:\/\/doi.org\/10.3892\/ijo.2016.3395 (2016).","journal-title":"Int. J. Oncol."},{"key":"52775_CR39","doi-asserted-by":"publisher","unstructured":"Jiang, C. et al. Ring domains are essential for GATOR2-dependent mTORC1 activation. Mol. Cell 83, 74\u201389 e79. https:\/\/doi.org\/10.1016\/j.molcel.2022.11.021 (2023).","DOI":"10.1016\/j.molcel.2022.11.021"},{"key":"52775_CR40","doi-asserted-by":"publisher","first-page":"106986","DOI":"10.1016\/j.isci.2023.106986","volume":"26","author":"EJ Rodger","year":"2023","unstructured":"Rodger, E. J. et al. An epigenetic signature of advanced colorectal cancer metastasis. iScience 26, 106986. https:\/\/doi.org\/10.1016\/j.isci.2023.106986 (2023).","journal-title":"iScience"},{"key":"52775_CR41","first-page":"1721","volume":"8","author":"MC Daly","year":"1993","unstructured":"Daly, M. C. et al. A homozygous deletion on chromosome 3 in a small cell lung cancer cell line correlates with a region of tumor suppressor activity. Oncogene 8, 1721\u20131729 (1993).","journal-title":"Oncogene"},{"key":"52775_CR42","first-page":"3439","volume":"61","author":"F Tschentscher","year":"2001","unstructured":"Tschentscher, F. et al. Partial deletions of the long and short arm of chromosome 3 point to two tumor suppressor genes in uveal melanoma. Cancer Res. 61, 3439\u20133442 (2001).","journal-title":"Cancer Res."},{"key":"52775_CR43","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.trecan.2020.02.003","volume":"6","author":"J Cao","year":"2020","unstructured":"Cao, J. &  Yan, Q. Cancer epigenetics, tumor immunity, and immunotherapy. Trends Cancer. 6, 580\u2013592. https:\/\/doi.org\/10.1016\/j.trecan.2020.02.003 (2020).","journal-title":"Trends Cancer"},{"key":"52775_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2025.08.057","author":"Y Lu","year":"2025","unstructured":"Lu, Y. et al. Epigenetic orchestration of cancer-immune dynamics: mechanisms, technologies, and clinical advancements. J. Adv. Res. https:\/\/doi.org\/10.1016\/j.jare.2025.08.057 (2025).","journal-title":"J. Adv. Res."},{"key":"52775_CR45","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.cell.2013.03.008","volume":"153","author":"H Shen","year":"2013","unstructured":"Shen, H. & Laird, P. W. Interplay between the cancer genome and epigenome. Cell 153, 38\u201355. https:\/\/doi.org\/10.1016\/j.cell.2013.03.008 (2013).","journal-title":"Cell"},{"key":"52775_CR46","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ccr.2012.06.008","volume":"22","author":"JS You","year":"2012","unstructured":"You, J. S. & Jones, P. A. Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell. 22, 9\u201320. https:\/\/doi.org\/10.1016\/j.ccr.2012.06.008 (2012).","journal-title":"Cancer Cell."},{"key":"52775_CR47","doi-asserted-by":"publisher","first-page":"1681555","DOI":"10.3389\/fcell.2025.1681555","volume":"13","author":"PS Ramalingam","year":"2025","unstructured":"Ramalingam, P. S. et al. The epitranscriptome meets non-coding RNA: m6A-mediated regulation in oncogenesis and therapy. Front. Cell. Dev. Biol. 13, 1681555. https:\/\/doi.org\/10.3389\/fcell.2025.1681555 (2025).","journal-title":"Front. Cell. Dev. Biol."},{"key":"52775_CR48","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1101\/gad.348508.121","volume":"35","author":"K Tsai","year":"2021","unstructured":"Tsai, K. et al. Epitranscriptomic addition of m(6)A regulates HIV-1 RNA stability and alternative splicing. Genes Dev. 35, 992\u20131004. https:\/\/doi.org\/10.1101\/gad.348508.121 (2021).","journal-title":"Genes Dev."},{"key":"52775_CR49","doi-asserted-by":"publisher","first-page":"4685","DOI":"10.1158\/1078-0432.CCR-21-0327","volume":"27","author":"L Marcus","year":"2021","unstructured":"Marcus, L. et al. FDA approval summary: Pembrolizumab for the treatment of tumor mutational burden-high solid tumors. Clin. Cancer Res. 27, 4685\u20134689. https:\/\/doi.org\/10.1158\/1078-0432.CCR-21-0327 (2021).","journal-title":"Clin. Cancer Res."},{"key":"52775_CR50","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1038\/s43018-025-00986-3","volume":"6","author":"K Aliazis","year":"2025","unstructured":"Aliazis, K. et al. The tumor microenvironment\u2019s role in the response to immune checkpoint blockade. Nat. Cancer. 6, 924\u2013937. https:\/\/doi.org\/10.1038\/s43018-025-00986-3 (2025).","journal-title":"Nat. Cancer"},{"key":"52775_CR51","doi-asserted-by":"publisher","unstructured":"Thorsson, V. et al. The immune landscape of cancer. Immunity 48, 812\u2013830 e814. https:\/\/doi.org\/10.1016\/j.immuni.2018.03.023 (2018).","DOI":"10.1016\/j.immuni.2018.03.023"},{"key":"52775_CR52","doi-asserted-by":"publisher","first-page":"868695","DOI":"10.3389\/fphar.2022.868695","volume":"13","author":"SK Kim","year":"2022","unstructured":"Kim, S. K. & Cho, S. W. The evasion mechanisms of cancer immunity and drug intervention in the tumor microenvironment. Front. Pharmacol. 13, 868695. https:\/\/doi.org\/10.3389\/fphar.2022.868695 (2022).","journal-title":"Front. Pharmacol."},{"key":"52775_CR53","doi-asserted-by":"publisher","unstructured":"Puyu, W., Shengshan, X., Qian, G. & Yulin, Z. Discovery of PAK2 as a key regulator of cancer stem cell in head and neck squamous cell carcinoma using multi-omic techniques. Stem Cells Int. https:\/\/doi.org\/10.1155\/sci\/1325262 (2025).","DOI":"10.1155\/sci\/1325262"},{"key":"52775_CR54","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2025.6508","author":"X Shengshan","year":"2026","unstructured":"Shengshan, X., Qian, G. & Zhuming, L. Physical activity, lifestyle, and cancer risk. JAMA Oncol. https:\/\/doi.org\/10.1001\/jamaoncol.2025.6508 (2026).","journal-title":"JAMA Oncol."},{"key":"52775_CR55","doi-asserted-by":"publisher","unstructured":"Yihan, W. et al. Antibody-drug conjugates as immuno-oncology agents in colorectal cancer: targets, payloads, and therapeutic synergies. Front. Immunol. 16 https:\/\/doi.org\/10.3389\/fimmu.2025.1678907 (2025).","DOI":"10.3389\/fimmu.2025.1678907"},{"key":"52775_CR56","doi-asserted-by":"publisher","unstructured":"Shengshan, X. et al. A novel signature integrated of immunoglobulin, glycosylation and anti-viral genes to predict prognosis for breast cancer. Front. Genet. 13 https:\/\/doi.org\/10.3389\/fgene.2022.834731 (2022).","DOI":"10.3389\/fgene.2022.834731"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-52775-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-52775-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-52775-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:53:14Z","timestamp":1783903994000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-026-52775-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,13]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["52775"],"URL":"https:\/\/doi.org\/10.1038\/s41598-026-52775-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,13]]},"assertion":[{"value":"6 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The Ethics Committee of The First Affiliated Hospital of Xinjiang Medical University (No. 230714-07) approved the human studies, which were performed in accordance with local legislation and institutional requirements; all participants signed informed consent forms prior to enrollment.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics statement"}}],"article-number":"21809"}}