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In this study, silver quantum dots (Ag QDs) were synthesized via an eco\u2011friendly green route using the aqueous bulb extract of\n                    <jats:italic>Drimia maritima<\/jats:italic>\n                    (L.) Stearn (\n                    <jats:italic>D. maritima)<\/jats:italic>\n                    , which served as a natural reducing and stabilizing agent. Physicochemical characterization confirmed the successful formation of well\u2011defined nanoscale Ag QDs with appropriate structural features. The antioxidant potential of the biosynthesized Ag QDs was systematically evaluated using various in vitro assays, including DPPH, ABTS, nitric oxide scavenging, ferric reducing antioxidant power (FRAP), and metal\u2011chelating activity. The results revealed a dual antioxidant behavior: Ag QDs showed enhanced free\u2011radical scavenging capacity, whereas the crude extract exhibited stronger reducing and chelating activities. The anticancer efficacy of Ag QDs was assessed in MCF\u20117 human breast cancer cells. MTT assay results revealed a significant cytotoxic effect, with an IC\u2085\u2080 value of approximately 14.7\u00a0\u00b5g\/mL, approaching that of cisplatin and markedly lower than that of the crude extract. Mechanistic studies indicated that Ag QDs induced excessive intracellular ROS generation, leading to mitochondrial dysfunction and activation of the intrinsic apoptotic pathway, characterized by pronounced caspase\u20119 and caspase\u20113 activation. These effects were accompanied by modulation of apoptosis\u2011 and redox\u2011related gene expression, favoring pro\u2011apoptotic signaling. Confocal microscopy further confirmed apoptotic morphology, including chromatin condensation and cytoskeletal disruption. Overall,\n                    <jats:italic>D. maritima<\/jats:italic>\n                    \u2011derived Ag QDs emerge as potent pro\u2011oxidant nanostructures capable of inducing ROS\u2011mediated mitochondrial apoptosis, highlighting their promise as a sustainable nanotherapeutic platform for breast cancer treatment.\n                  <\/jats:p>","DOI":"10.1038\/s41598-026-53467-7","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T13:26:01Z","timestamp":1779369961000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Plant\u2011mediated silver quantum dots from Drimia maritima: antioxidant modulation and ROS\u2011induced apoptosis in breast cancer cells"],"prefix":"10.1038","volume":"16","author":[{"given":"Narges","family":"Jalali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fateme","family":"Aghamir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghasem","family":"Eghlima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zinab Moradi","family":"Alvand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"53467_CR1","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/S0254-6272(17)30036-5","volume":"37","author":"M Bozorgi","year":"2017","unstructured":"Bozorgi, M., Amin, G., Shekarchi, M. & Rahimi, R. 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