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This study investigated the performance of venturi-inspired aspiration thrombectomy devices in a simplified cerebral artery segment representative of the middle cerebral artery (MCA), a frequent site of occlusion. Five designs (30\u00b0, 45\u00b0, 60\u00b0 venturi, 7\/11\u00b0 taper, and cylindrical control) were assessed using a combined computational\u2013experimental framework. On the computational side, unsteady Reynolds-averaged Navier\u2013Stokes (URANS) simulations were performed in ANSYS Fluent 19.2 with k\u2013\u03b5 turbulence closure. Blood\u2013clot interactions were modeled using a Volume of Fluid (VOF) multiphase formulation with Carreau\u2013Yasuda non-Newtonian rheology. In vitro, stereolithography-fabricated prototypes were tested with porcine thrombi in silicone arterial phantoms. CFD predicted extraction times of 2.12\u00a0s for the control and 1.64\u00a0s for the 45\u00b0 venturi, with efficiency plateauing beyond 45\u00b0. Experimental results confirmed this trend, showing the 45\u00b0 design as optimal and all venturi devices outperforming the control. Fragmentation analysis revealed a trade-off, with the 60\u00b0 venturi producing more than twice the fragments of the 30\u00b0. 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